UniProtKB - P30291 (WEE1_HUMAN)
Protein
Wee1-like protein kinase
Gene
WEE1
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Catalytic activityi
- EC:2.7.10.2PROSITE-ProRule annotation
Cofactori
Mg2+Note: Binds 2 magnesium ions per subunit.
Activity regulationi
Synthesis is increased during S and G2 phases, presumably by an increase in transcription; activity is decreased by phosphorylation during m phase. Protein levels fall in M phase as a result of decreased synthesis combined with degradation. Activity seems to be negatively regulated by phosphorylation upon entry into mitosis, although N-terminal phosphorylation might also regulate the protein stability via protection from proteolysis or might regulate the subcellular location.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 328 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 426 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Metal bindingi | 431 | Magnesium; via carbonyl oxygen1 Publication | 1 | |
Metal bindingi | 463 | Magnesium; via carbonyl oxygen1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 305 – 313 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- kinase activity Source: Reactome
- magnesium ion binding Source: InterPro
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
- protein kinase activity Source: GO_Central
- protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- establishment of cell polarity Source: Ensembl
- G2/M transition of mitotic cell cycle Source: Reactome
- microtubule cytoskeleton organization Source: Ensembl
- mitotic cell cycle checkpoint Source: GO_Central
- negative regulation of G1/S transition of mitotic cell cycle Source: Reactome
- neuron projection morphogenesis Source: Ensembl
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Cell cycle, Cell division, Mitosis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2 2681 |
Reactomei | R-HSA-156711 Polo-like kinase mediated events R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69478 G2/M DNA replication checkpoint R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-983231 Factors involved in megakaryocyte development and platelet production |
SignaLinki | P30291 |
SIGNORi | P30291 |
Names & Taxonomyi
Protein namesi | Recommended name: Wee1-like protein kinase (EC:2.7.10.2)Short name: WEE1hu Alternative name(s): Wee1A kinase |
Gene namesi | Name:WEE1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12761 WEE1 |
MIMi | 193525 gene |
neXtProti | NX_P30291 |
Subcellular locationi
Nucleus
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 53 | S → A: Abolishes phosphorylation by PLK1 and CDK1 and binding of the SCF(BTRC) complex, leading to stabilization of the protein; when associated with A-123. 1 Publication | 1 | |
Mutagenesisi | 116 – 117 | EE → AA: Impairs binding of the SCF(BTRC) complex. 1 Publication | 2 | |
Mutagenesisi | 123 | S → A: Abolishes phosphorylation by PLK1 and CDK1 and binding of the SCF(BTRC) complex, leading to stabilization of the protein; when associated with A-53. 1 Publication | 1 | |
Mutagenesisi | 328 | K → R: Abolishes activity. 1 Publication | 1 | |
Mutagenesisi | 642 | S → A: Abolishes phosphorylation by BRSK1 and BRSK2. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7465 |
OpenTargetsi | ENSG00000166483 |
PharmGKBi | PA366 |
Miscellaneous databases
Pharosi | P30291 |
Chemistry databases
ChEMBLi | CHEMBL5491 |
DrugBanki | DB07265 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID DB07257 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione DB08365 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide DB04608 9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE DB07006 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE DB12010 Fostamatinib DB11740 MK-1775 DB07226 N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE |
DrugCentrali | P30291 |
GuidetoPHARMACOLOGYi | 2278 |
Polymorphism and mutation databases
BioMutai | WEE1 |
DMDMi | 1351419 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086810 | 1 – 646 | Wee1-like protein kinaseAdd BLAST | 646 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 53 | Phosphoserine; by PLK11 Publication | 1 | |
Modified residuei | 78 | PhosphoserineBy similarity | 1 | |
Modified residuei | 85 | PhosphoserineCombined sources | 1 | |
Modified residuei | 123 | Phosphoserine; by CDK11 Publication | 1 | |
Modified residuei | 127 | PhosphoserineCombined sources | 1 | |
Modified residuei | 137 | PhosphoserineCombined sources | 1 | |
Modified residuei | 139 | PhosphoserineCombined sources | 1 | |
Modified residuei | 150 | PhosphoserineCombined sources | 1 | |
Modified residuei | 165 | PhosphoserineBy similarity | 1 | |
Modified residuei | 187 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 190 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 239 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 270 | PhosphoserineCombined sources | 1 | |
Modified residuei | 307 | PhosphoserineCombined sources | 1 | |
Modified residuei | 312 | PhosphoserineCombined sources | 1 | |
Modified residuei | 642 | Phosphoserine; by BRSK1 and BRSK22 Publications | 1 |
Post-translational modificationi
Phosphorylated during M and G1 phases. Also autophosphorylated. Phosphorylation at Ser-642 by BRSK1 and BRSK2 in post-mitotic neurons, leads to down-regulate WEE1 activity in polarized neurons. Phosphorylated at Ser-53 and Ser-123 by PLK1 and CDK1, respectively, generating an signal for degradation that can be recognized by the SCF(BTRC) complex, leading to its ubiquitination and degradation at the onset of G2/M phase.4 Publications
Dephosphorylated at Thr-239 by CTDP1.
