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Entry version 164 (18 Sep 2019)
Sequence version 2 (30 May 2000)
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Protein

NK-tumor recognition protein

Gene

NKTR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688).2 Publications

Caution

A report has suggested that the protein is expressed at the cell surface, associated with the cell membrane via its N-terminus. However, there is no direct evidence for that localization and the properties of the protein argue against it.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by cyclosporin A (CsA).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Rotamase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NK-tumor recognition protein1 Publication
Short name:
NK-TR protein1 Publication
Alternative name(s):
Natural-killer cells cyclophilin-related protein
Peptidyl-prolyl cis-trans isomerase NKTR1 Publication (EC:5.2.1.81 Publication)
Short name:
PPIase1 Publication
Rotamase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NKTRImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7833 NKTR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
161565 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P30414

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4820

Open Targets

More...
OpenTargetsi
ENSG00000114857

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31641

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NKTR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
8039798

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642171 – 1462NK-tumor recognition proteinAdd BLAST1462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki323Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei379PhosphoserineCombined sources1
Modified residuei401PhosphoserineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Cross-linki578Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki581Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei613PhosphoserineBy similarity1
Cross-linki639Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei648PhosphoserineCombined sources1
Cross-linki656Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki666Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei866PhosphoserineCombined sources1
Modified residuei887PhosphoserineCombined sources1
Modified residuei889PhosphoserineCombined sources1
Modified residuei891PhosphoserineCombined sources1
Modified residuei907PhosphoserineBy similarity1
Cross-linki1057Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1077PhosphoserineCombined sources1
Modified residuei1146PhosphoserineCombined sources1
Modified residuei1155PhosphothreonineCombined sources1
Cross-linki1163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei1203PhosphoserineCombined sources1
Cross-linki1216Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1225Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P30414

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P30414

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P30414

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P30414

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30414

PeptideAtlas

More...
PeptideAtlasi
P30414

PRoteomics IDEntifications database

More...
PRIDEi
P30414

ProteomicsDB human proteome resource

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ProteomicsDBi
54666

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P30414

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30414

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P30414

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P30414

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000114857 Expressed in 240 organ(s), highest expression level in pituitary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P30414 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P30414 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022120
HPA051576

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110885, 29 interactors

Protein interaction database and analysis system

More...
IntActi
P30414, 25 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000232978

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P30414

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P30414

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 175PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1311 – 1348Arg/Ser tandem repeat-richAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi194 – 244Arg/Ser-richAdd BLAST51
Compositional biasi219 – 240Arg/Lys-rich (basic)Add BLAST22
Compositional biasi421 – 457Arg/Lys-rich (basic)Add BLAST37
Compositional biasi466 – 574Arg/Ser-richAdd BLAST109
Compositional biasi664 – 814Arg/Ser-richAdd BLAST151
Compositional biasi970 – 1010Arg/Lys-rich (basic)Add BLAST41

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0546 Eukaryota
COG0652 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158548

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113792

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P30414

KEGG Orthology (KO)

More...
KOi
K12740

Identification of Orthologs from Complete Genome Data

More...
OMAi
MEICTPE

Database of Orthologous Groups

More...
OrthoDBi
1403619at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P30414

