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Protein

M-phase inducer phosphatase 1-B

Gene

cdc25-1-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei457By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase 1-B (EC:3.1.3.48)
Gene namesi
Name:cdc25-1-b
Synonyms:cdc25b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-944825 cdc25c

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001986521 – 550M-phase inducer phosphatase 1-BAdd BLAST550

PTM databases

iPTMnetiP30309

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Rps6ka3P186543EBI-15888737,EBI-397744From Mus musculus.

Protein-protein interaction databases

BioGridi99454, 1 interactor
DIPiDIP-176N
IntActiP30309, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP30309
SMRiP30309
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini401 – 508RhodanesePROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the MPI phosphatase family.Curated

Phylogenomic databases

HOVERGENiHBG052501
KOiK05867

Family and domain databases

CDDicd01530 Cdc25, 1 hit
Gene3Di3.40.250.10, 1 hit
InterProiView protein in InterPro
IPR000751 MPI_Phosphatase
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
PfamiView protein in Pfam
PF06617 M-inducer_phosp, 1 hit
PF00581 Rhodanese, 1 hit
PRINTSiPR00716 MPIPHPHTASE
SMARTiView protein in SMART
SM00450 RHOD, 1 hit
SUPFAMiSSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P30309-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESHIMSSE APPKTNTGLN FRTNCRMVLN LLREKDCSVT FSPEQPLTPV
60 70 80 90 100
TDLAVGFSNL STFSGETPKR CLDLSNLGDE TAPLPTESPD RISSGKVESP
110 120 130 140 150
KAQFVQFDGL FTPDLGWKAK KCPRGNMNSV LPRLLCSTPS FKKTSGGQRS
160 170 180 190 200
VSNKENEGEL FKSPNCKPVA LLLPQEVVDS QFSPTPENKV DISLDEDCEM
210 220 230 240 250
NILGSPISAD PPCLDGAHDD IKMQNLDGFA DFFSVDEEEM ENPPGAVGNL
260 270 280 290 300
SSSMAILLSG PLLNQDIEVS NVNNISLNRS RLYRSPSMPE KLDRPMLKRP
310 320 330 340 350
VRPLDSETPV RVKRRRSTSS SLQPQEENFQ PQRRGTSLKK TLSLCDVDIS
360 370 380 390 400
TVLDEDCGHR QLIGDFTKVY ALPTVTGRHQ DLRYITGETL AALIHGDFSS
410 420 430 440 450
LVEKIFIIDC RYPYEYDGGH IKGALNLHRQ EEVTDYFLKQ PLTPTMAQKR
460 470 480 490 500
LIIIFHCEFS SERGPKMCRF LREEDRARNE YPSLYYPELY LLKGGYKDFF
510 520 530 540 550
PEYKELCEPQ SYCPMHHQDF REELLKFRTK CKTSVGDRKR REQIARIMKL
Length:550
Mass (Da):62,183
Last modified:April 1, 1993 - v1
Checksum:iFCEC83AB66FCC5B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94262 mRNA Translation: AAA49671.1
M96858 mRNA Translation: AAA49674.1
PIRiA42679
RefSeqiNP_001081918.1, NM_001088449.1
XP_018106285.1, XM_018250796.1
UniGeneiXl.513

Genome annotation databases

GeneIDi398119
KEGGixla:398119

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94262 mRNA Translation: AAA49671.1
M96858 mRNA Translation: AAA49674.1
PIRiA42679
RefSeqiNP_001081918.1, NM_001088449.1
XP_018106285.1, XM_018250796.1
UniGeneiXl.513

3D structure databases

ProteinModelPortaliP30309
SMRiP30309
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi99454, 1 interactor
DIPiDIP-176N
IntActiP30309, 1 interactor

PTM databases

iPTMnetiP30309

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398119
KEGGixla:398119

Organism-specific databases

CTDi398119
XenbaseiXB-GENE-944825 cdc25c

Phylogenomic databases

HOVERGENiHBG052501
KOiK05867

Family and domain databases

CDDicd01530 Cdc25, 1 hit
Gene3Di3.40.250.10, 1 hit
InterProiView protein in InterPro
IPR000751 MPI_Phosphatase
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
PfamiView protein in Pfam
PF06617 M-inducer_phosp, 1 hit
PF00581 Rhodanese, 1 hit
PRINTSiPR00716 MPIPHPHTASE
SMARTiView protein in SMART
SM00450 RHOD, 1 hit
SUPFAMiSSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMPI1B_XENLA
AccessioniPrimary (citable) accession number: P30309
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 25, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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