CDC25B

Functionⁱ

Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.1 Publication

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.

Activity regulationⁱ

Stimulated by B-type cyclins.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	487			1

GO - Molecular functionⁱ

phosphoprotein phosphatase activity Source: Reactome
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12400006
- 15908796
protein tyrosine phosphatase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
female meiosis I Source: Ensembl
G2/M transition of mitotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mitotic cell cycle
Source: UniProtKB
Traceable author statementⁱ
- 9188863
oocyte maturation Source: Ensembl
positive regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 8276402
positive regulation of cytokinesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17332740
positive regulation of G2/MI transition of meiotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of G2/M transition of mitotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of mitotic cell cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17332740
positive regulation of protein kinase activity Source: Ensembl
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 17332740

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase
Biological process	Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BRENDAⁱ	3.1.3.48 2681
Reactomeⁱ	R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
SIGNORⁱ	P30305

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: M-phase inducer phosphatase 2 (EC:3.1.3.48) Alternative name(s): Dual specificity phosphatase Cdc25B
Gene namesⁱ	Name:CDC25B Synonyms:CDC25HU2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101224.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1726 CDC25B
MIMⁱ	116949 gene
neXtProtⁱ	NX_P30305

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	994
Open Targets More...OpenTargetsⁱ	ENSG00000101224
PharmGKBⁱ	PA26260

Chemistry databases

ChEMBLⁱ	CHEMBL4804
Drug and drug target database More...DrugBankⁱ	DB03661 Cysteinesulfonic Acid

Polymorphism and mutation databases

DMDMⁱ	21264471

DMDMⁱ

21264471

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000198644	1 – 580	M-phase inducer phosphatase 2Add BLAST		580

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	42	PhosphoserineBy similarity	1
Modified residueⁱ	169	Phosphoserine; by MELK1 Publication	1
Modified residueⁱ	249	PhosphoserineCombined sources	1
Modified residueⁱ	323	Phosphoserine; by MELK and MAPK14Combined sources3 Publications	1
Modified residueⁱ	353	Phosphoserine; by AURKACombined sources1 Publication	1
Modified residueⁱ	375	Phosphoserine; by BRSK1 and MAPK14Combined sources2 Publications	1
Modified residueⁱ	470	PhosphoserineCombined sources	1
Modified residueⁱ	563	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.8 Publications

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P30305
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P30305
PaxDbⁱ	P30305
PeptideAtlas More...PeptideAtlasⁱ	P30305
PRIDEⁱ	P30305
ProteomicsDBⁱ	54654 54655 [P30305-2] 54656 [P30305-3] 54657 [P30305-4]

PTM databases

DEPODⁱ	P30305
iPTMnetⁱ	P30305
PhosphoSitePlusⁱ	P30305

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101224 Expressed in 220 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_CDC25B
ExpressionAtlasⁱ	P30305 baseline and differential
Genevisibleⁱ	P30305 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038892 HPA038893 HPA075215

HPAⁱ

HPA038892
HPA038893
HPA075215

Interactionⁱ

Subunit structureⁱ

Interacts with MAPK14 and 14-3-3 proteins.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
YWHAB	P31946	5	EBI-1051746,EBI-359815
YWHAH	Q04917	4	EBI-1051746,EBI-306940
YWHAZ	P63104	5	EBI-1051746,EBI-347088

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12400006
- 15908796

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107429, 100 interactors
Database of interacting proteins More...DIPⁱ	DIP-323N
ELMⁱ	P30305
IntActⁱ	P30305, 16 interactors
Molecular INTeraction database More...MINTⁱ	P30305
STRINGⁱ	9606.ENSP00000245960

Chemistry databases

BindingDBⁱ

P30305

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	396 – 399	Combined sources	4
Helixⁱ	417 – 424	Combined sources	8
Turnⁱ	425 – 431	Combined sources	7
Beta strandⁱ	432 – 439	Combined sources	8
Helixⁱ	443 – 447	Combined sources	5
Helixⁱ	460 – 468	Combined sources	9
Turnⁱ	469 – 471	Combined sources	3
Beta strandⁱ	479 – 486	Combined sources	8
Beta strandⁱ	488 – 492	Combined sources	5
Helixⁱ	493 – 508	Combined sources	16
Beta strandⁱ	519 – 522	Combined sources	4
Helixⁱ	525 – 532	Combined sources	8
Helixⁱ	534 – 536	Combined sources	3
Beta strandⁱ	537 – 540	Combined sources	4
Helixⁱ	548 – 550	Combined sources	3
Helixⁱ	551 – 558	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P30305
SMRⁱ	P30305
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P30305

