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Protein

NK-tumor recognition protein

Gene

NKTR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688).2 Publications

Caution

A report has suggested that the protein is expressed at the cell surface, associated with the cell membrane via its N-terminus. However, there is no direct evidence for that localization and the properties of the protein argue against it.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).1 Publication

Activity regulationi

Inhibited by cyclosporin A (CsA).1 Publication

GO - Molecular functioni

  • cyclosporin A binding Source: UniProtKB
  • peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
NK-tumor recognition protein1 Publication
Short name:
NK-TR protein1 Publication
Alternative name(s):
Natural-killer cells cyclophilin-related protein
Peptidyl-prolyl cis-trans isomerase NKTR1 Publication (EC:5.2.1.81 Publication)
Short name:
PPIase1 Publication
Rotamase
Gene namesi
Name:NKTRImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114857.17
HGNCiHGNC:7833 NKTR
MIMi161565 gene
neXtProtiNX_P30414

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4820
OpenTargetsiENSG00000114857
PharmGKBiPA31641

Polymorphism and mutation databases

BioMutaiNKTR
DMDMi8039798

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642171 – 1462NK-tumor recognition proteinAdd BLAST1462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki323Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei379PhosphoserineCombined sources1
Modified residuei401PhosphoserineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Cross-linki578Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki581Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei613PhosphoserineBy similarity1
Cross-linki639Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei648PhosphoserineCombined sources1
Cross-linki656Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki666Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei866PhosphoserineCombined sources1
Modified residuei887PhosphoserineCombined sources1
Modified residuei889PhosphoserineCombined sources1
Modified residuei891PhosphoserineCombined sources1
Modified residuei907PhosphoserineBy similarity1
Cross-linki1057Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1077PhosphoserineCombined sources1
Modified residuei1146PhosphoserineCombined sources1
Modified residuei1155PhosphothreonineCombined sources1
Cross-linki1163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei1203PhosphoserineCombined sources1
Cross-linki1216Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1225Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP30414
MaxQBiP30414
PaxDbiP30414
PeptideAtlasiP30414
PRIDEiP30414
ProteomicsDBi54666

PTM databases

CarbonylDBiP30414
iPTMnetiP30414
PhosphoSitePlusiP30414

Miscellaneous databases

PMAP-CutDBiP30414

Expressioni

Gene expression databases

BgeeiENSG00000114857 Expressed in 240 organ(s), highest expression level in pituitary gland
CleanExiHS_NKTR
ExpressionAtlasiP30414 baseline and differential
GenevisibleiP30414 HS

Organism-specific databases

HPAiHPA022120
HPA051576

Interactioni

Protein-protein interaction databases

BioGridi110885, 29 interactors
IntActiP30414, 7 interactors
STRINGi9606.ENSP00000232978

Structurei

Secondary structure

11462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP30414
SMRiP30414
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30414

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 175PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1311 – 1348Arg/Ser tandem repeat-richAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi194 – 244Arg/Ser-richAdd BLAST51
Compositional biasi219 – 240Arg/Lys-rich (basic)Add BLAST22
Compositional biasi421 – 457Arg/Lys-rich (basic)Add BLAST37
Compositional biasi466 – 574Arg/Ser-richAdd BLAST109
Compositional biasi664 – 814Arg/Ser-richAdd BLAST151
Compositional biasi970 – 1010Arg/Lys-rich (basic)Add BLAST41

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0546 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00550000074595
HOGENOMiHOG000113792
HOVERGENiHBG052631
InParanoidiP30414
KOiK12740
OMAiQKPWKPS
OrthoDBiEOG091G0BGL
PhylomeDBiP30414
TreeFamiTF318563

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P30414-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAQDRPQCH FDIEINREPV GRIMFQLFSD ICPKTCKNFL CLCSGEKGLG
60 70 80 90 100
KTTGKKLCYK GSTFHRVVKN FMIQGGDFSE GNGKGGESIY GGYFKDENFI
110 120 130 140 150
LKHDRAFLLS MANRGKHTNG SQFFITTKPA PHLDGVHVVF GLVISGFEVI
160 170 180 190 200
EQIENLKTDA ASRPYADVRV IDCGVLATKS IKDVFEKKRK KPTHSEGSDS
210 220 230 240 250
SSNSSSSSES SSESELEHER SRRRKHKRRP KVKRSKKRRK EASSSEEPRN
260 270 280 290 300
KHAMNPKGHS ERSDTNEKRS VDSSAKREKP VVRPEEIPPV PENRFLLRRD
310 320 330 340 350
MPVVTAEPEP KIPDVAPIVS DQKPSVSKSG RKIKGRGTIR YHTPPRSRSC
360 370 380 390 400
SESDDDDSSE TPPHWKEEMQ RLRAYRPPSG EKWSKGDKLS DPCSSRWDER
410 420 430 440 450
SLSQRSRSWS YNGYYSDLST ARHSGHHKKR RKEKKVKHKK KGKKQKHCRR
460 470 480 490 500
HKQTKKRRIL IPSDIESSKS STRRMKSSCD RERSSRSSSL SSHHSSKRDW
510 520 530 540 550
SKSDKDVQSS LTHSSRDSYR SKSHSQSYSR GSSRSRTASK SSSHSRSRSK
560 570 580 590 600
SRSSSKSGHR KRASKSPRKT ASQLSENKPV KTEPLRATMA QNENVVVQPV
610 620 630 640 650
VAENIPVIPL SDSPPPSRWK PGQKPWKPSY ERIQEMKAKT THLLPIQSTY
660 670 680 690 700
SLANIKETGS SSSYHKREKN SESDQSTYSK YSDRSSESSP RSRSRSSRSR
710 720 730 740 750
SYSRSYTRSR SLASSHSRSR SPSSRSHSRN KYSDHSQCSR SSSYTSISSD
760 770 780 790 800
DGRRAKRRLR SSGKKNSVSH KKHSSSSEKT LHSKYVKGRD RSSCVRKYSE
810 820 830 840 850
SRSSLDYSSD SEQSSVQATQ SAQEKEKQGQ MERTHNKQEK NRGEEKSKSE
860 870 880 890 900
RECPHSKKRT LKENLSDHLR NGSKPKRKNY AGSKWDSESN SERDVTKNSK
910 920 930 940 950
NDSHPSSDKE EGEATSDSES EVSEIHIKVK PTTKSSTNTS LPDDNGAWKS
960 970 980 990 1000
SKQRTSTSDS EGSCSNSENN RGKPQKHKHG SKENLKREHT KKVKEKLKGK
1010 1020 1030 1040 1050
KDKKHKAPKR KQAFHWQPPL EFGEEEEEEI DDKQVTQESK EKKVSENNET
1060 1070 1080 1090 1100
IKDNILKTEK SSEEDLSGKH DTVTVSSDLD QFTKDDSKLS ISPTALNTEE
1110 1120 1130 1140 1150
NVACLQNIQH VEESVPNGVE DVLQTDDNME ICTPDRSSPA KVEETSPLGN
1160 1170 1180 1190 1200
ARLDTPDINI VLKQDMATEH PQAEVVKQES SMSESKVLGE VGKQDSSSAS
1210 1220 1230 1240 1250
LASAGESTGK KEVAEKSQIN LIDKKWKPLQ GVGNLAAPNA ATSSAVEVKV
1260 1270 1280 1290 1300
LTTVPEMKPQ GLRIEIKSKN KVRPGSLFDE VRKTARLNRR PRNQESSSDE
1310 1320 1330 1340 1350
QTPSRDDDSQ SRSPSRSRSK SETKSRHRTR SVSYSHSRSR SRSSTSSYRS
1360 1370 1380 1390 1400
RSYSRSRSRG WYSRGRTRSR SSSYRSYKSH RTSSRSRSRS SSYDPHSRSR
1410 1420 1430 1440 1450
SYTYDSYYSR SRSRSRSQRS DSYHRGRSYN RRSRSCRSYG SDSESDRSYS
1460
HHRSPSESSR YS
Length:1,462
Mass (Da):165,677
Last modified:May 30, 2000 - v2
Checksum:iD98A1147763EF527
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYW3A0A087WYW3_HUMAN
NK-tumor recognition protein
NKTR
1,162Annotation score:
C9JMM5C9JMM5_HUMAN
Peptidyl-prolyl cis-trans isomerase
NKTR
104Annotation score:
A8K7K2A8K7K2_HUMAN
Peptidyl-prolyl cis-trans isomerase
NKTR
105Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061765271V → G. Corresponds to variant dbSNP:rs35726114Ensembl.1
Natural variantiVAR_051773861L → V. Corresponds to variant dbSNP:rs33969824Ensembl.1
Natural variantiVAR_051774935S → L. Corresponds to variant dbSNP:rs35770315Ensembl.1
Natural variantiVAR_0617661182M → T. Corresponds to variant dbSNP:rs34897686Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04288 mRNA Translation: AAA35734.2
AF184110 Genomic DNA Translation: AAD56402.1
CCDSiCCDS2702.1
PIRiA47328
RefSeqiNP_005376.2, NM_005385.3
UniGeneiHs.529509

Genome annotation databases

EnsembliENST00000232978; ENSP00000232978; ENSG00000114857
GeneIDi4820
KEGGihsa:4820
UCSCiuc003clo.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04288 mRNA Translation: AAA35734.2
AF184110 Genomic DNA Translation: AAD56402.1
CCDSiCCDS2702.1
PIRiA47328
RefSeqiNP_005376.2, NM_005385.3
UniGeneiHs.529509

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HE9X-ray2.00A/B7-179[»]
ProteinModelPortaliP30414
SMRiP30414
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110885, 29 interactors
IntActiP30414, 7 interactors
STRINGi9606.ENSP00000232978

PTM databases

CarbonylDBiP30414
iPTMnetiP30414
PhosphoSitePlusiP30414

Polymorphism and mutation databases

BioMutaiNKTR
DMDMi8039798

Proteomic databases

EPDiP30414
MaxQBiP30414
PaxDbiP30414
PeptideAtlasiP30414
PRIDEiP30414
ProteomicsDBi54666

Protocols and materials databases

DNASUi4820
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232978; ENSP00000232978; ENSG00000114857
GeneIDi4820
KEGGihsa:4820
UCSCiuc003clo.4 human

Organism-specific databases

CTDi4820
DisGeNETi4820
EuPathDBiHostDB:ENSG00000114857.17
GeneCardsiNKTR
HGNCiHGNC:7833 NKTR
HPAiHPA022120
HPA051576
MIMi161565 gene
neXtProtiNX_P30414
OpenTargetsiENSG00000114857
PharmGKBiPA31641
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0546 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00550000074595
HOGENOMiHOG000113792
HOVERGENiHBG052631
InParanoidiP30414
KOiK12740
OMAiQKPWKPS
OrthoDBiEOG091G0BGL
PhylomeDBiP30414
TreeFamiTF318563

Miscellaneous databases

ChiTaRSiNKTR human
EvolutionaryTraceiP30414
GeneWikiiNKTR
GenomeRNAii4820
PMAP-CutDBiP30414
PROiPR:P30414
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114857 Expressed in 240 organ(s), highest expression level in pituitary gland
CleanExiHS_NKTR
ExpressionAtlasiP30414 baseline and differential
GenevisibleiP30414 HS

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNKTR_HUMAN
AccessioniPrimary (citable) accession number: P30414
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 30, 2000
Last modified: September 12, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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