TreeFam database of animal gene trees

More...
TreeFami
TF318563

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00160 Pro_isomerase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00153 CSAPPISMRASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50891 SSF50891, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P30414-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAQDRPQCH FDIEINREPV GRIMFQLFSD ICPKTCKNFL CLCSGEKGLG
60 70 80 90 100
KTTGKKLCYK GSTFHRVVKN FMIQGGDFSE GNGKGGESIY GGYFKDENFI
110 120 130 140 150
LKHDRAFLLS MANRGKHTNG SQFFITTKPA PHLDGVHVVF GLVISGFEVI
160 170 180 190 200
EQIENLKTDA ASRPYADVRV IDCGVLATKS IKDVFEKKRK KPTHSEGSDS
210 220 230 240 250
SSNSSSSSES SSESELEHER SRRRKHKRRP KVKRSKKRRK EASSSEEPRN
260 270 280 290 300
KHAMNPKGHS ERSDTNEKRS VDSSAKREKP VVRPEEIPPV PENRFLLRRD
310 320 330 340 350
MPVVTAEPEP KIPDVAPIVS DQKPSVSKSG RKIKGRGTIR YHTPPRSRSC
360 370 380 390 400
SESDDDDSSE TPPHWKEEMQ RLRAYRPPSG EKWSKGDKLS DPCSSRWDER
410 420 430 440 450
SLSQRSRSWS YNGYYSDLST ARHSGHHKKR RKEKKVKHKK KGKKQKHCRR
460 470 480 490 500
HKQTKKRRIL IPSDIESSKS STRRMKSSCD RERSSRSSSL SSHHSSKRDW
510 520 530 540 550
SKSDKDVQSS LTHSSRDSYR SKSHSQSYSR GSSRSRTASK SSSHSRSRSK
560 570 580 590 600
SRSSSKSGHR KRASKSPRKT ASQLSENKPV KTEPLRATMA QNENVVVQPV
610 620 630 640 650
VAENIPVIPL SDSPPPSRWK PGQKPWKPSY ERIQEMKAKT THLLPIQSTY
660 670 680 690 700
SLANIKETGS SSSYHKREKN SESDQSTYSK YSDRSSESSP RSRSRSSRSR
710 720 730 740 750
SYSRSYTRSR SLASSHSRSR SPSSRSHSRN KYSDHSQCSR SSSYTSISSD
760 770 780 790 800
DGRRAKRRLR SSGKKNSVSH KKHSSSSEKT LHSKYVKGRD RSSCVRKYSE
810 820 830 840 850
SRSSLDYSSD SEQSSVQATQ SAQEKEKQGQ MERTHNKQEK NRGEEKSKSE
860 870 880 890 900
RECPHSKKRT LKENLSDHLR NGSKPKRKNY AGSKWDSESN SERDVTKNSK
910 920 930 940 950
NDSHPSSDKE EGEATSDSES EVSEIHIKVK PTTKSSTNTS LPDDNGAWKS
960 970 980 990 1000
SKQRTSTSDS EGSCSNSENN RGKPQKHKHG SKENLKREHT KKVKEKLKGK
1010 1020 1030 1040 1050
KDKKHKAPKR KQAFHWQPPL EFGEEEEEEI DDKQVTQESK EKKVSENNET
1060 1070 1080 1090 1100
IKDNILKTEK SSEEDLSGKH DTVTVSSDLD QFTKDDSKLS ISPTALNTEE
1110 1120 1130 1140 1150
NVACLQNIQH VEESVPNGVE DVLQTDDNME ICTPDRSSPA KVEETSPLGN
1160 1170 1180 1190 1200
ARLDTPDINI VLKQDMATEH PQAEVVKQES SMSESKVLGE VGKQDSSSAS
1210 1220 1230 1240 1250
LASAGESTGK KEVAEKSQIN LIDKKWKPLQ GVGNLAAPNA ATSSAVEVKV
1260 1270 1280 1290 1300
LTTVPEMKPQ GLRIEIKSKN KVRPGSLFDE VRKTARLNRR PRNQESSSDE
1310 1320 1330 1340 1350
QTPSRDDDSQ SRSPSRSRSK SETKSRHRTR SVSYSHSRSR SRSSTSSYRS
1360 1370 1380 1390 1400
RSYSRSRSRG WYSRGRTRSR SSSYRSYKSH RTSSRSRSRS SSYDPHSRSR
1410 1420 1430 1440 1450
SYTYDSYYSR SRSRSRSQRS DSYHRGRSYN RRSRSCRSYG SDSESDRSYS
1460
HHRSPSESSR YS
Length:1,462
Mass (Da):165,677
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD98A1147763EF527
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYW3A0A087WYW3_HUMAN
NK-tumor recognition protein
NKTR
1,162Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JMM5C9JMM5_HUMAN
Peptidyl-prolyl cis-trans isomerase
NKTR
104Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8K7K2A8K7K2_HUMAN
Peptidyl-prolyl cis-trans isomerase
NKTR
105Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061765271V → G. Corresponds to variant dbSNP:rs35726114Ensembl.1
Natural variantiVAR_051773861L → V. Corresponds to variant dbSNP:rs33969824Ensembl.1
Natural variantiVAR_051774935S → L. Corresponds to variant dbSNP:rs35770315Ensembl.1
Natural variantiVAR_0617661182M → T. Corresponds to variant dbSNP:rs34897686Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L04288 mRNA Translation: AAA35734.2
AF184110 Genomic DNA Translation: AAD56402.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2702.1

Protein sequence database of the Protein Information Resource

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PIRi
A47328

NCBI Reference Sequences

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RefSeqi
NP_005376.2, NM_005385.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000232978; ENSP00000232978; ENSG00000114857

Database of genes from NCBI RefSeq genomes

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GeneIDi
4820

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4820

UCSC genome browser

More...
UCSCi
uc003clo.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04288 mRNA Translation: AAA35734.2
AF184110 Genomic DNA Translation: AAD56402.1
CCDSiCCDS2702.1
PIRiA47328
RefSeqiNP_005376.2, NM_005385.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HE9X-ray2.00A/B7-179[»]
SMRiP30414
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110885, 29 interactors
IntActiP30414, 25 interactors
STRINGi9606.ENSP00000232978

PTM databases

CarbonylDBiP30414
iPTMnetiP30414
PhosphoSitePlusiP30414

Polymorphism and mutation databases

BioMutaiNKTR
DMDMi8039798

Proteomic databases

EPDiP30414
jPOSTiP30414
MassIVEiP30414
MaxQBiP30414
PaxDbiP30414
PeptideAtlasiP30414
PRIDEiP30414
ProteomicsDBi54666

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4820
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232978; ENSP00000232978; ENSG00000114857
GeneIDi4820
KEGGihsa:4820
UCSCiuc003clo.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4820
DisGeNETi4820

GeneCards: human genes, protein and diseases

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GeneCardsi
NKTR
HGNCiHGNC:7833 NKTR
HPAiHPA022120
HPA051576
MIMi161565 gene
neXtProtiNX_P30414
OpenTargetsiENSG00000114857
PharmGKBiPA31641

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0546 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00940000158548
HOGENOMiHOG000113792
InParanoidiP30414
KOiK12740
OMAiMEICTPE
OrthoDBi1403619at2759
PhylomeDBiP30414
TreeFamiTF318563

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NKTR human
EvolutionaryTraceiP30414

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NKTR

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4820

Pharos

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Pharosi
P30414
PMAP-CutDBiP30414

Protein Ontology

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PROi
PR:P30414

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000114857 Expressed in 240 organ(s), highest expression level in pituitary gland
ExpressionAtlasiP30414 baseline and differential
GenevisibleiP30414 HS

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNKTR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30414
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 30, 2000
Last modified: September 18, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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