Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 146 (16 Oct 2019)
Sequence version 4 (28 Nov 2012)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

NK-tumor recognition protein

Gene

Nktr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumor-recognition complex involved in the function of NK cells.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by cyclosporin A (CsA).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Rotamase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NK-tumor recognition proteinCurated
Short name:
NK-TR proteinCurated
Alternative name(s):
Natural-killer cells cyclophilin-related protein
Peptidyl-prolyl cis-trans isomerase NKTRBy similarity (EC:5.2.1.8By similarity)
Short name:
PPIaseBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NktrImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97346 Nktr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642181 – 1453NK-tumor recognition proteinAdd BLAST1453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki323Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei379PhosphoserineBy similarity1
Modified residuei401PhosphoserineBy similarity1
Modified residuei416PhosphoserineBy similarity1
Cross-linki576Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki579Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei611PhosphoserineCombined sources1
Cross-linki637Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei646PhosphoserineBy similarity1
Cross-linki654Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki664Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei880PhosphoserineBy similarity1
Modified residuei882PhosphoserineBy similarity1
Modified residuei884PhosphoserineBy similarity1
Modified residuei900PhosphoserineCombined sources1
Modified residuei1139PhosphoserineBy similarity1
Modified residuei1148PhosphoserineCombined sources1
Modified residuei1195PhosphoserineBy similarity1
Cross-linki1208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P30415

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P30415

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P30415

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30415

PeptideAtlas

More...
PeptideAtlasi
P30415

PRoteomics IDEntifications database

More...
PRIDEi
P30415

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30415

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P30415

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032525 Expressed in 271 organ(s), highest expression level in ascending aorta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P30415 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P30415 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201775, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-59972N

Protein interaction database and analysis system

More...
IntActi
P30415, 3 interactors

Molecular INTeraction database

More...
MINTi
P30415

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035112

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P30415

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 175PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1303 – 1453Arg/Ser tandem repeat-richAdd BLAST151

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi198 – 273Arg/Ser-richAdd BLAST76
Compositional biasi222 – 241Arg/Lys-rich (basic)Add BLAST20
Compositional biasi422 – 459Arg/Lys-rich (basic)Add BLAST38
Compositional biasi468 – 565Arg/Ser-richAdd BLAST98
Compositional biasi658 – 812Arg/Ser-richAdd BLAST155
Compositional biasi964 – 1003Arg/Lys-rich (basic)Add BLAST40

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0546 Eukaryota
COG0652 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158548

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113792

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P30415

KEGG Orthology (KO)

More...
KOi
K12740

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSWSHNG

Database of Orthologous Groups

More...
OrthoDBi
1403619at2759

TreeFam database of animal gene trees

More...
TreeFami
TF318563

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00160 Pro_isomerase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00153 CSAPPISMRASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50891 SSF50891, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P30415-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAQDRPQCH FDIEINREPV GRIMFQLFSD ICPKTCKNFL CLCSGEKGLG
60 70 80 90 100
KTTGKKLCYK GSTFHRVVKN FMIQGGDFSE GNGKGGESIY GGYFKDENFI
110 120 130 140 150
LKHDRAFLLS MANRGKHTNG SQFFITTKPA PHLDGVHVVF GLVISGFEVI
160 170 180 190 200
EQIENLKTDA ASRPYADVRV IDCGVLATKL TKDVFEKKRK KPTCSEGSDS
210 220 230 240 250
SSRSSSSSES SSESEVERET IRRRRHKRRP KVRHAKKRRK EMSSSEEPRR
260 270 280 290 300
KRTVSPEGYS ERSDVNEKRS VDSNTKREKP VVRPEEIPPV PENRFLLRRD
310 320 330 340 350
MPAITVEPEQ NIPDVAPVVS DQKPSVSKSG RKIKGRGTIR YHTPPRSRSH
360 370 380 390 400
SESKDDDSSE TPPHWKEEMQ RLRAYRPPSG EKWSKGDKLS DPCSSRWDER
410 420 430 440 450
SLSQRSRSWS YNGYYSDLST ARHSDGHHKK HRKEKKFKHK KKAKKQKHCR
460 470 480 490 500
RHRQTKKRRI VMPDLEPSRS PTHRMKSSCV RERRSRASSS SSHHSSKRDW
510 520 530 540 550
SKSDQDDGSA STHSSRDSYR SKSHSRSDSR GSSRSRAVSK SSSRSLNRSK
560 570 580 590 600
SRSSSRSGPR RTSISPKKPA QLSENKPVKT EPLRPSVPQN GNVLVQPVAA
610 620 630 640 650
ENIPVIPLSD SPPPSRWKPG QKPWKPSYER IQEMKAKTTH LLPVQSTYSL
660 670 680 690 700
TNIKATVSSS SYHKREKPSE SDGSAYSKYS DRSSGSSGRS GSKSSRSRSS
710 720 730 740 750
SRSYTRSRSR SLPTSRSLSR SPSSRSHSPN KYSDGSQHSR SSSYTSVSSD
760 770 780 790 800
DGRRAMFRSN RKKSVTSHKR HRSNSEKTLH SKYVRGREKS SRHRKYSESR
810 820 830 840 850
SSLDYSSDSD QSHVQVYSAP EKEKQGKVEA LNDKQGKGRE EGKPKPEWEC
860 870 880 890 900
PRSKKRTPKD HSRDDSVSKG KNCAGSKWDS ESNSEQDVTK SRKSDPRRGS
910 920 930 940 950
EKEEGEASSD SESEVGQSHI KAKPPAKPPT STFLPGSDGA WKSRRPQSSA
960 970 980 990 1000
SESESSCSNL GNIRGEPQKQ KHSKDDLKGD HTKRAREKSK AKKDKKHKAP
1010 1020 1030 1040 1050
KRKQAFHWQP PLEFGDDEEE EMNGKQVTQD PKEKRHVSEK CEAVKDGIPN
1060 1070 1080 1090 1100
VEKTCDEGSS PSKPKKGTLE QDPLAEGGHD PSSCPAPLKV EDNTASSPPS
1110 1120 1130 1140 1150
AQHLEEHGPG GGEDVLQTDD NMEICTPDRT SPAKGEVVSP LANHRLDSPE
1160 1170 1180 1190 1200
VNIIPEQDEC MAHPRAGGEQ ESSMSESKTL GESGVKQDSS TSVTSPVETS
1210 1220 1230 1240 1250
GKKEGAEKSQ MNLTDKWKPL QGVGNLSVST ATTSSALDVK ALSTVPEVKP
1260 1270 1280 1290 1300
QGLRIEIKSK NKVRPGSLFD EVRKTARLNR RPRNQESSSD DQTPSRDGDS
1310 1320 1330 1340 1350
QSRSPHRSRS KSETKSRHRT RSVSYSHSRS RSRSSTSSYR SRSYSRSRSR
1360 1370 1380 1390 1400
DWYSRGRTRS RSSSYGSFHS HRTSSRSRSR SSSYDLHSRS RSYTYDSYYS
1410 1420 1430 1440 1450
RSRSRSRSQR SDSYHRGRSY NRRSRSGRSY GSDSESDRSY SHHRSPSESS

