UniProtKB - P30411 (BKRB2_HUMAN)
Protein
B2 bradykinin receptor
Gene
BDKRB2
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
GO - Molecular functioni
- bradykinin receptor activity Source: BHF-UCL
- G protein-coupled receptor activity Source: GO_Central
- phosphatidylinositol phospholipase C activity Source: ProtInc
- protease binding Source: BHF-UCL
- protein heterodimerization activity Source: BHF-UCL
- type 1 angiotensin receptor binding Source: BHF-UCL
GO - Biological processi
- arachidonic acid secretion Source: BHF-UCL
- blood circulation Source: ProtInc
- cell surface receptor signaling pathway Source: ProtInc
- G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: BHF-UCL
- negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator Source: Ensembl
- negative regulation of peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: ProtInc
- regulation of vascular permeability Source: BHF-UCL
- regulation of vasoconstriction Source: BHF-UCL
- response to salt stress Source: Ensembl
- smooth muscle contraction Source: BHF-UCL
- transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
- vasoconstriction Source: InterPro
- vasodilation Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P30411 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P30411 |
Protein family/group databases
TCDBi | 9.A.14.13.27, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: B2 bradykinin receptorShort name: B2R Short name: BK-2 receptor |
Gene namesi | Name:BDKRB2 Synonyms:BKR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168398.6 |
HGNCi | HGNC:1030, BDKRB2 |
MIMi | 113503, gene |
neXtProti | NX_P30411 |
Subcellular locationi
Plasma membrane
Endosome
- endosome Source: BHF-UCL
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 60 | ExtracellularSequence analysisAdd BLAST | 60 | |
Transmembranei | 61 – 84 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 85 – 93 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 94 – 118 | Helical; Name=2Sequence analysisAdd BLAST | 25 | |
Topological domaini | 119 – 131 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 132 – 153 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 154 – 175 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 176 – 198 | Helical; Name=4Sequence analysisAdd BLAST | 23 | |
Topological domaini | 199 – 221 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 222 – 248 | Helical; Name=5Sequence analysisAdd BLAST | 27 | |
Topological domaini | 249 – 267 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 268 – 292 | Helical; Name=6Sequence analysisAdd BLAST | 25 | |
Topological domaini | 293 – 311 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 312 – 335 | Helical; Name=7Sequence analysisAdd BLAST | 24 | |
Topological domaini | 336 – 391 | CytoplasmicSequence analysisAdd BLAST | 56 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 624 |
OpenTargetsi | ENSG00000168398 |
PharmGKBi | PA80 |
Miscellaneous databases
Pharosi | P30411, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3157 |
DrugBanki | DB05038, Anatibant DB06196, Icatibant DB06549, Labradimil |
DrugCentrali | P30411 |
GuidetoPHARMACOLOGYi | 42 |
Polymorphism and mutation databases
BioMutai | BDKRB2 |
DMDMi | 2506481 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069190 | 1 – 391 | B2 bradykinin receptorAdd BLAST | 391 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 30 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 39 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 130 ↔ 211 | PROSITE-ProRule annotation | ||
Modified residuei | 156 | PhosphotyrosineBy similarity | 1 | |
Glycosylationi | 207 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 347 | PhosphotyrosineBy similarity | 1 | |
Lipidationi | 351 | S-palmitoyl cysteineSequence analysis | 1 | |
Modified residuei | 366 | PhosphoserineBy similarity | 1 | |
Modified residuei | 369 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 373 | Phosphoserine; by GRK61 Publication | 1 | |
Modified residuei | 375 | Phosphoserine; by GRK61 Publication | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
MassIVEi | P30411 |
MaxQBi | P30411 |
PaxDbi | P30411 |
PeptideAtlasi | P30411 |
PRIDEi | P30411 |
ProteomicsDBi | 54664 [P30411-1] 54665 [P30411-2] |
PTM databases
GlyGeni | P30411, 3 sites |
iPTMneti | P30411 |
PhosphoSitePlusi | P30411 |
SwissPalmi | P30411 |
Expressioni
Tissue specificityi
Ubiquitous. Widespread in normal smooth muscle tissue and neurons.1 Publication
Gene expression databases
Bgeei | ENSG00000168398, Expressed in stromal cell of endometrium and 172 other tissues |
Genevisiblei | P30411, HS |
Organism-specific databases
HPAi | ENSG00000168398, Low tissue specificity |
Interactioni
Subunit structurei
Forms a complex with PECAM1 and GNAQ.