EvolutionaryTraceⁱ

P30305

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	431 – 538	RhodanesePROSITE-ProRule annotationAdd BLAST		108

Sequence similaritiesⁱ

Belongs to the MPI phosphatase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3772 Eukaryota COG5105 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018747
HOVERGENⁱ	HBG052501
InParanoidⁱ	P30305
KEGG Orthology (KO) More...KOⁱ	K05866
OMAⁱ	NEQFSIR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H0D
PhylomeDBⁱ	P30305
TreeFamⁱ	TF101056

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01530 Cdc25, 1 hit
Gene3Dⁱ	3.40.250.10, 1 hit
InterProⁱ	View protein in InterPro IPR000751 MPI_Phosphatase IPR001763 Rhodanese-like_dom IPR036873 Rhodanese-like_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06617 M-inducer_phosp, 1 hit PF00581 Rhodanese, 1 hit
PRINTSⁱ	PR00716 MPIPHPHTASE
SMARTⁱ	View protein in SMART SM00450 RHOD, 1 hit
SUPFAMⁱ	SSF52821 SSF52821, 1 hit
PROSITEⁱ	View protein in PROSITE PS50206 RHODANESE_3, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 3 (identifier: P30305-1) [UniParc]FASTA Add to basket

Also known as: CDC25B3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVPQPEPAP GSALSPAGVC GGAQRPGHLP GLLLGSHGLL GSPVRAAASS 
        60         70         80         90        100
PVTTLTQTMH DLAGLGSETP KSQVGTLLFR SRSRLTHLSL SRRASESSLS 
       110        120        130        140        150
SESSESSDAG LCMDSPSPMD PHMAEQTFEQ AIQAASRIIR NEQFAIRRFQ 
       160        170        180        190        200
SMPVRLLGHS PVLRNITNSQ APDGRRKSEA GSGAASSSGE DKENDGFVFK 
       210        220        230        240        250
MPWKPTHPSS THALAEWASR REAFAQRPSS APDLMCLSPD RKMEVEELSP 
       260        270        280        290        300
LALGRFSLTP AEGDTEEDDG FVDILESDLK DDDAVPPGME SLISAPLVKT 
       310        320        330        340        350
LEKEEEKDLV MYSKCQRLFR SPSMPCSVIR PILKRLERPQ DRDTPVQNKR 
       360        370        380        390        400
RRSVTPPEEQ QEAEEPKARV LRSKSLCHDE IENLLDSDHR ELIGDYSKAF 
       410        420        430        440        450
LLQTVDGKHQ DLKYISPETM VALLTGKFSN IVDKFVIVDC RYPYEYEGGH 
       460        470        480        490        500
IKTAVNLPLE RDAESFLLKS PIAPCSLDKR VILIFHCEFS SERGPRMCRF 
       510        520        530        540        550
IRERDRAVND YPSLYYPEMY ILKGGYKEFF PQHPNFCEPQ DYRPMNHEAF 
       560        570        580
KDELKTFRLK TRSWAGERSR RELCSRLQDQ

Length:580

Mass (Da):64,987

Last modified:May 27, 2002 - v2

Checksum:ⁱEDE24B0E84AC1BE3

GO

Isoform 1 (identifier: P30305-2) [UniParc]FASTA Add to basket

Also known as: CDC25B1

The sequence of this isoform differs from the canonical sequence as follows:
68-81: Missing.

