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Protein

Glycylpeptide N-tetradecanoyltransferase 1

Gene

NMT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.1.97 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-75108 Activation, myristolyation of BID and translocation to mitochondria

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P30419

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001287

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase 1 (EC:2.3.1.973 Publications)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase 1
Short name:
NMT 1
Short name:
Type I N-myristoyltransferase
Peptide N-myristoyltransferase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NMT1
Synonyms:NMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000136448.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7857 NMT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
160993 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P30419

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi492G → D or K: Reduced activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4836

Open Targets

More...
OpenTargetsi
ENSG00000136448

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31661

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2593

Drug and drug target database

More...
DrugBanki
DB03062 (1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NMT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12231020

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642211 – 496Glycylpeptide N-tetradecanoyltransferase 1Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei31PhosphoserineBy similarity1
Modified residuei47PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P30419

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P30419

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P30419

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30419

PeptideAtlas

More...
PeptideAtlasi
P30419

PRoteomics IDEntifications database

More...
PRIDEi
P30419

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54667
54668 [P30419-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P30419-2 [P30419-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30419

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P30419

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P30419

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Heart, gut, kidney, liver and placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136448 Expressed in 230 organ(s), highest expression level in frontal cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_NMT1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P30419 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P30419 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022949
HPA022963

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110899, 93 interactors

Protein interaction database and analysis system

More...
IntActi
P30419, 21 interactors

Molecular INTeraction database

More...
MINTi
P30419

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000258960

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P30419

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1496
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RXTX-ray3.00A/B/C/D1-496[»]
3IU1X-ray1.42A/B115-496[»]
3IU2X-ray1.73A/B115-496[»]
3IWEX-ray1.79A/B115-496[»]
3JTKX-ray1.61A/B115-496[»]
4C2YX-ray1.64A/B109-496[»]
4C2ZX-ray2.08A/B109-496[»]
5MU6X-ray1.88A/B109-496[»]
5NPQX-ray2.37A/B109-496[»]
5O6HX-ray1.29A/B109-496[»]
5O6JX-ray1.45A/B109-496[»]
5O9SX-ray2.70A/B99-496[»]
5O9TX-ray2.15A/B99-496[»]
5O9UX-ray1.85A/B99-496[»]
5O9VX-ray2.20A/B99-496[»]
5UUTX-ray2.25A/B109-496[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P30419

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P30419

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P30419

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni118 – 120Myristoyl-CoA binding2 Publications3
Regioni248 – 250Myristoyl-CoA binding2 Publications3
Regioni256 – 260Myristoyl-CoA binding2 Publications5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 67Poly-LysAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2779 Eukaryota
COG5092 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017837

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000189123

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003404

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P30419

KEGG Orthology (KO)

More...
KOi
K00671

Identification of Orthologs from Complete Genome Data

More...
OMAi
YNWRCPS

Database of Orthologous Groups

More...
OrthoDBi
1025421at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P30419

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000903 MyristoylCoA_TrFase
IPR022677 MyristoylCoA_TrFase_C
IPR022678 MyristoylCoA_TrFase_CS
IPR022676 MyristoylCoA_TrFase_N

The PANTHER Classification System

More...
PANTHERi
PTHR11377 PTHR11377, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01233 NMT, 1 hit
PF02799 NMT_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF015892 N-myristl_transf, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55729 SSF55729, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00975 NMT_1, 1 hit
PS00976 NMT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: P30419-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADESETAVK PPAPPLPQMM EGNGNGHEHC SDCENEEDNS YNRGGLSPAN
60 70 80 90 100
DTGAKKKKKK QKKKKEKGSE TDSAQDQPVK MNSLPAERIQ EIQKAIELFS
110 120 130 140 150
VGQGPAKTME EASKRSYQFW DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY
160 170 180 190 200
TLPQGFTWDA LDLGDRGVLK ELYTLLNENY VEDDDNMFRF DYSPEFLLWA
210 220 230 240 250
LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK KMVEINFLCV
260 270 280 290 300
HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS
310 320 330 340 350
LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP METKDIPVVH
360 370 380 390 400
QLLTRYLKQF HLTPVMSQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF
410 420 430 440 450
YTLPSTIMNH PTHKSLKAAY SFYNVHTQTP LLDLMSDALV LAKMKGFDVF
460 470 480 490
NALDLMENKT FLEKLKFGIG DGNLQYYLYN WKCPSMGAEK VGLVLQ
Length:496
Mass (Da):56,806
Last modified:January 11, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7661140D3837BE7A
GO
Isoform Short (identifier: P30419-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:416
Mass (Da):48,141
Checksum:iCF08D233B6DD9383
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EN42K7EN42_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z8J4B7Z8J4_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN82K7EN82_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC09294 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05028661Q → K. Corresponds to variant dbSNP:rs3087878Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0035701 – 80Missing in isoform Short. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF043324 mRNA Translation: AAC09294.1 Different initiation.
AF020500 mRNA Translation: AAB95316.1
AK291936 mRNA Translation: BAF84625.1
CH471178 Genomic DNA Translation: EAW51554.1
BC006538 mRNA Translation: AAH06538.1
BC006569 mRNA Translation: AAH06569.1
BC007258 mRNA Translation: AAH07258.2
BC008312 mRNA Translation: AAH08312.2
M86707 mRNA No translation available.
Y17208 mRNA Translation: CAA76685.1
Y17209 mRNA Translation: CAA76686.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11494.1 [P30419-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC1343

