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Protein

HLA class I histocompatibility antigen, B-39 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-39 alpha chain
Alternative name(s):
MHC class I antigen B*39
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932 HLA-B
MIMi142830 gene
neXtProtiNX_P30475

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 362CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3106
MalaCardsiHLA-B

Polymorphism and mutation databases

DMDMi231398

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001884325 – 362HLA class I histocompatibility antigen, B-39 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP30475
PeptideAtlasiP30475
PRIDEiP30475

PTM databases

SwissPalmiP30475

Expressioni

Gene expression databases

CleanExiHS_HLA-B

Interactioni

Subunit structurei

Dimer of alpha chain and a beta chain (beta-2-microglobulin).By similarity

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Helixi74 – 76Combined sources3
Helixi81 – 108Combined sources28
Beta strandi113 – 115Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 161Combined sources5
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 217Combined sources8
Beta strandi219 – 235Combined sources17
Beta strandi238 – 243Combined sources6
Helixi249 – 251Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 296Combined sources3

3D structure databases

ProteinModelPortaliP30475
SMRiP30475
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
HOVERGENiHBG016709
OrthoDBiEOG091G09OH

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI CKTNTQTDRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHNQF AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAARVAEQL RTYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,328
Last modified:April 1, 1993 - v1
Checksum:i422698063DEAB039
GO

Polymorphismi

The following alleles of B-39 are known: B*39:01 (B39.1), B*39:02 (B9.2), B*39:03, B*39:04 (B39N), B*39:05 (ST-16), B*39:06 (B39G), B*39:07 (B39uw3), B*39:09, B*39:10, B*39:12 (B3901v), B*39:23 (B39022v1) and B*39:24. The sequence shown is that of B*39:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0563554M → T. Corresponds to variant dbSNP:rs1050458Ensembl.1
Natural variantiVAR_0563569V → L. Corresponds to variant dbSNP:rs1050462Ensembl.1
Natural variantiVAR_05635717L → V. Corresponds to variant dbSNP:rs1131165Ensembl.1
Natural variantiVAR_01665933Y → D in allele B*39:12. 1
Natural variantiVAR_01642135S → A in allele B*39:04 and allele B*39:12. Corresponds to variant dbSNP:rs1131170Ensembl.1
Natural variantiVAR_01666036V → M in allele B*39:04. Corresponds to variant dbSNP:rs1050486Ensembl.1
Natural variantiVAR_06141048S → A. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_06141148S → P. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_06141248S → T. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_05635865A → TCombined sourcesCorresponds to variant dbSNP:rs1050529Ensembl.1
Natural variantiVAR_05635987N → D. Corresponds to variant dbSNP:rs1050570Ensembl.1
Natural variantiVAR_01642287N → E in allele B*39:02, allele B*39:08 and allele B*39:23; requires 2 nucleotide substitutions. Combined sources1
Natural variantiVAR_05947987N → K. Corresponds to variant dbSNP:rs1065386Ensembl.1
Natural variantiVAR_01642391C → S in allele B*39:02, allele B*39:08 and allele B*39:23. 1
Natural variantiVAR_01642491C → Y in allele B*39:10. 1
Natural variantiVAR_05636097T → A. Corresponds to variant dbSNP:rs1050393Ensembl.1
Natural variantiVAR_01642598D → Y in allele B*39:05, allele B*39:07 and allele B*39:08. Corresponds to variant dbSNP:rs1131215Ensembl.1
Natural variantiVAR_016426119L → W in allele B*39:06. 1
Natural variantiVAR_016427121R → S in allele B*39:03 and allele B*39:24. 1
Natural variantiVAR_016428121R → T in allele B*39:06. 1
Natural variantiVAR_016429122M → T in allele B*39:24. 1
Natural variantiVAR_016430123Y → S in allele B*39:09. 1
Natural variantiVAR_016431138N → D in allele B*39:07. 1
Natural variantiVAR_016432140F → S in allele B*39:07. 1
Natural variantiVAR_016433168Q → R in allele B*39:23. 1
Natural variantiVAR_016434180L → R in allele B*39:08. 1
Natural variantiVAR_056361306V → I. Corresponds to variant dbSNP:rs1131500Ensembl.1
Natural variantiVAR_056362329A → T. Corresponds to variant dbSNP:rs1051488Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94052 Genomic DNA Translation: AAA52658.1
M94051 Genomic DNA Translation: AAA52660.1
M94053 Genomic DNA Translation: AAA52659.1
U04243 mRNA Translation: AAA87396.1
L36318 mRNA Translation: AAA73942.1
L22649 Genomic DNA Translation: AAA69861.1
U29480 mRNA Translation: AAC50392.1
L42024 mRNA Translation: AAB59484.1
U29083 mRNA Translation: AAC32741.1
U56246 Genomic DNA Translation: AAB01985.1
Y09058 mRNA Translation: CAA70261.1
AB091216 Genomic DNA Translation: BAC11810.1
AB091218 Genomic DNA Translation: BAC11811.1
AF428252 mRNA Translation: AAN63555.1
L42280 Genomic DNA Translation: AAB51452.1
AH004887 Genomic DNA Translation: AAB39108.1
AB032097 Genomic DNA Translation: BAA84116.1
U15640 Genomic DNA Translation: AAA74047.1
PIRiI38876
I54314
I54505
I68850
I84488
UniGeneiHs.654404
Hs.726974
Hs.77961

Genome annotation databases

EnsembliENST00000425848; ENSP00000400842; ENSG00000223532

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei1B39_HUMAN
AccessioniPrimary (citable) accession number: P30475
Secondary accession number(s): O02960
, O78217, P30476, P79504, Q29665, Q29697, Q29749, Q29847, Q29852, Q29858, Q8HWF0, Q9TPQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 18, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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