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UniProtKB - P30419 (NMT1_HUMAN)

Entry version 208 (02 Jun 2021)
Sequence version 2 (11 Jan 2001)
Previous versions | rss
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Protein

Glycylpeptide N-tetradecanoyltransferase 1

Gene

NMT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.1.97, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P30419

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-162599, Late Phase of HIV Life Cycle
R-HSA-2514859, Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-75108, Activation, myristolyation of BID and translocation to mitochondria

SIGNOR Signaling Network Open Resource

More...SIGNORi		P30419

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001287

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase 1 (EC:2.3.1.974 Publications)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase 1
Short name:
NMT 1
Short name:
Type I N-myristoyltransferase
Peptide N-myristoyltransferase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NMT1
Synonyms:NMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7857, NMT1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		160993, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P30419

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000136448.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi492G → D or K: Reduced activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4836

Open Targets

More...OpenTargetsi		ENSG00000136448

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31661

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P30419, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2593

Drug and drug target database

More...DrugBanki		DB03062, (1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NMT1

Domain mapping of disease mutations (DMDM)

More...DMDMi		12231020

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642211 – 496Glycylpeptide N-tetradecanoyltransferase 1Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei31PhosphoserineBy similarity1
Modified residuei47PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P30419

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P30419

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P30419

MaxQB - The MaxQuant DataBase

More...MaxQBi		P30419

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P30419

PeptideAtlas

More...PeptideAtlasi		P30419

PRoteomics IDEntifications database

More...PRIDEi		P30419

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54667 [P30419-1]
54668 [P30419-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P30419-2 [P30419-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P30419

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P30419

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P30419

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P30419

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Heart, gut, kidney, liver and placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136448, Expressed in frontal cortex and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P30419, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P30419, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000136448, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110899, 111 interactors

Protein interaction database and analysis system

More...IntActi		P30419, 42 interactors

Molecular INTeraction database

More...MINTi		P30419

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000468424

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P30419

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P30419, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1496
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P30419

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P30419

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 82DisorderedSequence analysisAdd BLAST82
Regioni118 – 120Myristoyl-CoA binding2 Publications3
Regioni248 – 250Myristoyl-CoA binding2 Publications3
Regioni256 – 260Myristoyl-CoA binding2 Publications5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2779, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017837

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022882_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P30419

Identification of Orthologs from Complete Genome Data

More...OMAi		SHLARNM

Database of Orthologous Groups

More...OrthoDBi		1025421at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P30419

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR000903, MyristoylCoA_TrFase
IPR022677, MyristoylCoA_TrFase_C
IPR022678, MyristoylCoA_TrFase_CS
IPR022676, MyristoylCoA_TrFase_N

