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Entry version 203 (13 Feb 2019)
Sequence version 1 (01 Apr 1993)
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Protein

Vasopressin V2 receptor

Gene

AVPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • vasopressin receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-388479 Vasopressin-like receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9036092 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P30518

SIGNOR Signaling Network Open Resource

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SIGNORi
P30518

Protein family/group databases

Transport Classification Database

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TCDBi
9.A.14.10.3 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vasopressin V2 receptor
Short name:
V2R
Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AVPR2
Synonyms:ADHR, DIR, DIR3, V2R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000126895.13

Human Gene Nomenclature Database

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HGNCi
HGNC:897 AVPR2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300538 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P30518

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 63Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini64 – 77CytoplasmicSequence analysisAdd BLAST14
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 113ExtracellularSequence analysisAdd BLAST15
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 159CytoplasmicSequence analysisAdd BLAST24
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 200ExtracellularSequence analysisAdd BLAST20
Transmembranei201 – 220Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini221 – 271CytoplasmicSequence analysisAdd BLAST51
Transmembranei272 – 293Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini294 – 308ExtracellularSequence analysisAdd BLAST15
Transmembranei309 – 328Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini329 – 371CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Nephrogenic syndrome of inappropriate antidiuresis (NSIAD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis.
See also OMIM:300539
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025901137R → C in NSIAD; constitutively active. 1 PublicationCorresponds to variant dbSNP:rs104894761EnsemblClinVar.1
Natural variantiVAR_025902137R → L in NSIAD; constitutively active. 1 PublicationCorresponds to variant dbSNP:rs104894756EnsemblClinVar.1
Diabetes insipidus, nephrogenic, X-linked (XNDI)23 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. Characterized by excessive water drinking (polydipsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia.
See also OMIM:304800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01529743L → P in XNDI. 1 Publication1
Natural variantiVAR_00351744L → P in XNDI. 1 Publication1
Natural variantiVAR_01529846I → K in XNDI. 1 PublicationCorresponds to variant dbSNP:rs104894759EnsemblClinVar.1
Natural variantiVAR_01529953L → R in XNDI. 1
Natural variantiVAR_01530055N → D in XNDI. 1
Natural variantiVAR_01530155N → H in XNDI. 1
Natural variantiVAR_01530259L → P in XNDI. Corresponds to variant dbSNP:rs193922112EnsemblClinVar.1
Natural variantiVAR_00351862 – 64Missing in XNDI. 3
Natural variantiVAR_01530462L → P in XNDI. 1
Natural variantiVAR_00352080H → R in XNDI. 1 Publication1
Natural variantiVAR_01530581L → F in XNDI. 1
Natural variantiVAR_01530683L → P in XNDI. 1
Natural variantiVAR_01530783L → Q in XNDI. 1
Natural variantiVAR_01530884A → D in XNDI. 1
Natural variantiVAR_01530985D → N in XNDI. Corresponds to variant dbSNP:rs104894754EnsemblClinVar.1
Natural variantiVAR_00352188V → M in XNDI. 1 Publication1
Natural variantiVAR_01531092Q → R in XNDI. 1
Natural variantiVAR_01531194L → Q in XNDI. 1
Natural variantiVAR_01531295P → L in XNDI. 1
Natural variantiVAR_01531399W → R in XNDI. 1
Natural variantiVAR_015314104R → C in XNDI; binding capacity is 10% of wild-type, but binding affinity is stronger than wild-type. 1 PublicationCorresponds to variant dbSNP:rs104894760EnsemblClinVar.1
Natural variantiVAR_015315105F → V in XNDI. 1 PublicationCorresponds to variant dbSNP:rs104894758EnsemblClinVar.1
Natural variantiVAR_003522106R → C in XNDI. 2 Publications1