Interacts with PECAM1.
1 PublicationBinary interactionsi
P30411
With | #Exp. | IntAct |
---|---|---|
Bradykinin (PRO_0000006688) | 2 | EBI-6623386,EBI-6623273 |
GO - Molecular functioni
- protease binding Source: BHF-UCL
- protein heterodimerization activity Source: BHF-UCL
- type 1 angiotensin receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 107093, 4 interactors |
IntActi | P30411, 33 interactors |
MINTi | P30411 |
STRINGi | 9606.ENSP00000450482 |
Chemistry databases
BindingDBi | P30411 |
Miscellaneous databases
RNActi | P30411, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QTX6, Eukaryota |
GeneTreei | ENSGT01010000222307 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P30411 |
OMAi | DICNQIF |
OrthoDBi | 826485at2759 |
PhylomeDBi | P30411 |
TreeFami | TF330024 |
Family and domain databases
InterProi | View protein in InterPro IPR001504, Brdyknn_2_rcpt IPR000496, Brdyknn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00425, BRADYKININR PR00994, BRADYKINNB2R PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform Long (identifier: P30411-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFSPWKISMF LSVREDSVPT TASFSADMLN VTLQGPTLNG TFAQSKCPQV
60 70 80 90 100
EWLGWLNTIQ PPFLWVLFVL ATLENIFVLS VFCLHKSSCT VAEIYLGNLA
110 120 130 140 150
AADLILACGL PFWAITISNN FDWLFGETLC RVVNAIISMN LYSSICFLML
160 170 180 190 200
VSIDRYLALV KTMSMGRMRG VRWAKLYSLV IWGCTLLLSS PMLVFRTMKE
210 220 230 240 250
YSDEGHNVTA CVISYPSLIW EVFTNMLLNV VGFLLPLSVI TFCTMQIMQV
260 270 280 290 300
LRNNEMQKFK EIQTERRATV LVLVVLLLFI ICWLPFQIST FLDTLHRLGI
310 320 330 340 350
LSSCQDERII DVITQIASFM AYSNSCLNPL VYVIVGKRFR KKSWEVYQGV
360 370 380 390
CQKGGCRSEP IQMENSMGTL RTSISVERQI HKLQDWAGSR Q
Isoform Short (identifier: P30411-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-27: Missing.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003457 | 14 | R → C2 PublicationsCorresponds to variant dbSNP:rs1046248Ensembl. | 1 | |
Natural variantiVAR_012284 | 354 | G → E1 PublicationCorresponds to variant dbSNP:rs2227279EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001865 | 1 – 27 | Missing in isoform Short. 2 PublicationsAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M88714 mRNA Translation: AAB02793.1 S56772 Genomic DNA Translation: AAB25765.1 X69680 mRNA Translation: CAA49360.1 S45489 Genomic DNA Translation: AAB23467.1 L27594 Genomic DNA No translation available. X86165 mRNA Translation: CAA60109.1 X86164 mRNA Translation: CAA60108.1 AY275465 mRNA Translation: AAP32297.1 AF378542 Genomic DNA Translation: AAK56376.1 BC074894 mRNA Translation: AAH74894.1 BC074895 mRNA Translation: AAH74895.1 |
CCDSi | CCDS9942.1 [P30411-1] |
PIRi | JH0712, JQ1488 |
RefSeqi | NP_000614.1, NM_000623.3 [P30411-1] |
Genome annotation databases
Ensembli | ENST00000539359; ENSP00000438376; ENSG00000168398 [P30411-2] ENST00000542454; ENSP00000439459; ENSG00000168398 [P30411-2] ENST00000554311; ENSP00000450482; ENSG00000168398 [P30411-1] |
GeneIDi | 624 |
KEGGi | hsa:624 |