The PANTHER Classification System

More...PANTHERi		PTHR11377, PTHR11377, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01233, NMT, 1 hit
PF02799, NMT_C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF015892, N-myristl_transf, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55729, SSF55729, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00975, NMT_1, 1 hit
PS00976, NMT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: P30419-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADESETAVK PPAPPLPQMM EGNGNGHEHC SDCENEEDNS YNRGGLSPAN 
        60         70         80         90        100
DTGAKKKKKK QKKKKEKGSE TDSAQDQPVK MNSLPAERIQ EIQKAIELFS 
       110        120        130        140        150
VGQGPAKTME EASKRSYQFW DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY 
       160        170        180        190        200
TLPQGFTWDA LDLGDRGVLK ELYTLLNENY VEDDDNMFRF DYSPEFLLWA 
       210        220        230        240        250
LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK KMVEINFLCV 
       260        270        280        290        300
HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS 
       310        320        330        340        350
LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP METKDIPVVH 
       360        370        380        390        400
QLLTRYLKQF HLTPVMSQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF 
       410        420        430        440        450
YTLPSTIMNH PTHKSLKAAY SFYNVHTQTP LLDLMSDALV LAKMKGFDVF 
       460        470        480        490 
NALDLMENKT FLEKLKFGIG DGNLQYYLYN WKCPSMGAEK VGLVLQ
Length:496
Mass (Da):56,806
Last modified:January 11, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7661140D3837BE7A
GO
Isoform Short (identifier: P30419-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:416
Mass (Da):48,141
Checksum:iCF08D233B6DD9383
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A7I2V539A0A7I2V539_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT1
494Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V3X4A0A7I2V3X4_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT1
478Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V3U5A0A7I2V3U5_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT1
393Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V4Y5A0A7I2V4Y5_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT1
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z8J4B7Z8J4_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN42K7EN42_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN82K7EN82_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V5M6A0A7I2V5M6_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT1
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V3M5A0A7I2V3M5_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V5J6A0A7I2V5J6_HUMAN
Glycylpeptide N-tetradecanoyltransf...
NMT1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC09294 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05028661Q → K. Corresponds to variant dbSNP:rs3087878Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0035701 – 80Missing in isoform Short. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF043324 mRNA Translation: AAC09294.1 Different initiation.
AF020500 mRNA Translation: AAB95316.1
AK291936 mRNA Translation: BAF84625.1
CH471178 Genomic DNA Translation: EAW51554.1
BC006538 mRNA Translation: AAH06538.1
BC006569 mRNA Translation: AAH06569.1
BC007258 mRNA Translation: AAH07258.2
BC008312 mRNA Translation: AAH08312.2
M86707 mRNA No translation available.
Y17208 mRNA Translation: CAA76685.1
Y17209 mRNA Translation: CAA76686.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11494.1 [P30419-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC1343

NCBI Reference Sequences

More...RefSeqi		NP_066565.1, NM_021079.4 [P30419-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000258960; ENSP00000258960; ENSG00000136448 [P30419-1]
ENST00000592654; ENSP00000466827; ENSG00000136448 [P30419-2]
ENST00000592782; ENSP00000468424; ENSG00000136448 [P30419-1]
ENST00000676828; ENSP00000504192; ENSG00000136448 [P30419-1]
ENST00000678938; ENSP00000503621; ENSG00000136448 [P30419-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4836

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4836

UCSC genome browser

More...UCSCi		uc002ihz.4, human [P30419-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043324 mRNA Translation: AAC09294.1 Different initiation.
AF020500 mRNA Translation: AAB95316.1
AK291936 mRNA Translation: BAF84625.1
CH471178 Genomic DNA Translation: EAW51554.1
BC006538 mRNA Translation: AAH06538.1
BC006569 mRNA Translation: AAH06569.1
BC007258 mRNA Translation: AAH07258.2
BC008312 mRNA Translation: AAH08312.2
M86707 mRNA No translation available.
Y17208 mRNA Translation: CAA76685.1
Y17209 mRNA Translation: CAA76686.1
CCDSiCCDS11494.1 [P30419-1]
PIRiJC1343
RefSeqiNP_066565.1, NM_021079.4 [P30419-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RXTX-ray3.00A/B/C/D1-496[»]
3IU1X-ray1.42A/B115-496[»]
3IU2X-ray1.73A/B115-496[»]
3IWEX-ray1.79A/B115-496[»]
3JTKX-ray1.61A/B115-496[»]
4C2YX-ray1.64A/B109-496[»]
4C2ZX-ray2.08A/B109-496[»]
5MU6X-ray1.88A/B109-496[»]
5NPQX-ray2.37A/B109-496[»]
5O6HX-ray1.29A/B109-496[»]
5O6JX-ray1.45A/B109-496[»]
5O9SX-ray2.70A/B99-496[»]
5O9TX-ray2.15A/B99-496[»]
5O9UX-ray1.85A/B99-496[»]
5O9VX-ray2.20A/B99-496[»]
5UUTX-ray2.25A/B109-496[»]
6EHJX-ray2.10A/B109-496[»]
6F56X-ray1.94A/B/C/D109-496[»]
6FZ2X-ray2.05A/B115-496[»]
6FZ3X-ray2.00A/B115-496[»]
6FZ5X-ray1.89A/B115-496[»]
6PAVX-ray2.52A/B109-496[»]
6QRMX-ray2.30A/B99-496[»]
6SJZX-ray2.00A/B99-496[»]
6SK2X-ray1.90A/B99-496[»]
6SK3X-ray2.70A/B99-493[»]
6SK8X-ray1.87A/B99-493[»]
6SKJX-ray2.80A/B99-494[»]
SMRiP30419
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110899, 111 interactors
IntActiP30419, 42 interactors
MINTiP30419
STRINGi9606.ENSP00000468424