Natural variantiVAR_015316107G → E in XNDI. 1 Publication1
Natural variantiVAR_003523112C → R in XNDI. 2 Publications1
Natural variantiVAR_015317112C → Y in XNDI. 1
Natural variantiVAR_003524113R → W in XNDI. 3 PublicationsCorresponds to variant dbSNP:rs28935496EnsemblClinVar.1
Natural variantiVAR_062591122G → D in XNDI. 1 Publication1
Natural variantiVAR_015318122G → R in XNDI. 1
Natural variantiVAR_015319123M → K in XNDI. 1
Natural variantiVAR_003525126S → F in XNDI. 1 Publication1
Natural variantiVAR_015320127S → F in XNDI. 1
Natural variantiVAR_003526128Y → S in XNDI. 3 Publications1
Natural variantiVAR_015321130I → F in XNDI. 1 PublicationCorresponds to variant dbSNP:rs796052096EnsemblClinVar.1
Natural variantiVAR_003527132A → D in XNDI. 1 PublicationCorresponds to variant dbSNP:rs104894747EnsemblClinVar.1
Natural variantiVAR_015322135L → P in XNDI. 1
Natural variantiVAR_003528137R → H in XNDI; fails to activate the adenylyl cyclase system. 5 PublicationsCorresponds to variant dbSNP:rs104894756EnsemblClinVar.1
Natural variantiVAR_003529143R → P in XNDI. 2 Publications1
Natural variantiVAR_015324163A → P in XNDI. 1
Natural variantiVAR_003531164W → S in XNDI. 1 Publication1
Natural variantiVAR_003532167S → L in XNDI. 1 Publication1
Natural variantiVAR_003533167S → T in XNDI. 1 Publication1
Natural variantiVAR_015325173P → S in XNDI. 1
Natural variantiVAR_015326174Q → L in XNDI. 1
Natural variantiVAR_003534181R → C in XNDI. 3 PublicationsCorresponds to variant dbSNP:rs104894757EnsemblClinVar.1
Natural variantiVAR_003535185G → C in XNDI. 1 PublicationCorresponds to variant dbSNP:rs104894748EnsemblClinVar.1
Natural variantiVAR_015327191D → G in XNDI. 1
Natural variantiVAR_015328201G → D in XNDI. Corresponds to variant dbSNP:rs104894755EnsemblClinVar.1
Natural variantiVAR_003536202R → C in XNDI. 2 PublicationsCorresponds to variant dbSNP:rs782806507Ensembl.1
Natural variantiVAR_003537203R → C in XNDI. 1 PublicationCorresponds to variant dbSNP:rs104894750EnsemblClinVar.1
Natural variantiVAR_015329204T → N in XNDI. 1 Publication1
Natural variantiVAR_003538205Y → C in XNDI. 2 PublicationsCorresponds to variant dbSNP:rs104894749EnsemblClinVar.1
Natural variantiVAR_015330206V → D in XNDI. 1 Publication1
Natural variantiVAR_015331207T → N in XNDI. 1
Natural variantiVAR_015332209I → F in XNDI. 1
Natural variantiVAR_015333214F → S in XNDI. 1
Natural variantiVAR_015335217P → T in XNDI. 1
Natural variantiVAR_015336219L → P in XNDI. 1
Natural variantiVAR_015337219L → R in XNDI. 1
Natural variantiVAR_003539247 – 250Missing in XNDI. 1 Publication4
Natural variantiVAR_015339272M → K in XNDI. 1
Natural variantiVAR_015340277V → A in XNDI. 1
Natural variantiVAR_003540277Missing in XNDI. 4 Publications1
Natural variantiVAR_003541280Y → C in XNDI. 2 PublicationsCorresponds to variant dbSNP:rs104894752EnsemblClinVar.1
Natural variantiVAR_015341282L → P in XNDI. 1
Natural variantiVAR_003542285A → P in XNDI. 1 PublicationCorresponds to variant dbSNP:rs193922122EnsemblClinVar.1
Natural variantiVAR_003543286P → L in XNDI. 1 Publication1
Natural variantiVAR_003544286P → R in XNDI. 1 Publication1
Natural variantiVAR_015342286P → S in XNDI. 1
Natural variantiVAR_015343287F → L in XNDI. 1 Publication1
Natural variantiVAR_015344289L → P in XNDI. 1
Natural variantiVAR_003545292L → P in XNDI. 1 Publication1
Natural variantiVAR_015345294A → P in XNDI. 1
Natural variantiVAR_003546309L → P in XNDI. 1 Publication1
Natural variantiVAR_015346309L → R in XNDI. 1
Natural variantiVAR_015347315S → R in XNDI. 1
Natural variantiVAR_003547317N → K in XNDI. 1 Publication1
Natural variantiVAR_015349319C → R in XNDI. 1
Natural variantiVAR_015350321N → D in XNDI. 1
Natural variantiVAR_015351321N → K in XNDI. Corresponds to variant dbSNP:rs193922123EnsemblClinVar.1
Natural variantiVAR_015352321N → Y in XNDI. 1
Natural variantiVAR_015353322P → H in XNDI. 1
Natural variantiVAR_015354322P → S in XNDI. 1 Publication1
Natural variantiVAR_015355323W → R in XNDI. 1
Natural variantiVAR_003548323W → S in XNDI. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi341C → S: Reduced palmitoylation, reduced cell surface localization but coupling to G protein unaffected. 1 Publication1
Mutagenesisi342C → S: Reduced palmitoylation, reduced cell surface localization but coupling to G protein unaffected. 1 Publication1

