UniProtKB - P30309 (MPI1B_XENLA)
Protein
M-phase inducer phosphatase 1-B
Gene
cdc25-1-b
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.
Catalytic activityi
- EC:3.1.3.48
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 457 | By similarity | 1 |
GO - Molecular functioni
- protein tyrosine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- positive regulation of cell cycle G2/M phase transition Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Biological process | Cell cycle, Cell division, Mitosis |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:cdc25-1-b Synonyms:cdc25b |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-944825, cdc25c.L |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000198652 | 1 – 550 | M-phase inducer phosphatase 1-BAdd BLAST | 550 |
Proteomic databases
PRIDEi | P30309 |
PTM databases
iPTMneti | P30309 |
Interactioni
Binary interactionsi
P30309
With | #Exp. | IntAct |
---|---|---|
Rps6ka3 [P18654] from Mus musculus. | 3 | EBI-15888737,EBI-397744 |
Protein-protein interaction databases
BioGRIDi | 99454, 1 interactor |
DIPi | DIP-176N |
IntActi | P30309, 1 interactor |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 401 – 508 | RhodanesePROSITE-ProRule annotationAdd BLAST | 108 |
Sequence similaritiesi
Belongs to the MPI phosphatase family.Curated
Phylogenomic databases
OMAi | SKAWEGE |
OrthoDBi | 1423329at2759 |
Family and domain databases
CDDi | cd01530, Cdc25, 1 hit |
Gene3Di | 3.40.250.10, 1 hit |
InterProi | View protein in InterPro IPR000751, MPI_Phosphatase IPR001763, Rhodanese-like_dom IPR036873, Rhodanese-like_dom_sf |
Pfami | View protein in Pfam PF06617, M-inducer_phosp, 1 hit PF00581, Rhodanese, 1 hit |
PRINTSi | PR00716, MPIPHPHTASE |
SMARTi | View protein in SMART SM00450, RHOD, 1 hit |
SUPFAMi | SSF52821, SSF52821, 1 hit |
PROSITEi | View protein in PROSITE PS50206, RHODANESE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P30309-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAESHIMSSE APPKTNTGLN FRTNCRMVLN LLREKDCSVT FSPEQPLTPV
60 70 80 90 100
TDLAVGFSNL STFSGETPKR CLDLSNLGDE TAPLPTESPD RISSGKVESP
110 120 130 140 150
KAQFVQFDGL FTPDLGWKAK KCPRGNMNSV LPRLLCSTPS FKKTSGGQRS
160 170 180 190 200
VSNKENEGEL FKSPNCKPVA LLLPQEVVDS QFSPTPENKV DISLDEDCEM
210 220 230 240 250
NILGSPISAD PPCLDGAHDD IKMQNLDGFA DFFSVDEEEM ENPPGAVGNL
260 270 280 290 300
SSSMAILLSG PLLNQDIEVS NVNNISLNRS RLYRSPSMPE KLDRPMLKRP
310 320 330 340 350
VRPLDSETPV RVKRRRSTSS SLQPQEENFQ PQRRGTSLKK TLSLCDVDIS
360 370 380 390 400
TVLDEDCGHR QLIGDFTKVY ALPTVTGRHQ DLRYITGETL AALIHGDFSS
410 420 430 440 450
LVEKIFIIDC RYPYEYDGGH IKGALNLHRQ EEVTDYFLKQ PLTPTMAQKR
460 470 480 490 500
LIIIFHCEFS SERGPKMCRF LREEDRARNE YPSLYYPELY LLKGGYKDFF
510 520 530 540 550
PEYKELCEPQ SYCPMHHQDF REELLKFRTK CKTSVGDRKR REQIARIMKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M94262 mRNA Translation: AAA49671.1 M96858 mRNA Translation: AAA49674.1 |
PIRi | A42679 |
RefSeqi | NP_001081918.1, NM_001088449.1 XP_018106285.1, XM_018250796.1 |
Genome annotation databases
GeneIDi | 398119 |
KEGGi | xla:398119 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M94262 mRNA Translation: AAA49671.1 M96858 mRNA Translation: AAA49674.1 |
PIRi | A42679 |
RefSeqi | NP_001081918.1, NM_001088449.1 XP_018106285.1, XM_018250796.1 |
3D structure databases
SMRi | P30309 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 99454, 1 interactor |
DIPi | DIP-176N |
IntActi | P30309, 1 interactor |
PTM databases
iPTMneti | P30309 |
Proteomic databases
PRIDEi | P30309 |
Genome annotation databases
GeneIDi | 398119 |
KEGGi | xla:398119 |
Organism-specific databases
CTDi | 398119 |
Xenbasei | XB-GENE-944825, cdc25c.L |
Phylogenomic databases
OMAi | SKAWEGE |
OrthoDBi | 1423329at2759 |
Family and domain databases
CDDi | cd01530, Cdc25, 1 hit |
Gene3Di | 3.40.250.10, 1 hit |
InterProi | View protein in InterPro IPR000751, MPI_Phosphatase IPR001763, Rhodanese-like_dom IPR036873, Rhodanese-like_dom_sf |
Pfami | View protein in Pfam PF06617, M-inducer_phosp, 1 hit PF00581, Rhodanese, 1 hit |
PRINTSi | PR00716, MPIPHPHTASE |
SMARTi | View protein in SMART SM00450, RHOD, 1 hit |
SUPFAMi | SSF52821, SSF52821, 1 hit |
PROSITEi | View protein in PROSITE PS50206, RHODANESE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MPI1B_XENLA | |
Accessioni | P30309Primary (citable) accession number: P30309 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |