UniProtKB - P30283 (CGS5_YEAST)
Protein
S-phase entry cyclin-5
Gene
CLB5
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for efficient progression through S phase and possibly for the normal progression through meiosis. Interacts with CDC28.
Miscellaneous
Present with 521 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
GO - Biological processi
- cell division Source: UniProtKB-KW
- G1/S transition of mitotic cell cycle Source: SGD
- G2/M transition of mitotic cell cycle Source: SGD
- mitotic cell cycle phase transition Source: GO_Central
- positive regulation of DNA replication Source: SGD
- positive regulation of mitotic spindle pole body separation Source: SGD
- premeiotic DNA replication Source: SGD
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
- regulation of mitotic spindle assembly Source: SGD
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
Reactomei | R-SCE-69017, CDK-mediated phosphorylation and removal of Cdc6 R-SCE-69202, Cyclin E associated events during G1/S transition |
Names & Taxonomyi
Protein namesi | Recommended name: S-phase entry cyclin-5 |
Gene namesi | Name:CLB5 Ordered Locus Names:YPR120C ORF Names:P9642.8 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YPR120C |
SGDi | S000006324, CLB5 |
Subcellular locationi
Nucleus
- nucleus Source: SGD
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080408 | 1 – 435 | S-phase entry cyclin-5Add BLAST | 435 |
Proteomic databases
PaxDbi | P30283 |
PTM databases
iPTMneti | P30283 |
Expressioni
Developmental stagei
Maximally expressed just before cell cycle start.
Interactioni
Binary interactionsi
P30283
With | #Exp. | IntAct |
---|---|---|
CDC28 [P00546] | 5 | EBI-4538,EBI-4253 |
Protein-protein interaction databases
BioGRIDi | 36288, 322 interactors |
ComplexPortali | CPX-1702, CLB5-CDC28 kinase complex |
DIPi | DIP-2710N |
ELMi | P30283 |
IntActi | P30283, 24 interactors |
MINTi | P30283 |
STRINGi | 4932.YPR120C |
Miscellaneous databases
RNActi | P30283, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0653, Eukaryota |
GeneTreei | ENSGT00940000176489 |
HOGENOMi | CLU_020695_12_4_1 |
InParanoidi | P30283 |
OMAi | SDNAYNR |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
PIRSFi | PIRSF001771, Cyclin_A_B_D_E, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
i Sequence
Sequence statusi: Complete.
P30283-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGENHDHEQS IKRNSMIYNE NERQLCNSNL KILQNKRALS KNDSSSKQQV
60 70 80 90 100
QDSKPRRALT DVPVNNNPLS QNKRIVAGSK AAKVRREENI RPIVSAVQKR
110 120 130 140 150
QIYNDRTAAE QEEEEEEEGE DDDAASIVNK KRRIDAEGVS EIVGWQDLDY
160 170 180 190 200
VEKDDTAMVA EYSAEIFAFL YRRELETLPS HNYLLDKTSK YYLRPSMRTI
210 220 230 240 250
LVDWLVEVHE KFQCYPETLF LSINLMDRFL AKNKVTMNKL QLLAVTSLFI
260 270 280 290 300
AAKFEEVNLP KLAEYAYITD GAASKNDIKN AEMFMLTSLE FNIGWPNPLN
310 320 330 340 350
FLRRISKADD YDPVNRNIGK FILEYAYCCH QFIHLPPSTV SAMAMYIARR
360 370 380 390 400
MTNRNKNELW NGTLQHYSGG IDPIHDEAFQ SLCIDLVKDI ASSKTHLDSL
410 420 430
ILKYKKPRYG SVYFQTFKWC TSEMHSNFQN LFNLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91209 Genomic DNA Translation: AAA34503.1 X70435 Genomic DNA Translation: CAA49893.1 U40828 Genomic DNA Translation: AAB68061.1 BK006949 Genomic DNA Translation: DAA11535.1 |
PIRi | S31290 |
RefSeqi | NP_015445.1, NM_001184217.1 |
Genome annotation databases
EnsemblFungii | YPR120C_mRNA; YPR120C; YPR120C |
GeneIDi | 856237 |
KEGGi | sce:YPR120C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91209 Genomic DNA Translation: AAA34503.1 X70435 Genomic DNA Translation: CAA49893.1 U40828 Genomic DNA Translation: AAB68061.1 BK006949 Genomic DNA Translation: DAA11535.1 |
PIRi | S31290 |
RefSeqi | NP_015445.1, NM_001184217.1 |
3D structure databases
SMRi | P30283 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36288, 322 interactors |
ComplexPortali | CPX-1702, CLB5-CDC28 kinase complex |
DIPi | DIP-2710N |
ELMi | P30283 |
IntActi | P30283, 24 interactors |
MINTi | P30283 |
STRINGi | 4932.YPR120C |
PTM databases
iPTMneti | P30283 |
Proteomic databases
PaxDbi | P30283 |
Genome annotation databases
EnsemblFungii | YPR120C_mRNA; YPR120C; YPR120C |
GeneIDi | 856237 |
KEGGi | sce:YPR120C |
Organism-specific databases
EuPathDBi | FungiDB:YPR120C |
SGDi | S000006324, CLB5 |
Phylogenomic databases
eggNOGi | KOG0653, Eukaryota |
GeneTreei | ENSGT00940000176489 |
HOGENOMi | CLU_020695_12_4_1 |
InParanoidi | P30283 |
OMAi | SDNAYNR |
Enzyme and pathway databases
Reactomei | R-SCE-69017, CDK-mediated phosphorylation and removal of Cdc6 R-SCE-69202, Cyclin E associated events during G1/S transition |
Miscellaneous databases
PROi | PR:P30283 |
RNActi | P30283, protein |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
PIRSFi | PIRSF001771, Cyclin_A_B_D_E, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CGS5_YEAST | |
Accessioni | P30283Primary (citable) accession number: P30283 Secondary accession number(s): D6W4B9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD