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Protein

NK-tumor recognition protein

Gene

Nktr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumor-recognition complex involved in the function of NK cells.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).By similarity

Activity regulationi

Inhibited by cyclosporin A (CsA).By similarity

GO - Molecular functioni

  • cyclosporin A binding Source: UniProtKB
  • peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB
  • unfolded protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
NK-tumor recognition proteinCurated
Short name:
NK-TR proteinCurated
Alternative name(s):
Natural-killer cells cyclophilin-related protein
Peptidyl-prolyl cis-trans isomerase NKTRBy similarity (EC:5.2.1.8By similarity)
Short name:
PPIaseBy similarity
Gene namesi
Name:NktrImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97346 Nktr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642181 – 1453NK-tumor recognition proteinAdd BLAST1453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki323Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei379PhosphoserineBy similarity1
Modified residuei401PhosphoserineBy similarity1
Modified residuei416PhosphoserineBy similarity1
Cross-linki576Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki579Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei611PhosphoserineCombined sources1
Cross-linki637Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei646PhosphoserineBy similarity1
Cross-linki654Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki664Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei880PhosphoserineBy similarity1
Modified residuei882PhosphoserineBy similarity1
Modified residuei884PhosphoserineBy similarity1
Modified residuei900PhosphoserineCombined sources1
Modified residuei1139PhosphoserineBy similarity1
Modified residuei1148PhosphoserineCombined sources1
Modified residuei1195PhosphoserineBy similarity1
Cross-linki1208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP30415
MaxQBiP30415
PaxDbiP30415
PeptideAtlasiP30415
PRIDEiP30415

PTM databases

iPTMnetiP30415
PhosphoSitePlusiP30415

Expressioni

Gene expression databases

BgeeiENSMUSG00000032525 Expressed in 271 organ(s), highest expression level in ascending aorta
CleanExiMM_NKTR
ExpressionAtlasiP30415 baseline and differential
GenevisibleiP30415 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201775, 1 interactor
DIPiDIP-59972N
IntActiP30415, 3 interactors
MINTiP30415
STRINGi10090.ENSMUSP00000035112

Structurei

3D structure databases

ProteinModelPortaliP30415
SMRiP30415
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 175PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1303 – 1453Arg/Ser tandem repeat-richAdd BLAST151

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 273Arg/Ser-richAdd BLAST76
Compositional biasi222 – 241Arg/Lys-rich (basic)Add BLAST20
Compositional biasi422 – 459Arg/Lys-rich (basic)Add BLAST38
Compositional biasi468 – 565Arg/Ser-richAdd BLAST98
Compositional biasi658 – 812Arg/Ser-richAdd BLAST155
Compositional biasi964 – 1003Arg/Lys-rich (basic)Add BLAST40

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0546 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00550000074595
HOGENOMiHOG000113792
HOVERGENiHBG052631
InParanoidiP30415
KOiK12740
OMAiSRSRGWY
OrthoDBiEOG091G0BGL
TreeFamiTF318563

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P30415-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAQDRPQCH FDIEINREPV GRIMFQLFSD ICPKTCKNFL CLCSGEKGLG
60 70 80 90 100
KTTGKKLCYK GSTFHRVVKN FMIQGGDFSE GNGKGGESIY GGYFKDENFI
110 120 130 140 150
LKHDRAFLLS MANRGKHTNG SQFFITTKPA PHLDGVHVVF GLVISGFEVI
160 170 180 190 200
EQIENLKTDA ASRPYADVRV IDCGVLATKL TKDVFEKKRK KPTCSEGSDS
210 220 230 240 250
SSRSSSSSES SSESEVERET IRRRRHKRRP KVRHAKKRRK EMSSSEEPRR
260 270 280 290 300
KRTVSPEGYS ERSDVNEKRS VDSNTKREKP VVRPEEIPPV PENRFLLRRD
310 320 330 340 350
MPAITVEPEQ NIPDVAPVVS DQKPSVSKSG RKIKGRGTIR YHTPPRSRSH
360 370 380 390 400
SESKDDDSSE TPPHWKEEMQ RLRAYRPPSG EKWSKGDKLS DPCSSRWDER
410 420 430 440 450
SLSQRSRSWS YNGYYSDLST ARHSDGHHKK HRKEKKFKHK KKAKKQKHCR
460 470 480 490 500
RHRQTKKRRI VMPDLEPSRS PTHRMKSSCV RERRSRASSS SSHHSSKRDW
510 520 530 540 550
SKSDQDDGSA STHSSRDSYR SKSHSRSDSR GSSRSRAVSK SSSRSLNRSK
560 570 580 590 600
SRSSSRSGPR RTSISPKKPA QLSENKPVKT EPLRPSVPQN GNVLVQPVAA
610 620 630 640 650
ENIPVIPLSD SPPPSRWKPG QKPWKPSYER IQEMKAKTTH LLPVQSTYSL
660 670 680 690 700
TNIKATVSSS SYHKREKPSE SDGSAYSKYS DRSSGSSGRS GSKSSRSRSS
710 720 730 740 750
SRSYTRSRSR SLPTSRSLSR SPSSRSHSPN KYSDGSQHSR SSSYTSVSSD
760 770 780 790 800
DGRRAMFRSN RKKSVTSHKR HRSNSEKTLH SKYVRGREKS SRHRKYSESR
810 820 830 840 850
SSLDYSSDSD QSHVQVYSAP EKEKQGKVEA LNDKQGKGRE EGKPKPEWEC
860 870 880 890 900
PRSKKRTPKD HSRDDSVSKG KNCAGSKWDS ESNSEQDVTK SRKSDPRRGS
910 920 930 940 950
EKEEGEASSD SESEVGQSHI KAKPPAKPPT STFLPGSDGA WKSRRPQSSA
960 970 980 990 1000
SESESSCSNL GNIRGEPQKQ KHSKDDLKGD HTKRAREKSK AKKDKKHKAP
1010 1020 1030 1040 1050
KRKQAFHWQP PLEFGDDEEE EMNGKQVTQD PKEKRHVSEK CEAVKDGIPN
1060 1070 1080 1090 1100
VEKTCDEGSS PSKPKKGTLE QDPLAEGGHD PSSCPAPLKV EDNTASSPPS
1110 1120 1130 1140 1150
AQHLEEHGPG GGEDVLQTDD NMEICTPDRT SPAKGEVVSP LANHRLDSPE
1160 1170 1180 1190 1200
VNIIPEQDEC MAHPRAGGEQ ESSMSESKTL GESGVKQDSS TSVTSPVETS
1210 1220 1230 1240 1250
GKKEGAEKSQ MNLTDKWKPL QGVGNLSVST ATTSSALDVK ALSTVPEVKP
1260 1270 1280 1290 1300
QGLRIEIKSK NKVRPGSLFD EVRKTARLNR RPRNQESSSD DQTPSRDGDS
1310 1320 1330 1340 1350
QSRSPHRSRS KSETKSRHRT RSVSYSHSRS RSRSSTSSYR SRSYSRSRSR
1360 1370 1380 1390 1400
DWYSRGRTRS RSSSYGSFHS HRTSSRSRSR SSSYDLHSRS RSYTYDSYYS
1410 1420 1430 1440 1450
RSRSRSRSQR SDSYHRGRSY NRRSRSGRSY GSDSESDRSY SHHRSPSESS

