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Protein

Heme oxygenase 2

Gene

HMOX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi45Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • heme binding Source: GO_Central
  • heme oxygenase (decyclizing) activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.99.3 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-189483 Heme degradation
R-HSA-6798695 Neutrophil degranulation
R-HSA-917937 Iron uptake and transport

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P30519

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heme oxygenase 2 (EC:1.14.14.18By similarity)
Short name:
HO-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HMOX2
Synonyms:HO2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000103415.11

Human Gene Nomenclature Database

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HGNCi
HGNC:5014 HMOX2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
141251 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P30519

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3163

Open Targets

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OpenTargetsi
ENSG00000103415

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29342

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2546

Drug and drug target database

More...
DrugBanki
DB00157 NADH
DB04912 Stannsoporfin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HMOX2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1170328

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002096912 – 316Heme oxygenase 2Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei2PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P30519

MaxQB - The MaxQuant DataBase

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MaxQBi
P30519

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P30519

PeptideAtlas

More...
PeptideAtlasi
P30519

PRoteomics IDEntifications database

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PRIDEi
P30519

ProteomicsDB human proteome resource

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ProteomicsDBi
54710

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P30519

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P30519

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P30519

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P30519

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Heme oxygenase 2 activity is non-inducible.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000103415 Expressed in 225 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

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CleanExi
HS_HMOX2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P30519 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P30519 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025464
HPA040611

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109406, 59 interactors

Database of interacting proteins

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DIPi
DIP-53564N

Protein interaction database and analysis system

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IntActi
P30519, 71 interactors

Molecular INTeraction database

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MINTi
P30519

STRING: functional protein association networks

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STRINGi
9606.ENSP00000219700

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P30519

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P30519

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P30519

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati264 – 269HRM 16
Repeati281 – 286HRM 26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4480 Eukaryota
COG5398 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000017673

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233221

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005982

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P30519

KEGG Orthology (KO)

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KOi
K21418

Database for complete collections of gene phylogenies

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PhylomeDBi
P30519

TreeFam database of animal gene trees

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TreeFami
TF314786

Family and domain databases

Conserved Domains Database

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CDDi
cd00232 HemeO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.910.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002051 Haem_Oase
IPR016053 Haem_Oase-like
IPR016084 Haem_Oase-like_multi-hlx
IPR018207 Haem_oxygenase_CS

The PANTHER Classification System

More...
PANTHERi
PTHR10720 PTHR10720, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01126 Heme_oxygenase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000343 Haem_Oase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00088 HAEMOXYGNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48613 SSF48613, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00593 HEME_OXYGENASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P30519-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAEVETSEG VDESEKKNSG ALEKENQMRM ADLSELLKEG TKEAHDRAEN
60 70 80 90 100
TQFVKDFLKG NIKKELFKLA TTALYFTYSA LEEEMERNKD HPAFAPLYFP
110 120 130 140 150
MELHRKEALT KDMEYFFGEN WEEQVQCPKA AQKYVERIHY IGQNEPELLV
160 170 180 190 200
AHAYTRYMGD LSGGQVLKKV AQRALKLPST GEGTQFYLFE NVDNAQQFKQ
210 220 230 240 250
LYRARMNALD LNMKTKERIV EEANKAFEYN MQIFNELDQA GSTLARETLE
260 270 280 290 300
DGFPVHDGKG DMRKCPFYAA EQDKGALEGS SCPFRTAMAV LRKPSLQFIL
310
AAGVALAAGL LAWYYM
Length:316
Mass (Da):36,033
Last modified:November 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF4B6A341F1A81AC
GO
Isoform 2 (identifier: P30519-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:287
Mass (Da):32,837
Checksum:iE03CE816D6C72A30
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1F5I3L1F5_HUMAN
Heme oxygenase 2
HMOX2
238Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L159I3L159_HUMAN
Heme oxygenase 2
HMOX2
229Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WT44A0A087WT44_HUMAN
Heme oxygenase 2
HMOX2
370Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1Y2I3L1Y2_HUMAN
Heme oxygenase 2
HMOX2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L463I3L463_HUMAN
Heme oxygenase 2
HMOX2
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4P8I3L4P8_HUMAN
Heme oxygenase 2
HMOX2
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L276I3L276_HUMAN
Heme oxygenase 2
HMOX2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GXH0A0A1B0GXH0_HUMAN
Heme oxygenase 2
HMOX2
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence W38932 differs from that shown. Reason: Frameshift at position 82.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti107E → T in W38932 (Ref. 8) Curated1
Sequence conflicti165 – 166QV → KC in AAC05297 (Ref. 10) Curated2
Sequence conflicti222Missing in AAB22110 (PubMed:1575508).Curated1
Sequence conflicti276Missing in AAB22110 (PubMed:1575508).Curated1
Sequence conflicti281 – 288SCPFRTAM → LSLPTSY in AAB22110 (PubMed:1575508).Curated8