NCBI Reference Sequences

More...
RefSeqi
NP_066565.1, NM_021079.4 [P30419-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.532790

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258960; ENSP00000258960; ENSG00000136448 [P30419-1]
ENST00000592782; ENSP00000468424; ENSG00000136448 [P30419-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4836

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4836

UCSC genome browser

More...
UCSCi
uc002ihz.4 human [P30419-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043324 mRNA Translation: AAC09294.1 Different initiation.
AF020500 mRNA Translation: AAB95316.1
AK291936 mRNA Translation: BAF84625.1
CH471178 Genomic DNA Translation: EAW51554.1
BC006538 mRNA Translation: AAH06538.1
BC006569 mRNA Translation: AAH06569.1
BC007258 mRNA Translation: AAH07258.2
BC008312 mRNA Translation: AAH08312.2
M86707 mRNA No translation available.
Y17208 mRNA Translation: CAA76685.1
Y17209 mRNA Translation: CAA76686.1
CCDSiCCDS11494.1 [P30419-1]
PIRiJC1343
RefSeqiNP_066565.1, NM_021079.4 [P30419-1]
UniGeneiHs.532790

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RXTX-ray3.00A/B/C/D1-496[»]
3IU1X-ray1.42A/B115-496[»]
3IU2X-ray1.73A/B115-496[»]
3IWEX-ray1.79A/B115-496[»]
3JTKX-ray1.61A/B115-496[»]
4C2YX-ray1.64A/B109-496[»]
4C2ZX-ray2.08A/B109-496[»]
5MU6X-ray1.88A/B109-496[»]
5NPQX-ray2.37A/B109-496[»]
5O6HX-ray1.29A/B109-496[»]
5O6JX-ray1.45A/B109-496[»]
5O9SX-ray2.70A/B99-496[»]
5O9TX-ray2.15A/B99-496[»]
5O9UX-ray1.85A/B99-496[»]
5O9VX-ray2.20A/B99-496[»]
5UUTX-ray2.25A/B109-496[»]
ProteinModelPortaliP30419
SMRiP30419
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110899, 93 interactors
IntActiP30419, 21 interactors
MINTiP30419
STRINGi9606.ENSP00000258960

Chemistry databases

BindingDBiP30419
ChEMBLiCHEMBL2593
DrugBankiDB03062 (1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone
SwissLipidsiSLP:000001287

PTM databases

iPTMnetiP30419
PhosphoSitePlusiP30419
SwissPalmiP30419

Polymorphism and mutation databases

BioMutaiNMT1
DMDMi12231020

Proteomic databases

EPDiP30419
jPOSTiP30419
MaxQBiP30419
PaxDbiP30419
PeptideAtlasiP30419
PRIDEiP30419
ProteomicsDBi54667
54668 [P30419-2]
TopDownProteomicsiP30419-2 [P30419-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4836
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258960; ENSP00000258960; ENSG00000136448 [P30419-1]
ENST00000592782; ENSP00000468424; ENSG00000136448 [P30419-1]
GeneIDi4836
KEGGihsa:4836
UCSCiuc002ihz.4 human [P30419-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4836
DisGeNETi4836
EuPathDBiHostDB:ENSG00000136448.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NMT1
HGNCiHGNC:7857 NMT1
HPAiHPA022949
HPA022963
MIMi160993 gene
neXtProtiNX_P30419
OpenTargetsiENSG00000136448
PharmGKBiPA31661

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2779 Eukaryota
COG5092 LUCA
GeneTreeiENSGT00390000017837
HOGENOMiHOG000189123
HOVERGENiHBG003404
InParanoidiP30419
KOiK00671
OMAiYNWRCPS
OrthoDBi1025421at2759
PhylomeDBiP30419

Enzyme and pathway databases

BRENDAi2.3.1.97 2681
ReactomeiR-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-75108 Activation, myristolyation of BID and translocation to mitochondria
SIGNORiP30419

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NMT1 human
EvolutionaryTraceiP30419

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
N-myristoyltransferase_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4836

Protein Ontology

More...
PROi
PR:P30419

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136448 Expressed in 230 organ(s), highest expression level in frontal cortex
CleanExiHS_NMT1
ExpressionAtlasiP30419 baseline and differential
GenevisibleiP30419 HS

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000903 MyristoylCoA_TrFase
IPR022677 MyristoylCoA_TrFase_C
IPR022678 MyristoylCoA_TrFase_CS
IPR022676 MyristoylCoA_TrFase_N
PANTHERiPTHR11377 PTHR11377, 1 hit
PfamiView protein in Pfam
PF01233 NMT, 1 hit
PF02799 NMT_C, 1 hit
PIRSFiPIRSF015892 N-myristl_transf, 1 hit
SUPFAMiSSF55729 SSF55729, 2 hits
PROSITEiView protein in PROSITE
PS00975 NMT_1, 1 hit
PS00976 NMT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNMT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30419
Secondary accession number(s): A8K7C1, Q9UE09
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 11, 2001
Last modified: January 16, 2019
This is version 191 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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