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UniProtKB - P30314 (DPOL_BPSP1)

Entry version 101 (23 Feb 2022)
Sequence version 2 (01 Feb 1994)
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Protein

DNA polymerase

Gene

31

Organism
Bacillus phage SP01 (Bacteriophage SP01)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Replicates viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'-5' direction.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replication, Viral DNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase (EC:2.7.7.7, EC:3.1.11.-By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:31
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus phage SP01 (Bacteriophage SP01)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10685 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Duplodnaviria › Heunggongvirae › Uroviricota › Caudoviricetes › Caudovirales › Herelleviridae › Spounavirinae › Okubovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiBacillus subtilis [TaxID: 1423]

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001012651 – 924DNA polymeraseAdd BLAST924

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		P30314

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P30314

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini235 – 3863'-5' exonucleaseSequence analysisAdd BLAST152

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.420.10, 1 hit
3.40.470.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002562, 3'-5'_exonuclease_dom
IPR019760, DNA-dir_DNA_pol_A_CS
IPR001098, DNA-dir_DNA_pol_A_palm_dom
IPR043502, DNA/RNA_pol_sf
IPR002298, DNA_polymerase_A
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR005122, Uracil-DNA_glycosylase-like
IPR036895, Uracil-DNA_glycosylase-like_sf

The PANTHER Classification System

More...PANTHERi		PTHR10133, PTHR10133, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00476, DNA_pol_A, 1 hit
PF01612, DNA_pol_A_exo1, 1 hit
PF03167, UDG, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00868, DNAPOLI

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00474, 35EXOc, 1 hit
SM00482, POLAc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52141, SSF52141, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00447, DNA_POLYMERASE_A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P30314-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSALDTLKE FNPKPMKGQG SKKARIIIVQ ENPFDYEYRK KKYMTGKAGK 
        60         70         80         90        100
LLKFGLAEVG IDPDEDVYYT SIVKYPTPEN RLPTPDEIKE SMDYMWAEIE 
       110        120        130        140        150
VIDPDIIIPT GNLSLKFLTK MTAITKVRGK LYEIEGRKFF PMIHPNTVLK 
       160        170        180        190        200
QPKYQDFFIK DLEILASLLE GKTPKNVLAF TKERRYCDTF EDAIDEIKRY 
       210        220        230        240        250
LELPAGSRVV IDLETVKTNP FIEKVTMKKT TLEAYPMSQQ PKIVGIGLSD 
       260        270        280        290        300
RSGYGCAIPL YHRENLMKGN QIGTIVKFLR KLLEREDLEF IAHNGKFDIR 
       310        320        330        340        350
WLRASLDIYL DISIWDTMLI HIIDYRGERY SWSKRLAWLE TDMGGYDDAL 
       360        370        380        390        400
DGEKPKGEDE GNYDLIPWDI LKVYLADDCD VTFRLSEKYI PLVEENEEKK 
       410        420        430        440        450
WLWENIMVPG YYTLLDIEMD GIHVDREWLE VLRVSYEKEI SRLEDKMREF 
       460        470        480        490        500
PEGVAMEREM RDKWKERVMI GNIKSANRTP EQQDKFKKYK KYDPSKGGDK 
       510        520        530        540        550
INFGSTKQLG ELLFERMGLE TVIFTDKGAP STNDDSLKFM GSQSDFVKVL 
       560        570        580        590        600
MEFRKANHLY NNFVSKLSLM IDPDNIVHPS YNIHGTVTGR LSSNEPNAQQ 
       610        620        630        640        650
FPRKVNTPTL FQYNFEIKKM FNSRFGDGGV IVQFDYSQLE LRILVCYYSR 
       660        670        680        690        700
PYTIDLYRSG ADLHKAVASD AFGVAIEEVS KDQRTASKKI QFGIVYQESA 
       710        720        730        740        750
RGLSEDLRAE GITMSEDECE IFIKKYFKRF PKVSKWIRDT KKHVKDISTV 
       760        770        780        790        800
KTLTGATRNL PDIDSIDQSK ANEAERQAVN TPIQGTGSDC TLMSLILINQ 
       810        820        830        840        850
WLRESGLRSR ICITVHDSIV LDCPKDEVLE VAKKVKHIME NLGEYNEFYK 
       860        870        880        890        900
FLGDVPILSE MEIGRNYGDA FEATIEDIEE HGVDGFIEMK EKEKLEKDMK 
       910        920 
EFTKIIEDGG SIPDYARIYW ENIS
Length:924
Mass (Da):106,837
Last modified:February 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F821B13B5A05EE6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M84415 Unassigned DNA Translation: AAA03732.1 Sequence problems.
M37686 Genomic DNA Translation: AAA64535.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC1269

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84415 Unassigned DNA Translation: AAA03732.1 Sequence problems.
M37686 Genomic DNA Translation: AAA64535.1
PIRiJC1269

3D structure databases

SMRiP30314
ModBaseiSearch...

Proteomic databases

PRIDEiP30314

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.40.470.10, 1 hit
InterProiView protein in InterPro
IPR002562, 3'-5'_exonuclease_dom
IPR019760, DNA-dir_DNA_pol_A_CS
IPR001098, DNA-dir_DNA_pol_A_palm_dom
IPR043502, DNA/RNA_pol_sf
IPR002298, DNA_polymerase_A
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR005122, Uracil-DNA_glycosylase-like
IPR036895, Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR10133, PTHR10133, 1 hit
PfamiView protein in Pfam
PF00476, DNA_pol_A, 1 hit
PF01612, DNA_pol_A_exo1, 1 hit
PF03167, UDG, 1 hit
PRINTSiPR00868, DNAPOLI
SMARTiView protein in SMART
SM00474, 35EXOc, 1 hit
SM00482, POLAc, 1 hit
SUPFAMiSSF52141, SSF52141, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS00447, DNA_POLYMERASE_A, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOL_BPSP1
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30314
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 1, 1994
Last modified: February 23, 2022
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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