LRPAP1

Functionⁱ

Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.1 Publication

GO - Molecular functionⁱ

amyloid-beta binding
Source: ARUK-UCL
Traceable author statementⁱ
- 22383525
heparin binding Source: UniProtKB-KW
lipase binding Source: Ensembl
low-density lipoprotein particle receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 7774585
receptor antagonist activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8083232
signaling receptor binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 14645246
very-low-density lipoprotein particle receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8083232

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

extracellular negative regulation of signal transduction
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 14645246
negative regulation of amyloid-beta clearance
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 19098903
negative regulation of cell death
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 23386614
negative regulation of protein binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 8083232
negative regulation of receptor internalization
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 23386614
negative regulation of very-low-density lipoprotein particle clearance
Source: BHF-UCL
Inferred from direct assayⁱ
- 8083232
positive regulation of amyloid-beta clearance
Source: ARUK-UCL
Traceable author statementⁱ
- 22383525
regulation of receptor-mediated endocytosis
Source: UniProtKB
Inferred from direct assayⁱ
- 7774585
transcytosis
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 26005850

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Heparin-binding

Molecular function

Heparin-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-2-macroglobulin receptor-associated protein Short name: Alpha-2-MRAP Alternative name(s): Low density lipoprotein receptor-related protein-associated protein 1 Short name: RAP
Gene namesⁱ	Name:LRPAP1 Synonyms:A2MRAP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163956.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6701 LRPAP1
MIMⁱ	104225 gene
neXtProtⁱ	NX_P30533

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Endosome, Golgi apparatus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	283	H → A: Strongly reduced interaction with LRP1; when associated with A-291; A-293; A-302; A-307 and A-341. 1 Publication	1
Mutagenesisⁱ	291	H → A: Strongly reduced interaction with LRP1; when associated with A-283; A-293; A-302; A-307 and A-341. 1 Publication	1
Mutagenesisⁱ	293	H → A: Strongly reduced interaction with LRP1; when associated with A-283; A-291; A-302; A-307 and A-341. 1 Publication	1
Mutagenesisⁱ	302	H → A: Strongly reduced interaction with LRP1; when associated with A-283; A-291; A-293; A-307 and A-341. 1 Publication	1
Mutagenesisⁱ	307	H → A: Strongly reduced interaction with LRP1; when associated with A-283; A-291; A-293; A-302 and A-341. 1 Publication	1
Mutagenesisⁱ	341	H → A: Strongly reduced interaction with LRP1; when associated with A-283; A-291; A-293; A-302 and A-307. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4043
MalaCards human disease database More...MalaCardsⁱ	LRPAP1
MIMⁱ	615431 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000163956
Orphanetⁱ	98619 Rare isolated myopia
PharmGKBⁱ	PA30458

Polymorphism and mutation databases

BioMutaⁱ	LRPAP1
DMDMⁱ	231539

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 34	Sequence analysisAdd BLAST		34
ChainⁱPRO_0000020724	35 – 357	Alpha-2-macroglobulin receptor-associated proteinAdd BLAST		323

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	50	PhosphoserineBy similarity	1
Modified residueⁱ	135	PhosphoserineBy similarity	1
Modified residueⁱ	248	PhosphothreonineCombined sources	1
Glycosylationⁱ	268	N-linked (GlcNAc...) asparagine1 Publication	1

Post-translational modificationⁱ

N-glycosylated.3 Publications

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P30533
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P30533
PaxDbⁱ	P30533
PeptideAtlas More...PeptideAtlasⁱ	P30533
PRIDEⁱ	P30533
ProteomicsDBⁱ	54716
TopDownProteomicsⁱ	P30533

PTM databases

GlyConnectⁱ	1004
iPTMnetⁱ	P30533
PhosphoSitePlusⁱ	P30533

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163956 Expressed in 233 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_LRPAP1
ExpressionAtlasⁱ	P30533 baseline and differential
Genevisibleⁱ	P30533 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025518 HPA008001

HPAⁱ

CAB025518
HPA008001

Interactionⁱ

Subunit structureⁱ

Interacts with the LRP1/alpha-2-macroglobulin receptor heavy and light chains; the interaction is transient and coincides with a reduction of ligand binding by the receptor (PubMed:1712782, PubMed:1400426, PubMed:7774585, PubMed:16938309, PubMed:16678114). Interacts with LRP2/glycoprotein 330 (PubMed:1400426). Interacts with LRP1B; binding is followed by internalization and degradation (PubMed:11384978). Interacts with LDLR (PubMed:16630895).7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SORT1	Q99523	2	EBI-715927,EBI-1057058
VLDLR	P98155	5	EBI-715927,EBI-9004309

GO - Molecular functionⁱ

lipase binding Source: Ensembl
low-density lipoprotein particle receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 7774585
receptor antagonist activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8083232
signaling receptor binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 14645246
very-low-density lipoprotein particle receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8083232

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110221, 24 interactors
Database of interacting proteins More...DIPⁱ	DIP-39355N
IntActⁱ	P30533, 18 interactors
Molecular INTeraction database More...MINTⁱ	P30533
STRINGⁱ	9606.ENSP00000421922

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	53 – 56	Combined sources	4
Helixⁱ	57 – 68	Combined sources	12
Helixⁱ	73 – 99	Combined sources	27
Helixⁱ	107 – 122	Combined sources	16
Beta strandⁱ	124 – 126	Combined sources	3
Beta strandⁱ	127 – 130	Combined sources	4
Helixⁱ	149 – 161	Combined sources	13
Helixⁱ	166 – 195	Combined sources	30
Beta strandⁱ	208 – 210	Combined sources	3
Beta strandⁱ	213 – 216	Combined sources	4
Helixⁱ	217 – 243	Combined sources	27
Beta strandⁱ	246 – 249	Combined sources	4
Helixⁱ	255 – 265	Combined sources	11
Helixⁱ	271 – 311	Combined sources	41
Turnⁱ	314 – 316	Combined sources	3
Helixⁱ	317 – 353	Combined sources	37

Show more details

3D structure databases

ProteinModelPortalⁱ	P30533
SMRⁱ	P30533
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P30533

EvolutionaryTraceⁱ

P30533

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	237 – 353	LDL receptor bindingSequence analysisAdd BLAST		117

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	219 – 310	Sequence analysisAdd BLAST		92

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	354 – 357	Prevents secretion from ER1 Publication		4

Sequence similaritiesⁱ

Belongs to the alpha-2-MRAP family.Curated

Keywords - Domainⁱ

Coiled coil, Signal

Phylogenomic databases

eggNOGⁱ	KOG3956 Eukaryota ENOG410YJFP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004855
HOGENOMⁱ	HOG000033926
HOVERGENⁱ	HBG000197
InParanoidⁱ	P30533
KEGG Orthology (KO) More...KOⁱ	K22290
OMAⁱ	NQVWEKA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EO4
PhylomeDBⁱ	P30533
TreeFamⁱ	TF320678

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14806 RAP_D1, 1 hit cd14807 RAP_D2, 1 hit cd14808 RAP_D3, 1 hit
Gene3Dⁱ	1.20.81.10, 3 hits
InterProⁱ	View protein in InterPro IPR038003 A2-macroglobuin_RAP IPR010483 Alpha_2_MRAP_C IPR009066 MG_RAP_rcpt_1 IPR038001 RAP_D2 IPR037999 RAP_D3 IPR036744 RAP_sf
PANTHERⁱ	PTHR16560 PTHR16560, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06401 Alpha-2-MRAP_C, 1 hit PF06400 Alpha-2-MRAP_N, 1 hit
SUPFAMⁱ	SSF47045 SSF47045, 3 hits
PROSITEⁱ	View protein in PROSITE PS00014 ER_TARGET, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P30533-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPRRVRSFL RGLPALLLLL LFLGPWPAAS HGGKYSREKN QPKPSPKRES 
        60         70         80         90        100
GEEFRMEKLN QLWEKAQRLH LPPVRLAELH ADLKIQERDE LAWKKLKLDG 
       110        120        130        140        150
LDEDGEKEAR LIRNLNVILA KYGLDGKKDA RQVTSNSLSG TQEDGLDDPR 
       160        170        180        190        200
LEKLWHKAKT SGKFSGEELD KLWREFLHHK EKVHEYNVLL ETLSRTEEIH 
       210        220        230        240        250
ENVISPSDLS DIKGSVLHSR HTELKEKLRS INQGLDRLRR VSHQGYSTEA 
       260        270        280        290        300
EFEEPRVIDL WDLAQSANLT DKELEAFREE LKHFEAKIEK HNHYQKQLEI 
       310        320        330        340        350
AHEKLRHAES VGDGERVSRS REKHALLEGR TKELGYTVKK HLQDLSGRIS 

RARHNEL

Length:357

Mass (Da):41,466

Last modified:April 1, 1993 - v1

Checksum:ⁱD56A7DA754125CFA

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6REW6	D6REW6_HUMAN		Alpha-2-macroglobulin receptor-asso... Alpha-2-macroglobulin receptor-associated protein	LRPAP1	105	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	100	G → D in BAD96247 (Ref. 3) Curated	1
Sequence conflictⁱ	183	V → A in BAD96224 (Ref. 3) Curated	1
Sequence conflictⁱ	339	K → M in BAD96247 (Ref. 3) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050660	114	N → S. Corresponds to variant dbSNP:rs2228158Ensembl.		1
Natural variantⁱVAR_011821	311	V → M1 PublicationCorresponds to variant dbSNP:rs1800493Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M63959 mRNA Translation: AAA51553.1 AF035767 AF035766 Genomic DNA Translation: AAC67373.1 AK222504 mRNA Translation: BAD96224.1 AK222527 mRNA Translation: BAD96247.1 AL590235 Genomic DNA No translation available. CH471131 Genomic DNA Translation: EAW82460.1 CH471131 Genomic DNA Translation: EAW82461.1 BC105074 mRNA Translation: AAI05075.1 BC112067 mRNA Translation: AAI12068.1 U06976 Genomic DNA Translation: AAA87889.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3371.1
PIRⁱ	A39875
NCBI Reference Sequences More...RefSeqⁱ	NP_002328.1, NM_002337.3
UniGeneⁱ	Hs.40966

Genome annotation databases

Ensemblⁱ	ENST00000500728; ENSP00000421922; ENSG00000163956
GeneIDⁱ	4043
KEGGⁱ	hsa:4043
UCSC genome browser More...UCSCⁱ	uc003ghh.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P30533	Uncharacterized protein		RHIBE		435	UniRef90_P30533
Uncharacterized protein		MACFA		415
Uncharacterized protein		MACMU		358
LDL receptor related protein associated protein 1		GORGO		365
Uncharacterized protein		CERAT		360
+35

Protein	Similar proteins		Species	Score	Length	Source
P30533	Alpha-2-macroglobulin receptor-associated protein		MOUSE		360	UniRef50_P30533
Alpha-2-macroglobulin receptor-associated protein		RAT		360
Uncharacterized protein		RHIBE		435
Uncharacterized protein		MACFA		415
Uncharacterized protein		MACMU		358
+167

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M63959 mRNA Translation: AAA51553.1 AF035767 AF035766 Genomic DNA Translation: AAC67373.1 AK222504 mRNA Translation: BAD96224.1 AK222527 mRNA Translation: BAD96247.1 AL590235 Genomic DNA No translation available. CH471131 Genomic DNA Translation: EAW82460.1 CH471131 Genomic DNA Translation: EAW82461.1 BC105074 mRNA Translation: AAI05075.1 BC112067 mRNA Translation: AAI12068.1 U06976 Genomic DNA Translation: AAA87889.1
CCDSⁱ	CCDS3371.1
PIRⁱ	A39875
RefSeqⁱ	NP_002328.1, NM_002337.3
UniGeneⁱ	Hs.40966

