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UniProtKB - P30533 (AMRP_HUMAN)

Entry version 197 (23 Feb 2022)
Sequence version 1 (01 Apr 1993)
Previous versions | rss
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Protein

Alpha-2-macroglobulin receptor-associated protein

Gene

LRPAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P30533

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P30533

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-2-macroglobulin receptor-associated proteinCurated
Short name:
Alpha-2-MRAP
Alternative name(s):
Low density lipoprotein receptor-related protein-associated protein 1
Short name:
RAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRPAP1Imported
Synonyms:A2MRAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6701, LRPAP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		104225, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P30533

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163956

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myopia 23, autosomal recessive (MYP23)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi283H → A: Strongly reduced interaction with LRP1; when associated with A-291; A-293; A-302; A-307 and A-341. 1 Publication1
Mutagenesisi290K → A: Reduces competition with MAPT for binding to LRP1; when associated with A-304. 1 Publication1
Mutagenesisi291H → A: Strongly reduced interaction with LRP1; when associated with A-283; A-293; A-302; A-307 and A-341. 1 Publication1
Mutagenesisi293H → A: Strongly reduced interaction with LRP1; when associated with A-283; A-291; A-302; A-307 and A-341. 1 Publication1
Mutagenesisi302H → A: Strongly reduced interaction with LRP1; when associated with A-283; A-291; A-293; A-307 and A-341. 1 Publication1
Mutagenesisi304K → A: Reduces competition with MAPT for binding to LRP1; when associated with A-290. 1 Publication1
Mutagenesisi307H → A: Strongly reduced interaction with LRP1; when associated with A-283; A-291; A-293; A-302 and A-341. 1 Publication1
Mutagenesisi341H → A: Strongly reduced interaction with LRP1; when associated with A-283; A-291; A-293; A-302 and A-307. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4043

MalaCards human disease database

More...MalaCardsi		LRPAP1
MIMi615431, phenotype

Open Targets

More...OpenTargetsi		ENSG00000163956

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		98619, Rare isolated myopia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30458

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P30533, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LRPAP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		231539

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002072435 – 357Alpha-2-macroglobulin receptor-associated proteinAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50PhosphoserineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei248PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi268N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.3 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P30533

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P30533

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P30533

MaxQB - The MaxQuant DataBase

More...MaxQBi		P30533

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P30533

PeptideAtlas

More...PeptideAtlasi		P30533

PRoteomics IDEntifications database

More...PRIDEi		P30533

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54716

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P30533

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1004, 12 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P30533, 2 sites, 11 N-linked glycans (1 site), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P30533

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P30533

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163956, Expressed in caudate nucleus and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P30533, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P30533, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163956, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the LRP1/alpha-2-macroglobulin receptor heavy and light chains; the interaction is transient and coincides with a reduction of ligand binding by the receptor (PubMed:1712782, PubMed:1400426, PubMed:7774585, PubMed:16938309, PubMed:16678114, PubMed:32296178).

Interacts with LRP2/glycoprotein 330 (PubMed:1400426).

Interacts with LRP1B; binding is followed by internalization and degradation (PubMed:11384978).

Interacts with LDLR (PubMed:16630895).

Interacts with SORL1 (PubMed:8940146, PubMed:11294867, PubMed:12530537, PubMed:15053742, PubMed:15364913, PubMed:26858303).

Interacts with LRP1; this interaction is followed by rapid internalization (PubMed:15053742).

