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Protein

B2 bradykinin receptor

Gene

BDKRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • bradykinin receptor activity Source: BHF-UCL
  • phosphatidylinositol phospholipase C activity Source: ProtInc
  • protease binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • type 1 angiotensin receptor binding Source: BHF-UCL

GO - Biological processi

  • arachidonic acid secretion Source: BHF-UCL
  • blood circulation Source: ProtInc
  • cell surface receptor signaling pathway Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: Reactome
  • inflammatory response Source: BHF-UCL
  • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator Source: Ensembl
  • negative regulation of peptidyl-serine phosphorylation Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc
  • regulation of vascular permeability Source: BHF-UCL
  • regulation of vasoconstriction Source: BHF-UCL
  • response to salt stress Source: Ensembl
  • smooth muscle contraction Source: BHF-UCL
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
  • vasoconstriction Source: InterPro
  • vasodilation Source: Ensembl

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
SIGNORiP30411

Names & Taxonomyi

Protein namesi
Recommended name:
B2 bradykinin receptor
Short name:
B2R
Short name:
BK-2 receptor
Gene namesi
Name:BDKRB2
Synonyms:BKR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000168398.6
HGNCiHGNC:1030 BDKRB2
MIMi113503 gene
neXtProtiNX_P30411

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 60ExtracellularSequence analysisAdd BLAST60
Transmembranei61 – 84Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini85 – 93CytoplasmicSequence analysis9
Transmembranei94 – 118Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini119 – 131ExtracellularSequence analysisAdd BLAST13
Transmembranei132 – 153Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini154 – 175CytoplasmicSequence analysisAdd BLAST22
Transmembranei176 – 198Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini199 – 221ExtracellularSequence analysisAdd BLAST23
Transmembranei222 – 248Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini249 – 267CytoplasmicSequence analysisAdd BLAST19
Transmembranei268 – 292Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini293 – 311ExtracellularSequence analysisAdd BLAST19
Transmembranei312 – 335Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini336 – 391CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi624
OpenTargetsiENSG00000168398
PharmGKBiPA80

Chemistry databases

ChEMBLiCHEMBL3157
DrugBankiDB05038 Anatibant
DB06196 Icatibant
GuidetoPHARMACOLOGYi42

Polymorphism and mutation databases

BioMutaiBDKRB2
DMDMi2506481

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691901 – 391B2 bradykinin receptorAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi130 ↔ 211PROSITE-ProRule annotation
Modified residuei156PhosphotyrosineBy similarity1
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei347PhosphotyrosineBy similarity1
Lipidationi351S-palmitoyl cysteineSequence analysis1
Modified residuei366PhosphoserineBy similarity1
Modified residuei369PhosphothreonineBy similarity1
Modified residuei373Phosphoserine; by GRK61 Publication1
Modified residuei375Phosphoserine; by GRK61 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP30411
PaxDbiP30411
PeptideAtlasiP30411
PRIDEiP30411
ProteomicsDBi54664
54665 [P30411-2]

PTM databases

iPTMnetiP30411
PhosphoSitePlusiP30411
SwissPalmiP30411

Expressioni

Tissue specificityi

Ubiquitous. Widespread in normal smooth muscle tissue and neurons.1 Publication

Gene expression databases

BgeeiENSG00000168398
CleanExiHS_BDKRB2
GenevisibleiP30411 HS

Organism-specific databases

HPAiHPA050841

Interactioni

Subunit structurei

Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KNG1P010422EBI-6623386,EBI-6623273

GO - Molecular functioni

  • protease binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • type 1 angiotensin receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107093, 4 interactors
IntActiP30411, 11 interactors
MINTiP30411
STRINGi9606.ENSP00000307713

Chemistry databases

BindingDBiP30411

Structurei

3D structure databases

ProteinModelPortaliP30411
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INT3 Eukaryota
ENOG41117RA LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000010314
HOVERGENiHBG103183
InParanoidiP30411
KOiK03916
OMAiENSMGTL
OrthoDBiEOG091G0AAK
PhylomeDBiP30411
TreeFamiTF330024

Family and domain databases

InterProiView protein in InterPro
IPR001504 Brdyknn_2_rcpt
IPR000496 Brdyknn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00425 BRADYKININR
PR00994 BRADYKINNB2R
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P30411-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSPWKISMF LSVREDSVPT TASFSADMLN VTLQGPTLNG TFAQSKCPQV
60 70 80 90 100
EWLGWLNTIQ PPFLWVLFVL ATLENIFVLS VFCLHKSSCT VAEIYLGNLA
110 120 130 140 150
AADLILACGL PFWAITISNN FDWLFGETLC RVVNAIISMN LYSSICFLML
160 170 180 190 200
VSIDRYLALV KTMSMGRMRG VRWAKLYSLV IWGCTLLLSS PMLVFRTMKE
210 220 230 240 250
YSDEGHNVTA CVISYPSLIW EVFTNMLLNV VGFLLPLSVI TFCTMQIMQV
260 270 280 290 300
LRNNEMQKFK EIQTERRATV LVLVVLLLFI ICWLPFQIST FLDTLHRLGI
310 320 330 340 350
LSSCQDERII DVITQIASFM AYSNSCLNPL VYVIVGKRFR KKSWEVYQGV
360 370 380 390
CQKGGCRSEP IQMENSMGTL RTSISVERQI HKLQDWAGSR Q
Length:391
Mass (Da):44,461
Last modified:November 1, 1997 - v2
Checksum:i066940ED3D18BB66
GO
Isoform Short (identifier: P30411-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:364
Mass (Da):41,441
Checksum:i8FDC67EFC6600FB6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00345714R → C2 PublicationsCorresponds to variant dbSNP:rs1046248Ensembl.1
Natural variantiVAR_012284354G → E1 PublicationCorresponds to variant dbSNP:rs2227279Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0018651 – 27Missing in isoform Short. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88714 mRNA Translation: AAB02793.1
S56772 Genomic DNA Translation: AAB25765.1
X69680 mRNA Translation: CAA49360.1
S45489 Genomic DNA Translation: AAB23467.1
L27594 Genomic DNA No translation available.
X86165 mRNA Translation: CAA60109.1
X86164 mRNA Translation: CAA60108.1
AY275465 mRNA Translation: AAP32297.1
AF378542 Genomic DNA Translation: AAK56376.1
BC074894 mRNA Translation: AAH74894.1
BC074895 mRNA Translation: AAH74895.1
CCDSiCCDS9942.1 [P30411-1]
PIRiJH0712 JQ1488
RefSeqiNP_000614.1, NM_000623.3 [P30411-1]
UniGeneiHs.654542
Hs.726620

Genome annotation databases

EnsembliENST00000539359; ENSP00000438376; ENSG00000168398 [P30411-2]
ENST00000542454; ENSP00000439459; ENSG00000168398 [P30411-2]
ENST00000554311; ENSP00000450482; ENSG00000168398 [P30411-1]
GeneIDi624
KEGGihsa:624
UCSCiuc001yfg.3 human [P30411-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBKRB2_HUMAN
AccessioniPrimary (citable) accession number: P30411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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