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LRE	NMR	-	A	51-131	[»]
	1NRE	NMR	-	A	51-131	[»]
	1OP1	NMR	-	A	51-132	[»]
	1OV2	NMR	-	A	35-133	[»]
	2FCW	X-ray	1.26	A	249-357	[»]
	2FTU	NMR	-	A	240-357	[»]
	2FYL	NMR	-	A	51-131	[»]
	2P01	NMR	-	A	35-357	[»]
	2P03	NMR	-	A	35-357	[»]
ProteinModelPortalⁱ	P30533
SMRⁱ	P30533
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110221, 24 interactors
DIPⁱ	DIP-39355N
IntActⁱ	P30533, 18 interactors
MINTⁱ	P30533
STRINGⁱ	9606.ENSP00000421922

PTM databases

GlyConnectⁱ	1004
iPTMnetⁱ	P30533
PhosphoSitePlusⁱ	P30533

Polymorphism and mutation databases

BioMutaⁱ	LRPAP1
DMDMⁱ	231539

Proteomic databases

EPDⁱ	P30533
MaxQBⁱ	P30533
PaxDbⁱ	P30533
PeptideAtlasⁱ	P30533
PRIDEⁱ	P30533
ProteomicsDBⁱ	54716
TopDownProteomicsⁱ	P30533

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000500728; ENSP00000421922; ENSG00000163956
GeneIDⁱ	4043
KEGGⁱ	hsa:4043
UCSCⁱ	uc003ghh.5 human

Organism-specific databases

CTDⁱ	4043
DisGeNETⁱ	4043
EuPathDBⁱ	HostDB:ENSG00000163956.10
GeneCardsⁱ	LRPAP1
HGNCⁱ	HGNC:6701 LRPAP1
HPAⁱ	CAB025518 HPA008001
MalaCardsⁱ	LRPAP1
MIMⁱ	104225 gene 615431 phenotype
neXtProtⁱ	NX_P30533
OpenTargetsⁱ	ENSG00000163956
Orphanetⁱ	98619 Rare isolated myopia
PharmGKBⁱ	PA30458
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3956 Eukaryota ENOG410YJFP LUCA
GeneTreeⁱ	ENSGT00390000004855
HOGENOMⁱ	HOG000033926
HOVERGENⁱ	HBG000197
InParanoidⁱ	P30533
KOⁱ	K22290
OMAⁱ	NQVWEKA
OrthoDBⁱ	EOG091G0EO4
PhylomeDBⁱ	P30533
TreeFamⁱ	TF320678

Miscellaneous databases

ChiTaRSⁱ	LRPAP1 human
EvolutionaryTraceⁱ	P30533
GeneWikiⁱ	LDL-receptor-related_protein_associated_protein
GenomeRNAiⁱ	4043
Protein Ontology More...PROⁱ	PR:P30533
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163956 Expressed in 233 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_LRPAP1
ExpressionAtlasⁱ	P30533 baseline and differential
Genevisibleⁱ	P30533 HS

Family and domain databases

CDDⁱ	cd14806 RAP_D1, 1 hit cd14807 RAP_D2, 1 hit cd14808 RAP_D3, 1 hit
Gene3Dⁱ	1.20.81.10, 3 hits
InterProⁱ	View protein in InterPro IPR038003 A2-macroglobuin_RAP IPR010483 Alpha_2_MRAP_C IPR009066 MG_RAP_rcpt_1 IPR038001 RAP_D2 IPR037999 RAP_D3 IPR036744 RAP_sf
PANTHERⁱ	PTHR16560 PTHR16560, 1 hit
Pfamⁱ	View protein in Pfam PF06401 Alpha-2-MRAP_C, 1 hit PF06400 Alpha-2-MRAP_N, 1 hit
SUPFAMⁱ	SSF47045 SSF47045, 3 hits
PROSITEⁱ	View protein in PROSITE PS00014 ER_TARGET, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AMRP_HUMAN
Accessionⁱ	P30533Primary (citable) accession number: P30533 Secondary accession number(s): D3DVR9 , Q2M310, Q53HQ3, Q53HS6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	April 1, 1993
	Last modified:	October 10, 2018
	This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P30533 (AMRP_HUMAN)

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Alpha-2-macroglobulin receptor-associated protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Golgi apparatus

Endosome

Other locations

Endoplasmic reticulum

Endosome

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