RYS
Length:1,453
Mass (Da):163,449
Last modified:November 28, 2012 - v4
Checksum:iAA536CDA355CF272
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R1C3S4R1C3_MOUSE
Peptidyl-prolyl cis-trans isomerase
Nktr
101Annotation score:
Q3TQ51Q3TQ51_MOUSE
Peptidyl-prolyl cis-trans isomerase
Nktr
105Annotation score:
Q8CBP6Q8CBP6_MOUSE
NK-tumor recognition protein
Nktr
966Annotation score:
S4R1L7S4R1L7_MOUSE
NK-tumor recognition protein
Nktr
69Annotation score:
S4R2L3S4R2L3_MOUSE
NK-tumor recognition protein
Nktr
99Annotation score:
S4R2C2S4R2C2_MOUSE
NK-tumor recognition protein
Nktr
95Annotation score:
S4R220S4R220_MOUSE
NK-tumor recognition protein
Nktr
100Annotation score:

Sequence cautioni

The sequence AAA37500 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112A → V in BAE25777 (PubMed:16141072).Curated1
Sequence conflicti567K → Q in BAE25777 (PubMed:16141072).Curated1
Sequence conflicti601E → G in BAE25777 (PubMed:16141072).Curated1
Sequence conflicti740R → K in BAE25777 (PubMed:16141072).Curated1
Sequence conflicti806S → T in AAA37500 (PubMed:8421688).Curated1
Sequence conflicti856 – 859RTPK → ENSE in AAA37500 (PubMed:8421688).Curated4
Sequence conflicti1203K → R in BAE25777 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04289 mRNA Translation: AAA37500.2 Different initiation.
AK144214 mRNA Translation: BAE25777.1
AC159810 Genomic DNA No translation available.
AC165080 Genomic DNA No translation available.
CCDSiCCDS23636.1
RefSeqiNP_035048.3, NM_010918.2
UniGeneiMm.32842
Mm.441099

Genome annotation databases

EnsembliENSMUST00000035112; ENSMUSP00000035112; ENSMUSG00000032525
GeneIDi18087
KEGGimmu:18087
UCSCiuc009sdr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04289 mRNA Translation: AAA37500.2 Different initiation.
AK144214 mRNA Translation: BAE25777.1
AC159810 Genomic DNA No translation available.
AC165080 Genomic DNA No translation available.
CCDSiCCDS23636.1
RefSeqiNP_035048.3, NM_010918.2
UniGeneiMm.32842
Mm.441099

3D structure databases

ProteinModelPortaliP30415
SMRiP30415
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201775, 1 interactor
DIPiDIP-59972N
IntActiP30415, 3 interactors
MINTiP30415
STRINGi10090.ENSMUSP00000035112

PTM databases

iPTMnetiP30415
PhosphoSitePlusiP30415

Proteomic databases

EPDiP30415
MaxQBiP30415
PaxDbiP30415
PeptideAtlasiP30415
PRIDEiP30415

Protocols and materials databases

DNASUi18087
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035112; ENSMUSP00000035112; ENSMUSG00000032525
GeneIDi18087
KEGGimmu:18087
UCSCiuc009sdr.1 mouse

Organism-specific databases

CTDi4820
MGIiMGI:97346 Nktr

Phylogenomic databases

eggNOGiKOG0546 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00550000074595
HOGENOMiHOG000113792
HOVERGENiHBG052631
InParanoidiP30415
KOiK12740
OMAiSRSRGWY
OrthoDBiEOG091G0BGL
TreeFamiTF318563

Miscellaneous databases

ChiTaRSiNktr mouse
PROiPR:P30415
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032525 Expressed in 271 organ(s), highest expression level in ascending aorta
CleanExiMM_NKTR
ExpressionAtlasiP30415 baseline and differential
GenevisibleiP30415 MM

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNKTR_MOUSE
AccessioniPrimary (citable) accession number: P30415
Secondary accession number(s): F8VPR8, Q3UNH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 28, 2012
Last modified: November 7, 2018
This is version 141 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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