UniProtKB - P30438 (FEL1A_FELCA)

BLAST

>sp|P30438|FEL1A_FELCA Major allergen I polypeptide chain 1 OS=Felis catus OX=9685 GN=CH1 PE=1 SV=2
MKGACVLVLLWAALLLISGGNCEICPAVKRDVDLFLTGTPDEYVEQVAQYKALPVVLENA
RILKNCVDAKMTEEDKENALSVLDKIYTSPLC

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History
Entry version 110 (23 May 2018)
Sequence version 2 (01 Nov 1995)
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Protein

Major allergen I polypeptide chain 1

Gene

CH1

Organism

Felis catus (Cat) (Felis silvestris catus)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

steroid binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Major allergen I polypeptide chain 1 Alternative name(s): AG4 Allergen Cat-1 Allergen Fel d I-A Short name: Allergen FdI Short name: Allergen Fel dI Allergen: Fel d 1-A
Gene namesⁱ	Name:CH1
Organismⁱ	Felis catus (Cat) (Felis silvestris catus)
Taxonomic identifierⁱ	9685 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis
Proteomesⁱ	UP000011712 Componentⁱ: Unplaced

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Allergenic propertiesⁱ

Causes an allergic reaction in human. Binds to IgE. Major allergen produced by the domestic cat. Implicated as an asthma-inducing agent in human. This protein is sticky and easily adheres to walls, carpet, clothing, furniture and bedding.

Keywords - Diseaseⁱ

Allergen

Protein family/group databases

Allergomeⁱ	3278 Fel d 1.0101 345 Fel d 1

Allergomeⁱ

3278 Fel d 1.0101
345 Fel d 1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	1 PublicationAdd BLAST		22
ChainⁱPRO_0000036370	23 – 92	Major allergen I polypeptide chain 1Add BLAST		70

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	25	Interchain (with C-90 in chain 2)
Disulfide bondⁱ	66	Interchain (with C-65 in chain 2)
Disulfide bondⁱ	92	Interchain (with C-24 in chain 2)

Keywords - PTMⁱ

Disulfide bond

Expressionⁱ

Tissue specificityⁱ

Saliva and sebaceous glands.

Interactionⁱ

Subunit structureⁱ

Heterotetramer composed of two non-covalently linked disulfide-linked heterodimer of chains 1 and 2.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	26 – 37	Combined sources	12
Helixⁱ	40 – 50	Combined sources	11
Helixⁱ	54 – 70	Combined sources	17
Helixⁱ	73 – 87	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	P30438
SMRⁱ	P30438
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P30438

EvolutionaryTraceⁱ

P30438

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the secretoglobin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

HOVERGENⁱ	HBG051604
InParanoidⁱ	P30438

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00633 Secretoglobin, 1 hit
InterProⁱ	View protein in InterPro IPR006178 Allergen_Fel_d_I_chain1 IPR016126 Secretoglobin IPR035960 Secretoglobin_sf
PANTHERⁱ	PTHR21226 PTHR21226, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01099 Uteroglobin, 1 hit
PRINTSⁱ	PR00827 FELALLERGEN
SUPFAMⁱ	SSF48201 SSF48201, 1 hit
PROSITEⁱ	View protein in PROSITE PS51311 SCGB, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P30438-1) [UniParc]FASTA Add to basket

Also known as: Leader A, Major

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGACVLVLL WAALLLISGG NCEICPAVKR DVDLFLTGTP DEYVEQVAQY 
        60         70         80         90 
KALPVVLENA RILKNCVDAK MTEEDKENAL SVLDKIYTSP LC

Length:92

Mass (Da):10,086

Last modified:November 1, 1995 - v2

Checksum:ⁱ083145F55EE8AAB3

Isoform 2 (identifier: P30438-2) [UniParc]FASTA Add to basket

Also known as: Leader B, Minor

The sequence of this isoform differs from the canonical sequence as follows:
1-21: MKGACVLVLLWAALLLISGGN → MLDAALPPCPTVAATAD

« Hide

        10         20         30         40         50
MLDAALPPCP TVAATADCEI CPAVKRDVDL FLTGTPDEYV EQVAQYKALP 
        60         70         80 
VVLENARILK NCVDAKMTEE DKENALSVLD KIYTSPLC

Show »

Length:88

Mass (Da):9,600

Checksum:ⁱB378D6D99B547B57

Sequence cautionⁱ

The sequence CAA44343 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAA44344 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	5	C → R in AAC37318 (PubMed:1946388).Curated	1
Sequence conflictⁱ	18	S → W in AAC37318 (PubMed:1946388).Curated	1
Sequence conflictⁱ	82	V → L in AAC41617 (PubMed:1946388).Curated	1
Sequence conflictⁱ	82	V → L in AAC37318 (PubMed:1946388).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱ	51	K → N.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_015665	1 – 21	MKGAC…ISGGN → MLDAALPPCPTVAATAD in isoform 2. CuratedAdd BLAST		21

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74952 mRNA Translation: AAC37318.1 M74953 mRNA Translation: AAC41617.1 X62477 Genomic DNA Translation: CAA44344.1 Different initiation. X62477 Genomic DNA Translation: CAA44343.1 Different initiation.
PIRⁱ	A56413 JC1136
NCBI Reference Sequences More...RefSeqⁱ	NP_001041618.1, NM_001048153.1

Genome annotation databases

GeneIDⁱ	677877

GeneIDⁱ

677877

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P30438	Isoform 2 of Major allergen I polypeptide chain 1		FELCA		88	UniRef50_P30438
Androgen-binding protein (Fragment)		RAT		92
Uncharacterized protein		MYOLU		94
Uncharacterized protein		HORSE		92
Uncharacterized protein (Fragment)		AILME		83
+21

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74952 mRNA Translation: AAC37318.1 M74953 mRNA Translation: AAC41617.1 X62477 Genomic DNA Translation: CAA44344.1 Different initiation. X62477 Genomic DNA Translation: CAA44343.1 Different initiation.
PIRⁱ	A56413 JC1136
RefSeqⁱ	NP_001041618.1, NM_001048153.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1PUO	X-ray	1.85	A/B	23-92	[»]
	1ZKR	X-ray	1.64	A/B	23-92	[»]
	2EJN	X-ray	1.64	A/B	23-92	[»]
	5VYF	X-ray	2.90	C/F	23-92	[»]
ProteinModelPortalⁱ	P30438
SMRⁱ	P30438
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

Allergomeⁱ	3278 Fel d 1.0101 345 Fel d 1

Allergomeⁱ

3278 Fel d 1.0101
345 Fel d 1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	677877

GeneIDⁱ

677877

Phylogenomic databases

HOVERGENⁱ	HBG051604
InParanoidⁱ	P30438

Miscellaneous databases

EvolutionaryTraceⁱ	P30438

EvolutionaryTraceⁱ

P30438

Family and domain databases

CDDⁱ	cd00633 Secretoglobin, 1 hit
InterProⁱ	View protein in InterPro IPR006178 Allergen_Fel_d_I_chain1 IPR016126 Secretoglobin IPR035960 Secretoglobin_sf
PANTHERⁱ	PTHR21226 PTHR21226, 1 hit
Pfamⁱ	View protein in Pfam PF01099 Uteroglobin, 1 hit
PRINTSⁱ	PR00827 FELALLERGEN
SUPFAMⁱ	SSF48201 SSF48201, 1 hit
PROSITEⁱ	View protein in PROSITE PS51311 SCGB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FEL1A_FELCA
Accessionⁱ	P30438Primary (citable) accession number: P30438 Secondary accession number(s): P30439
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	November 1, 1995
	Last modified:	May 23, 2018
	This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P30438 (FEL1A_FELCA)

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Major allergen I polypeptide chain 1

CH1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Protein family/group databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