UniProtKB - P30367 (IL4_BOVIN)
Protein
Interleukin-4
Gene
IL4
Organism
Bos taurus (Bovine)
Status
Functioni
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.By similarity
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- interleukin-4 receptor binding Source: InterPro
GO - Biological processi
- activation of Janus kinase activity Source: GO_Central
- B cell activation Source: UniProtKB-KW
- B cell costimulation Source: GO_Central
- extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
- innate immune response in mucosa Source: GO_Central
- microglial cell activation Source: GO_Central
- myeloid dendritic cell differentiation Source: GO_Central
- negative regulation of acute inflammatory response Source: GO_Central
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cellular response to transforming growth factor beta stimulus Source: Ensembl
- negative regulation of chronic inflammatory response Source: GO_Central
- negative regulation of complement-dependent cytotoxicity Source: GO_Central
- negative regulation of endothelial cell apoptotic process Source: GO_Central
- negative regulation of epithelial cell migration Source: GO_Central
- negative regulation of extrinsic apoptotic signaling pathway Source: GO_Central
- negative regulation of macrophage activation Source: GO_Central
- negative regulation of osteoclast differentiation Source: UniProtKB
- negative regulation of T-helper 17 cell differentiation Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- negative regulation of tumor necrosis factor production Source: GO_Central
- positive regulation of amyloid-beta clearance Source: GO_Central
- positive regulation of B cell proliferation Source: UniProtKB
- positive regulation of cell population proliferation Source: GO_Central
- positive regulation of chemokine production Source: GO_Central
- positive regulation of defense response to virus by host Source: GO_Central
- positive regulation of eosinophil chemotaxis Source: GO_Central
- positive regulation of interleukin-10 production Source: GO_Central
- positive regulation of interleukin-13 production Source: GO_Central
- positive regulation of isotype switching to IgE isotypes Source: UniProtKB
- positive regulation of isotype switching to IgG isotypes Source: UniProtKB
- positive regulation of macroautophagy Source: UniProtKB
- positive regulation of mast cell degranulation Source: GO_Central
- positive regulation of MHC class II biosynthetic process Source: UniProtKB
- positive regulation of mononuclear cell migration Source: GO_Central
- positive regulation of myoblast fusion Source: GO_Central
- positive regulation of receptor-mediated endocytosis Source: GO_Central
- positive regulation of T cell differentiation Source: GO_Central
- positive regulation of T cell proliferation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of tyrosine phosphorylation of STAT protein Source: GO_Central
- regulation of immune response Source: UniProtKB
- regulation of phosphorylation Source: UniProtKB
- T-helper 2 cell cytokine production Source: GO_Central
- T-helper 2 cell differentiation Source: GO_Central
Keywordsi
Molecular function | Cytokine, Growth factor |
Biological process | B-cell activation |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-4Short name: IL-4 Alternative name(s): B-cell stimulatory factor 1 Short name: BSF-1 Lymphocyte stimulatory factor 1 |
Gene namesi | Name:IL4 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:30161, IL4 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | By similarityAdd BLAST | 24 | |
ChainiPRO_0000015524 | 25 – 135 | Interleukin-4Add BLAST | 111 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 135 | By similarity | ||
Disulfide bondi | 48 ↔ 85 | By similarity | ||
Glycosylationi | 62 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 70 ↔ 105 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P30367 |
PRIDEi | P30367 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000015957, Expressed in spleen and 4 other tissues |
Interactioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- interleukin-4 receptor binding Source: InterPro
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000021215 |
Family & Domainsi
Sequence similaritiesi
Belongs to the IL-4/IL-13 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3886, Eukaryota |
GeneTreei | ENSGT00390000013108 |
HOGENOMi | CLU_154691_0_0_1 |
InParanoidi | P30367 |
OMAi | SCMELTV |
OrthoDBi | 1495672at2759 |
TreeFami | TF336383 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR002354, IL-4 IPR001325, IL-4/IL-13 IPR018096, IL-4/IL-13_CS |
PANTHERi | PTHR47401, PTHR47401, 1 hit |
Pfami | View protein in Pfam PF00727, IL4, 1 hit |
PIRSFi | PIRSF001941, Interleukin_4, 1 hit |
PRINTSi | PR00431, INTERLEUKIN4 |
SMARTi | View protein in SMART SM00190, IL4_13, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00838, INTERLEUKIN_4_13, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P30367-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLTSQLIPV LVCLLVCTSH FVHGHKCDIT LAEIIKTLNI LTTRKNSCME
60 70 80 90 100
LPVADVFAAP KNTTEKETFC RVGIELRRIY RSHTCLNKFL GGLDRNLNSL
110 120 130
ASKTCSVNEA KTSTSTLKDL LERLKTIMKE KYSKC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | S → Y in AAA30587 (PubMed:1601309).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77120 mRNA Translation: AAA30587.1 U14160, U14131, U14159 Genomic DNA Translation: AAA82730.1 EU276069 mRNA Translation: ABX72067.1 |
PIRi | JH0684 |
RefSeqi | NP_776346.1, NM_173921.2 |
Genome annotation databases
Ensembli | ENSBTAT00000021215; ENSBTAP00000021215; ENSBTAG00000015957 |
GeneIDi | 280824 |
KEGGi | bta:280824 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77120 mRNA Translation: AAA30587.1 U14160, U14131, U14159 Genomic DNA Translation: AAA82730.1 EU276069 mRNA Translation: ABX72067.1 |
PIRi | JH0684 |
RefSeqi | NP_776346.1, NM_173921.2 |
3D structure databases
SMRi | P30367 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000021215 |
Proteomic databases
PaxDbi | P30367 |
PRIDEi | P30367 |
Genome annotation databases
Ensembli | ENSBTAT00000021215; ENSBTAP00000021215; ENSBTAG00000015957 |
GeneIDi | 280824 |
KEGGi | bta:280824 |
Organism-specific databases
CTDi | 3565 |
VGNCi | VGNC:30161, IL4 |
Phylogenomic databases
eggNOGi | KOG3886, Eukaryota |
GeneTreei | ENSGT00390000013108 |
HOGENOMi | CLU_154691_0_0_1 |
InParanoidi | P30367 |
OMAi | SCMELTV |
OrthoDBi | 1495672at2759 |
TreeFami | TF336383 |
Gene expression databases
Bgeei | ENSBTAG00000015957, Expressed in spleen and 4 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR002354, IL-4 IPR001325, IL-4/IL-13 IPR018096, IL-4/IL-13_CS |
PANTHERi | PTHR47401, PTHR47401, 1 hit |
Pfami | View protein in Pfam PF00727, IL4, 1 hit |
PIRSFi | PIRSF001941, Interleukin_4, 1 hit |
PRINTSi | PR00431, INTERLEUKIN4 |
SMARTi | View protein in SMART SM00190, IL4_13, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00838, INTERLEUKIN_4_13, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL4_BOVIN | |
Accessioni | P30367Primary (citable) accession number: P30367 Secondary accession number(s): A9QWQ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | March 18, 2008 | |
Last modified: | February 10, 2021 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families