cdc25-1-b

Functionⁱ

This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	457	By similarity		1

GO - Molecular functionⁱ

protein tyrosine phosphatase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
positive regulation of cell cycle G2/M phase transition Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase
Biological process	Cell cycle, Cell division, Mitosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: M-phase inducer phosphatase 1-B (EC:3.1.3.48)
Gene namesⁱ	Name:cdc25-1-b Synonyms:cdc25b
Organismⁱ	Xenopus laevis (African clawed frog)
Taxonomic identifierⁱ	8355 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Organism-specific databases

Xenbaseⁱ	XB-GENE-944825 cdc25c

Xenbaseⁱ

XB-GENE-944825 cdc25c

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000198652	1 – 550	M-phase inducer phosphatase 1-BAdd BLAST		550

PTM databases

iPTMnetⁱ	P30309

iPTMnetⁱ

P30309

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Rps6ka3	P18654	3	EBI-15888737,EBI-397744	From Mus musculus.

With

Entry

#Exp.

IntAct

Notes

Rps6ka3

P18654

3

EBI-15888737,EBI-397744

From Mus musculus.

Protein-protein interaction databases

BioGridⁱ	99454, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-176N
IntActⁱ	P30309, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P30309
SMRⁱ	P30309
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	401 – 508	RhodanesePROSITE-ProRule annotationAdd BLAST		108

Sequence similaritiesⁱ

Belongs to the MPI phosphatase family.Curated

Phylogenomic databases

HOVERGENⁱ	HBG052501
KEGG Orthology (KO) More...KOⁱ	K05867

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01530 Cdc25, 1 hit
Gene3Dⁱ	3.40.250.10, 1 hit
InterProⁱ	View protein in InterPro IPR000751 MPI_Phosphatase IPR001763 Rhodanese-like_dom IPR036873 Rhodanese-like_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06617 M-inducer_phosp, 1 hit PF00581 Rhodanese, 1 hit
PRINTSⁱ	PR00716 MPIPHPHTASE
SMARTⁱ	View protein in SMART SM00450 RHOD, 1 hit
SUPFAMⁱ	SSF52821 SSF52821, 1 hit
PROSITEⁱ	View protein in PROSITE PS50206 RHODANESE_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P30309-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAESHIMSSE APPKTNTGLN FRTNCRMVLN LLREKDCSVT FSPEQPLTPV 
        60         70         80         90        100
TDLAVGFSNL STFSGETPKR CLDLSNLGDE TAPLPTESPD RISSGKVESP 
       110        120        130        140        150
KAQFVQFDGL FTPDLGWKAK KCPRGNMNSV LPRLLCSTPS FKKTSGGQRS 
       160        170        180        190        200
VSNKENEGEL FKSPNCKPVA LLLPQEVVDS QFSPTPENKV DISLDEDCEM 
       210        220        230        240        250
NILGSPISAD PPCLDGAHDD IKMQNLDGFA DFFSVDEEEM ENPPGAVGNL 
       260        270        280        290        300
SSSMAILLSG PLLNQDIEVS NVNNISLNRS RLYRSPSMPE KLDRPMLKRP 
       310        320        330        340        350
VRPLDSETPV RVKRRRSTSS SLQPQEENFQ PQRRGTSLKK TLSLCDVDIS 
       360        370        380        390        400
TVLDEDCGHR QLIGDFTKVY ALPTVTGRHQ DLRYITGETL AALIHGDFSS 
       410        420        430        440        450
LVEKIFIIDC RYPYEYDGGH IKGALNLHRQ EEVTDYFLKQ PLTPTMAQKR 
       460        470        480        490        500
LIIIFHCEFS SERGPKMCRF LREEDRARNE YPSLYYPELY LLKGGYKDFF 
       510        520        530        540        550
PEYKELCEPQ SYCPMHHQDF REELLKFRTK CKTSVGDRKR REQIARIMKL

Length:550

Mass (Da):62,183

Last modified:April 1, 1993 - v1

Checksum:ⁱFCEC83AB66FCC5B0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M94262 mRNA Translation: AAA49671.1 M96858 mRNA Translation: AAA49674.1
PIRⁱ	A42679
NCBI Reference Sequences More...RefSeqⁱ	NP_001081918.1, NM_001088449.1 XP_018106285.1, XM_018250796.1
UniGeneⁱ	Xl.513

Genome annotation databases

GeneIDⁱ	398119
KEGGⁱ	xla:398119

Protein	Similar proteins		Species	Score	Length	Source
P30309	Tyrosine phosphatase		XENLA		550	UniRef100_P30309

Protein	Similar proteins		Species	Score	Length	Source
P30309	M-phase inducer phosphatase 2		XENLA		599	UniRef90_P30309
M-phase inducer phosphatase 3	)	XENLA		572
M-phase inducer phosphatase 1-A		XENLA		550
Tyrosine phosphatase		XENLA		550
Uncharacterized protein		XENLA		550
+4

Protein	Similar proteins		Species	Score	Length	Source
P30309	M-phase inducer phosphatase 2		XENLA		599	UniRef50_P30309
Cell division cycle 25C		LATCH		561
Cell division cycle 25C		XENTR		562
UPI00042BFAA9		CHEMY		507
UPI000388D2C1		CHRPI		514
+18

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M94262 mRNA Translation: AAA49671.1 M96858 mRNA Translation: AAA49674.1
PIRⁱ	A42679
RefSeqⁱ	NP_001081918.1, NM_001088449.1 XP_018106285.1, XM_018250796.1
UniGeneⁱ	Xl.513

3D structure databases

ProteinModelPortalⁱ	P30309
SMRⁱ	P30309
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	99454, 1 interactor
DIPⁱ	DIP-176N
IntActⁱ	P30309, 1 interactor

PTM databases

iPTMnetⁱ	P30309

iPTMnetⁱ

P30309

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	398119
KEGGⁱ	xla:398119

Organism-specific databases

CTDⁱ	398119
Xenbaseⁱ	XB-GENE-944825 cdc25c

Phylogenomic databases

HOVERGENⁱ	HBG052501
KOⁱ	K05867

Family and domain databases

CDDⁱ	cd01530 Cdc25, 1 hit
Gene3Dⁱ	3.40.250.10, 1 hit
InterProⁱ	View protein in InterPro IPR000751 MPI_Phosphatase IPR001763 Rhodanese-like_dom IPR036873 Rhodanese-like_dom_sf
Pfamⁱ	View protein in Pfam PF06617 M-inducer_phosp, 1 hit PF00581 Rhodanese, 1 hit
PRINTSⁱ	PR00716 MPIPHPHTASE
SMARTⁱ	View protein in SMART SM00450 RHOD, 1 hit
SUPFAMⁱ	SSF52821 SSF52821, 1 hit
PROSITEⁱ	View protein in PROSITE PS50206 RHODANESE_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MPI1B_XENLA
Accessionⁱ	P30309Primary (citable) accession number: P30309
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	April 1, 1993
	Last modified:	October 25, 2017
	This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - P30309 (MPI1B_XENLA)

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M-phase inducer phosphatase 1-B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