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UniProtKB - P30411 (BKRB2_HUMAN)

Entry version 184 (13 Feb 2019)
Sequence version 2 (01 Nov 1997)
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Protein

B2 bradykinin receptor

Gene

BDKRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • bradykinin receptor activity Source: BHF-UCL
  • phosphatidylinositol phospholipase C activity Source: ProtInc
  • protease binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • type 1 angiotensin receptor binding Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

More...SIGNORi		P30411

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
B2 bradykinin receptor
Short name:
B2R
Short name:
BK-2 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BDKRB2
Synonyms:BKR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000168398.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:1030 BDKRB2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		113503 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P30411

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 60ExtracellularSequence analysisAdd BLAST60
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei61 – 84Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini85 – 93CytoplasmicSequence analysis9
Transmembranei94 – 118Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini119 – 131ExtracellularSequence analysisAdd BLAST13
Transmembranei132 – 153Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini154 – 175CytoplasmicSequence analysisAdd BLAST22
Transmembranei176 – 198Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini199 – 221ExtracellularSequence analysisAdd BLAST23
Transmembranei222 – 248Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini249 – 267CytoplasmicSequence analysisAdd BLAST19
Transmembranei268 – 292Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini293 – 311ExtracellularSequence analysisAdd BLAST19
Transmembranei312 – 335Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini336 – 391CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		624

Open Targets

More...OpenTargetsi		ENSG00000168398

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA80

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3157

Drug and drug target database

More...DrugBanki		DB05038 Anatibant
DB06196 Icatibant

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		42

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BDKRB2

Domain mapping of disease mutations (DMDM)

More...DMDMi		2506481

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000691901 – 391B2 bradykinin receptorAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi130 ↔ 211PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei156PhosphotyrosineBy similarity1
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei347PhosphotyrosineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi351S-palmitoyl cysteineSequence analysis1
Modified residuei366PhosphoserineBy similarity1
Modified residuei369PhosphothreonineBy similarity1
Modified residuei373Phosphoserine; by GRK61 Publication1
Modified residuei375Phosphoserine; by GRK61 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P30411

MaxQB - The MaxQuant DataBase

More...MaxQBi		P30411

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P30411

PeptideAtlas

More...PeptideAtlasi		P30411

PRoteomics IDEntifications database

More...PRIDEi		P30411

ProteomicsDB human proteome resource

More...ProteomicsDBi		54664
54665 [P30411-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P30411

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P30411

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P30411

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Widespread in normal smooth muscle tissue and neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168398 Expressed in 165 organ(s), highest expression level in mucosa of urinary bladder

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P30411 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA050841

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
KNG1P010422EBI-6623386,EBI-6623273

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107093, 4 interactors

Protein interaction database and analysis system

More...IntActi		P30411, 33 interactors

Molecular INTeraction database

More...MINTi		P30411

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000307713

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P30411

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P30411

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410INT3 Eukaryota
ENOG41117RA LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158162

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000010314

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG103183

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P30411

KEGG Orthology (KO)

More...KOi		K03916

Identification of Orthologs from Complete Genome Data

More...OMAi		PFWAINI

Database of Orthologous Groups

More...OrthoDBi		826485at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P30411

TreeFam database of animal gene trees

More...TreeFami		TF330024

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001504 Brdyknn_2_rcpt
IPR000496 Brdyknn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00425 BRADYKININR
PR00994 BRADYKINNB2R
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: P30411-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSPWKISMF LSVREDSVPT TASFSADMLN VTLQGPTLNG TFAQSKCPQV 
        60         70         80         90        100
EWLGWLNTIQ PPFLWVLFVL ATLENIFVLS VFCLHKSSCT VAEIYLGNLA 
       110        120        130        140        150
AADLILACGL PFWAITISNN FDWLFGETLC RVVNAIISMN LYSSICFLML 
       160        170        180        190        200
VSIDRYLALV KTMSMGRMRG VRWAKLYSLV IWGCTLLLSS PMLVFRTMKE 
       210        220        230        240        250
YSDEGHNVTA CVISYPSLIW EVFTNMLLNV VGFLLPLSVI TFCTMQIMQV 
       260        270        280        290        300
LRNNEMQKFK EIQTERRATV LVLVVLLLFI ICWLPFQIST FLDTLHRLGI 
       310        320        330        340        350
LSSCQDERII DVITQIASFM AYSNSCLNPL VYVIVGKRFR KKSWEVYQGV 
       360        370        380        390 
CQKGGCRSEP IQMENSMGTL RTSISVERQI HKLQDWAGSR Q
Length:391
Mass (Da):44,461
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i066940ED3D18BB66
GO
Isoform Short (identifier: P30411-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:364
Mass (Da):41,441
Checksum:i8FDC67EFC6600FB6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00345714R → C2 PublicationsCorresponds to variant dbSNP:rs1046248Ensembl.1
Natural variantiVAR_012284354G → E1 PublicationCorresponds to variant dbSNP:rs2227279Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0018651 – 27Missing in isoform Short. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M88714 mRNA Translation: AAB02793.1
S56772 Genomic DNA Translation: AAB25765.1
X69680 mRNA Translation: CAA49360.1
S45489 Genomic DNA Translation: AAB23467.1
L27594 Genomic DNA No translation available.
X86165 mRNA Translation: CAA60109.1
X86164 mRNA Translation: CAA60108.1
AY275465 mRNA Translation: AAP32297.1
AF378542 Genomic DNA Translation: AAK56376.1
BC074894 mRNA Translation: AAH74894.1
BC074895 mRNA Translation: AAH74895.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9942.1 [P30411-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JH0712 JQ1488

