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Protein

Peptidyl-prolyl cis-trans isomerase F, mitochondrial

Gene

PPIF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F1F0 ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by cyclosporin A (CsA) (PubMed:20676357). Is displaced by CsA from the mPTP leading to a lower open probability of the mPTP.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cyclosporin A binding Source: UniProtKB
  • peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB
  • unfolded protein binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Rotamase
Biological processApoptosis, Necrosis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
5.2.1.8 2681

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (EC:5.2.1.81 Publication)
Short name:
PPIase F
Alternative name(s):
Cyclophilin D
Short name:
CyP-D
Short name:
CypD
Cyclophilin F
Mitochondrial cyclophilin
Short name:
CyP-M
Rotamase F
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPIF
Synonyms:CYP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000108179.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9259 PPIF

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604486 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P30405

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi203C → S: Blocks Ca(2+)-induced mPTP opening and reduces hydrogen peroxide-induced cell death. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10105

Open Targets

More...
OpenTargetsi
ENSG00000108179

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33584

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3325306

Drug and drug target database

More...
DrugBanki
DB02078 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane
DB08168 7-AMINO-4-METHYL-CHROMEN-2-ONE
DB00091 Cyclosporine
DB00172 L-Proline

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPIF

Domain mapping of disease mutations (DMDM)

More...
DMDMi
231968

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002548930 – 207Peptidyl-prolyl cis-trans isomerase F, mitochondrialAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei67N6-acetyllysine; alternateBy similarity1
Modified residuei67N6-succinyllysine; alternateBy similarity1
Modified residuei86N6-succinyllysineBy similarity1
Modified residuei167N6-acetyllysineBy similarity1
Modified residuei175N6-succinyllysineBy similarity1
Modified residuei190N6-succinyllysineBy similarity1
Modified residuei203S-nitrosocysteineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Deacteylated at Lys-167 by SIRT3.By similarity

Keywords - PTMi

Acetylation, S-nitrosylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P30405

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P30405

MaxQB - The MaxQuant DataBase

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MaxQBi
P30405

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30405

PeptideAtlas

More...
PeptideAtlasi
P30405

PRoteomics IDEntifications database

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PRIDEi
P30405

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54662

Consortium for Top Down Proteomics

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TopDownProteomicsi
P30405-1 [P30405-1]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P30405

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P30405

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30405

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P30405

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P30405

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000108179 Expressed in 230 organ(s), highest expression level in amniotic fluid

CleanEx database of gene expression profiles

More...
CleanExi
HS_PPIF

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P30405 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P30405 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA077416

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the mitochondrial membrane ATP synthase F1F0 ATP synthase; the association is increased by inorganic phosphate (Pi) and decreased by cyclosporin A (CsA). Interacts with ATP5F1B; ATP5PD and ATP5PO. Interacts with SLC25A3; the interaction is impaired by CsA. Interacts with BCL2; the interaction is impaired by CsA. Interacts with TP53; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by CsA. Interacts with C1QBP. Interacts with MCUR1 (PubMed:26976564). Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF (PubMed:26387735). Interacts with SPG7 (PubMed:26387735).6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115411, 36 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P30405

Protein interaction database and analysis system

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IntActi
P30405, 26 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000225174

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P30405

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BITX-ray1.71X43-207[»]
2BIUX-ray1.71X43-207[»]
2Z6WX-ray0.96A/B44-207[»]
3QYUX-ray1.54A44-207[»]
3R49X-ray1.77A43-207[»]
3R4GX-ray1.05A43-207[»]
3R54X-ray1.35A43-207[»]
3R56X-ray1.40A43-207[»]
3R57X-ray1.71A43-207[»]
3R59X-ray1.10A43-207[»]
3RCFX-ray1.15A43-207[»]
3RCGX-ray0.97A43-207[»]
3RCIX-ray1.44X43-207[»]
3RCKX-ray1.26X43-207[»]
3RCLX-ray1.70A43-207[»]
3RD9X-ray1.40X43-207[»]
3RDAX-ray1.07X43-207[»]
3RDBX-ray1.55A43-207[»]
3RDCX-ray1.94A43-207[»]
4J58X-ray1.28A44-207[»]
4J59X-ray1.92A44-207[»]
4J5AX-ray1.58X44-207[»]
4J5BX-ray2.01A44-207[»]
4J5CX-ray1.03X44-207[»]
4J5DX-ray1.32X44-207[»]
4J5EX-ray0.99X44-207[»]
4O8HX-ray0.85A43-207[»]
4O8IX-ray1.45A43-207[»]
4XNCX-ray2.23A44-207[»]
4ZSCX-ray1.50A44-207[»]
4ZSDX-ray1.45A44-207[»]
5A0EX-ray1.25A/B43-207[»]
5CBTX-ray1.45A44-207[»]
5CBUX-ray1.40A44-207[»]
5CBVX-ray1.80A44-207[»]
5CBWX-ray1.80A44-207[»]
5CCNX-ray1.80A44-207[»]
5CCQX-ray1.80A44-207[»]
5CCRX-ray1.90A44-207[»]
5CCSX-ray2.10X44-207[»]
5NWOX-ray1.45A44-207[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P30405

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P30405

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P30405

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 205PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST157

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0865 Eukaryota
COG0652 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156008

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065981

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001065

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P30405

KEGG Orthology (KO)

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KOi
K09565

Identification of Orthologs from Complete Genome Data

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OMAi
ELKHTGS

Database of Orthologous Groups

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OrthoDBi
1403619at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P30405

TreeFam database of animal gene trees

More...
TreeFami
TF312801

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11071 PTHR11071, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00160 Pro_isomerase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001467 Peptidylpro_ismrse, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00153 CSAPPISMRASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50891 SSF50891, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P30405-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLALRCGSRW LGLLSVPRSV PLRLPAARAC SKGSGDPSSS SSSGNPLVYL
60 70 80 90 100
DVDANGKPLG RVVLELKADV VPKTAENFRA LCTGEKGFGY KGSTFHRVIP
110 120 130 140 150
SFMCQAGDFT NHNGTGGKSI YGSRFPDENF TLKHVGPGVL SMANAGPNTN
160 170 180 190 200
GSQFFICTIK TDWLDGKHVV FGHVKEGMDV VKKIESFGSK SGRTSKKIVI

TDCGQLS
Length:207
Mass (Da):22,040
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7C76F1D4049F16A
GO
Isoform 2 (identifier: P30405-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-207: VLSMANAGPN...IVITDCGQLS → WMASMLCSVTSKRAWTS

Show »
Length:155
Mass (Da):16,541
Checksum:iBA0C086F1899B2DF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y548H0Y548_HUMAN
Peptidyl-prolyl cis-trans isomerase
PPIF
165Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN99R4GN99_HUMAN
Peptidyl-prolyl cis-trans isomerase
PPIF
145Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056286139 – 207VLSMA…CGQLS → WMASMLCSVTSKRAWTS in isoform 2. 2 PublicationsAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M80254 mRNA Translation: AAA58434.1
AK296669 mRNA Translation: BAG59266.1
AL133481 Genomic DNA No translation available.
AL391665 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54645.1
BC005020 mRNA Translation: AAH05020.1
BC110299 mRNA Translation: AAI10300.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7358.1 [P30405-1]

Protein sequence database of the Protein Information Resource

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PIRi
A41581

NCBI Reference Sequences

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RefSeqi
NP_005720.1, NM_005729.3 [P30405-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.381072

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000225174; ENSP00000225174; ENSG00000108179 [P30405-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10105

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10105

UCSC genome browser

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UCSCi
uc001kai.4 human [P30405-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80254 mRNA Translation: AAA58434.1
AK296669 mRNA Translation: BAG59266.1
AL133481 Genomic DNA No translation available.
AL391665 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54645.1
BC005020 mRNA Translation: AAH05020.1
BC110299 mRNA Translation: AAI10300.1
CCDSiCCDS7358.1 [P30405-1]
PIRiA41581
RefSeqiNP_005720.1, NM_005729.3 [P30405-1]
UniGeneiHs.381072