Keywords - Diseasei

Diabetes insipidus, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
554

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
AVPR2

MalaCards human disease database

More...
MalaCardsi
AVPR2
MIMi300539 phenotype
304800 phenotype

Open Targets

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OpenTargetsi
ENSG00000126895

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
223 Nephrogenic diabetes insipidus
93606 Nephrogenic syndrome of inappropriate antidiuresis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25189

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1790

Drug and drug target database

More...
DrugBanki
DB00872 Conivaptan
DB00035 Desmopressin
DB05091 M0002
DB05838 OPC-51803
DB02638 Terlipressin
DB06212 Tolvaptan
DB00067 Vasopressin

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
368

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
AVPR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
267256

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000702081 – 371Vasopressin V2 receptorAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi341S-palmitoyl cysteine1 Publication1
Lipidationi342S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30518

PeptideAtlas

More...
PeptideAtlasi
P30518

PRoteomics IDEntifications database

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PRIDEi
P30518

ProteomicsDB human proteome resource

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ProteomicsDBi
54708
54709 [P30518-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P30518-2 [P30518-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P30518

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P30518

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P30518

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126895 Expressed in 107 organ(s), highest expression level in apex of heart

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P30518 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P30518 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046678

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARRDC4. Identified in a complex containing at least ARRDC4, V2R and HGS.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ARRDC4Q8NCT12EBI-11675746,EBI-11673273

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107035, 15 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P30518

Protein interaction database and analysis system

More...
IntActi
P30518, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000338072

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P30518

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JQIX-ray2.60V343-371[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P30518

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P30518

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155054

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237331

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG105710

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P30518

KEGG Orthology (KO)

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KOi
K04228

Identification of Orthologs from Complete Genome Data

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OMAi
HIFIGHL

Database of Orthologous Groups

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OrthoDBi
890925at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P30518

TreeFam database of animal gene trees

More...
TreeFami
TF106499

Family and domain databases

Conserved Domains Database

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CDDi
cd15388 7tmA_V2R, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001817 Vasoprsn_rcpt
IPR000161 Vprsn_rcpt_V2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN
PR00896 VASOPRESSINR
PR00898 VASOPRSNV2R

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P30518-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLMASTTSAV PGHPSLPSLP SNSSQERPLD TRDPLLARAE LALLSIVFVA
60 70 80 90 100
VALSNGLVLA ALARRGRRGH WAPIHVFIGH LCLADLAVAL FQVLPQLAWK
110 120 130 140 150
ATDRFRGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH
160 170 180 190 200
GSGAHWNRPV LVAWAFSLLL SLPQLFIFAQ RNVEGGSGVT DCWACFAEPW
210 220 230 240 250
GRRTYVTWIA LMVFVAPTLG IAACQVLIFR EIHASLVPGP SERPGGRRRG
260 270 280 290 300
RRTGSPGEGA HVSAAVAKTV RMTLVIVVVY VLCWAPFFLV QLWAAWDPEA
310 320 330 340 350
PLEGAPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCARGRTPPS
360 370
LGPQDESCTT ASSSLAKDTS S
Length:371
Mass (Da):40,279
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F87D20A3C0ECB0D
GO
Isoform 2 (identifier: P30518-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-309: APFVL → GCSRG
     310-371: Missing.

Show »
Length:309
Mass (Da):33,743
Checksum:iCAB6A8B0A682ED0F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JV81C9JV81_HUMAN
Vasopressin V2 receptor
AVPR2
372Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WET1F8WET1_HUMAN
Vasopressin V2 receptor
AVPR2
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0035167T → S. Corresponds to variant dbSNP:rs5196EnsemblClinVar.1
Natural variantiVAR_01529612G → E. Corresponds to variant dbSNP:rs2071126EnsemblClinVar.1
Natural variantiVAR_01185842A → V. Corresponds to variant dbSNP:rs5198EnsemblClinVar.1
Natural variantiVAR_01529743L → P in XNDI. 1 Publication1
Natural variantiVAR_00351744L → P in XNDI. 1 Publication1
Natural variantiVAR_01529846I → K in XNDI. 1 PublicationCorresponds to variant dbSNP:rs104894759EnsemblClinVar.1
Natural variantiVAR_01529953L → R in XNDI. 1
Natural variantiVAR_01530055N → D in XNDI. 1
Natural variantiVAR_01530155N → H in XNDI. 1
Natural variantiVAR_01530259L → P in XNDI. Corresponds to variant dbSNP:rs193922112EnsemblClinVar.1
Natural variantiVAR_01530361A → V. 1
Natural variantiVAR_00351862 – 64Missing in XNDI. 3
Natural variantiVAR_01530462L → P in XNDI. 1
Natural variantiVAR_00351964R → W. Corresponds to variant dbSNP:rs150351033Ensembl.1
Natural variantiVAR_00352080H → R in XNDI. 1 Publication1
Natural variantiVAR_01530581L → F in XNDI. 1
Natural variantiVAR_01530683L → P in XNDI. 1
Natural variantiVAR_01530783L → Q in XNDI. 1
Natural variantiVAR_01530884A → D in XNDI. 1
Natural variantiVAR_01530985D → N in XNDI. Corresponds to variant dbSNP:rs104894754EnsemblClinVar.1
Natural variantiVAR_00352188V → M in XNDI. 1 Publication1
Natural variantiVAR_01531092Q → R in XNDI. 1
Natural variantiVAR_01531194L → Q in XNDI. 1
Natural variantiVAR_01531295P → L in XNDI. 1
Natural variantiVAR_01531399W → R in XNDI. 1
Natural variantiVAR_015314104R → C in XNDI; binding capacity is 10% of wild-type, but binding affinity is stronger than wild-type. 1 PublicationCorresponds to variant dbSNP:rs104894760EnsemblClinVar.1
