UniProtKB - P30532 (ACHA5_HUMAN)

BLAST

>sp|P30532|ACHA5_HUMAN Neuronal acetylcholine receptor subunit alpha-5 OS=Homo sapiens OX=9606 GN=CHRNA5 PE=1 SV=2
MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYER
WVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKV
IRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFD
LQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYV
TYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIE
EIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTL
PKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDW
KFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK

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History
Entry version 177 (07 Nov 2018)
Sequence version 2 (01 Nov 1997)
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Protein

Neuronal acetylcholine receptor subunit alpha-5

Gene

CHRNA5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functionⁱ

acetylcholine-gated cation-selective channel activity
Source: DFLAT
Traceable author statementⁱ
- 20438829
acetylcholine receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 1542648
ligand-gated ion channel activity
Source: DFLAT
Traceable author statementⁱ
- 20438829

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

behavioral response to nicotine
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18227835
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ion transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nervous system process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neuromuscular synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of membrane potential
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of synaptic vesicle exocytosis Source: Ensembl
response to nicotine
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
synaptic transmission, cholinergic
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channel, Receptor
Biological process	Ion transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Reactomeⁱ

R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuronal acetylcholine receptor subunit alpha-5
Gene namesⁱ	Name:CHRNA5 Synonyms:NACHRA5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169684.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1959 CHRNA5
MIMⁱ	118505 gene
neXtProtⁱ	NX_P30532

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	23 – 254	ExtracellularSequence analysisAdd BLAST	232
Transmembraneⁱ	255 – 275	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	282 – 302	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	317 – 337	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	338 – 429	CytoplasmicSequence analysisAdd BLAST	92
Transmembraneⁱ	430 – 451	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	452 – 468	ExtracellularSequence analysisAdd BLAST	17

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1138
MalaCards human disease database More...MalaCardsⁱ	CHRNA5
MIMⁱ	612052 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000169684
PharmGKBⁱ	PA26491

Chemistry databases

ChEMBLⁱ	CHEMBL3137273
Drug and drug target database More...DrugBankⁱ	DB00898 Ethanol DB00674 Galantamine DB00184 Nicotine

Polymorphism and mutation databases

BioMutaⁱ	CHRNA5
DMDMⁱ	2506126

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_0000000356	23 – 468	Neuronal acetylcholine receptor subunit alpha-5Add BLAST		446

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	155	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	170 ↔ 184	By similarity
Glycosylationⁱ	183	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	229	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	234 ↔ 235	Associated with receptor activationBy similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P30532
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P30532
PaxDbⁱ	P30532
PeptideAtlas More...PeptideAtlasⁱ	P30532
PRIDEⁱ	P30532
ProteomicsDBⁱ	54715

PTM databases

iPTMnetⁱ	P30532
PhosphoSitePlusⁱ	P30532

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000169684 Expressed in 102 organ(s), highest expression level in testis
CleanExⁱ	HS_CHRNA5
ExpressionAtlasⁱ	P30532 baseline and differential
Genevisibleⁱ	P30532 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054381

HPAⁱ

HPA054381

Interactionⁱ

Subunit structureⁱ

Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (beta). Interacts with LYPD6 (PubMed:27344019).1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CHRNB2	P17787	3	EBI-6657490,EBI-9008612

With

Entry

#Exp.

IntAct

Notes

CHRNB2

P17787

EBI-6657490,EBI-9008612

Protein-protein interaction databases

BioGridⁱ	107560, 9 interactors
ComplexPortalⁱ	CPX-187 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2 CPX-210 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta4 CPX-218 Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2
IntActⁱ	P30532, 4 interactors
STRINGⁱ	9606.ENSP00000299565

Chemistry databases

BindingDBⁱ

P30532

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P30532
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily. [View classification]Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3645 Eukaryota ENOG410XQGR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118930
HOGENOMⁱ	HOG000006756
HOVERGENⁱ	HBG003756
InParanoidⁱ	P30532
KEGG Orthology (KO) More...KOⁱ	K04807
OMAⁱ	RHVMKEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R20
PhylomeDBⁱ	P30532
TreeFamⁱ	TF315605