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021067137R → Q1 PublicationCorresponds to variant dbSNP:rs17884623Ensembl.1
Natural variantiVAR_021068146P → L1 PublicationCorresponds to variant dbSNP:rs17880805Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0550311 – 29Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D21243 mRNA Translation: BAA04789.1
S34389 mRNA Translation: AAB22110.2
BT019788 mRNA Translation: AAV38591.1
AY771350 Genomic DNA Translation: AAV28730.1
AC007606 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85299.1
CH471112 Genomic DNA Translation: EAW85300.1
BC002396 mRNA Translation: AAH02396.1
W38932 mRNA No translation available.
AF051306 mRNA Translation: AAC05297.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10517.1 [P30519-1]
CCDS66931.1 [P30519-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
I60119
S21700

NCBI Reference Sequences

More...
RefSeqi
NP_001120676.1, NM_001127204.1 [P30519-1]
NP_001120677.1, NM_001127205.1 [P30519-1]
NP_001120678.1, NM_001127206.2 [P30519-1]
NP_001273196.1, NM_001286267.1
NP_001273197.1, NM_001286268.1 [P30519-1]
NP_001273198.1, NM_001286269.1 [P30519-1]
NP_001273199.1, NM_001286270.1 [P30519-1]
NP_001273200.1, NM_001286271.1 [P30519-2]
NP_002125.3, NM_002134.3 [P30519-1]
XP_016878685.1, XM_017023196.1 [P30519-1]
XP_016878686.1, XM_017023197.1 [P30519-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.284279

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000219700; ENSP00000219700; ENSG00000103415 [P30519-1]
ENST00000398595; ENSP00000381595; ENSG00000103415 [P30519-1]
ENST00000406590; ENSP00000385100; ENSG00000103415 [P30519-1]
ENST00000414777; ENSP00000391637; ENSG00000103415 [P30519-1]
ENST00000458134; ENSP00000394103; ENSG00000103415 [P30519-1]
ENST00000570646; ENSP00000459214; ENSG00000103415 [P30519-1]
ENST00000575120; ENSP00000460926; ENSG00000103415 [P30519-2]
ENST00000612525; ENSP00000481295; ENSG00000277424 [P30519-1]
ENST00000615778; ENSP00000484422; ENSG00000277424 [P30519-1]
ENST00000619528; ENSP00000484423; ENSG00000103415 [P30519-1]
ENST00000619913; ENSP00000484467; ENSG00000103415 [P30519-1]
ENST00000620445; ENSP00000478785; ENSG00000277424 [P30519-1]
ENST00000621065; ENSP00000481811; ENSG00000277424 [P30519-1]
ENST00000622146; ENSP00000483319; ENSG00000277424 [P30519-1]
ENST00000631540; ENSP00000487673; ENSG00000277424 [P30519-1]
ENST00000631677; ENSP00000488579; ENSG00000277424 [P30519-1]
ENST00000632458; ENSP00000488880; ENSG00000277424 [P30519-1]
ENST00000633319; ENSP00000488769; ENSG00000277424 [P30519-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3163

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3163

UCSC genome browser

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UCSCi
uc002cwq.5 human [P30519-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21243 mRNA Translation: BAA04789.1
S34389 mRNA Translation: AAB22110.2
BT019788 mRNA Translation: AAV38591.1
AY771350 Genomic DNA Translation: AAV28730.1
AC007606 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85299.1
CH471112 Genomic DNA Translation: EAW85300.1
BC002396 mRNA Translation: AAH02396.1
W38932 mRNA No translation available.
AF051306 mRNA Translation: AAC05297.1
CCDSiCCDS10517.1 [P30519-1]
CCDS66931.1 [P30519-2]
PIRiI60119
S21700
RefSeqiNP_001120676.1, NM_001127204.1 [P30519-1]
NP_001120677.1, NM_001127205.1 [P30519-1]
NP_001120678.1, NM_001127206.2 [P30519-1]
NP_001273196.1, NM_001286267.1
NP_001273197.1, NM_001286268.1 [P30519-1]
NP_001273198.1, NM_001286269.1 [P30519-1]
NP_001273199.1, NM_001286270.1 [P30519-1]
NP_001273200.1, NM_001286271.1 [P30519-2]
NP_002125.3, NM_002134.3 [P30519-1]
XP_016878685.1, XM_017023196.1 [P30519-1]
XP_016878686.1, XM_017023197.1 [P30519-1]
UniGeneiHs.284279

