BDKRB2

Functionⁱ

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functionⁱ

bradykinin receptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 17077303
phosphatidylinositol phospholipase C activity
Source: ProtInc
Traceable author statementⁱ
- 8302267
protease binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17077303
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10993080
type 1 angiotensin receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10993080

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

arachidonic acid secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 17077303
blood circulation
Source: ProtInc
Non-traceable author statementⁱ
- 7835885
cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 7916737
G protein-coupled receptor signaling pathway Source: Reactome
inflammatory response
Source: BHF-UCL
Inferred by curatorⁱ
- 17077303
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator Source: Ensembl
negative regulation of peptidyl-serine phosphorylation Source: Ensembl
positive regulation of cytosolic calcium ion concentration
Source: ProtInc
Traceable author statementⁱ
- 10653985
regulation of vascular permeability
Source: BHF-UCL
Inferred by curatorⁱ
- 17077303
regulation of vasoconstriction
Source: BHF-UCL
Inferred by curatorⁱ
- 17077303
response to salt stress Source: Ensembl
smooth muscle contraction
Source: BHF-UCL
Inferred by curatorⁱ
- 17077303
transmembrane receptor protein tyrosine kinase signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10653985
vasoconstriction Source: InterPro
vasodilation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	P30411

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: B2 bradykinin receptor Short name: B2R Short name: BK-2 receptor
Gene namesⁱ	Name:BDKRB2 Synonyms:BKR2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168398.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1030 BDKRB2
MIMⁱ	113503 gene
neXtProtⁱ	NX_P30411

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 60	ExtracellularSequence analysisAdd BLAST	60
Transmembraneⁱ	61 – 84	Helical; Name=1Sequence analysisAdd BLAST	24
Topological domainⁱ	85 – 93	CytoplasmicSequence analysis	9
Transmembraneⁱ	94 – 118	Helical; Name=2Sequence analysisAdd BLAST	25
Topological domainⁱ	119 – 131	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	132 – 153	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	154 – 175	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	176 – 198	Helical; Name=4Sequence analysisAdd BLAST	23
Topological domainⁱ	199 – 221	ExtracellularSequence analysisAdd BLAST	23
Transmembraneⁱ	222 – 248	Helical; Name=5Sequence analysisAdd BLAST	27
Topological domainⁱ	249 – 267	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	268 – 292	Helical; Name=6Sequence analysisAdd BLAST	25
Topological domainⁱ	293 – 311	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	312 – 335	Helical; Name=7Sequence analysisAdd BLAST	24
Topological domainⁱ	336 – 391	CytoplasmicSequence analysisAdd BLAST	56

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	624
Open Targets More...OpenTargetsⁱ	ENSG00000168398
PharmGKBⁱ	PA80

Chemistry databases

ChEMBLⁱ	CHEMBL3157
Drug and drug target database More...DrugBankⁱ	DB05038 Anatibant DB06196 Icatibant
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	42

Polymorphism and mutation databases

BioMutaⁱ	BDKRB2
DMDMⁱ	2506481

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069190	1 – 391	B2 bradykinin receptorAdd BLAST		391

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	30	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	39	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	130 ↔ 211	PROSITE-ProRule annotation
Modified residueⁱ	156	PhosphotyrosineBy similarity	1
Glycosylationⁱ	207	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	347	PhosphotyrosineBy similarity	1
Lipidationⁱ	351	S-palmitoyl cysteineSequence analysis	1
Modified residueⁱ	366	PhosphoserineBy similarity	1
Modified residueⁱ	369	PhosphothreonineBy similarity	1
Modified residueⁱ	373	Phosphoserine; by GRK61 Publication	1
Modified residueⁱ	375	Phosphoserine; by GRK61 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P30411
PaxDbⁱ	P30411
PeptideAtlas More...PeptideAtlasⁱ	P30411
PRIDEⁱ	P30411
ProteomicsDBⁱ	54664 54665 [P30411-2]

PTM databases

iPTMnetⁱ	P30411
PhosphoSitePlusⁱ	P30411
SwissPalmⁱ	P30411

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Widespread in normal smooth muscle tissue and neurons.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000168398 Expressed in 165 organ(s), highest expression level in mucosa of urinary bladder
CleanExⁱ	HS_BDKRB2
Genevisibleⁱ	P30411 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA050841

HPAⁱ

HPA050841

Interactionⁱ

Subunit structureⁱ

Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
KNG1	P01042	2	EBI-6623386,EBI-6623273

With

Entry

#Exp.

IntAct

Notes

KNG1

P01042

2

EBI-6623386,EBI-6623273

GO - Molecular functionⁱ

protease binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17077303
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10993080
type 1 angiotensin receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10993080

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107093, 4 interactors
IntActⁱ	P30411, 11 interactors
Molecular INTeraction database More...MINTⁱ	P30411
STRINGⁱ	9606.ENSP00000307713

Chemistry databases

BindingDBⁱ

P30411

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P30411
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410INT3 Eukaryota ENOG41117RA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119055
HOGENOMⁱ	HOG000010314
HOVERGENⁱ	HBG103183
InParanoidⁱ	P30411
KEGG Orthology (KO) More...KOⁱ	K03916
OMAⁱ	PFWAINI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AAK
PhylomeDBⁱ	P30411
TreeFamⁱ	TF330024

Family and domain databases

InterProⁱ	View protein in InterPro IPR001504 Brdyknn_2_rcpt IPR000496 Brdyknn_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00425 BRADYKININR PR00994 BRADYKINNB2R PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform Long (identifier: P30411-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSPWKISMF LSVREDSVPT TASFSADMLN VTLQGPTLNG TFAQSKCPQV 
        60         70         80         90        100
EWLGWLNTIQ PPFLWVLFVL ATLENIFVLS VFCLHKSSCT VAEIYLGNLA 
       110        120        130        140        150
AADLILACGL PFWAITISNN FDWLFGETLC RVVNAIISMN LYSSICFLML 
       160        170        180        190        200
VSIDRYLALV KTMSMGRMRG VRWAKLYSLV IWGCTLLLSS PMLVFRTMKE 
       210        220        230        240        250
YSDEGHNVTA CVISYPSLIW EVFTNMLLNV VGFLLPLSVI TFCTMQIMQV 
       260        270        280        290        300
LRNNEMQKFK EIQTERRATV LVLVVLLLFI ICWLPFQIST FLDTLHRLGI 
       310        320        330        340        350
LSSCQDERII DVITQIASFM AYSNSCLNPL VYVIVGKRFR KKSWEVYQGV 
       360        370        380        390 
CQKGGCRSEP IQMENSMGTL RTSISVERQI HKLQDWAGSR Q

Length:391

Mass (Da):44,461

Last modified:November 1, 1997 - v2

Checksum:ⁱ066940ED3D18BB66

GO

Isoform Short (identifier: P30411-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-27: Missing.

« Hide

        10         20         30         40         50
MLNVTLQGPT LNGTFAQSKC PQVEWLGWLN TIQPPFLWVL FVLATLENIF 
        60         70         80         90        100
VLSVFCLHKS SCTVAEIYLG NLAAADLILA CGLPFWAITI SNNFDWLFGE 
       110        120        130        140        150
TLCRVVNAII SMNLYSSICF LMLVSIDRYL ALVKTMSMGR MRGVRWAKLY 
       160        170        180        190        200
SLVIWGCTLL LSSPMLVFRT MKEYSDEGHN VTACVISYPS LIWEVFTNML 
       210        220        230        240        250
LNVVGFLLPL SVITFCTMQI MQVLRNNEMQ KFKEIQTERR ATVLVLVVLL 
       260        270        280        290        300
LFIICWLPFQ ISTFLDTLHR LGILSSCQDE RIIDVITQIA SFMAYSNSCL 
       310        320        330        340        350
NPLVYVIVGK RFRKKSWEVY QGVCQKGGCR SEPIQMENSM GTLRTSISVE 
       360 
RQIHKLQDWA GSRQ

Show »

Length:364

Mass (Da):41,441

Checksum:ⁱ8FDC67EFC6600FB6

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_003457	14	R → C2 PublicationsCorresponds to variant dbSNP:rs1046248Ensembl.		1
Natural variantⁱVAR_012284	354	G → E1 PublicationCorresponds to variant dbSNP:rs2227279Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001865	1 – 27	Missing in isoform Short. 2 PublicationsAdd BLAST		27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M88714 mRNA Translation: AAB02793.1 S56772 Genomic DNA Translation: AAB25765.1 X69680 mRNA Translation: CAA49360.1 S45489 Genomic DNA Translation: AAB23467.1 L27594 Genomic DNA No translation available. X86165 mRNA Translation: CAA60109.1 X86164 mRNA Translation: CAA60108.1 AY275465 mRNA Translation: AAP32297.1 AF378542 Genomic DNA Translation: AAK56376.1 BC074894 mRNA Translation: AAH74894.1 BC074895 mRNA Translation: AAH74895.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9942.1 [P30411-1]
PIRⁱ	JH0712 JQ1488
NCBI Reference Sequences More...RefSeqⁱ	NP_000614.1, NM_000623.3 [P30411-1]
UniGeneⁱ	Hs.654542 Hs.726620