RYS
Length:1,453
Mass (Da):163,449
Last modified:November 28, 2012 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA536CDA355CF272
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R1C3S4R1C3_MOUSE
Peptidyl-prolyl cis-trans isomerase
Nktr
101Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3TQ51Q3TQ51_MOUSE
Peptidyl-prolyl cis-trans isomerase
Nktr
105Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8CBP6Q8CBP6_MOUSE
NK-tumor recognition protein
Nktr
966Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2C2S4R2C2_MOUSE
NK-tumor recognition protein
Nktr
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R220S4R220_MOUSE
NK-tumor recognition protein
Nktr
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1L7S4R1L7_MOUSE
NK-tumor recognition protein
Nktr
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2L3S4R2L3_MOUSE
NK-tumor recognition protein
Nktr
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA37500 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti112A → V in BAE25777 (PubMed:16141072).Curated1
Sequence conflicti567K → Q in BAE25777 (PubMed:16141072).Curated1
Sequence conflicti601E → G in BAE25777 (PubMed:16141072).Curated1
Sequence conflicti740R → K in BAE25777 (PubMed:16141072).Curated1
Sequence conflicti806S → T in AAA37500 (PubMed:8421688).Curated1
Sequence conflicti856 – 859RTPK → ENSE in AAA37500 (PubMed:8421688).Curated4
Sequence conflicti1203K → R in BAE25777 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L04289 mRNA Translation: AAA37500.2 Different initiation.
AK144214 mRNA Translation: BAE25777.1
AC159810 Genomic DNA No translation available.
AC165080 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23636.1

NCBI Reference Sequences

More...
RefSeqi
NP_035048.3, NM_010918.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035112; ENSMUSP00000035112; ENSMUSG00000032525

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18087

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18087

UCSC genome browser

More...
UCSCi
uc009sdr.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04289 mRNA Translation: AAA37500.2 Different initiation.
AK144214 mRNA Translation: BAE25777.1
AC159810 Genomic DNA No translation available.
AC165080 Genomic DNA No translation available.
CCDSiCCDS23636.1
RefSeqiNP_035048.3, NM_010918.2

3D structure databases

SMRiP30415
ModBaseiSearch...

Protein-protein interaction databases

BioGridi201775, 2 interactors
DIPiDIP-59972N
IntActiP30415, 3 interactors
MINTiP30415
STRINGi10090.ENSMUSP00000035112

PTM databases

iPTMnetiP30415
PhosphoSitePlusiP30415

Proteomic databases

EPDiP30415
jPOSTiP30415
MaxQBiP30415
PaxDbiP30415
PeptideAtlasiP30415
PRIDEiP30415

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
18087

Genome annotation databases

EnsembliENSMUST00000035112; ENSMUSP00000035112; ENSMUSG00000032525
GeneIDi18087
KEGGimmu:18087
UCSCiuc009sdr.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4820
MGIiMGI:97346 Nktr

Phylogenomic databases

eggNOGiKOG0546 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00940000158548
HOGENOMiHOG000113792
InParanoidiP30415
KOiK12740
OMAiRSWSHNG
OrthoDBi1403619at2759
TreeFamiTF318563

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nktr mouse

Protein Ontology

More...
PROi
PR:P30415

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032525 Expressed in 271 organ(s), highest expression level in ascending aorta
ExpressionAtlasiP30415 baseline and differential
GenevisibleiP30415 MM

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNKTR_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30415
Secondary accession number(s): F8VPR8, Q3UNH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 28, 2012
Last modified: October 16, 2019
This is version 146 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again