14 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110221, 137 interactors

Database of interacting proteins

More...DIPi		DIP-39355N

Protein interaction database and analysis system

More...IntActi		P30533, 36 interactors

Molecular INTeraction database

More...MINTi		P30533

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000421922

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P30533, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1357
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P30533

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P30533

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P30533

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni32 – 52DisorderedSequence analysisAdd BLAST21
Regioni237 – 353LDL receptor bindingSequence analysisAdd BLAST117

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili219 – 310Sequence analysisAdd BLAST92

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi354 – 357Prevents secretion from ER1 Publication4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 52Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alpha-2-MRAP family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3956, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004855

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_064512_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P30533

Identification of Orthologs from Complete Genome Data

More...OMAi		EKHQHYQ

Database of Orthologous Groups

More...OrthoDBi		908725at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P30533

TreeFam database of animal gene trees

More...TreeFami		TF320678

Family and domain databases

Conserved Domains Database

More...CDDi		cd14806, RAP_D1, 1 hit
cd14807, RAP_D2, 1 hit
cd14808, RAP_D3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.81.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038003, A2-macroglobuin_RAP
IPR010483, Alpha_2_MRAP_C
IPR009066, MG_RAP_rcpt_1
IPR038001, RAP_D2
IPR037999, RAP_D3
IPR036744, RAP_sf

The PANTHER Classification System

More...PANTHERi		PTHR16560, PTHR16560, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06401, Alpha-2-MRAP_C, 1 hit
PF06400, Alpha-2-MRAP_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47045, SSF47045, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00014, ER_TARGET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P30533-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPRRVRSFL RGLPALLLLL LFLGPWPAAS HGGKYSREKN QPKPSPKRES 
        60         70         80         90        100
GEEFRMEKLN QLWEKAQRLH LPPVRLAELH ADLKIQERDE LAWKKLKLDG 
       110        120        130        140        150
LDEDGEKEAR LIRNLNVILA KYGLDGKKDA RQVTSNSLSG TQEDGLDDPR 
       160        170        180        190        200
LEKLWHKAKT SGKFSGEELD KLWREFLHHK EKVHEYNVLL ETLSRTEEIH 
       210        220        230        240        250
ENVISPSDLS DIKGSVLHSR HTELKEKLRS INQGLDRLRR VSHQGYSTEA 
       260        270        280        290        300
EFEEPRVIDL WDLAQSANLT DKELEAFREE LKHFEAKIEK HNHYQKQLEI 
       310        320        330        340        350
AHEKLRHAES VGDGERVSRS REKHALLEGR TKELGYTVKK HLQDLSGRIS 

RARHNEL
Length:357
Mass (Da):41,466
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD56A7DA754125CFA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IRQ7A0A3B3IRQ7_HUMAN
Alpha-2-macroglobulin receptor-asso...
LRPAP1
279Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REW6D6REW6_HUMAN
Alpha-2-macroglobulin receptor-asso...
LRPAP1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti100G → D in BAD96247 (Ref. 3) Curated1
Sequence conflicti183V → A in BAD96224 (Ref. 3) Curated1
Sequence conflicti339K → M in BAD96247 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050660114N → S. Corresponds to variant dbSNP:rs2228158Ensembl.1
Natural variantiVAR_011821311V → M1 PublicationCorresponds to variant dbSNP:rs1800493Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M63959 mRNA Translation: AAA51553.1
AF035767 AF035766 Genomic DNA Translation: AAC67373.1
AK222504 mRNA Translation: BAD96224.1
AK222527 mRNA Translation: BAD96247.1
AL590235 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82460.1
CH471131 Genomic DNA Translation: EAW82461.1
BC105074 mRNA Translation: AAI05075.1
BC112067 mRNA Translation: AAI12068.1
U06976 Genomic DNA Translation: AAA87889.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3371.1

Protein sequence database of the Protein Information Resource

More...PIRi		A39875

NCBI Reference Sequences

More...RefSeqi		NP_002328.1, NM_002337.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000650182; ENSP00000497444; ENSG00000163956

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4043

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4043

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000650182.1; ENSP00000497444.1; NM_002337.4; NP_002328.1