Ubiquitinated and degraded at the onset of G2/M phase.1 Publication
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P30291 |
jPOSTi | P30291 |
MassIVEi | P30291 |
MaxQBi | P30291 |
PaxDbi | P30291 |
PeptideAtlasi | P30291 |
PRIDEi | P30291 |
ProteomicsDBi | 3755 54650 [P30291-1] |
PTM databases
iPTMneti | P30291 |
PhosphoSitePlusi | P30291 |
Miscellaneous databases
PMAP-CutDBi | P30291 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166483 Expressed in 203 organ(s), highest expression level in female gonad |
ExpressionAtlasi | P30291 baseline and differential |
Genevisiblei | P30291 HS |
Organism-specific databases
HPAi | CAB004619 HPA068845 |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 113303, 81 interactors |
DIPi | DIP-37969N |
IntActi | P30291, 25 interactors |
MINTi | P30291 |
STRINGi | 9606.ENSP00000402084 |
Chemistry databases
BindingDBi | P30291 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P30291 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P30291 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 299 – 569 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 271 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 12 | Poly-Pro | 4 | |
Compositional biasi | 34 – 43 | Poly-Glu | 10 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0601 Eukaryota ENOG410XS1M LUCA |
GeneTreei | ENSGT00940000157939 |
HOGENOMi | HOG000004824 |
InParanoidi | P30291 |
KOi | K06632 |
OMAi | NKKRCRT |
OrthoDBi | 1063695at2759 |
PhylomeDBi | P30291 |
TreeFami | TF101088 |
Family and domain databases
DisProti | DP00611 |
InterProi | View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS IPR017164 Wee1-like_protein_kinase |
Pfami | View protein in Pfam PF00069 Pkinase, 1 hit |
PIRSFi | PIRSF037281 Wee1-like_protein_kinase, 1 hit |
SMARTi | View protein in SMART SM00220 S_TKc, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P30291-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSFLSRQQPP PPRRAGAACT LRQKLIFSPC SDCEEEEEEE EEEGSGHSTG
60 70 80 90 100
EDSAFQEPDS PLPPARSPTE PGPERRRSPG PAPGSPGELE EDLLLPGACP
110 120 130 140 150
GADEAGGGAE GDSWEEEGFG SSSPVKSPAA PYFLGSSFSP VRCGGPGDAS
160 170 180 190 200
PRGCGARRAG EGRRSPRPDH PGTPPHKTFR KLRLFDTPHT PKSLLSKARG
210 220 230 240 250
IDSSSVKLRG SSLFMDTEKS GKREFDVRQT PQVNINPFTP DSLLLHSSGQ
260 270 280 290 300
CRRRKRTYWN DSCGEDMEAS DYELEDETRP AKRITITESN MKSRYTTEFH
310 320 330 340 350
ELEKIGSGEF GSVFKCVKRL DGCIYAIKRS KKPLAGSVDE QNALREVYAH
360 370 380 390 400
AVLGQHSHVV RYFSAWAEDD HMLIQNEYCN GGSLADAISE NYRIMSYFKE
410 420 430 440 450
AELKDLLLQV GRGLRYIHSM SLVHMDIKPS NIFISRTSIP NAASEEGDED
460 470 480 490 500
DWASNKVMFK IGDLGHVTRI SSPQVEEGDS RFLANEVLQE NYTHLPKADI
510 520 530 540 550
FALALTVVCA AGAEPLPRNG DQWHEIRQGR LPRIPQVLSQ EFTELLKVMI
560 570 580 590 600
HPDPERRPSA MALVKHSVLL SASRKSAEQL RIELNAEKFK NSLLQKELKK
610 620 630 640
AQMAKAAAEE RALFTDRMAT RSTTQSNRTS RLIGKKMNRS VSLTIY
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PRI3 | E9PRI3_HUMAN | Wee1-like protein kinase | WEE1 | 99 | Annotation score: | ||
E9PRU3 | E9PRU3_HUMAN | Wee1-like protein kinase | WEE1 | 214 | Annotation score: | ||
