UniProtKB - P30516 (1B01_SAGOE)
Protein
Class I histocompatibility antigen, B alpha chain
Gene
N/A
Organism
Saguinus oedipus (Cotton-top tamarin)
Status
Functioni
Involved in the presentation of foreign antigens to the immune system.
GO - Biological processi
- antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
- immune response Source: InterPro
Keywordsi
Biological process | Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: Class I histocompatibility antigen, B alpha chain |
Organismi | Saguinus oedipus (Cotton-top tamarin) |
Taxonomic identifieri | 9490 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Callitrichinae › Saguinus |
Subcellular locationi
Other locations
Plasma Membrane
- MHC class I protein complex Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 308 | ExtracellularSequence analysisAdd BLAST | 284 | |
Transmembranei | 309 – 332 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 333 – 365 | CytoplasmicSequence analysisAdd BLAST | 33 |
Keywords - Cellular componenti
Membrane, MHC IPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | By similarityAdd BLAST | 24 | |
ChainiPRO_0000018921 | 25 – 365 | Class I histocompatibility antigen, B alpha chainAdd BLAST | 341 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 110 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Disulfide bondi | 125 ↔ 188 | PROSITE-ProRule annotation | ||
Disulfide bondi | 227 ↔ 283 | PROSITE-ProRule annotation | ||
Modified residuei | 356 | PhosphoserineBy similarity | 1 | |
Modified residuei | 359 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinInteractioni
Subunit structurei
Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 209 – 297 | Ig-like C1-typeAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 114 | Alpha-1Add BLAST | 90 | |
Regioni | 115 – 206 | Alpha-2Add BLAST | 92 | |
Regioni | 207 – 298 | Alpha-3Add BLAST | 92 | |
Regioni | 299 – 308 | Connecting peptide | 10 |
Sequence similaritiesi
Belongs to the MHC class I family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 IPR010579, MHC_I_a_C |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit PF06623, MHC_I_C, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P30516-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTVMAPRTLL LLLSGALVLT ETWAGSHSMR YFSTAVSRPG REEPRYIEVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRME PRAQWVEKEG REYWEEETQR AKAFAQTFRV
110 120 130 140 150
NLQTALGYYN QSEAGSHTIQ MMSGCDLGPD GRLLRGYDQH AYDGKDYISL
160 170 180 190 200
NEDLRSWTAA DVAAQITQRK WEAANEAERT RAYLEGTCVE WLHRYLENGK
210 220 230 240 250
ETLQRAEPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DMELVETRPT GNGTFQKWAA VVVLSGEEHR YTCHVQHEGL PEPLTLRWEP
310 320 330 340 350
PSQPTIPIMG IVAILAILGA VVTGAVVTAV MWRKKSSDKK GGSYSQAARS
360
DSAQGSDVSL TACKV
Sequence cautioni
The sequence AAA36952 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M33476 mRNA Translation: AAA36952.1 Different initiation. |
PIRi | I72217 S11141 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M33476 mRNA Translation: AAA36952.1 Different initiation. |
PIRi | I72217 S11141 |
3D structure databases
SMRi | P30516 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 IPR010579, MHC_I_a_C |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit PF06623, MHC_I_C, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 1B01_SAGOE | |
Accessioni | P30516Primary (citable) accession number: P30516 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | October 7, 2020 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |