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Protein

Major allergen I polypeptide chain 1

Gene

CH1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen I polypeptide chain 1
Alternative name(s):
AG4
Allergen Cat-1
Allergen Fel d I-A
Short name:
Allergen FdI
Short name:
Allergen Fel dI
Allergen: Fel d 1-A
Gene namesi
Name:CH1
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE. Major allergen produced by the domestic cat. Implicated as an asthma-inducing agent in human. This protein is sticky and easily adheres to walls, carpet, clothing, furniture and bedding.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3278 Fel d 1.0101
345 Fel d 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000003637023 – 92Major allergen I polypeptide chain 1Add BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25Interchain (with C-90 in chain 2)
Disulfide bondi66Interchain (with C-65 in chain 2)
Disulfide bondi92Interchain (with C-24 in chain 2)

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Saliva and sebaceous glands.

Interactioni

Subunit structurei

Heterotetramer composed of two non-covalently linked disulfide-linked heterodimer of chains 1 and 2.

Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 37Combined sources12
Helixi40 – 50Combined sources11
Helixi54 – 70Combined sources17
Helixi73 – 87Combined sources15

3D structure databases

ProteinModelPortaliP30438
SMRiP30438
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30438

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG051604
InParanoidiP30438

Family and domain databases

CDDicd00633 Secretoglobin, 1 hit
InterProiView protein in InterPro
IPR006178 Allergen_Fel_d_I_chain1
IPR016126 Secretoglobin
IPR035960 Secretoglobin_sf
PANTHERiPTHR21226 PTHR21226, 1 hit
PfamiView protein in Pfam
PF01099 Uteroglobin, 1 hit
PRINTSiPR00827 FELALLERGEN
SUPFAMiSSF48201 SSF48201, 1 hit
PROSITEiView protein in PROSITE
PS51311 SCGB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30438-1) [UniParc]FASTAAdd to basket
Also known as: Leader A, Major

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGACVLVLL WAALLLISGG NCEICPAVKR DVDLFLTGTP DEYVEQVAQY
60 70 80 90
KALPVVLENA RILKNCVDAK MTEEDKENAL SVLDKIYTSP LC
Length:92
Mass (Da):10,086
Last modified:November 1, 1995 - v2
Checksum:i083145F55EE8AAB3
GO
Isoform 2 (identifier: P30438-2) [UniParc]FASTAAdd to basket
Also known as: Leader B, Minor

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MKGACVLVLLWAALLLISGGN → MLDAALPPCPTVAATAD

Show »
Length:88
Mass (Da):9,600
Checksum:iB378D6D99B547B57
GO

Sequence cautioni

The sequence CAA44343 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA44344 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5C → R in AAC37318 (PubMed:1946388).Curated1
Sequence conflicti18S → W in AAC37318 (PubMed:1946388).Curated1
Sequence conflicti82V → L in AAC41617 (PubMed:1946388).Curated1
Sequence conflicti82V → L in AAC37318 (PubMed:1946388).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti51K → N. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0156651 – 21MKGAC…ISGGN → MLDAALPPCPTVAATAD in isoform 2. CuratedAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74952 mRNA Translation: AAC37318.1
M74953 mRNA Translation: AAC41617.1
X62477 Genomic DNA Translation: CAA44344.1 Different initiation.
X62477 Genomic DNA Translation: CAA44343.1 Different initiation.
PIRiA56413
JC1136
RefSeqiNP_001041618.1, NM_001048153.1

Genome annotation databases

GeneIDi677877

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFEL1A_FELCA
AccessioniPrimary (citable) accession number: P30438
Secondary accession number(s): P30439
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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