E9PQ51 | E9PQ51_HUMAN | Wee1-like protein kinase | WEE1 | 162 | Annotation score: | ||
H0YEJ2 | H0YEJ2_HUMAN | Wee1-like protein kinase | WEE1 | 145 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 65 | A → E in CAA43979 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041302 | 210 | G → C1 PublicationCorresponds to variant dbSNP:rs34412975Ensembl. | 1 | |
Natural variantiVAR_041303 | 472 | S → I1 PublicationCorresponds to variant dbSNP:rs56411856Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044959 | 1 – 214 | Missing in isoform 2. 1 PublicationAdd BLAST | 214 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10564 mRNA Translation: AAB60401.1 AJ277546 Genomic DNA Translation: CAC14173.1 AK122837 mRNA Translation: BAG53753.1 AC011979 Genomic DNA No translation available. AC122179 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68586.1 CH471064 Genomic DNA Translation: EAW68587.1 CH471064 Genomic DNA Translation: EAW68588.1 X62048 mRNA Translation: CAA43979.1 |
CCDSi | CCDS44536.1 [P30291-2] CCDS7800.1 [P30291-1] |
PIRi | S55048 |
RefSeqi | NP_001137448.1, NM_001143976.1 [P30291-2] NP_003381.1, NM_003390.3 [P30291-1] |
Genome annotation databases
Ensembli | ENST00000299613; ENSP00000299613; ENSG00000166483 [P30291-2] ENST00000450114; ENSP00000402084; ENSG00000166483 [P30291-1] |
GeneIDi | 7465 |
KEGGi | hsa:7465 |
UCSCi | uc001mhs.4 human [P30291-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10564 mRNA Translation: AAB60401.1 AJ277546 Genomic DNA Translation: CAC14173.1 AK122837 mRNA Translation: BAG53753.1 AC011979 Genomic DNA No translation available. AC122179 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68586.1 CH471064 Genomic DNA Translation: EAW68587.1 CH471064 Genomic DNA Translation: EAW68588.1 X62048 mRNA Translation: CAA43979.1 |
CCDSi | CCDS44536.1 [P30291-2] CCDS7800.1 [P30291-1] |
PIRi | S55048 |
RefSeqi | NP_001137448.1, NM_001143976.1 [P30291-2] NP_003381.1, NM_003390.3 [P30291-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1X8B | X-ray | 1.81 | A | 291-575 | [»] | |
2IN6 | X-ray | 1.90 | A | 291-575 | [»] | |
2IO6 | X-ray | 2.20 | A | 291-575 | [»] | |
2Z2W | X-ray | 2.22 | A | 291-575 | [»] | |
3BI6 | X-ray | 2.20 | A | 291-575 | [»] | |
3BIZ | X-ray | 2.20 | A | 291-575 | [»] | |
3CQE | X-ray | 2.50 | A | 291-575 | [»] | |
3CR0 | X-ray | 2.30 | A | 291-575 | [»] | |
5V5Y | X-ray | 1.90 | A | 291-575 | [»] | |
5VC3 | X-ray | 1.97 | A | 291-575 | [»] | |
5VC4 | X-ray | 2.10 | A | 291-575 | [»] | |
5VC5 | X-ray | 1.93 | A | 291-575 | [»] | |
5VC6 | X-ray | 2.00 | A | 291-575 | [»] | |
5VD2 | X-ray | 2.05 | A | 291-575 | [»] | |
5VD4 | X-ray | 2.02 | A | 291-575 | [»] | |
5VD5 | X-ray | 2.05 | A | 291-575 | [»] | |
5VD7 | X-ray | 2.08 | A | 291-575 | [»] | |
5VD8 | X-ray | 1.85 | A | 291-575 | [»] | |
5VD9 | X-ray | 1.87 | A | 291-575 | [»] | |
5VDA | X-ray | 2.10 | A | 291-575 | [»] | |
SMRi | P30291 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 113303, 81 interactors |
DIPi | DIP-37969N |
IntActi | P30291, 25 interactors |
MINTi | P30291 |
STRINGi | 9606.ENSP00000402084 |
Chemistry databases
BindingDBi | P30291 |
