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Protein

HLA class I histocompatibility antigen, Cw-8 alpha chain

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, Cw-8 alpha chain
Alternative name(s):
MHC class I antigen Cw*8
Gene namesi
Name:HLA-C
Synonyms:HLAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4933 HLA-C
MIMi142840 gene
neXtProtiNX_P30505

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 333HelicalSequence analysisAdd BLAST25
Topological domaini334 – 366CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3107
MalaCardsiHLA-C

Polymorphism and mutation databases

DMDMi231434

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001887525 – 366HLA class I histocompatibility antigen, Cw-8 alpha chainAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP30505
PeptideAtlasiP30505
PRIDEiP30505

PTM databases

GlyConnecti1364
SwissPalmiP30505

Expressioni

Gene expression databases

CleanExiHS_HLA-C

Interactioni

Subunit structurei

Dimer of alpha chain and a beta chain (beta-2-microglobulin).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KIR2DL3P436282EBI-6163567,EBI-8632435

Protein-protein interaction databases

IntActiP30505, 7 interactors

Structurei

Secondary structure

1366
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP30505
SMRiP30505
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 297Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 54 potential isoforms that are computationally mapped.Show allAlign All

P30505-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVMAPRTLI LLLSGALALT ETWACSHSMR YFYTAVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVQF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ RMYGCDLGPD GRLLRGYNQF AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAARTAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
KTLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWGP
310 320 330 340 350
SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGG KGGSCSQAAS
360
SNSAQGSDES LIACKA
Length:366
Mass (Da):40,773
Last modified:April 1, 1993 - v1
Checksum:i2A84D41389A0486A
GO

Computationally mapped potential isoform sequencesi

There are 54 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P103211C07_HUMAN
HLA class I histocompatibility anti...
HLA-C HLAC
366Annotation score:
P304991C01_HUMAN
HLA class I histocompatibility anti...
HLA-C HLAC
366Annotation score:
Q299631C06_HUMAN
HLA class I histocompatibility anti...
HLA-C HLAC
366Annotation score:
P305041C04_HUMAN
HLA class I histocompatibility anti...
HLA-C HLAC
366Annotation score:
P042221C03_HUMAN
HLA class I histocompatibility anti...
HLA-C HLAC
366Annotation score:
P305011C02_HUMAN
HLA class I histocompatibility anti...
HLA-C HLAC
366Annotation score:
Q070001C15_HUMAN
HLA class I histocompatibility anti...
HLA-C HLAC
366Annotation score:
P305081C12_HUMAN
HLA class I histocompatibility anti...
HLA-C HLAC
366Annotation score:
Q956041C17_HUMAN
HLA class I histocompatibility anti...
HLA-C D6S204, HLA-JY3, HLAC
372Annotation score:
Q9TNN71C05_HUMAN
HLA class I histocompatibility anti...
HLA-C HLAC
366Annotation score:
There are more potential isoformsShow all

Polymorphismi

The following alleles of Cw-8 are known: Cw*08:01 (Cw8.1), Cw*08:02 (Cw8.2) and Cw*08:03. The sequence shown is that of Cw*08:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05648373A → E. Corresponds to variant dbSNP:rs1050409Ensembl.1
Natural variantiVAR_05648476V → M. Corresponds to variant dbSNP:rs1065382Ensembl.1
Natural variantiVAR_05648590K → N. Corresponds to variant dbSNP:rs28626310Ensembl.1
Natural variantiVAR_016586162T → K in allele Cw*08:02. 1
Natural variantiVAR_016587176T → E in allele Cw*08:02; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016588180L → R in allele Cw*08:02. 1
Natural variantiVAR_016589199G → R in allele Cw*08:03. 1
Natural variantiVAR_056486272V → MCombined sourcesCorresponds to variant dbSNP:rs1050276Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84173 mRNA Translation: AAA59687.1
M84174 mRNA Translation: AAA59688.1
Z15144 mRNA Translation: CAA78850.1
PIRiI37135
I81232
UniGeneiHs.656020
Hs.743218

Genome annotation databases

EnsembliENST00000400341; ENSP00000383195; ENSG00000206435
ENST00000400394; ENSP00000383244; ENSG00000206452

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84173 mRNA Translation: AAA59687.1
M84174 mRNA Translation: AAA59688.1
Z15144 mRNA Translation: CAA78850.1
PIRiI37135
I81232
UniGeneiHs.656020
Hs.743218

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NT6X-ray1.84A26-298[»]
ProteinModelPortaliP30505
SMRiP30505
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP30505, 7 interactors

PTM databases

GlyConnecti1364
SwissPalmiP30505

Polymorphism and mutation databases

DMDMi231434

Proteomic databases

MaxQBiP30505
PeptideAtlasiP30505
PRIDEiP30505

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400341; ENSP00000383195; ENSG00000206435
ENST00000400394; ENSP00000383244; ENSG00000206452

Organism-specific databases

DisGeNETi3107
GeneCardsiHLA-C
HGNCiHGNC:4933 HLA-C
MalaCardsiHLA-C
MIMi142840 gene
neXtProtiNX_P30505
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

ChiTaRSiHLA-C human
SOURCEiSearch...

Gene expression databases

CleanExiHS_HLA-C

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei1C08_HUMAN
AccessioniPrimary (citable) accession number: P30505
Secondary accession number(s): P30506, P30507
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 10, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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