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Entry version 193 (17 Jun 2020)
Sequence version 2 (25 Nov 2002)
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Protein

Furin-like protease 2

Gene

Fur2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors. EC:3.4.21.75

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei417Charge relay systemPROSITE-ProRule annotation1
Active sitei456Charge relay systemPROSITE-ProRule annotation1
Active sitei637Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1592389 Activation of Matrix Metalloproteinases
R-DME-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-DME-186797 Signaling by PDGF
R-DME-2173789 TGF-beta receptor signaling activates SMADs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P30432

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S08.049

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Furin-like protease 2 (EC:3.4.21.75)
Short name:
Furin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fur2
ORF Names:CG18734
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004598 Fur2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1512 – 1532HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1533 – 1679CytoplasmicSequence analysisAdd BLAST147

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – ?Sequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000027024? – 318Sequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000027025319 – 1679Furin-like protease 2Add BLAST1361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi442N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi473 ↔ 629By similarity
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi565 ↔ 595By similarity
Disulfide bondi720 ↔ 748By similarity
Glycosylationi927N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1060N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1277N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1439N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30432

PRoteomics IDEntifications database

More...
PRIDEi
P30432

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Transient expression in a subset of central nervous system neurons during embryonic stages 12-13. Expression in developing tracheal tree from stage 13 to end of embryonic development.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004598 Expressed in cleaving embryo and 27 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P30432 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P30432 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
58944, 19 interactors

Protein interaction database and analysis system

More...
IntActi
P30432, 6 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0074038

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P30432

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini383 – 705Peptidase S8PROSITE-ProRule annotationAdd BLAST323
Domaini714 – 852P/Homo BPROSITE-ProRule annotationAdd BLAST139
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati961 – 1006FU 1Add BLAST46
Repeati1009 – 1056FU 2Add BLAST48
Repeati1060 – 1104FU 3Add BLAST45
Repeati1107 – 1152FU 4Add BLAST46
Repeati1156 – 1204FU 5Add BLAST49
Repeati1208 – 1253FU 6Add BLAST46
Repeati1256 – 1299FU 7Add BLAST44
Repeati1301 – 1346FU 8Add BLAST46
Repeati1348 – 1393FU 9Add BLAST46
Repeati1396 – 1443FU 10Add BLAST48

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S8 family. Furin subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3525 Eukaryota
COG1404 LUCA
COG4935 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167869

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P30432

KEGG Orthology (KO)

More...
KOi
K01349

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P30432

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00064 FU, 9 hits
cd04059 Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR006212 Furin_repeat
IPR008979 Galactose-bd-like_sf
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14843 GF_recep_IV, 1 hit
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF16470 S8_pro-domain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00723 SUBTILISIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 8 hits
SM00261 FU, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
SSF57184 SSF57184, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS51892 SUBTILASE, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform D (identifier: P30432-1) [UniParc]FASTAAdd to basket
Also known as: E, F, G