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BITX-ray1.71X43-207[»]
2BIUX-ray1.71X43-207[»]
2Z6WX-ray0.96A/B44-207[»]
3QYUX-ray1.54A44-207[»]
3R49X-ray1.77A43-207[»]
3R4GX-ray1.05A43-207[»]
3R54X-ray1.35A43-207[»]
3R56X-ray1.40A43-207[»]
3R57X-ray1.71A43-207[»]
3R59X-ray1.10A43-207[»]
3RCFX-ray1.15A43-207[»]
3RCGX-ray0.97A43-207[»]
3RCIX-ray1.44X43-207[»]
3RCKX-ray1.26X43-207[»]
3RCLX-ray1.70A43-207[»]
3RD9X-ray1.40X43-207[»]
3RDAX-ray1.07X43-207[»]
3RDBX-ray1.55A43-207[»]
3RDCX-ray1.94A43-207[»]
4J58X-ray1.28A44-207[»]
4J59X-ray1.92A44-207[»]
4J5AX-ray1.58X44-207[»]
4J5BX-ray2.01A44-207[»]
4J5CX-ray1.03X44-207[»]
4J5DX-ray1.32X44-207[»]
4J5EX-ray0.99X44-207[»]
4O8HX-ray0.85A43-207[»]
4O8IX-ray1.45A43-207[»]
4XNCX-ray2.23A44-207[»]
4ZSCX-ray1.50A44-207[»]
4ZSDX-ray1.45A44-207[»]
5A0EX-ray1.25A/B43-207[»]
5CBTX-ray1.45A44-207[»]
5CBUX-ray1.40A44-207[»]
5CBVX-ray1.80A44-207[»]
5CBWX-ray1.80A44-207[»]
5CCNX-ray1.80A44-207[»]
5CCQX-ray1.80A44-207[»]
5CCRX-ray1.90A44-207[»]
5CCSX-ray2.10X44-207[»]
5NWOX-ray1.45A44-207[»]
ProteinModelPortaliP30405
SMRiP30405
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115411, 36 interactors
CORUMiP30405
IntActiP30405, 26 interactors
STRINGi9606.ENSP00000225174

Chemistry databases

BindingDBiP30405
ChEMBLiCHEMBL3325306
DrugBankiDB02078 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane
DB08168 7-AMINO-4-METHYL-CHROMEN-2-ONE
DB00091 Cyclosporine
DB00172 L-Proline

PTM databases

iPTMnetiP30405
PhosphoSitePlusiP30405
SwissPalmiP30405

Polymorphism and mutation databases

BioMutaiPPIF
DMDMi231968

2D gel databases

OGPiP30405
UCD-2DPAGEiP30405

Proteomic databases

EPDiP30405
jPOSTiP30405
MaxQBiP30405
PaxDbiP30405
PeptideAtlasiP30405
PRIDEiP30405
ProteomicsDBi54662
TopDownProteomicsiP30405-1 [P30405-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10105
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225174; ENSP00000225174; ENSG00000108179 [P30405-1]
GeneIDi10105
KEGGihsa:10105
UCSCiuc001kai.4 human [P30405-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10105
DisGeNETi10105
EuPathDBiHostDB:ENSG00000108179.13

GeneCards: human genes, protein and diseases

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GeneCardsi
PPIF
HGNCiHGNC:9259 PPIF
HPAiHPA077416
MIMi604486 gene
neXtProtiNX_P30405
OpenTargetsiENSG00000108179
PharmGKBiPA33584

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00940000156008
HOGENOMiHOG000065981
HOVERGENiHBG001065
InParanoidiP30405
KOiK09565
OMAiELKHTGS
OrthoDBi1403619at2759
PhylomeDBiP30405
TreeFamiTF312801

Enzyme and pathway databases

BRENDAi5.2.1.8 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPIF human
EvolutionaryTraceiP30405

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PPIF

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10105

Protein Ontology

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PROi
PR:P30405

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108179 Expressed in 230 organ(s), highest expression level in amniotic fluid
CleanExiHS_PPIF
ExpressionAtlasiP30405 baseline and differential
GenevisibleiP30405 HS

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPIF_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30405
Secondary accession number(s): Q2YDB7, Q5W131
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: January 16, 2019
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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