Natural variantiVAR_015315105F → V in XNDI. 1 PublicationCorresponds to variant dbSNP:rs104894758EnsemblClinVar.1
Natural variantiVAR_003522106R → C in XNDI. 2 Publications1
Natural variantiVAR_015316107G → E in XNDI. 1 Publication1
Natural variantiVAR_003523112C → R in XNDI. 2 Publications1
Natural variantiVAR_015317112C → Y in XNDI. 1
Natural variantiVAR_003524113R → W in XNDI. 3 PublicationsCorresponds to variant dbSNP:rs28935496EnsemblClinVar.1
Natural variantiVAR_062591122G → D in XNDI. 1 Publication1
Natural variantiVAR_015318122G → R in XNDI. 1
Natural variantiVAR_015319123M → K in XNDI. 1
Natural variantiVAR_003525126S → F in XNDI. 1 Publication1
Natural variantiVAR_015320127S → F in XNDI. 1
Natural variantiVAR_003526128Y → S in XNDI. 3 Publications1
Natural variantiVAR_015321130I → F in XNDI. 1 PublicationCorresponds to variant dbSNP:rs796052096EnsemblClinVar.1
Natural variantiVAR_003527132A → D in XNDI. 1 PublicationCorresponds to variant dbSNP:rs104894747EnsemblClinVar.1
Natural variantiVAR_015322135L → P in XNDI. 1
Natural variantiVAR_025901137R → C in NSIAD; constitutively active. 1 PublicationCorresponds to variant dbSNP:rs104894761EnsemblClinVar.1
Natural variantiVAR_003528137R → H in XNDI; fails to activate the adenylyl cyclase system. 5 PublicationsCorresponds to variant dbSNP:rs104894756EnsemblClinVar.1
Natural variantiVAR_025902137R → L in NSIAD; constitutively active. 1 PublicationCorresponds to variant dbSNP:rs104894756EnsemblClinVar.1
Natural variantiVAR_015323139R → S. 1
Natural variantiVAR_003529143R → P in XNDI. 2 Publications1
Natural variantiVAR_003530147A → V. Corresponds to variant dbSNP:rs5200EnsemblClinVar.1
Natural variantiVAR_015324163A → P in XNDI. 1
Natural variantiVAR_003531164W → S in XNDI. 1 Publication1
Natural variantiVAR_003532167S → L in XNDI. 1 Publication1
Natural variantiVAR_003533167S → T in XNDI. 1 Publication1
Natural variantiVAR_015325173P → S in XNDI. 1
Natural variantiVAR_015326174Q → L in XNDI. 1
Natural variantiVAR_003534181R → C in XNDI. 3 PublicationsCorresponds to variant dbSNP:rs104894757EnsemblClinVar.1
Natural variantiVAR_003535185G → C in XNDI. 1 PublicationCorresponds to variant dbSNP:rs104894748EnsemblClinVar.1
Natural variantiVAR_015327191D → G in XNDI. 1
Natural variantiVAR_015328201G → D in XNDI. Corresponds to variant dbSNP:rs104894755EnsemblClinVar.1
Natural variantiVAR_003536202R → C in XNDI. 2 PublicationsCorresponds to variant dbSNP:rs782806507Ensembl.1
Natural variantiVAR_003537203R → C in XNDI. 1 PublicationCorresponds to variant dbSNP:rs104894750EnsemblClinVar.1
Natural variantiVAR_015329204T → N in XNDI. 1 Publication1
Natural variantiVAR_003538205Y → C in XNDI. 2 PublicationsCorresponds to variant dbSNP:rs104894749EnsemblClinVar.1
Natural variantiVAR_015330206V → D in XNDI. 1 Publication1
Natural variantiVAR_015331207T → N in XNDI. 1
Natural variantiVAR_015332209I → F in XNDI. 1
Natural variantiVAR_015333214F → S in XNDI. 1
Natural variantiVAR_015334215V → M. Corresponds to variant dbSNP:rs112109182EnsemblClinVar.1
Natural variantiVAR_015335217P → T in XNDI. 1
Natural variantiVAR_015336219L → P in XNDI. 1
Natural variantiVAR_015337219L → R in XNDI. 1
Natural variantiVAR_003539247 – 250Missing in XNDI. 1 Publication4
Natural variantiVAR_035769247R → H in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs149668713EnsemblClinVar.1
Natural variantiVAR_015338252R → W. Corresponds to variant dbSNP:rs61733407EnsemblClinVar.1
Natural variantiVAR_015339272M → K in XNDI. 1
Natural variantiVAR_015340277V → A in XNDI. 1
Natural variantiVAR_003540277Missing in XNDI. 4 Publications1
Natural variantiVAR_003541280Y → C in XNDI. 2 PublicationsCorresponds to variant dbSNP:rs104894752EnsemblClinVar.1
Natural variantiVAR_015341282L → P in XNDI. 1
Natural variantiVAR_003542285A → P in XNDI. 1 PublicationCorresponds to variant dbSNP:rs193922122EnsemblClinVar.1
Natural variantiVAR_003543286P → L in XNDI. 1 Publication1
Natural variantiVAR_003544286P → R in XNDI. 1 Publication1
Natural variantiVAR_015342286P → S in XNDI. 1
Natural variantiVAR_015343287F → L in XNDI. 1 Publication1
Natural variantiVAR_015344289L → P in XNDI. 1
Natural variantiVAR_003545292L → P in XNDI. 1 Publication1
Natural variantiVAR_015345294A → P in XNDI. 1
Natural variantiVAR_003546309L → P in XNDI. 1 Publication1
Natural variantiVAR_015346309L → R in XNDI. 1
Natural variantiVAR_015347315S → R in XNDI. 1
Natural variantiVAR_003547317N → K in XNDI. 1 Publication1
Natural variantiVAR_015348318S → T. 1
Natural variantiVAR_015349319C → R in XNDI. 1
Natural variantiVAR_015350321N → D in XNDI. 1
Natural variantiVAR_015351321N → K in XNDI. Corresponds to variant dbSNP:rs193922123EnsemblClinVar.1
Natural variantiVAR_015352321N → Y in XNDI. 1
Natural variantiVAR_015353322P → H in XNDI. 1
Natural variantiVAR_015354322P → S in XNDI. 1 Publication1
Natural variantiVAR_015355323W → R in XNDI. 1
Natural variantiVAR_003548323W → S in XNDI. 1 Publication1
Natural variantiVAR_015356352G → D. Corresponds to variant dbSNP:rs146350208EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036990305 – 309APFVL → GCSRG in isoform 2. 1 Publication5
Alternative sequenceiVSP_036991310 – 371Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L22206 Genomic DNA Translation: AAA03651.1
Z11687 mRNA Translation: CAA77746.1
U04357 Genomic DNA Translation: AAC09005.1
AF030626 mRNA Translation: AAB86428.1
AF101727 mRNA Translation: AAD16444.1
AF032388 mRNA Translation: AAB87678.1
AY242131 mRNA Translation: AAO92298.1
FJ411207 Genomic DNA Translation: ACR39021.1
CH471172 Genomic DNA Translation: EAW72783.1
CH471172 Genomic DNA Translation: EAW72784.1
CH471172 Genomic DNA Translation: EAW72785.1
BC101484 mRNA Translation: AAI01485.1
BC112181 mRNA Translation: AAI12182.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14735.1 [P30518-1]
CCDS55539.1 [P30518-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
I51865