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNTTRSSRV TIGRIGTTPQ ITDPWSSGLE KQRPSRCGGP KSLAEPTYRK
60 70 80 90 100
IGRRKMMLHM RVHDPGTTVT QRAKETATAK LNRIYLCTFN RMAQSCIYFV
110 120 130 140 150
LFLVILSPNT SCALRSSAGE TQNYVGILSN DSATTTYDVS SLHSSRRTNP
160 170 180 190 200
PSSSSSSSSN VDVDYRNDRE LHKVDLVGLG GERAGQAETI SGGKYDYNYE
210 220 230 240 250
NTHTNASAKD EIVERQSNSL DFDGVDMFGA FSIPEEAIYT NEFAVNIPAG
260 270 280 290 300
KQMADVIATK HGFINRGQIG SLDNYYLFQH HHVSKRSLRS SRKHQGALKS
310 320 330 340 350
ENEVKWMQQQ HEKVRRKRDG PYQDLPTYSP YNLLRQHGGY VVDPNPHLSF
360 370 380 390 400
SPESISLASH SQRMEYRDVS SHFIFPDPLF KEQWYLNGGA KDGLDMNVGP
410 420 430 440 450
AWQKGYTGKG VVVSILDDGI QTNHPDLAQN YDPEASFDIN GNDSDPTPQD
460 470 480 490 500
NGDNKHGTRC AGEVAAVAFN NFCGVGVAYN ASIGGVRMLD GKVNDVVEAQ
510 520 530 540 550
ALSLNPSHID IYSASWGPED DGSTVDGPGP LARRAFIYGV TSGRQGKGSI
560 570 580 590 600
FVWASGNGGR YTDSCNCDGY TNSIFTLSIS SATQAGFKPW YLEECSSTLA
610 620 630 640 650
TTYSSGTPGH DKSVATVDMD GSLRPDHICT VEHTGTSASA PLAAGICALA
660 670 680 690 700
LEANPELTWR DMQYLVVYTS RPAPLEKENG WTLNGVKRKY SHKFGYGLMD
710 720 730 740 750
AGAMVSLAEQ WTSVPPQHIC KSRENNEDRK IDGAYGSTLS THMDVNGCAG
760 770 780 790 800
TINEVRYLEH VQCRITLRFF PRGNLRILLT SPMGTTSTLL FERPRDIVKS
810 820 830 840 850
NFDDWPFLSV HFWGEKAEGR WTLQVINGGR RRVNQPGILS KWQLIFYGTS
860 870 880 890 900
TQPMRLKSEL LNSSPQLRSP SSSNPFLFPS ASNIGQPANE GGNFNTDSFA
910 920 930 940 950
SYLNYQNIFS SAGSDPEPAT ATLDGQNVTA AIAGGSSAES LGFTASAAQL
960 970 980 990 1000
VAAPETRDGD KKILHSCDAE CDSSGCYGRG PTQCVACSHY RLDNTCVSRC
1010 1020 1030 1040 1050
PPRSFPNQVG ICWPCHDTCE TCAGAGPDSC LTCAPAHLHV IDLAVCLQFC
1060 1070 1080 1090 1100
PDGYFENSRN RTCVPCEPNC ASCQDHPEYC TSCDHHLVMH EHKCYSACPL
1110 1120 1130 1140 1150
DTYETEDNKC AFCHSTCATC NGPTDQDCIT CRSSRYAWQN KCLISCPDGF
1160 1170 1180 1190 1200
YADKKRLECM PCQEGCKTCT SNGVCSECLQ NWTLNKRDKC IVSGSEGCSE
1210 1220 1230 1240 1250
SEFYSQVEGQ CRPCHASCGS CNGPADTSCT SCPPNRLLEQ SRCVSGCREG
1260 1270 1280 1290 1300
FFVEAGSLCS PCLHTCSQCV SRTNCSNCSK GLELQNGECR TTCADGYYSD
1310 1320 1330 1340 1350
RGICAKCYLS CHTCSGPRRN QCVQCPAGWQ LAAGECHPEC PEGFYKSDFG
1360 1370 1380 1390 1400
CQKCHHYCKT CNDAGPLACT SCPPHSMLDG GLCMECLSSQ YYDTTSATCK
1410 1420 1430 1440 1450
TCHDSCRSCF GPGQFSCKGC VPPLHLDQLN SQCVSCCQNQ TLAEKTSSAA
1460 1470 1480 1490 1500
CCNCDGETGE CKATSTGGKR RTVVGSGSAY KSSESKHGSF ENDGNAREFV
1510 1520 1530 1540 1550
LRLDSPLTAI TAIAVAICLL IITIFSIIFA VLQRNSNHVS RNSVRYRKIA
1560 1570 1580 1590 1600
NTSSGRRKNL SAKPTSDARF IFNIGEDDDT DGDNSDDELD GNVGTDINNR
1610 1620 1630 1640 1650
IVYDRKGNDH GHEFYIESTN DIDAIEFHCN GAGAQKAETQ LQRCNANGDD
1660 1670
DDILHYDRHT NAERKNHPSS TTSRTNIRS
Length:1,679
Mass (Da):183,370
Last modified:November 25, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F9E749F0B021CF6
GO
Isoform A (identifier: P30432-2) [UniParc]FASTAAdd to basket
Also known as: B, C

The sequence of this isoform differs from the canonical sequence as follows:
     386-386: L → LVSK

Show »
Length:1,682
Mass (Da):183,684
Checksum:iF0BC981646F1C49F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JJL4E1JJL4_DROME
Furin 2, isoform I
Fur2 154521_at, CG4235, Dfur2, Dfurin2, Dmel\CG18734
1,655Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JJL5E1JJL5_DROME
Furin 2, isoform H
Fur2 154521_at, CG4235, Dfur2, Dfurin2, Dmel\CG18734
586Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL48024 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAX33562 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti152 – 153Missing in AAA28551 (PubMed:1512259).Curated2
Sequence conflicti177V → F in AAA28551 (PubMed:1512259).Curated1
Sequence conflicti213V → VDQL in AAA28551 (PubMed:1512259).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009365386L → LVSK in isoform A. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M94375 mRNA Translation: AAA28551.1
L33831 Genomic DNA Translation: AAA69860.1
AE014298 Genomic DNA Translation: AAF48598.2
AE014298 Genomic DNA Translation: AAF48599.2
AE014298 Genomic DNA Translation: AAN09399.1
AE014298 Genomic DNA Translation: AAN09400.1
AE014298 Genomic DNA Translation: AAN09401.1
AE014298 Genomic DNA Translation: AAN09402.1
AE014298 Genomic DNA Translation: AAS65387.1
BT021414 mRNA Translation: AAX33562.1 Sequence problems.
AY070553 mRNA Translation: AAL48024.1 Different initiation.

