UniProtKB - P30371 (TGFB2_CHICK)
Protein
Transforming growth factor beta-2 proprotein
Gene
TGFB2
Organism
Gallus gallus (Chicken)
Status
Functioni
Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.By similarity
Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2.By similarity
Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).By similarity
GO - Molecular functioni
- amyloid-beta binding Source: UniProtKB
- growth factor activity Source: UniProtKB-KW
- protein homodimerization activity Source: UniProtKB
- signaling receptor binding Source: UniProtKB
- transforming growth factor beta receptor binding Source: UniProtKB
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: UniProtKB
GO - Biological processi
- activation of protein kinase activity Source: UniProtKB
- animal organ development Source: AgBase
- cardiac epithelial to mesenchymal transition Source: UniProtKB
- cardiac muscle cell proliferation Source: UniProtKB
- cardioblast differentiation Source: UniProtKB
- cartilage development Source: AgBase
- cell-cell junction organization Source: UniProtKB
- cell cycle arrest Source: UniProtKB
- cell death Source: UniProtKB
- cell migration Source: UniProtKB
- cell morphogenesis Source: UniProtKB
- collagen fibril organization Source: UniProtKB
- dopamine biosynthetic process Source: UniProtKB
- embryo development ending in birth or egg hatching Source: AgBase
- embryonic digestive tract development Source: AgBase
- embryonic organ development Source: AgBase
- endothelial cell activation Source: AgBase
- epithelial to mesenchymal transition Source: UniProtKB
- epithelial to mesenchymal transition involved in endocardial cushion formation Source: DFLAT
- extrinsic apoptotic signaling pathway Source: AgBase
- eye development Source: AgBase
- female gonad development Source: AgBase
- glial cell migration Source: UniProtKB
- gonad development Source: AgBase
- heart development Source: AgBase
- heart morphogenesis Source: UniProtKB
- hemopoiesis Source: UniProtKB
- lung development Source: AgBase
- male gonad development Source: AgBase
- negative regulation of alkaline phosphatase activity Source: UniProtKB
- negative regulation of cell adhesion Source: AgBase
- negative regulation of cell growth Source: AgBase
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of epithelial cell proliferation Source: UniProtKB
- negative regulation of macrophage cytokine production Source: UniProtKB
- nervous system development Source: AgBase
- neural tube development Source: AgBase
- neuron development Source: UniProtKB
- neutrophil chemotaxis Source: UniProtKB
- pathway-restricted SMAD protein phosphorylation Source: UniProtKB
- positive regulation of cardioblast differentiation Source: UniProtKB
- positive regulation of cell adhesion mediated by integrin Source: UniProtKB
- positive regulation of cell cycle Source: UniProtKB
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell growth Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of epithelial cell migration Source: UniProtKB
- positive regulation of epithelial to mesenchymal transition Source: UniProtKB
- positive regulation of heart contraction Source: UniProtKB
- positive regulation of immune response Source: UniProtKB
- positive regulation of integrin biosynthetic process Source: UniProtKB
- positive regulation of neuron apoptotic process Source: UniProtKB
- positive regulation of ossification Source: AgBase
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of protein secretion Source: UniProtKB
- positive regulation of stress-activated MAPK cascade Source: UniProtKB
- positive regulation of timing of catagen Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of cell differentiation Source: AgBase
- regulation of cell population proliferation Source: AgBase
- regulation of complement-dependent cytotoxicity Source: AgBase
- regulation of growth Source: AgBase
- regulation of SMAD protein signal transduction Source: AgBase
- regulation of transforming growth factor beta2 production Source: UniProtKB
- response to drug Source: UniProtKB
- response to growth hormone Source: AgBase
- response to hypoxia Source: UniProtKB
- response to progesterone Source: UniProtKB
- response to virus Source: AgBase
- response to wounding Source: AgBase
- salivary gland morphogenesis Source: AgBase
- signal transduction by protein phosphorylation Source: AgBase
- skeletal muscle tissue development Source: AgBase
- SMAD protein signal transduction Source: BHF-UCL
- somatic stem cell division Source: UniProtKB
- somitogenesis Source: AgBase
- spleen development Source: AgBase
- transforming growth factor beta receptor signaling pathway Source: UniProtKB
- wound healing Source: UniProtKB
Keywordsi
Molecular function | Growth factor, Mitogen |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta-2 proproteinCleaved into the following 2 chains: |
Gene namesi | Name:TGFB2 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular matrix Source: UniProtKB
- extracellular region Source: UniProtKB
- extracellular space Source: AgBase
Other locations
- axon Source: UniProtKB
- neuronal cell body Source: UniProtKB
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000033792 | 21 – 300 | Latency-associated peptideBy similarityAdd BLAST | 280 | |
ChainiPRO_0000033793 | 301 – 412 | Transforming growth factor beta-2By similarityAdd BLAST | 112 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 72 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 139 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 240 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 307 ↔ 316 | By similarity | ||
Disulfide bondi | 315 ↔ 378 | By similarity | ||
Disulfide bondi | 344 ↔ 409 | By similarity | ||
Disulfide bondi | 348 ↔ 411 | By similarity | ||
Disulfide bondi | 377 | InterchainBy similarity |
Post-translational modificationi
Transforming growth factor beta-2 proprotein: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-2 (TGF-beta-2) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-2 inactive.By similarity
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P30371 |
Interactioni
Subunit structurei
Latency-associated peptide:
Interacts with Transforming growth factor beta-2 (TGF-beta-2) chain; interaction is non-covalent and maintains (TGF-beta-2) in a latent state (By similarity). Transforming growth factor beta-2: Homodimer; disulfide-linked (By similarity). Transforming growth factor beta-2:
Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).
By similarityGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- protein homodimerization activity Source: UniProtKB
- signaling receptor binding Source: UniProtKB
- transforming growth factor beta receptor binding Source: UniProtKB
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000031309 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
InParanoidi | P30371 |
PhylomeDBi | P30371 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P30371-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHCYLLSVFL TLDLAAVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL
60 70 80 90 100
TSPPDEYPEP EEVPPEVISI YNSTRDLLQE KANHRAATCE RERSDEEYYA
110 120 130 140 150
KEVYKIDMQP FYPENAIPPS YYSLYFRIVR FDVSAMEKNA SNLVKAEFRV
160 170 180 190 200
FRLQNSKARV SEQRIELYQV LKSKELSSPG QRYIDSKVVK TRAEGEWLSF
210 220 230 240 250
DVTEAVHEWL HHRDRNLGFK ISLHCPCCTF VPSNNYIIPN KSEEPEARFA
260 270 280 290 300
GIDDYTYSSG DVKALKSNRK KYSGKTPHLL LMLLPSYRLE SQQPSRRKKR
310 320 330 340 350
ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYH ANFCAGACPY
360 370 380 390 400
LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ
410
LSNMIVKSCK CS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58071 , X59082, X59081, X59080 Genomic DNA Translation: CAA41101.1 |
PIRi | A39489 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58071 , X59082, X59081, X59080 Genomic DNA Translation: CAA41101.1 |
PIRi | A39489 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000031309 |
Proteomic databases
PaxDbi | P30371 |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
InParanoidi | P30371 |
PhylomeDBi | P30371 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGFB2_CHICK | |
Accessioni | P30371Primary (citable) accession number: P30371 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | October 7, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families