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 2 hits
PRINTSⁱ	PR00254 NICOTINICR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P30532-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAARGSGPRA LRLLLLVQLV AGRCGLAGAA GGAQRGLSEP SSIAKHEDSL 
        60         70         80         90        100
LKDLFQDYER WVRPVEHLND KIKIKFGLAI SQLVDVDEKN QLMTTNVWLK 
       110        120        130        140        150
QEWIDVKLRW NPDDYGGIKV IRVPSDSVWT PDIVLFDNAD GRFEGTSTKT 
       160        170        180        190        200
VIRYNGTVTW TPPANYKSSC TIDVTFFPFD LQNCSMKFGS WTYDGSQVDI 
       210        220        230        240        250
ILEDQDVDKR DFFDNGEWEI VSATGSKGNR TDSCCWYPYV TYSFVIKRLP 
       260        270        280        290        300
LFYTLFLIIP CIGLSFLTVL VFYLPSNEGE KICLCTSVLV SLTVFLLVIE 
       310        320        330        340        350
EIIPSSSKVI PLIGEYLVFT MIFVTLSIMV TVFAINIHHR SSSTHNAMAP 
       360        370        380        390        400
LVRKIFLHTL PKLLCMRSHV DRYFTQKEET ESGSGPKSSR NTLEAALDSI 
       410        420        430        440        450
RYITRHIMKE NDVREVVEDW KFIAQVLDRM FLWTFLFVSI VGSLGLFVPV 
       460 
IYKWANILIP VHIGNANK

Length:468

Mass (Da):53,054

Last modified:November 1, 1997 - v2

Checksum:ⁱ7FE91A2E362289C0

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YM98	H0YM98_HUMAN	Cholinergic receptor, nicotinic, al... Cholinergic receptor, nicotinic, alpha 5, isoform CRA_b (Neuronal acetylcholine receptor subunit alpha-5)	CHRNA5 hCG_95858	160	Annotation score:
H7BYM0	H7BYM0_HUMAN	Neuronal acetylcholine receptor sub... Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	182	Annotation score:
H0YK34	H0YK34_HUMAN	Neuronal acetylcholine receptor sub... Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	56	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	23 – 34	RCGLA…AGGAQ → ALRSSRARRAAR in AAA58357 (PubMed:1542648).CuratedAdd BLAST	12
Sequence conflictⁱ	128	V → S in AAA58357 (PubMed:1542648).Curated	1
Sequence conflictⁱ	365	C → S in AAA58357 (PubMed:1542648).Curated	1
Sequence conflictⁱ	405	R → T in AAA58357 (PubMed:1542648).Curated	1

Polymorphismⁱ

Genetic variations in CHRNA5 have been associated with susceptibility to smoking-related behavioral traits and lung cancer, contributing to the smoking quantitative trait locus 3 (SQTL3) [MIMⁱ:612052].

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_046211	134	V → I. Corresponds to variant dbSNP:rs2229961Ensembl.		1
Natural variantⁱVAR_046212	398	D → N Associated with susceptibility to lung cancer. 2 PublicationsCorresponds to variant dbSNP:rs16969968EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83712 mRNA Translation: AAA58357.1 U62434 mRNA Translation: AAB40112.1 Y08419 mRNA Translation: CAA69696.1 AJ306481 AJ306486 Genomic DNA Translation: CAC34820.1 BC033639 mRNA Translation: AAH33639.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10304.1
PIRⁱ	A38223
NCBI Reference Sequences More...RefSeqⁱ	NP_000736.2, NM_000745.3
UniGeneⁱ	Hs.1614 Hs.719767

Genome annotation databases

Ensemblⁱ	ENST00000299565; ENSP00000299565; ENSG00000169684
GeneIDⁱ	1138
KEGGⁱ	hsa:1138
UCSC genome browser More...UCSCⁱ	uc002bdy.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P30532	Neuronal acetylcholine receptor subunit alpha-5		PANTR		468	UniRef90_P30532
CHRNA5 isoform 1		PONAB		468
Uncharacterized protein		CHLSB		468
Cholinergic receptor nicotinic alpha 5 subunit		AOTNA		445
neuronal acetylcholine receptor subunit alpha-5		TARSY		440
+15

