UniProtKB - P30404 (PPIF_BOVIN)
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
PPIF
Functioni
Catalytic activityi
- EC:5.2.1.8By similarity
Activity regulationi
GO - Molecular functioni
- cyclosporin A binding Source: UniProtKB
- peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cellular response to arsenic-containing substance Source: UniProtKB
- cellular response to calcium ion Source: UniProtKB
- cellular response to hydrogen peroxide Source: UniProtKB
- mitochondrial outer membrane permeabilization involved in programmed cell death Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of ATPase activity Source: UniProtKB
- negative regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
- negative regulation of oxidative phosphorylation Source: UniProtKB
- negative regulation of oxidative phosphorylation uncoupler activity Source: UniProtKB
- negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
- positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
- protein folding Source: GO_Central
- protein peptidyl-prolyl isomerization Source: UniProtKB
- regulation of mitochondrial membrane permeability Source: UniProtKB
- regulation of mitochondrial membrane permeability involved in programmed necrotic cell death Source: UniProtKB
- regulation of proton-transporting ATPase activity, rotational mechanism Source: UniProtKB
- response to ischemia Source: UniProtKB
Keywordsi
Molecular function | Isomerase, Rotamase |
Biological process | Apoptosis, Necrosis |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidyl-prolyl cis-trans isomerase F, mitochondrial (EC:5.2.1.8By similarity)Short name: PPIase F Alternative name(s): Cyclophilin D Short name: CyP-D Short name: CypD Cyclophilin F Rotamase F |
Gene namesi | Name:PPIF Synonyms:CYP3 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrial permeability transition pore complex Source: UniProtKB
- mitochondrion Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 30 | MitochondrionAdd BLAST | 30 | |
ChainiPRO_0000064149 | 31 – 208 | Peptidyl-prolyl cis-trans isomerase F, mitochondrialAdd BLAST | 178 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 68 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 68 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 87 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 168 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 176 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 191 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 204 | S-nitrosocysteineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, S-nitrosylationProteomic databases
PaxDbi | P30404 |
PeptideAtlasi | P30404 |
PRIDEi | P30404 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000016711, Expressed in placenta and 18 other tissues |
Interactioni
Subunit structurei
Associates with the mitochondrial membrane ATP synthase F1F0 ATP synthase; the association is increased by inorganic phosphate (Pi) and decreased by cyclosporin A (CsA) (By similarity).
Interacts with ATP5F1B; ATP5PD and ATP5PO (PubMed:19801635).
Interacts with SLC25A3; the interaction is impaired by CsA.
Interacts with BCL2; the interaction is impaired by CsA.
Interacts with TP53; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by CsA.
Interacts with C1QBP.
Interacts with MCUR1.
Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF.
Interacts with SPG7 (By similarity).
By similarity1 PublicationProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000022213 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 50 – 206 | PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST | 157 |
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0865, Eukaryota |
HOGENOMi | CLU_012062_4_3_1 |
InParanoidi | P30404 |
OMAi | WLDRQYS |
OrthoDBi | 1403619at2759 |
Family and domain databases
Gene3Di | 2.40.100.10, 1 hit |
InterProi | View protein in InterPro IPR029000, Cyclophilin-like_dom_sf IPR020892, Cyclophilin-type_PPIase_CS IPR002130, Cyclophilin-type_PPIase_dom |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SUPFAMi | SSF50891, SSF50891, 1 hit |
PROSITEi | View protein in PROSITE PS00170, CSA_PPIASE_1, 1 hit PS50072, CSA_PPIASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MMLALRCGPR LLGLLSGPRS AHLRLPAVRA CSSGSGSHGS SSSSGNPLVY
60 70 80 90 100
LDVGADGQPL GRVVLELKAD VVPKTAENFR ALCTGEKGFG YKGSTFHRVI
110 120 130 140 150
PSFMCQAGDF TNHNGTGGKS IYGSRFPDEN FKLKHEGPGV LSMANAGPNT
160 170 180 190 200
NGSQFFICTI KTDWLDGKHV VFGHVKEGMD VVKKIESFGS KSGKTSKKIV
ITDCGQLS
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 30 | A → V in AAT02663 (Ref. 1) Curated | 1 | |
Sequence conflicti | 30 | A → V in EH176460 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY594335 mRNA Translation: AAT02663.1 Sequence problems. EH176460 mRNA No translation available. AAFC03123307 Genomic DNA No translation available. |
PIRi | PC1237 |
RefSeqi | NP_001001597.1, NM_001001597.1 |
Genome annotation databases
GeneIDi | 414346 |
KEGGi | bta:414346 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY594335 mRNA Translation: AAT02663.1 Sequence problems. EH176460 mRNA No translation available. AAFC03123307 Genomic DNA No translation available. |
PIRi | PC1237 |
RefSeqi | NP_001001597.1, NM_001001597.1 |
3D structure databases
BMRBi | P30404 |
SMRi | P30404 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000022213 |
Proteomic databases
PaxDbi | P30404 |
PeptideAtlasi | P30404 |
PRIDEi | P30404 |
Genome annotation databases
GeneIDi | 414346 |
KEGGi | bta:414346 |
Organism-specific databases
CTDi | 10105 |
Phylogenomic databases
eggNOGi | KOG0865, Eukaryota |
HOGENOMi | CLU_012062_4_3_1 |
InParanoidi | P30404 |
OMAi | WLDRQYS |
OrthoDBi | 1403619at2759 |
Gene expression databases
Bgeei | ENSBTAG00000016711, Expressed in placenta and 18 other tissues |
Family and domain databases
Gene3Di | 2.40.100.10, 1 hit |
InterProi | View protein in InterPro IPR029000, Cyclophilin-like_dom_sf IPR020892, Cyclophilin-type_PPIase_CS IPR002130, Cyclophilin-type_PPIase_dom |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SUPFAMi | SSF50891, SSF50891, 1 hit |
PROSITEi | View protein in PROSITE PS00170, CSA_PPIASE_1, 1 hit PS50072, CSA_PPIASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPIF_BOVIN | |
Accessioni | P30404Primary (citable) accession number: P30404 Secondary accession number(s): Q6PMK8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | March 6, 2013 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families