Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-X-C motif chemokine 2

Gene

Cxcl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation.

GO - Molecular functioni

  • chemokine activity Source: RGD
  • CXCR chemokine receptor binding Source: GO_Central

GO - Biological processi

  • cellular response to interleukin-1 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • chemokine-mediated signaling pathway Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • leukocyte chemotaxis Source: RGD
  • neuron death Source: RGD
  • neutrophil chemotaxis Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of neutrophil chemotaxis Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • response to amphetamine Source: RGD
  • response to estradiol Source: RGD
  • response to gamma radiation Source: RGD
  • response to glucocorticoid Source: RGD
  • response to heat Source: RGD
  • wound healing Source: RGD

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-RNO-380108 Chemokine receptors bind chemokines
R-RNO-418594 G alpha (i) signalling events
R-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 2
Alternative name(s):
Cytokine-induced neutrophil chemoattractant 3
Short name:
CINC-3
Macrophage inflammatory protein 2
Short name:
MIP2
Gene namesi
Name:Cxcl2
Synonyms:Cinc3, Mip-2, Mip2, Scyb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi70069 Cxcl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 313 PublicationsAdd BLAST31
ChainiPRO_000000506232 – 100C-X-C motif chemokine 2Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 62By similarity
Disulfide bondi38 ↔ 78By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP30348
PRIDEiP30348

Expressioni

Tissue specificityi

At least expressed in the lung and trachea.

Inductioni

By lipopolysaccharide (LPS) and inflammation; in lung.

Gene expression databases

BgeeiENSRNOG00000002792
GenevisibleiP30348 RN

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

  • chemokine activity Source: RGD
  • CXCR chemokine receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi250284, 1 interactor
STRINGi10116.ENSRNOP00000003745

Structurei

3D structure databases

ProteinModelPortaliP30348
SMRiP30348
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE Eukaryota
ENOG410ZT1C LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP30348
KOiK05505
OMAiNGKKACL
OrthoDBiEOG091G14TE
PhylomeDBiP30348
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPTRQLLN AVLVLLLLLA TNHQGTGVVV ASELRCQCLT TLPRVDFKNI
60 70 80 90 100
QSLTVTPPGP HCAQTEVIAT LKDGHEVCLN PEAPLVQRIV QKILNKGKAN
Length:100
Mass (Da):10,783
Last modified:April 1, 1993 - v1
Checksum:i4299DFE68FF37A9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65647 mRNA Translation: CAA46599.1
S77604 mRNA Translation: AAB33749.1
U45965 mRNA Translation: AAA92438.1
AB060092 mRNA Translation: BAB41105.1
S45855 mRNA No translation available.
PIRiS21467
RefSeqiNP_446099.1, NM_053647.1
UniGeneiRn.10230

Genome annotation databases

EnsembliENSRNOT00000003745; ENSRNOP00000003745; ENSRNOG00000002792
GeneIDi114105
KEGGirno:114105
UCSCiRGD:70069 rat

Similar proteinsi

Entry informationi

Entry nameiCXCL2_RAT
AccessioniPrimary (citable) accession number: P30348
Secondary accession number(s): Q5WA60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health