NCBI Reference Sequences

More...RefSeqi		NP_000614.1, NM_000623.3 [P30411-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.654542
Hs.726620

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000539359; ENSP00000438376; ENSG00000168398 [P30411-2]
ENST00000542454; ENSP00000439459; ENSG00000168398 [P30411-2]
ENST00000554311; ENSP00000450482; ENSG00000168398 [P30411-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		624

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:624

UCSC genome browser

More...UCSCi		uc001yfg.3 human [P30411-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Bradykinin receptor entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88714 mRNA Translation: AAB02793.1
S56772 Genomic DNA Translation: AAB25765.1
X69680 mRNA Translation: CAA49360.1
S45489 Genomic DNA Translation: AAB23467.1
L27594 Genomic DNA No translation available.
X86165 mRNA Translation: CAA60109.1
X86164 mRNA Translation: CAA60108.1
AY275465 mRNA Translation: AAP32297.1
AF378542 Genomic DNA Translation: AAK56376.1
BC074894 mRNA Translation: AAH74894.1
BC074895 mRNA Translation: AAH74895.1
CCDSiCCDS9942.1 [P30411-1]
PIRiJH0712 JQ1488
RefSeqiNP_000614.1, NM_000623.3 [P30411-1]
UniGeneiHs.654542
Hs.726620

3D structure databases

ProteinModelPortaliP30411
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107093, 4 interactors
IntActiP30411, 33 interactors
MINTiP30411
STRINGi9606.ENSP00000307713

Chemistry databases

BindingDBiP30411
ChEMBLiCHEMBL3157
DrugBankiDB05038 Anatibant
DB06196 Icatibant
GuidetoPHARMACOLOGYi42

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiP30411
PhosphoSitePlusiP30411
SwissPalmiP30411

Polymorphism and mutation databases

BioMutaiBDKRB2
DMDMi2506481

Proteomic databases

jPOSTiP30411
MaxQBiP30411
PaxDbiP30411
PeptideAtlasiP30411
PRIDEiP30411
ProteomicsDBi54664
54665 [P30411-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000539359; ENSP00000438376; ENSG00000168398 [P30411-2]
ENST00000542454; ENSP00000439459; ENSG00000168398 [P30411-2]
ENST00000554311; ENSP00000450482; ENSG00000168398 [P30411-1]
GeneIDi624
KEGGihsa:624
UCSCiuc001yfg.3 human [P30411-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		624
DisGeNETi624
EuPathDBiHostDB:ENSG00000168398.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		BDKRB2
HGNCiHGNC:1030 BDKRB2
HPAiHPA050841
MIMi113503 gene
neXtProtiNX_P30411
OpenTargetsiENSG00000168398
PharmGKBiPA80

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410INT3 Eukaryota
ENOG41117RA LUCA
GeneTreeiENSGT00940000158162
HOGENOMiHOG000010314
HOVERGENiHBG103183
InParanoidiP30411
KOiK03916
OMAiPFWAINI
OrthoDBi826485at2759
PhylomeDBiP30411
TreeFamiTF330024

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
SIGNORiP30411

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BDKRB2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Bradykinin_receptor_B2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		624

Protein Ontology

More...PROi		PR:P30411

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168398 Expressed in 165 organ(s), highest expression level in mucosa of urinary bladder
GenevisibleiP30411 HS

Family and domain databases

InterProiView protein in InterPro
IPR001504 Brdyknn_2_rcpt
IPR000496 Brdyknn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00425 BRADYKININR
PR00994 BRADYKINNB2R
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBKRB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30411
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1997
Last modified: February 13, 2019
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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