« Hide

        10         20         30         40         50
MEVPQPEPAP GSALSPAGVC GGAQRPGHLP GLLLGSHGLL GSPVRAAASS 
        60         70         80         90        100
PVTTLTQTMH DLAGLGSRSR LTHLSLSRRA SESSLSSESS ESSDAGLCMD 
       110        120        130        140        150
SPSPMDPHMA EQTFEQAIQA ASRIIRNEQF AIRRFQSMPV RLLGHSPVLR 
       160        170        180        190        200
NITNSQAPDG RRKSEAGSGA ASSSGEDKEN DGFVFKMPWK PTHPSSTHAL 
       210        220        230        240        250
AEWASRREAF AQRPSSAPDL MCLSPDRKME VEELSPLALG RFSLTPAEGD 
       260        270        280        290        300
TEEDDGFVDI LESDLKDDDA VPPGMESLIS APLVKTLEKE EEKDLVMYSK 
       310        320        330        340        350
CQRLFRSPSM PCSVIRPILK RLERPQDRDT PVQNKRRRSV TPPEEQQEAE 
       360        370        380        390        400
EPKARVLRSK SLCHDEIENL LDSDHRELIG DYSKAFLLQT VDGKHQDLKY 
       410        420        430        440        450
ISPETMVALL TGKFSNIVDK FVIVDCRYPY EYEGGHIKTA VNLPLERDAE 
       460        470        480        490        500
SFLLKSPIAP CSLDKRVILI FHCEFSSERG PRMCRFIRER DRAVNDYPSL 
       510        520        530        540        550
YYPEMYILKG GYKEFFPQHP NFCEPQDYRP MNHEAFKDEL KTFRLKTRSW 
       560 
AGERSRRELC SRLQDQ

Show »

Length:566

Mass (Da):63,443

Checksum:ⁱ7C54E3E799ECDA50

GO

Isoform 2 (identifier: P30305-3) [UniParc]FASTA Add to basket

Also known as: CDC25B2

The sequence of this isoform differs from the canonical sequence as follows:
154-194: Missing.

« Hide

        10         20         30         40         50
MEVPQPEPAP GSALSPAGVC GGAQRPGHLP GLLLGSHGLL GSPVRAAASS 
        60         70         80         90        100
PVTTLTQTMH DLAGLGSETP KSQVGTLLFR SRSRLTHLSL SRRASESSLS 
       110        120        130        140        150
SESSESSDAG LCMDSPSPMD PHMAEQTFEQ AIQAASRIIR NEQFAIRRFQ 
       160        170        180        190        200
SMPDGFVFKM PWKPTHPSST HALAEWASRR EAFAQRPSSA PDLMCLSPDR 
       210        220        230        240        250
KMEVEELSPL ALGRFSLTPA EGDTEEDDGF VDILESDLKD DDAVPPGMES 
       260        270        280        290        300
LISAPLVKTL EKEEEKDLVM YSKCQRLFRS PSMPCSVIRP ILKRLERPQD 
       310        320        330        340        350
RDTPVQNKRR RSVTPPEEQQ EAEEPKARVL RSKSLCHDEI ENLLDSDHRE 
       360        370        380        390        400
LIGDYSKAFL LQTVDGKHQD LKYISPETMV ALLTGKFSNI VDKFVIVDCR 
       410        420        430        440        450
YPYEYEGGHI KTAVNLPLER DAESFLLKSP IAPCSLDKRV ILIFHCEFSS 
       460        470        480        490        500
ERGPRMCRFI RERDRAVNDY PSLYYPEMYI LKGGYKEFFP QHPNFCEPQD 
       510        520        530 
YRPMNHEAFK DELKTFRLKT RSWAGERSRR ELCSRLQDQ

Show »

Length:539

Mass (Da):60,756

Checksum:ⁱCDA92929F8183BE9

GO

Isoform 4 (identifier: P30305-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
68-81: Missing.
194-194: N → NVRFWKAGVGALREEEGACWGGSLACEDPPLPSWLQ

« Hide

        10         20         30         40         50
MEVPQPEPAP GSALSPAGVC GGAQRPGHLP GLLLGSHGLL GSPVRAAASS 
        60         70         80         90        100
PVTTLTQTMH DLAGLGSRSR LTHLSLSRRA SESSLSSESS ESSDAGLCMD 
       110        120        130        140        150
SPSPMDPHMA EQTFEQAIQA ASRIIRNEQF AIRRFQSMPV RLLGHSPVLR 
       160        170        180        190        200
NITNSQAPDG RRKSEAGSGA ASSSGEDKEN VRFWKAGVGA LREEEGACWG 
       210        220        230        240        250
GSLACEDPPL PSWLQDGFVF KMPWKPTHPS STHALAEWAS RREAFAQRPS 
       260        270        280        290        300
SAPDLMCLSP DRKMEVEELS PLALGRFSLT PAEGDTEEDD GFVDILESDL 
       310        320        330        340        350
KDDDAVPPGM ESLISAPLVK TLEKEEEKDL VMYSKCQRLF RSPSMPCSVI 
       360        370        380        390        400
RPILKRLERP QDRDTPVQNK RRRSVTPPEE QQEAEEPKAR VLRSKSLCHD 
       410        420        430        440        450
EIENLLDSDH RELIGDYSKA FLLQTVDGKH QDLKYISPET MVALLTGKFS 
       460        470        480        490        500
NIVDKFVIVD CRYPYEYEGG HIKTAVNLPL ERDAESFLLK SPIAPCSLDK 
       510        520        530        540        550
RVILIFHCEF SSERGPRMCR FIRERDRAVN DYPSLYYPEM YILKGGYKEF 
       560        570        580        590        600
FPQHPNFCEP QDYRPMNHEA FKDELKTFRL KTRSWAGERS RRELCSRLQD 

Q

Note: No experimental confirmation available.

Show »

Length:601

Mass (Da):67,241

Checksum:ⁱ8E32AEC15A3845D7

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G8JLH2	G8JLH2_HUMAN	M-phase inducer phosphatase 2 M-phase inducer phosphatase 2	CDC25B	489	Annotation score:
B4DIG0	B4DIG0_HUMAN	M-phase inducer phosphatase 2 M-phase inducer phosphatase 2 (cDNA FLJ53333, highly similar to M-phase inducer phosphatase 2)	CDC25B	516	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	575	S → D in AAB21139 (PubMed:1662986).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_020933	548	E → K1 PublicationCorresponds to variant dbSNP:rs11570019Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_000861	68 – 81	Missing in isoform 1 and isoform 4. 2 PublicationsAdd BLAST	14
Alternative sequenceⁱVSP_000862	154 – 194	Missing in isoform 2. 1 PublicationAdd BLAST	41
Alternative sequenceⁱVSP_012587	194	N → NVRFWKAGVGALREEEGACW GGSLACEDPPLPSWLQ in isoform 4. Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M81934 mRNA Translation: AAA58416.1 S78187 mRNA Translation: AAB21139.1 X96436 Genomic DNA Translation: CAA65303.1 Z68092 mRNA Translation: CAA92108.1 AY494082 Genomic DNA Translation: AAR26469.1 AL109804 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10491.1 CH471133 Genomic DNA Translation: EAX10492.1 CH471133 Genomic DNA Translation: EAX10493.1 CH471133 Genomic DNA Translation: EAX10494.1 CH471133 Genomic DNA Translation: EAX10496.1 CH471133 Genomic DNA Translation: EAX10497.1 CH471133 Genomic DNA Translation: EAX10498.1 CH471133 Genomic DNA Translation: EAX10499.1 BC006395 mRNA Translation: AAH06395.1 BC009953 mRNA Translation: AAH09953.1 BC051711 mRNA Translation: AAH51711.1 AF036233 Genomic DNA Translation: AAB94622.1 AF036233 Genomic DNA Translation: AAB94624.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13065.1 [P30305-2] CCDS13066.1 [P30305-3] CCDS13067.1 [P30305-1]
PIRⁱ	B41648
NCBI Reference Sequences More...RefSeqⁱ	NP_001274448.1, NM_001287519.1 NP_001274453.1, NM_001287524.1 NP_004349.1, NM_004358.4 [P30305-2] NP_068658.1, NM_021872.3 [P30305-3] NP_068659.1, NM_021873.3 [P30305-1]
UniGeneⁱ	Hs.153752

Genome annotation databases

Ensemblⁱ	ENST00000245960; ENSP00000245960; ENSG00000101224 [P30305-1] ENST00000340833; ENSP00000339170; ENSG00000101224 [P30305-3] ENST00000439880; ENSP00000405972; ENSG00000101224 [P30305-2]
GeneIDⁱ	994
KEGGⁱ	hsa:994
UCSC genome browser More...UCSCⁱ	uc002wjn.5 human [P30305-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P30305	HCG39252, isoform CRA_g		HUMAN		468	UniRef100_P30305
P30305-2	Cdc25B phosphatase (Fragment)		HUMAN		283	UniRef100_P30305-2
P30305-3	Isoform CDC25B7		HUMAN		427	UniRef100_E1YMX4
UPI0003D3E6FC		HUMAN		388
P30305-4	HCG39252, isoform CRA_a		HUMAN		161	UniRef100_D3DVY6
UPI0000110E22		HUMAN		178
UPI0000110E21		HUMAN		211

Protein	Similar proteins		Species	Score	Length	Source
P30305	HCG39252, isoform CRA_g		HUMAN		468	UniRef90_P30305
Cell division cycle 25B		CALJA		588
Cell division cycle 25B		CHLSB		584
Cell division cycle 25B		SAIBB		580
Uncharacterized protein		CERAT		580
+85
P30305-3	Uncharacterized protein		AOTNA		539	UniRef90_A0A2K5CXZ9
CDC25B isoform 6		PANTR		539
Cell division cycle 25B		SAIBB		539
Uncharacterized protein		MACMU		539
Uncharacterized protein		PAPAN		539
+19
P30305-4	M-phase inducer phosphatase 2 isoform 1 (Fragment)		MACMU		377	UniRef90_H9F5R8
Uncharacterized protein		MACFA		573
HCG39252, isoform CRA_a		HUMAN		161
UPI0005F4E312		CERAT		624
UPI000533C4C3		SAIBB		647
+21

Protein	Similar proteins		Species	Score	Length	Source
P30305	M-phase inducer phosphatase 2		MOUSE		576	UniRef50_P30305
HCG39252, isoform CRA_g		HUMAN		468
Cell division cycle 25B		CALJA		588
Cell division cycle 25B		CHLSB		584
Cell division cycle 25B		SAIBB		580
+221
P30305-3	M-phase inducer phosphatase 2		RAT		574	UniRef50_P48966
M-phase inducer phosphatase 2		PTEAL		574
M-phase inducer phosphatase 2 isoform X2		DELLE		502
M-phase inducer phosphatase 2 isoform X2		Yangtze finless porpoise		502
M-phase inducer phosphatase 2 isoform X3		PHYCD		502
+240

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M81934 mRNA Translation: AAA58416.1 S78187 mRNA Translation: AAB21139.1 X96436 Genomic DNA Translation: CAA65303.1 Z68092 mRNA Translation: CAA92108.1 AY494082 Genomic DNA Translation: AAR26469.1 AL109804 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10491.1 CH471133 Genomic DNA Translation: EAX10492.1 CH471133 Genomic DNA Translation: EAX10493.1 CH471133 Genomic DNA Translation: EAX10494.1 CH471133 Genomic DNA Translation: EAX10496.1 CH471133 Genomic DNA Translation: EAX10497.1 CH471133 Genomic DNA Translation: EAX10498.1 CH471133 Genomic DNA Translation: EAX10499.1 BC006395 mRNA Translation: AAH06395.1 BC009953 mRNA Translation: AAH09953.1 BC051711 mRNA Translation: AAH51711.1 AF036233 Genomic DNA Translation: AAB94622.1 AF036233 Genomic DNA Translation: AAB94624.1
CCDSⁱ	CCDS13065.1 [P30305-2] CCDS13066.1 [P30305-3] CCDS13067.1 [P30305-1]
PIRⁱ	B41648
RefSeqⁱ	NP_001274448.1, NM_001287519.1 NP_001274453.1, NM_001287524.1 NP_004349.1, NM_004358.4 [P30305-2] NP_068658.1, NM_021872.3 [P30305-3] NP_068659.1, NM_021873.3 [P30305-1]
UniGeneⁱ	Hs.153752

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1CWR	X-ray	2.10	A	370-580	[»]
	1CWS	X-ray	2.00	A	370-580	[»]
	1CWT	X-ray	2.30	A	388-565	[»]
	1QB0	X-ray	1.91	A	370-580	[»]
	1YM9	X-ray	2.00	A	391-564	[»]
	1YMD	X-ray	1.70	A	391-564	[»]
	1YMK	X-ray	1.70	A	391-564	[»]
	1YML	X-ray	1.70	A	391-564	[»]
	1YS0	X-ray	2.00	A	391-564	[»]
	2A2K	X-ray	1.52	A	391-564	[»]
	2IFD	X-ray	2.00	A	391-564	[»]
	2IFV	X-ray	1.60	A	391-564	[»]
	2UZQ	X-ray	2.38	A/B/C/D/E/F	391-580	[»]
	3FQT	X-ray	1.80	C	38-46	[»]
	3FQU	X-ray	1.80	C	38-46	[»]
	4WH7	X-ray	1.62	A	386-565	[»]
	4WH9	X-ray	1.50	A	386-565	[»]
ProteinModelPortalⁱ	P30305
SMRⁱ	P30305
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107429, 100 interactors
DIPⁱ	DIP-323N
ELMⁱ	P30305
IntActⁱ	P30305, 16 interactors
MINTⁱ	P30305
STRINGⁱ	9606.ENSP00000245960