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q32X-ray2.40A/B1-264[»]
2QPPX-ray2.61A/B1-264[»]
2RGZX-ray2.61A/B1-264[»]
4WMHX-ray2.50A31-237[»]
5UC8X-ray2.00A/B/C/D30-242[»]
5UC9X-ray1.90A/B/C/D30-242[»]
5UCAX-ray2.12A/B/C/D30-242[»]
ProteinModelPortaliP30519
SMRiP30519
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109406, 59 interactors
DIPiDIP-53564N
IntActiP30519, 71 interactors
MINTiP30519
STRINGi9606.ENSP00000219700

Chemistry databases

ChEMBLiCHEMBL2546
DrugBankiDB00157 NADH
DB04912 Stannsoporfin

PTM databases

iPTMnetiP30519
PhosphoSitePlusiP30519
SwissPalmiP30519

Polymorphism and mutation databases

BioMutaiHMOX2
DMDMi1170328

Proteomic databases

EPDiP30519
MaxQBiP30519
PaxDbiP30519
PeptideAtlasiP30519
PRIDEiP30519
ProteomicsDBi54710

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3163
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219700; ENSP00000219700; ENSG00000103415 [P30519-1]
ENST00000398595; ENSP00000381595; ENSG00000103415 [P30519-1]
ENST00000406590; ENSP00000385100; ENSG00000103415 [P30519-1]
ENST00000414777; ENSP00000391637; ENSG00000103415 [P30519-1]
ENST00000458134; ENSP00000394103; ENSG00000103415 [P30519-1]
ENST00000570646; ENSP00000459214; ENSG00000103415 [P30519-1]
ENST00000575120; ENSP00000460926; ENSG00000103415 [P30519-2]
ENST00000612525; ENSP00000481295; ENSG00000277424 [P30519-1]
ENST00000615778; ENSP00000484422; ENSG00000277424 [P30519-1]
ENST00000619528; ENSP00000484423; ENSG00000103415 [P30519-1]
ENST00000619913; ENSP00000484467; ENSG00000103415 [P30519-1]
ENST00000620445; ENSP00000478785; ENSG00000277424 [P30519-1]
ENST00000621065; ENSP00000481811; ENSG00000277424 [P30519-1]
ENST00000622146; ENSP00000483319; ENSG00000277424 [P30519-1]
ENST00000631540; ENSP00000487673; ENSG00000277424 [P30519-1]
ENST00000631677; ENSP00000488579; ENSG00000277424 [P30519-1]
ENST00000632458; ENSP00000488880; ENSG00000277424 [P30519-1]
ENST00000633319; ENSP00000488769; ENSG00000277424 [P30519-2]
GeneIDi3163
KEGGihsa:3163
UCSCiuc002cwq.5 human [P30519-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3163
DisGeNETi3163
EuPathDBiHostDB:ENSG00000103415.11

GeneCards: human genes, protein and diseases

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GeneCardsi
HMOX2
HGNCiHGNC:5014 HMOX2
HPAiCAB025464
HPA040611
MIMi141251 gene
neXtProtiNX_P30519
OpenTargetsiENSG00000103415
PharmGKBiPA29342

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4480 Eukaryota
COG5398 LUCA
GeneTreeiENSGT00390000017673
HOGENOMiHOG000233221
HOVERGENiHBG005982
InParanoidiP30519
KOiK21418
PhylomeDBiP30519
TreeFamiTF314786

Enzyme and pathway databases

BRENDAi1.14.99.3 2681
ReactomeiR-HSA-189483 Heme degradation
R-HSA-6798695 Neutrophil degranulation
R-HSA-917937 Iron uptake and transport
SIGNORiP30519

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HMOX2 human
EvolutionaryTraceiP30519

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HMOX2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3163
PMAP-CutDBiP30519

Protein Ontology

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PROi
PR:P30519

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103415 Expressed in 225 organ(s), highest expression level in testis
CleanExiHS_HMOX2
ExpressionAtlasiP30519 baseline and differential
GenevisibleiP30519 HS

Family and domain databases

CDDicd00232 HemeO, 1 hit
Gene3Di1.20.910.10, 1 hit
InterProiView protein in InterPro
IPR002051 Haem_Oase
IPR016053 Haem_Oase-like
IPR016084 Haem_Oase-like_multi-hlx
IPR018207 Haem_oxygenase_CS
PANTHERiPTHR10720 PTHR10720, 1 hit
PfamiView protein in Pfam
PF01126 Heme_oxygenase, 1 hit
PIRSFiPIRSF000343 Haem_Oase, 1 hit
PRINTSiPR00088 HAEMOXYGNASE
SUPFAMiSSF48613 SSF48613, 1 hit
PROSITEiView protein in PROSITE
PS00593 HEME_OXYGENASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMOX2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30519
Secondary accession number(s): A8MT35
, D3DUD5, I3L430, O60605
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1995
Last modified: December 5, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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