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Protein

Heme oxygenase 2

Gene

HMOX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Catalytic activityi

Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H2O.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Iron (heme axial ligand)1

GO - Molecular functioni

  • heme binding Source: GO_Central
  • heme oxygenase (decyclizing) activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.99.3 2681
ReactomeiR-HSA-189483 Heme degradation
R-HSA-6798695 Neutrophil degranulation
R-HSA-917937 Iron uptake and transport
SIGNORiP30519

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase 2 (EC:1.14.14.18By similarity)
Short name:
HO-2
Gene namesi
Name:HMOX2
Synonyms:HO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103415.11
HGNCiHGNC:5014 HMOX2
MIMi141251 gene
neXtProtiNX_P30519

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi3163
OpenTargetsiENSG00000103415
PharmGKBiPA29342

Chemistry databases

ChEMBLiCHEMBL2546
DrugBankiDB00157 NADH
DB04912 Stannsoporfin

Polymorphism and mutation databases

BioMutaiHMOX2
DMDMi1170328

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002096912 – 316Heme oxygenase 2Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei2PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP30519
MaxQBiP30519
PaxDbiP30519
PeptideAtlasiP30519
PRIDEiP30519
ProteomicsDBi54710

PTM databases

iPTMnetiP30519
PhosphoSitePlusiP30519
SwissPalmiP30519

Miscellaneous databases

PMAP-CutDBiP30519

Expressioni

Inductioni

Heme oxygenase 2 activity is non-inducible.

Gene expression databases

BgeeiENSG00000103415 Expressed in 225 organ(s), highest expression level in testis
CleanExiHS_HMOX2
ExpressionAtlasiP30519 baseline and differential
GenevisibleiP30519 HS

Organism-specific databases

HPAiCAB025464
HPA040611

Interactioni

Protein-protein interaction databases

BioGridi109406, 58 interactors
DIPiDIP-53564N
IntActiP30519, 71 interactors
MINTiP30519
STRINGi9606.ENSP00000219700

Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP30519
SMRiP30519
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30519

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati264 – 269HRM 16
Repeati281 – 286HRM 26

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4480 Eukaryota
COG5398 LUCA
GeneTreeiENSGT00390000017673
HOGENOMiHOG000233221
HOVERGENiHBG005982
InParanoidiP30519
KOiK21418
PhylomeDBiP30519
TreeFamiTF314786

Family and domain databases

CDDicd00232 HemeO, 1 hit
Gene3Di1.20.910.10, 1 hit
InterProiView protein in InterPro
IPR002051 Haem_Oase
IPR016053 Haem_Oase-like
IPR016084 Haem_Oase-like_multi-hlx
IPR018207 Haem_oxygenase_CS
PANTHERiPTHR10720 PTHR10720, 1 hit
PfamiView protein in Pfam
PF01126 Heme_oxygenase, 1 hit
PIRSFiPIRSF000343 Haem_Oase, 1 hit
PRINTSiPR00088 HAEMOXYGNASE
SUPFAMiSSF48613 SSF48613, 1 hit
PROSITEiView protein in PROSITE
PS00593 HEME_OXYGENASE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P30519-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAEVETSEG VDESEKKNSG ALEKENQMRM ADLSELLKEG TKEAHDRAEN
60 70 80 90 100
TQFVKDFLKG NIKKELFKLA TTALYFTYSA LEEEMERNKD HPAFAPLYFP
110 120 130 140 150
MELHRKEALT KDMEYFFGEN WEEQVQCPKA AQKYVERIHY IGQNEPELLV
160 170 180 190 200
AHAYTRYMGD LSGGQVLKKV AQRALKLPST GEGTQFYLFE NVDNAQQFKQ
210 220 230 240 250
LYRARMNALD LNMKTKERIV EEANKAFEYN MQIFNELDQA GSTLARETLE
260 270 280 290 300
DGFPVHDGKG DMRKCPFYAA EQDKGALEGS SCPFRTAMAV LRKPSLQFIL
310
AAGVALAAGL LAWYYM
Length:316
Mass (Da):36,033
Last modified:November 1, 1995 - v2
Checksum:iBF4B6A341F1A81AC
GO
Isoform 2 (identifier: P30519-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:287
Mass (Da):32,837
Checksum:iE03CE816D6C72A30
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT44A0A087WT44_HUMAN
Heme oxygenase 2
HMOX2
370Annotation score:
I3L159I3L159_HUMAN
Heme oxygenase 2
HMOX2
229Annotation score:
I3L1F5I3L1F5_HUMAN
Heme oxygenase 2
HMOX2
238Annotation score:
I3L1Y2I3L1Y2_HUMAN
Heme oxygenase 2
HMOX2
110Annotation score:
I3L463I3L463_HUMAN
Heme oxygenase 2
HMOX2
132Annotation score:
I3L276I3L276_HUMAN
Heme oxygenase 2
HMOX2
110Annotation score:
I3L4P8I3L4P8_HUMAN
Heme oxygenase 2
HMOX2
130Annotation score:
A0A1B0GXH0A0A1B0GXH0_HUMAN
Heme oxygenase 2
HMOX2
131Annotation score:

Sequence cautioni

The sequence W38932 differs from that shown. Reason: Frameshift at position 82.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107E → T in W38932 (Ref. 8) Curated1
Sequence conflicti165 – 166QV → KC in AAC05297 (Ref. 10) Curated2
Sequence conflicti222Missing in AAB22110 (PubMed:1575508).Curated1
Sequence conflicti276Missing in AAB22110 (PubMed:1575508).Curated1
Sequence conflicti281 – 288SCPFRTAM → LSLPTSY in AAB22110 (PubMed:1575508).Curated8

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021067137R → Q1 PublicationCorresponds to variant dbSNP:rs17884623Ensembl.1
Natural variantiVAR_021068146P → L1 PublicationCorresponds to variant dbSNP:rs17880805Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0550311 – 29Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21243 mRNA Translation: BAA04789.1
S34389 mRNA Translation: AAB22110.2
BT019788 mRNA Translation: AAV38591.1
AY771350 Genomic DNA Translation: AAV28730.1
AC007606 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85299.1
CH471112 Genomic DNA Translation: EAW85300.1
BC002396 mRNA Translation: AAH02396.1
W38932 mRNA No translation available.
AF051306 mRNA Translation: AAC05297.1
CCDSiCCDS10517.1 [P30519-1]
CCDS66931.1 [P30519-2]
PIRiI60119
S21700
RefSeqiNP_001120676.1, NM_001127204.1 [P30519-1]
NP_001120677.1, NM_001127205.1 [P30519-1]
NP_001120678.1, NM_001127206.2 [P30519-1]
NP_001273196.1, NM_001286267.1
NP_001273197.1, NM_001286268.1 [P30519-1]
NP_001273198.1, NM_001286269.1 [P30519-1]
NP_001273199.1, NM_001286270.1 [P30519-1]
NP_001273200.1, NM_001286271.1 [P30519-2]
NP_002125.3, NM_002134.3 [P30519-1]
XP_016878685.1, XM_017023196.1 [P30519-1]
XP_016878686.1, XM_017023197.1 [P30519-1]
UniGeneiHs.284279

Genome annotation databases

EnsembliENST00000219700; ENSP00000219700; ENSG00000103415 [P30519-1]
ENST00000398595; ENSP00000381595; ENSG00000103415 [P30519-1]
ENST00000406590; ENSP00000385100; ENSG00000103415 [P30519-1]
ENST00000414777; ENSP00000391637; ENSG00000103415 [P30519-1]
ENST00000458134; ENSP00000394103; ENSG00000103415 [P30519-1]
ENST00000570646; ENSP00000459214; ENSG00000103415 [P30519-1]
ENST00000575120; ENSP00000460926; ENSG00000103415 [P30519-2]
ENST00000612525; ENSP00000481295; ENSG00000277424 [P30519-1]
ENST00000615778; ENSP00000484422; ENSG00000277424 [P30519-1]
ENST00000619528; ENSP00000484423; ENSG00000103415 [P30519-1]
ENST00000619913; ENSP00000484467; ENSG00000103415 [P30519-1]
ENST00000620445; ENSP00000478785; ENSG00000277424 [P30519-1]
ENST00000621065; ENSP00000481811; ENSG00000277424 [P30519-1]
ENST00000622146; ENSP00000483319; ENSG00000277424 [P30519-1]
ENST00000631540; ENSP00000487673; ENSG00000277424 [P30519-1]
ENST00000631677; ENSP00000488579; ENSG00000277424 [P30519-1]
ENST00000632458; ENSP00000488880; ENSG00000277424 [P30519-1]
ENST00000633319; ENSP00000488769; ENSG00000277424 [P30519-2]
GeneIDi3163
KEGGihsa:3163
UCSCiuc002cwq.5 human [P30519-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21243 mRNA Translation: BAA04789.1
S34389 mRNA Translation: AAB22110.2
BT019788 mRNA Translation: AAV38591.1
AY771350 Genomic DNA Translation: AAV28730.1
AC007606 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85299.1
CH471112 Genomic DNA Translation: EAW85300.1
BC002396 mRNA Translation: AAH02396.1
W38932 mRNA No translation available.
AF051306 mRNA Translation: AAC05297.1
CCDSiCCDS10517.1 [P30519-1]
CCDS66931.1 [P30519-2]
PIRiI60119
S21700
RefSeqiNP_001120676.1, NM_001127204.1 [P30519-1]
NP_001120677.1, NM_001127205.1 [P30519-1]
NP_001120678.1, NM_001127206.2 [P30519-1]
NP_001273196.1, NM_001286267.1
NP_001273197.1, NM_001286268.1 [P30519-1]
NP_001273198.1, NM_001286269.1 [P30519-1]
NP_001273199.1, NM_001286270.1 [P30519-1]
NP_001273200.1, NM_001286271.1 [P30519-2]
NP_002125.3, NM_002134.3 [P30519-1]
XP_016878685.1, XM_017023196.1 [P30519-1]
XP_016878686.1, XM_017023197.1 [P30519-1]
UniGeneiHs.284279

