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Protein

HLA class I histocompatibility antigen, A-34 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-34 alpha chain
Alternative name(s):
Aw-34
HLA class I histocompatibility antigen, A-10 alpha chain
MHC class I antigen A*34
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4931 HLA-A
MIMi142800 gene
neXtProtiNX_P30453

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 365CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3105
MalaCardsiHLA-A

Polymorphism and mutation databases

DMDMi231368

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001882625 – 365HLA class I histocompatibility antigen, A-34 alpha chainAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation
Modified residuei343PhosphoserineCombined sources1
Modified residuei344PhosphotyrosineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1
Modified residuei350PhosphoserineBy similarity1
Modified residuei352PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP30453
MaxQBiP30453
PeptideAtlasiP30453
PRIDEiP30453

PTM databases

GlyConnecti1323
iPTMnetiP30453
SwissPalmiP30453

Expressioni

Gene expression databases

CleanExiHS_HLA-A

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP30453
SMRiP30453
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 47 potential isoforms that are computationally mapped.Show allAlign All

P30453-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRK VKAQSQTDRV
110 120 130 140 150
DLGTLRGYYN QSEDGSHTIQ RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITQRK WETAHEAEQW RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQPTIPIVG ILAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS
360
DSAQGSDMSL TACKV
Length:365
Mass (Da):41,055
Last modified:April 1, 1993 - v1
Checksum:i063BF63E6E6E01F6
GO

Computationally mapped potential isoform sequencesi

There are 47 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P018921A02_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P304431A01_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P018911A68_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P044391A03_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P137461A11_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P055341A24_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P161881A30_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P304501A26_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P103141A32_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P304591A74_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
There are more potential isoformsShow all

Polymorphismi

The following alleles of A-34 are known: A*34:01 (Aw-34.1) and A*34:02 (Aw-34.2). The sequence shown is that of A*34:01.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0043793I → V in allele A*34:02. 2 Publications1
Natural variantiVAR_00438090K → N in allele A*34:02. 2 Publications1
Natural variantiVAR_056288101D → N. Corresponds to variant dbSNP:rs1136688Ensembl.1
Natural variantiVAR_004381121R → I in allele A*34:02. 2 Publications1
Natural variantiVAR_004382129P → S in allele A*34:02. 2 Publications1
Natural variantiVAR_004383138Q → R in allele A*34:02. 2 Publications1
Natural variantiVAR_056289151N → K. Corresponds to variant dbSNP:rs1059509Ensembl.1
Natural variantiVAR_056290166I → T. Corresponds to variant dbSNP:rs1059516Ensembl.1
Natural variantiVAR_004384180W → L in allele A*34:02. 2 Publications1
Natural variantiVAR_004385312L → I in allele A*34:02. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61704 mRNA Translation: CAA43873.1
X61705 mRNA Translation: CAA43874.1
PIRiI37477
I37483
UniGeneiHs.181244
Hs.713441

Genome annotation databases

EnsembliENST00000383605; ENSP00000373100; ENSG00000206505

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61704 mRNA Translation: CAA43873.1
X61705 mRNA Translation: CAA43874.1
PIRiI37477
I37483
UniGeneiHs.181244
Hs.713441

3D structure databases

ProteinModelPortaliP30453
SMRiP30453
ModBaseiSearch...
MobiDBiSearch...

PTM databases

GlyConnecti1323
iPTMnetiP30453
SwissPalmiP30453

Polymorphism and mutation databases

DMDMi231368

Proteomic databases

EPDiP30453
MaxQBiP30453
PeptideAtlasiP30453
PRIDEiP30453

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383605; ENSP00000373100; ENSG00000206505

Organism-specific databases

DisGeNETi3105
GeneCardsiHLA-A
HGNCiHGNC:4931 HLA-A
MalaCardsiHLA-A
MIMi142800 gene
neXtProtiNX_P30453
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

ChiTaRSiHLA-A human
SOURCEiSearch...

Gene expression databases

CleanExiHS_HLA-A

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei1A34_HUMAN
AccessioniPrimary (citable) accession number: P30453
Secondary accession number(s): P30454
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 10, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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