Protein	Similar proteins		Species	Score	Length	Source
P30532	Neuronal acetylcholine receptor subunit alpha-5		PANTR		468	UniRef50_P30532
Neuronal acetylcholine receptor subunit non-alpha-3		CARAU		466
Neuronal acetylcholine receptor subunit alpha-5		MOUSE		467
Neuronal acetylcholine receptor subunit alpha-5		RAT		452
Neuronal acetylcholine receptor subunit alpha-5		CHICK		454
+548

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83712 mRNA Translation: AAA58357.1 U62434 mRNA Translation: AAB40112.1 Y08419 mRNA Translation: CAA69696.1 AJ306481 AJ306486 Genomic DNA Translation: CAC34820.1 BC033639 mRNA Translation: AAH33639.1
CCDSⁱ	CCDS10304.1
PIRⁱ	A38223
RefSeqⁱ	NP_000736.2, NM_000745.3
UniGeneⁱ	Hs.1614 Hs.719767

3D structure databases

ProteinModelPortalⁱ	P30532
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107560, 9 interactors
ComplexPortalⁱ	CPX-187 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2 CPX-210 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta4 CPX-218 Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2
IntActⁱ	P30532, 4 interactors
STRINGⁱ	9606.ENSP00000299565

Chemistry databases

BindingDBⁱ	P30532
ChEMBLⁱ	CHEMBL3137273
DrugBankⁱ	DB00898 Ethanol DB00674 Galantamine DB00184 Nicotine

PTM databases

iPTMnetⁱ	P30532
PhosphoSitePlusⁱ	P30532

Polymorphism and mutation databases

BioMutaⁱ	CHRNA5
DMDMⁱ	2506126

Proteomic databases

EPDⁱ	P30532
MaxQBⁱ	P30532
PaxDbⁱ	P30532
PeptideAtlasⁱ	P30532
PRIDEⁱ	P30532
ProteomicsDBⁱ	54715

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1138
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000299565; ENSP00000299565; ENSG00000169684
GeneIDⁱ	1138
KEGGⁱ	hsa:1138
UCSCⁱ	uc002bdy.3 human

Organism-specific databases

CTDⁱ	1138
DisGeNETⁱ	1138
EuPathDBⁱ	HostDB:ENSG00000169684.13
GeneCardsⁱ	CHRNA5
HGNCⁱ	HGNC:1959 CHRNA5
HPAⁱ	HPA054381
MalaCardsⁱ	CHRNA5
MIMⁱ	118505 gene 612052 phenotype
neXtProtⁱ	NX_P30532
OpenTargetsⁱ	ENSG00000169684
PharmGKBⁱ	PA26491
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3645 Eukaryota ENOG410XQGR LUCA
GeneTreeⁱ	ENSGT00760000118930
HOGENOMⁱ	HOG000006756
HOVERGENⁱ	HBG003756
InParanoidⁱ	P30532
KOⁱ	K04807
OMAⁱ	RHVMKEN
OrthoDBⁱ	EOG091G0R20
PhylomeDBⁱ	P30532
TreeFamⁱ	TF315605

Enzyme and pathway databases

Reactomeⁱ	R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Reactomeⁱ

R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Miscellaneous databases

GeneWikiⁱ	CHRNA5
GenomeRNAiⁱ	1138
Protein Ontology More...PROⁱ	PR:P30532
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000169684 Expressed in 102 organ(s), highest expression level in testis
CleanExⁱ	HS_CHRNA5
ExpressionAtlasⁱ	P30532 baseline and differential
Genevisibleⁱ	P30532 HS

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit
Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 2 hits
PRINTSⁱ	PR00254 NICOTINICR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACHA5_HUMAN
Accessionⁱ	P30532Primary (citable) accession number: P30532 Secondary accession number(s): Q15824, Q99554
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

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UniProtKB - P30532 (ACHA5_HUMAN)

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Neuronal acetylcholine receptor subunit alpha-5

CHRNA5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