NCBI Reference Sequences

More...
RefSeqi
NP_000045.1, NM_000054.4 [P30518-1]
NP_001139623.1, NM_001146151.1 [P30518-2]
XP_006724891.1, XM_006724828.3 [P30518-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.567240

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337474; ENSP00000338072; ENSG00000126895 [P30518-1]
ENST00000358927; ENSP00000351805; ENSG00000126895 [P30518-1]
ENST00000370049; ENSP00000359066; ENSG00000126895 [P30518-2]
ENST00000646375; ENSP00000496396; ENSG00000126895 [P30518-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
554

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:554

UCSC genome browser

More...
UCSCi
uc004fjh.5 human [P30518-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22206 Genomic DNA Translation: AAA03651.1
Z11687 mRNA Translation: CAA77746.1
U04357 Genomic DNA Translation: AAC09005.1
AF030626 mRNA Translation: AAB86428.1
AF101727 mRNA Translation: AAD16444.1
AF032388 mRNA Translation: AAB87678.1
AY242131 mRNA Translation: AAO92298.1
FJ411207 Genomic DNA Translation: ACR39021.1
CH471172 Genomic DNA Translation: EAW72783.1
CH471172 Genomic DNA Translation: EAW72784.1
CH471172 Genomic DNA Translation: EAW72785.1
BC101484 mRNA Translation: AAI01485.1
BC112181 mRNA Translation: AAI12182.1
CCDSiCCDS14735.1 [P30518-1]
CCDS55539.1 [P30518-2]
PIRiI51865
RefSeqiNP_000045.1, NM_000054.4 [P30518-1]
NP_001139623.1, NM_001146151.1 [P30518-2]
XP_006724891.1, XM_006724828.3 [P30518-1]
UniGeneiHs.567240

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JQIX-ray2.60V343-371[»]
ProteinModelPortaliP30518
SMRiP30518
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107035, 15 interactors
ELMiP30518
IntActiP30518, 4 interactors
STRINGi9606.ENSP00000338072

Chemistry databases

BindingDBiP30518
ChEMBLiCHEMBL1790
DrugBankiDB00872 Conivaptan
DB00035 Desmopressin
DB05091 M0002
DB05838 OPC-51803
DB02638 Terlipressin
DB06212 Tolvaptan
DB00067 Vasopressin
GuidetoPHARMACOLOGYi368

Protein family/group databases

TCDBi9.A.14.10.3 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP30518
PhosphoSitePlusiP30518
SwissPalmiP30518

Polymorphism and mutation databases

BioMutaiAVPR2
DMDMi267256

Proteomic databases

PaxDbiP30518
PeptideAtlasiP30518
PRIDEiP30518
ProteomicsDBi54708
54709 [P30518-2]
TopDownProteomicsiP30518-2 [P30518-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337474; ENSP00000338072; ENSG00000126895 [P30518-1]
ENST00000358927; ENSP00000351805; ENSG00000126895 [P30518-1]
ENST00000370049; ENSP00000359066; ENSG00000126895 [P30518-2]
ENST00000646375; ENSP00000496396; ENSG00000126895 [P30518-1]
GeneIDi554
KEGGihsa:554
UCSCiuc004fjh.5 human [P30518-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
554
DisGeNETi554
EuPathDBiHostDB:ENSG00000126895.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AVPR2
GeneReviewsiAVPR2
HGNCiHGNC:897 AVPR2
HPAiHPA046678
MalaCardsiAVPR2
MIMi300538 gene
300539 phenotype
304800 phenotype
neXtProtiNX_P30518
OpenTargetsiENSG00000126895
Orphaneti223 Nephrogenic diabetes insipidus
93606 Nephrogenic syndrome of inappropriate antidiuresis
PharmGKBiPA25189

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000155054
HOGENOMiHOG000237331
HOVERGENiHBG105710
InParanoidiP30518
KOiK04228
OMAiHIFIGHL
OrthoDBi890925at2759
PhylomeDBiP30518
TreeFamiTF106499

Enzyme and pathway databases

ReactomeiR-HSA-388479 Vasopressin-like receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9036092 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
SignaLinkiP30518
SIGNORiP30518

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Arginine_vasopressin_receptor_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
554

Protein Ontology

More...
PROi
PR:P30518

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126895 Expressed in 107 organ(s), highest expression level in apex of heart
ExpressionAtlasiP30518 baseline and differential
GenevisibleiP30518 HS

Family and domain databases

CDDicd15388 7tmA_V2R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001817 Vasoprsn_rcpt
IPR000161 Vprsn_rcpt_V2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00896 VASOPRESSINR
PR00898 VASOPRSNV2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiV2R_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30518
Secondary accession number(s): C5HF20
, O43192, Q3MJD3, Q9UCV9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 13, 2019
This is version 203 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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