UCSC genome browser

More...UCSCi		uc003ghh.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63959 mRNA Translation: AAA51553.1
AF035767 AF035766 Genomic DNA Translation: AAC67373.1
AK222504 mRNA Translation: BAD96224.1
AK222527 mRNA Translation: BAD96247.1
AL590235 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82460.1
CH471131 Genomic DNA Translation: EAW82461.1
BC105074 mRNA Translation: AAI05075.1
BC112067 mRNA Translation: AAI12068.1
U06976 Genomic DNA Translation: AAA87889.1
CCDSiCCDS3371.1
PIRiA39875
RefSeqiNP_002328.1, NM_002337.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LRENMR-A51-131[»]
1NRENMR-A51-131[»]
1OP1NMR-A51-132[»]
1OV2NMR-A35-133[»]
2FCWX-ray1.26A249-357[»]
2FTUNMR-A240-357[»]
2FYLNMR-A51-131[»]
2P01NMR-A35-357[»]
2P03NMR-A35-357[»]
BMRBiP30533
SMRiP30533
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110221, 137 interactors
DIPiDIP-39355N
IntActiP30533, 36 interactors
MINTiP30533
STRINGi9606.ENSP00000421922

PTM databases

GlyConnecti1004, 12 N-Linked glycans (1 site)
GlyGeniP30533, 2 sites, 11 N-linked glycans (1 site), 1 O-linked glycan (1 site)
iPTMnetiP30533
PhosphoSitePlusiP30533

Genetic variation databases

BioMutaiLRPAP1
DMDMi231539

Proteomic databases

EPDiP30533
jPOSTiP30533
MassIVEiP30533
MaxQBiP30533
PaxDbiP30533
PeptideAtlasiP30533
PRIDEiP30533
ProteomicsDBi54716
TopDownProteomicsiP30533

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1334, 499 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		4043

Genome annotation databases

EnsembliENST00000650182; ENSP00000497444; ENSG00000163956
GeneIDi4043
KEGGihsa:4043
MANE-SelectiENST00000650182.1; ENSP00000497444.1; NM_002337.4; NP_002328.1
UCSCiuc003ghh.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4043
DisGeNETi4043

GeneCards: human genes, protein and diseases

More...GeneCardsi		LRPAP1
HGNCiHGNC:6701, LRPAP1
HPAiENSG00000163956, Low tissue specificity
MalaCardsiLRPAP1
MIMi104225, gene
615431, phenotype
neXtProtiNX_P30533
OpenTargetsiENSG00000163956
Orphaneti98619, Rare isolated myopia
PharmGKBiPA30458
VEuPathDBiHostDB:ENSG00000163956

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3956, Eukaryota
GeneTreeiENSGT00390000004855
HOGENOMiCLU_064512_0_0_1
InParanoidiP30533
OMAiEKHQHYQ
OrthoDBi908725at2759
PhylomeDBiP30533
TreeFamiTF320678

Enzyme and pathway databases

PathwayCommonsiP30533
SignaLinkiP30533

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4043, 8 hits in 1044 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LRPAP1, human
EvolutionaryTraceiP30533

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LDL-receptor-related_protein_associated_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4043
PharosiP30533, Tbio

Protein Ontology

More...PROi		PR:P30533
RNActiP30533, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163956, Expressed in caudate nucleus and 247 other tissues
ExpressionAtlasiP30533, baseline and differential
GenevisibleiP30533, HS

Family and domain databases

CDDicd14806, RAP_D1, 1 hit
cd14807, RAP_D2, 1 hit
cd14808, RAP_D3, 1 hit
Gene3Di1.20.81.10, 3 hits
InterProiView protein in InterPro
IPR038003, A2-macroglobuin_RAP
IPR010483, Alpha_2_MRAP_C
IPR009066, MG_RAP_rcpt_1
IPR038001, RAP_D2
IPR037999, RAP_D3
IPR036744, RAP_sf
PANTHERiPTHR16560, PTHR16560, 1 hit
PfamiView protein in Pfam
PF06401, Alpha-2-MRAP_C, 1 hit
PF06400, Alpha-2-MRAP_N, 1 hit
SUPFAMiSSF47045, SSF47045, 3 hits
PROSITEiView protein in PROSITE
PS00014, ER_TARGET, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMRP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30533
Secondary accession number(s): D3DVR9
, Q2M310, Q53HQ3, Q53HS6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 23, 2022
This is version 197 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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