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q32X-ray2.40A/B1-264[»]
2QPPX-ray2.61A/B1-264[»]
2RGZX-ray2.61A/B1-264[»]
4WMHX-ray2.50A31-237[»]
5UC8X-ray2.00A/B/C/D30-242[»]
5UC9X-ray1.90A/B/C/D30-242[»]
5UCAX-ray2.12A/B/C/D30-242[»]
ProteinModelPortaliP30519
SMRiP30519
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109406, 58 interactors
DIPiDIP-53564N
IntActiP30519, 71 interactors
MINTiP30519
STRINGi9606.ENSP00000219700

Chemistry databases

ChEMBLiCHEMBL2546
DrugBankiDB00157 NADH
DB04912 Stannsoporfin

PTM databases

iPTMnetiP30519
PhosphoSitePlusiP30519
SwissPalmiP30519

Polymorphism and mutation databases

BioMutaiHMOX2
DMDMi1170328

Proteomic databases

EPDiP30519
MaxQBiP30519
PaxDbiP30519
PeptideAtlasiP30519
PRIDEiP30519
ProteomicsDBi54710

Protocols and materials databases

DNASUi3163
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219700; ENSP00000219700; ENSG00000103415 [P30519-1]
ENST00000398595; ENSP00000381595; ENSG00000103415 [P30519-1]
ENST00000406590; ENSP00000385100; ENSG00000103415 [P30519-1]
ENST00000414777; ENSP00000391637; ENSG00000103415 [P30519-1]
ENST00000458134; ENSP00000394103; ENSG00000103415 [P30519-1]
ENST00000570646; ENSP00000459214; ENSG00000103415 [P30519-1]
ENST00000575120; ENSP00000460926; ENSG00000103415 [P30519-2]
ENST00000612525; ENSP00000481295; ENSG00000277424 [P30519-1]
ENST00000615778; ENSP00000484422; ENSG00000277424 [P30519-1]
ENST00000619528; ENSP00000484423; ENSG00000103415 [P30519-1]
ENST00000619913; ENSP00000484467; ENSG00000103415 [P30519-1]
ENST00000620445; ENSP00000478785; ENSG00000277424 [P30519-1]
ENST00000621065; ENSP00000481811; ENSG00000277424 [P30519-1]
ENST00000622146; ENSP00000483319; ENSG00000277424 [P30519-1]
ENST00000631540; ENSP00000487673; ENSG00000277424 [P30519-1]
ENST00000631677; ENSP00000488579; ENSG00000277424 [P30519-1]
ENST00000632458; ENSP00000488880; ENSG00000277424 [P30519-1]
ENST00000633319; ENSP00000488769; ENSG00000277424 [P30519-2]
GeneIDi3163
KEGGihsa:3163
UCSCiuc002cwq.5 human [P30519-1]

Organism-specific databases

CTDi3163
DisGeNETi3163
EuPathDBiHostDB:ENSG00000103415.11
GeneCardsiHMOX2
HGNCiHGNC:5014 HMOX2
HPAiCAB025464
HPA040611
MIMi141251 gene
neXtProtiNX_P30519
OpenTargetsiENSG00000103415
PharmGKBiPA29342
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4480 Eukaryota
COG5398 LUCA
GeneTreeiENSGT00390000017673
HOGENOMiHOG000233221
HOVERGENiHBG005982
InParanoidiP30519
KOiK21418
PhylomeDBiP30519
TreeFamiTF314786

Enzyme and pathway databases

BRENDAi1.14.99.3 2681
ReactomeiR-HSA-189483 Heme degradation
R-HSA-6798695 Neutrophil degranulation
R-HSA-917937 Iron uptake and transport
SIGNORiP30519

Miscellaneous databases

ChiTaRSiHMOX2 human
EvolutionaryTraceiP30519
GeneWikiiHMOX2
GenomeRNAii3163
PMAP-CutDBiP30519
PROiPR:P30519
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103415 Expressed in 225 organ(s), highest expression level in testis
CleanExiHS_HMOX2
ExpressionAtlasiP30519 baseline and differential
GenevisibleiP30519 HS

Family and domain databases

CDDicd00232 HemeO, 1 hit
Gene3Di1.20.910.10, 1 hit
InterProiView protein in InterPro
IPR002051 Haem_Oase
IPR016053 Haem_Oase-like
IPR016084 Haem_Oase-like_multi-hlx
IPR018207 Haem_oxygenase_CS
PANTHERiPTHR10720 PTHR10720, 1 hit
PfamiView protein in Pfam
PF01126 Heme_oxygenase, 1 hit
PIRSFiPIRSF000343 Haem_Oase, 1 hit
PRINTSiPR00088 HAEMOXYGNASE
SUPFAMiSSF48613 SSF48613, 1 hit
PROSITEiView protein in PROSITE
PS00593 HEME_OXYGENASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMOX2_HUMAN
AccessioniPrimary (citable) accession number: P30519
Secondary accession number(s): A8MT35
, D3DUD5, I3L430, O60605
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health

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