ChEMBLi | CHEMBL5491 |
DrugBanki | DB07265 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID DB07257 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione DB08365 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide DB04608 9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE DB07006 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE DB12010 Fostamatinib DB11740 MK-1775 DB07226 N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE |
DrugCentrali | P30291 |
GuidetoPHARMACOLOGYi | 2278 |
PTM databases
iPTMneti | P30291 |
PhosphoSitePlusi | P30291 |
Polymorphism and mutation databases
BioMutai | WEE1 |
DMDMi | 1351419 |
Proteomic databases
EPDi | P30291 |
jPOSTi | P30291 |
MassIVEi | P30291 |
MaxQBi | P30291 |
PaxDbi | P30291 |
PeptideAtlasi | P30291 |
PRIDEi | P30291 |
ProteomicsDBi | 3755 54650 [P30291-1] |
Protocols and materials databases
DNASUi | 7465 |
Genome annotation databases
Ensembli | ENST00000299613; ENSP00000299613; ENSG00000166483 [P30291-2] ENST00000450114; ENSP00000402084; ENSG00000166483 [P30291-1] |
GeneIDi | 7465 |
KEGGi | hsa:7465 |
UCSCi | uc001mhs.4 human [P30291-1] |
Organism-specific databases
CTDi | 7465 |
DisGeNETi | 7465 |
GeneCardsi | WEE1 |
HGNCi | HGNC:12761 WEE1 |
HPAi | CAB004619 HPA068845 |
MIMi | 193525 gene |
neXtProti | NX_P30291 |
OpenTargetsi | ENSG00000166483 |
PharmGKBi | PA366 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0601 Eukaryota ENOG410XS1M LUCA |
GeneTreei | ENSGT00940000157939 |
HOGENOMi | HOG000004824 |
InParanoidi | P30291 |
KOi | K06632 |
OMAi | NKKRCRT |
OrthoDBi | 1063695at2759 |
PhylomeDBi | P30291 |
TreeFami | TF101088 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2 2681 |
Reactomei | R-HSA-156711 Polo-like kinase mediated events R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69478 G2/M DNA replication checkpoint R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-983231 Factors involved in megakaryocyte development and platelet production |
SignaLinki | P30291 |
SIGNORi | P30291 |
Miscellaneous databases
ChiTaRSi | WEE1 human |
EvolutionaryTracei | P30291 |
GeneWikii | Wee1-like_protein_kinase |
GenomeRNAii | 7465 |
Pharosi | P30291 |
PMAP-CutDBi | P30291 |
PROi | PR:P30291 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166483 Expressed in 203 organ(s), highest expression level in female gonad |
ExpressionAtlasi | P30291 baseline and differential |
Genevisiblei | P30291 HS |
Family and domain databases
DisProti | DP00611 |
InterProi | View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS IPR017164 Wee1-like_protein_kinase |
Pfami | View protein in Pfam PF00069 Pkinase, 1 hit |
PIRSFi | PIRSF037281 Wee1-like_protein_kinase, 1 hit |
SMARTi | View protein in SMART SM00220 S_TKc, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WEE1_HUMAN | |
Accessioni | P30291Primary (citable) accession number: P30291 Secondary accession number(s): B3KVE1, D3DQV0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | February 1, 1996 | |
Last modified: | October 16, 2019 | |
This is version 205 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references