UCSCi | uc001yfg.3, human [P30411-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Bradykinin receptor entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M88714 mRNA Translation: AAB02793.1 S56772 Genomic DNA Translation: AAB25765.1 X69680 mRNA Translation: CAA49360.1 S45489 Genomic DNA Translation: AAB23467.1 L27594 Genomic DNA No translation available. X86165 mRNA Translation: CAA60109.1 X86164 mRNA Translation: CAA60108.1 AY275465 mRNA Translation: AAP32297.1 AF378542 Genomic DNA Translation: AAK56376.1 BC074894 mRNA Translation: AAH74894.1 BC074895 mRNA Translation: AAH74895.1 |
CCDSi | CCDS9942.1 [P30411-1] |
PIRi | JH0712, JQ1488 |
RefSeqi | NP_000614.1, NM_000623.3 [P30411-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 107093, 4 interactors |
IntActi | P30411, 33 interactors |
MINTi | P30411 |
STRINGi | 9606.ENSP00000450482 |
Chemistry databases
BindingDBi | P30411 |
ChEMBLi | CHEMBL3157 |
DrugBanki | DB05038, Anatibant DB06196, Icatibant DB06549, Labradimil |
DrugCentrali | P30411 |
GuidetoPHARMACOLOGYi | 42 |
Protein family/group databases
TCDBi | 9.A.14.13.27, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P30411, 3 sites |
iPTMneti | P30411 |
PhosphoSitePlusi | P30411 |
SwissPalmi | P30411 |
Polymorphism and mutation databases
BioMutai | BDKRB2 |
DMDMi | 2506481 |
Proteomic databases
MassIVEi | P30411 |
MaxQBi | P30411 |
PaxDbi | P30411 |
PeptideAtlasi | P30411 |
PRIDEi | P30411 |
ProteomicsDBi | 54664 [P30411-1] 54665 [P30411-2] |
Protocols and materials databases
Antibodypediai | 14184, 280 antibodies |
Genome annotation databases
Ensembli | ENST00000539359; ENSP00000438376; ENSG00000168398 [P30411-2] ENST00000542454; ENSP00000439459; ENSG00000168398 [P30411-2] ENST00000554311; ENSP00000450482; ENSG00000168398 [P30411-1] |
GeneIDi | 624 |
KEGGi | hsa:624 |
UCSCi | uc001yfg.3, human [P30411-1] |
Organism-specific databases
CTDi | 624 |
DisGeNETi | 624 |
EuPathDBi | HostDB:ENSG00000168398.6 |
GeneCardsi | BDKRB2 |
HGNCi | HGNC:1030, BDKRB2 |
HPAi | ENSG00000168398, Low tissue specificity |
MIMi | 113503, gene |
neXtProti | NX_P30411 |
OpenTargetsi | ENSG00000168398 |
PharmGKBi | PA80 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTX6, Eukaryota |
GeneTreei | ENSGT01010000222307 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P30411 |
OMAi | DICNQIF |
OrthoDBi | 826485at2759 |
PhylomeDBi | P30411 |
TreeFami | TF330024 |
Enzyme and pathway databases
PathwayCommonsi | P30411 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P30411 |
Miscellaneous databases
BioGRID-ORCSi | 624, 3 hits in 844 CRISPR screens |
ChiTaRSi | BDKRB2, human |
GeneWikii | Bradykinin_receptor_B2 |
GenomeRNAii | 624 |
Pharosi | P30411, Tclin |
PROi | PR:P30411 |
RNActi | P30411, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168398, Expressed in stromal cell of endometrium and 172 other tissues |
Genevisiblei | P30411, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001504, Brdyknn_2_rcpt IPR000496, Brdyknn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00425, BRADYKININR PR00994, BRADYKINNB2R PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BKRB2_HUMAN | |
Accessioni | P30411Primary (citable) accession number: P30411 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 196 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries