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Protein

Interleukin-4

Gene

IL4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processB-cell activation

Enzyme and pathway databases

ReactomeiR-BTA-6785807 Interleukin-4 and 13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-4
Short name:
IL-4
Alternative name(s):
B-cell stimulatory factor 1
Short name:
BSF-1
Lymphocyte stimulatory factor 1
Gene namesi
Name:IL4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:30161 IL4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001552425 – 135Interleukin-4Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 135By similarity
Disulfide bondi48 ↔ 85By similarity
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi70 ↔ 105By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30367
PRIDEiP30367

Expressioni

Gene expression databases

BgeeiENSBTAG00000015957

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021215

Structurei

3D structure databases

ProteinModelPortaliP30367
SMRiP30367
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3886 Eukaryota
ENOG410XQ0R LUCA
GeneTreeiENSGT00390000013108
HOGENOMiHOG000254781
HOVERGENiHBG000290
InParanoidiP30367
KOiK05430
OMAiLACTSNF
OrthoDBiEOG091G0WDE
TreeFamiTF336383

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002354 IL-4
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PfamiView protein in Pfam
PF00727 IL4, 1 hit
PIRSFiPIRSF001941 Interleukin_4, 1 hit
PRINTSiPR00431 INTERLEUKIN4
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTSQLIPV LVCLLVCTSH FVHGHKCDIT LAEIIKTLNI LTTRKNSCME
60 70 80 90 100
LPVADVFAAP KNTTEKETFC RVGIELRRIY RSHTCLNKFL GGLDRNLNSL
110 120 130
ASKTCSVNEA KTSTSTLKDL LERLKTIMKE KYSKC
Length:135
Mass (Da):15,119
Last modified:March 18, 2008 - v2
Checksum:iECF0B18B88B4271C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5S → Y in AAA30587 (PubMed:1601309).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77120 mRNA Translation: AAA30587.1
U14160, U14131, U14159 Genomic DNA Translation: AAA82730.1
EU276069 mRNA Translation: ABX72067.1
PIRiJH0684
RefSeqiNP_776346.1, NM_173921.2
UniGeneiBt.423

Genome annotation databases

EnsembliENSBTAT00000021215; ENSBTAP00000021215; ENSBTAG00000015957
GeneIDi280824
KEGGibta:280824

Similar proteinsi

Entry informationi

Entry nameiIL4_BOVIN
AccessioniPrimary (citable) accession number: P30367
Secondary accession number(s): A9QWQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: March 18, 2008
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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