Genome annotation databases

Ensemblⁱ	ENST00000539359; ENSP00000438376; ENSG00000168398 [P30411-2] ENST00000542454; ENSP00000439459; ENSG00000168398 [P30411-2] ENST00000554311; ENSP00000450482; ENSG00000168398 [P30411-1]
GeneIDⁱ	624
KEGGⁱ	hsa:624
UCSC genome browser More...UCSCⁱ	uc001yfg.3 human [P30411-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P30411	Isoform Short of B2 bradykinin receptor		HUMAN		364	UniRef90_P30411
Bradykinin receptor B2		PANTR		391
Uncharacterized protein		PANPA		391
Bradykinin receptor B2		CERAT		391
BDKRB2 isoform 2		PONAB		391
+18

Protein	Similar proteins		Species	Score	Length	Source
P30411	Isoform Short of B2 bradykinin receptor		HUMAN		364	UniRef50_P30411
Bradykinin receptor B2		CERAT		391
Uncharacterized protein		MACFA		391
Bradykinin receptor B2		PANTR		391
Uncharacterized protein		PANPA		391
+180

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Bradykinin receptor entry

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M88714 mRNA Translation: AAB02793.1 S56772 Genomic DNA Translation: AAB25765.1 X69680 mRNA Translation: CAA49360.1 S45489 Genomic DNA Translation: AAB23467.1 L27594 Genomic DNA No translation available. X86165 mRNA Translation: CAA60109.1 X86164 mRNA Translation: CAA60108.1 AY275465 mRNA Translation: AAP32297.1 AF378542 Genomic DNA Translation: AAK56376.1 BC074894 mRNA Translation: AAH74894.1 BC074895 mRNA Translation: AAH74895.1
CCDSⁱ	CCDS9942.1 [P30411-1]
PIRⁱ	JH0712 JQ1488
RefSeqⁱ	NP_000614.1, NM_000623.3 [P30411-1]
UniGeneⁱ	Hs.654542 Hs.726620

3D structure databases

ProteinModelPortalⁱ	P30411
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107093, 4 interactors
IntActⁱ	P30411, 11 interactors
MINTⁱ	P30411
STRINGⁱ	9606.ENSP00000307713

Chemistry databases

BindingDBⁱ	P30411
ChEMBLⁱ	CHEMBL3157
DrugBankⁱ	DB05038 Anatibant DB06196 Icatibant
GuidetoPHARMACOLOGYⁱ	42

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P30411
PhosphoSitePlusⁱ	P30411
SwissPalmⁱ	P30411

Polymorphism and mutation databases

BioMutaⁱ	BDKRB2
DMDMⁱ	2506481

Proteomic databases

MaxQBⁱ	P30411
PaxDbⁱ	P30411
PeptideAtlasⁱ	P30411
PRIDEⁱ	P30411
ProteomicsDBⁱ	54664 54665 [P30411-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000539359; ENSP00000438376; ENSG00000168398 [P30411-2] ENST00000542454; ENSP00000439459; ENSG00000168398 [P30411-2] ENST00000554311; ENSP00000450482; ENSG00000168398 [P30411-1]
GeneIDⁱ	624
KEGGⁱ	hsa:624
UCSCⁱ	uc001yfg.3 human [P30411-1]

Organism-specific databases

CTDⁱ	624
DisGeNETⁱ	624
EuPathDBⁱ	HostDB:ENSG00000168398.6
GeneCardsⁱ	BDKRB2
HGNCⁱ	HGNC:1030 BDKRB2
HPAⁱ	HPA050841
MIMⁱ	113503 gene
neXtProtⁱ	NX_P30411
OpenTargetsⁱ	ENSG00000168398
PharmGKBⁱ	PA80
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410INT3 Eukaryota ENOG41117RA LUCA
GeneTreeⁱ	ENSGT00760000119055
HOGENOMⁱ	HOG000010314
HOVERGENⁱ	HBG103183
InParanoidⁱ	P30411
KOⁱ	K03916
OMAⁱ	PFWAINI
OrthoDBⁱ	EOG091G0AAK
PhylomeDBⁱ	P30411
TreeFamⁱ	TF330024

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	P30411

Miscellaneous databases

ChiTaRSⁱ	BDKRB2 human
GeneWikiⁱ	Bradykinin_receptor_B2
GenomeRNAiⁱ	624
Protein Ontology More...PROⁱ	PR:P30411
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168398 Expressed in 165 organ(s), highest expression level in mucosa of urinary bladder
CleanExⁱ	HS_BDKRB2
Genevisibleⁱ	P30411 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001504 Brdyknn_2_rcpt IPR000496 Brdyknn_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00425 BRADYKININR PR00994 BRADYKINNB2R PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BKRB2_HUMAN
Accessionⁱ	P30411Primary (citable) accession number: P30411
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P30411 (BKRB2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

B2 bradykinin receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endosome

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