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Protein

Omega-agatoxin-Aa4a

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Omega-agatoxins inhibit neuronal voltage-gated calcium channels. This toxin acts by modifying the gating of the high voltage activated P-type Cav2.1/CACNA1A channel. Is a potent blocker in both insect and mammalian central neurons.7 Publications

Miscellaneous

This toxin is a diagnostic ligand for P-type channels Ca2.1/CACNA1A in the mammalian brain.
The binding site for this toxin has been localized in part to the extracellular S3-S4 loop in repeat IV of the alpha1 subunit of mammalian Cav2.1/CACNA1A channels, which is proximal to the S4 sensor domain.

GO - Molecular functioni

  • calcium channel inhibitor activity Source: CACAO
  • toxin activity Source: UniProtKB-KW

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Protein family/group databases

TCDBi8.B.6.1.1 the ca(2+) channel-targeting spider toxin (cst) family

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-agatoxin-Aa4a
Short name:
Omega-AGTX-Aa4a
Alternative name(s):
Omega-agatoxin IVA
Short name:
Omega-Aga-IVA
Omega-agatoxin-4A
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000182 omega-agatoxin-Aa4a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000876101 – 48Omega-agatoxin-Aa4aAdd BLAST48

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 20
Disulfide bondi12 ↔ 25
Disulfide bondi19 ↔ 36
Disulfide bondi27 ↔ 34

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP30288
SMRiP30288
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30288

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

CDDicd12960 Spider_toxin, 1 hit
InterProiView protein in InterPro
IPR004169 Spidertoxin
PfamiView protein in Pfam
PF02819 Toxin_9, 1 hit

Sequencei

Sequence statusi: Complete.

P30288-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
KKKCIAKDYG RCKWGGTPCC RGRGCICSIM GTNCECKPRL IMEGLGLA
Length:48
Mass (Da):5,210
Last modified:April 1, 1993 - v1
Checksum:i945054B55EAE81FD
GO

Sequence databases

PIRiS20256

Cross-referencesi

Sequence databases

PIRiS20256

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IVANMR-A1-48[»]
1OAVNMR-A1-48[»]
1OAWNMR-A1-48[»]
2NDBNMR-A1-48[»]
ProteinModelPortaliP30288
SMRiP30288
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.B.6.1.1 the ca(2+) channel-targeting spider toxin (cst) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000182 omega-agatoxin-Aa4a

Miscellaneous databases

EvolutionaryTraceiP30288

Family and domain databases

CDDicd12960 Spider_toxin, 1 hit
InterProiView protein in InterPro
IPR004169 Spidertoxin
PfamiView protein in Pfam
PF02819 Toxin_9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTX23A_AGEAP
AccessioniPrimary (citable) accession number: P30288
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 12, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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