Protein sequence database of the Protein Information Resource

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PIRi
A43434

NCBI Reference Sequences

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RefSeqi
NP_523368.2, NM_078644.4 [P30432-1]
NP_727963.1, NM_167506.3 [P30432-2]
NP_727964.1, NM_167507.3 [P30432-2]
NP_727965.1, NM_167508.2 [P30432-2]
NP_727966.1, NM_167509.3 [P30432-1]
NP_727967.1, NM_167510.3 [P30432-1]
NP_996486.1, NM_206763.2 [P30432-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0074261; FBpp0074038; FBgn0004598 [P30432-2]
FBtr0074262; FBpp0074039; FBgn0004598 [P30432-1]
FBtr0074263; FBpp0074040; FBgn0004598 [P30432-2]
FBtr0074264; FBpp0074041; FBgn0004598 [P30432-1]
FBtr0074265; FBpp0074042; FBgn0004598 [P30432-2]
FBtr0074266; FBpp0074043; FBgn0004598 [P30432-1]
FBtr0074267; FBpp0089399; FBgn0004598 [P30432-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
32604

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG18734

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94375 mRNA Translation: AAA28551.1
L33831 Genomic DNA Translation: AAA69860.1
AE014298 Genomic DNA Translation: AAF48598.2
AE014298 Genomic DNA Translation: AAF48599.2
AE014298 Genomic DNA Translation: AAN09399.1
AE014298 Genomic DNA Translation: AAN09400.1
AE014298 Genomic DNA Translation: AAN09401.1
AE014298 Genomic DNA Translation: AAN09402.1
AE014298 Genomic DNA Translation: AAS65387.1
BT021414 mRNA Translation: AAX33562.1 Sequence problems.
AY070553 mRNA Translation: AAL48024.1 Different initiation.
PIRiA43434
RefSeqiNP_523368.2, NM_078644.4 [P30432-1]
NP_727963.1, NM_167506.3 [P30432-2]
NP_727964.1, NM_167507.3 [P30432-2]
NP_727965.1, NM_167508.2 [P30432-2]
NP_727966.1, NM_167509.3 [P30432-1]
NP_727967.1, NM_167510.3 [P30432-1]
NP_996486.1, NM_206763.2 [P30432-1]

3D structure databases

SMRiP30432
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi58944, 19 interactors
IntActiP30432, 6 interactors
STRINGi7227.FBpp0074038

Protein family/group databases

MEROPSiS08.049

Proteomic databases

PaxDbiP30432
PRIDEiP30432

Genome annotation databases

EnsemblMetazoaiFBtr0074261; FBpp0074038; FBgn0004598 [P30432-2]
FBtr0074262; FBpp0074039; FBgn0004598 [P30432-1]
FBtr0074263; FBpp0074040; FBgn0004598 [P30432-2]
FBtr0074264; FBpp0074041; FBgn0004598 [P30432-1]
FBtr0074265; FBpp0074042; FBgn0004598 [P30432-2]
FBtr0074266; FBpp0074043; FBgn0004598 [P30432-1]
FBtr0074267; FBpp0089399; FBgn0004598 [P30432-1]
GeneIDi32604
KEGGidme:Dmel_CG18734

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32604
FlyBaseiFBgn0004598 Fur2

Phylogenomic databases

eggNOGiKOG3525 Eukaryota
COG1404 LUCA
COG4935 LUCA
GeneTreeiENSGT00940000167869
InParanoidiP30432
KOiK01349
PhylomeDBiP30432

Enzyme and pathway databases

ReactomeiR-DME-1592389 Activation of Matrix Metalloproteinases
R-DME-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-DME-186797 Signaling by PDGF
R-DME-2173789 TGF-beta receptor signaling activates SMADs
SignaLinkiP30432

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
32604 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32604

Protein Ontology

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PROi
PR:P30432

Gene expression databases

BgeeiFBgn0004598 Expressed in cleaving embryo and 27 other tissues
ExpressionAtlasiP30432 baseline and differential
GenevisibleiP30432 DM

Family and domain databases

CDDicd00064 FU, 9 hits
cd04059 Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit
Gene3Di2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR006212 Furin_repeat
IPR008979 Galactose-bd-like_sf
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF14843 GF_recep_IV, 1 hit
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00261 FU, 10 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
SSF57184 SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS51892 SUBTILASE, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUR2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30432
Secondary accession number(s): A4V4M0
, A4V4M2, Q24301, Q5BI10, Q8SZS2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 25, 2002
Last modified: June 17, 2020
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. Peptidase families
    Classification of peptidase families and list of entries
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