Chemistry databases

BindingDBiP30419
ChEMBLiCHEMBL2593
DrugBankiDB03062, (1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone
SwissLipidsiSLP:000001287

PTM databases

iPTMnetiP30419
MetOSiteiP30419
PhosphoSitePlusiP30419
SwissPalmiP30419

Genetic variation databases

BioMutaiNMT1
DMDMi12231020

Proteomic databases

EPDiP30419
jPOSTiP30419
MassIVEiP30419
MaxQBiP30419
PaxDbiP30419
PeptideAtlasiP30419
PRIDEiP30419
ProteomicsDBi54667 [P30419-1]
54668 [P30419-2]
TopDownProteomicsiP30419-2 [P30419-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17578, 188 antibodies

The DNASU plasmid repository

More...DNASUi		4836

Genome annotation databases

EnsembliENST00000258960; ENSP00000258960; ENSG00000136448 [P30419-1]
ENST00000592654; ENSP00000466827; ENSG00000136448 [P30419-2]
ENST00000592782; ENSP00000468424; ENSG00000136448 [P30419-1]
ENST00000676828; ENSP00000504192; ENSG00000136448 [P30419-1]
ENST00000678938; ENSP00000503621; ENSG00000136448 [P30419-2]
GeneIDi4836
KEGGihsa:4836
UCSCiuc002ihz.4, human [P30419-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4836
DisGeNETi4836

GeneCards: human genes, protein and diseases

More...GeneCardsi		NMT1
HGNCiHGNC:7857, NMT1
HPAiENSG00000136448, Low tissue specificity
MIMi160993, gene
neXtProtiNX_P30419
OpenTargetsiENSG00000136448
PharmGKBiPA31661
VEuPathDBiHostDB:ENSG00000136448.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2779, Eukaryota
GeneTreeiENSGT00390000017837
HOGENOMiCLU_022882_1_0_1
InParanoidiP30419
OMAiSHLARNM
OrthoDBi1025421at2759
PhylomeDBiP30419

Enzyme and pathway databases

BRENDAi2.3.1.97, 2681
PathwayCommonsiP30419
ReactomeiR-HSA-162599, Late Phase of HIV Life Cycle
R-HSA-2514859, Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-75108, Activation, myristolyation of BID and translocation to mitochondria
SIGNORiP30419

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4836, 454 hits in 997 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NMT1, human
EvolutionaryTraceiP30419

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		N-myristoyltransferase_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4836
PharosiP30419, Tchem

Protein Ontology

More...PROi		PR:P30419
RNActiP30419, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136448, Expressed in frontal cortex and 240 other tissues
ExpressionAtlasiP30419, baseline and differential
GenevisibleiP30419, HS

Family and domain databases

InterProiView protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR000903, MyristoylCoA_TrFase
IPR022677, MyristoylCoA_TrFase_C
IPR022678, MyristoylCoA_TrFase_CS
IPR022676, MyristoylCoA_TrFase_N
PANTHERiPTHR11377, PTHR11377, 1 hit
PfamiView protein in Pfam
PF01233, NMT, 1 hit
PF02799, NMT_C, 1 hit
PIRSFiPIRSF015892, N-myristl_transf, 1 hit
SUPFAMiSSF55729, SSF55729, 2 hits
PROSITEiView protein in PROSITE
PS00975, NMT_1, 1 hit
PS00976, NMT_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNMT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30419
Secondary accession number(s): A8K7C1, Q9UE09
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 11, 2001
Last modified: June 2, 2021
This is version 208 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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