Chemistry databases

BindingDBⁱ	P30305
ChEMBLⁱ	CHEMBL4804
DrugBankⁱ	DB03661 Cysteinesulfonic Acid

PTM databases

DEPODⁱ	P30305
iPTMnetⁱ	P30305
PhosphoSitePlusⁱ	P30305

Polymorphism and mutation databases

DMDMⁱ	21264471

DMDMⁱ

21264471

Proteomic databases

EPDⁱ	P30305
MaxQBⁱ	P30305
PaxDbⁱ	P30305
PeptideAtlasⁱ	P30305
PRIDEⁱ	P30305
ProteomicsDBⁱ	54654 54655 [P30305-2] 54656 [P30305-3] 54657 [P30305-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	994
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000245960; ENSP00000245960; ENSG00000101224 [P30305-1] ENST00000340833; ENSP00000339170; ENSG00000101224 [P30305-3] ENST00000439880; ENSP00000405972; ENSG00000101224 [P30305-2]
GeneIDⁱ	994
KEGGⁱ	hsa:994
UCSCⁱ	uc002wjn.5 human [P30305-1]

Organism-specific databases

CTDⁱ	994
DisGeNETⁱ	994
EuPathDBⁱ	HostDB:ENSG00000101224.17
GeneCardsⁱ	CDC25B
HGNCⁱ	HGNC:1726 CDC25B
HPAⁱ	HPA038892 HPA038893 HPA075215
MIMⁱ	116949 gene
neXtProtⁱ	NX_P30305
OpenTargetsⁱ	ENSG00000101224
PharmGKBⁱ	PA26260
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3772 Eukaryota COG5105 LUCA
GeneTreeⁱ	ENSGT00390000018747
HOVERGENⁱ	HBG052501
InParanoidⁱ	P30305
KOⁱ	K05866
OMAⁱ	NEQFSIR
OrthoDBⁱ	EOG091G0H0D
PhylomeDBⁱ	P30305
TreeFamⁱ	TF101056

Enzyme and pathway databases

BRENDAⁱ	3.1.3.48 2681
Reactomeⁱ	R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
SIGNORⁱ	P30305

Miscellaneous databases

ChiTaRSⁱ	CDC25B human
EvolutionaryTraceⁱ	P30305
GeneWikiⁱ	CDC25B
GenomeRNAiⁱ	994
Protein Ontology More...PROⁱ	PR:P30305
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101224 Expressed in 220 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_CDC25B
ExpressionAtlasⁱ	P30305 baseline and differential
Genevisibleⁱ	P30305 HS

Family and domain databases

CDDⁱ	cd01530 Cdc25, 1 hit
Gene3Dⁱ	3.40.250.10, 1 hit
InterProⁱ	View protein in InterPro IPR000751 MPI_Phosphatase IPR001763 Rhodanese-like_dom IPR036873 Rhodanese-like_dom_sf
Pfamⁱ	View protein in Pfam PF06617 M-inducer_phosp, 1 hit PF00581 Rhodanese, 1 hit
PRINTSⁱ	PR00716 MPIPHPHTASE
SMARTⁱ	View protein in SMART SM00450 RHOD, 1 hit
SUPFAMⁱ	SSF52821 SSF52821, 1 hit
PROSITEⁱ	View protein in PROSITE PS50206 RHODANESE_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MPIP2_HUMAN
Accessionⁱ	P30305Primary (citable) accession number: P30305 Secondary accession number(s): D3DVY1 Q9BRA6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	May 27, 2002
	Last modified:	November 7, 2018
	This is version 194 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P30305 (MPIP2_HUMAN)

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M-phase inducer phosphatase 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - PTMi

Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Keywords - Coding sequence diversityi

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