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Protein

G1/S-specific cyclin-D3

Gene

CCND3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  • cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
  • protein kinase binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-69231 Cyclin D associated events in G1
R-HSA-8934593 Regulation of RUNX1 Expression and Activity

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P30281

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P30281

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G1/S-specific cyclin-D3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCND3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000112576.12

Human Gene Nomenclature Database

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HGNCi
HGNC:1585 CCND3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
123834 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P30281

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
896

Open Targets

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OpenTargetsi
ENSG00000112576

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26152

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2422

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CCND3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20981685

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000804421 – 292G1/S-specific cyclin-D3Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei264PhosphoserineBy similarity1
Modified residuei279PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P30281

MaxQB - The MaxQuant DataBase

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MaxQBi
P30281

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30281

PeptideAtlas

More...
PeptideAtlasi
P30281

PRoteomics IDEntifications database

More...
PRIDEi
P30281

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54648
54649 [P30281-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30281

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P30281

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000112576 Expressed in 225 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

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CleanExi
HS_CCND3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P30281 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P30281 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB000116

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107336, 52 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-2012 Cyclin D3-CDK4 complex
CPX-2013 Cyclin D3-CDK6 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P30281

Database of interacting proteins

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DIPi
DIP-31734N

Protein interaction database and analysis system

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IntActi
P30281, 36 interactors

Molecular INTeraction database

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MINTi
P30281

STRING: functional protein association networks

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STRINGi
9606.ENSP00000362082

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P30281

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1292
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P30281

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P30281

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P30281

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 152Cyclin N-terminalAdd BLAST126

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0656 Eukaryota
ENOG410XRKC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160743

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000008182

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050837

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P30281

KEGG Orthology (KO)

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KOi
K10152

Identification of Orthologs from Complete Genome Data

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OMAi
WMHEVCE

Database of Orthologous Groups

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OrthoDBi
EOG091G0URX

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P30281

TreeFam database of animal gene trees

More...
TreeFami
TF101004

Family and domain databases

Conserved Domains Database

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CDDi
cd00043 CYCLIN, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR015451 Cyclin_D
IPR006671 Cyclin_N

The PANTHER Classification System

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PANTHERi
PTHR10177 PTHR10177, 1 hit
PTHR10177:SF65 PTHR10177:SF65, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF001771 Cyclin_A_B_D_E, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954 SSF47954, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00292 CYCLINS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P30281-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELLCCEGTR HAPRAGPDPR LLGDQRVLQS LLRLEERYVP RASYFQCVQR
60 70 80 90 100
EIKPHMRKML AYWMLEVCEE QRCEEEVFPL AMNYLDRYLS CVPTRKAQLQ
110 120 130 140 150
LLGAVCMLLA SKLRETTPLT IEKLCIYTDH AVSPRQLRDW EVLVLGKLKW
160 170 180 190 200
DLAAVIAHDF LAFILHRLSL PRDRQALVKK HAQTFLALCA TDYTFAMYPP
210 220 230 240 250
SMIATGSIGA AVQGLGACSM SGDELTELLA GITGTEVDCL RACQEQIEAA
260 270 280 290
LRESLREASQ TSSSPAPKAP RGSSSQGPSQ TSTPTDVTAI HL
Length:292
Mass (Da):32,520
Last modified:May 15, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16E7B1604FEB0029
GO
Isoform 2 (identifier: P30281-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: No experimental confirmation available.
Show »
Length:211
Mass (Da):22,887
Checksum:iF88EA393BA1B96DB
GO
Isoform 3 (identifier: P30281-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-138: Missing.

Note: No experimental confirmation available.
Show »
Length:220
Mass (Da):24,238
Checksum:i15BC01266FE6BF4B
GO
Isoform 4 (identifier: P30281-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Note: No experimental confirmation available.
Show »
Length:96
Mass (Da):9,736
Checksum:i83F7CF9D0B743ED7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T8J1Q5T8J1_HUMAN
G1/S-specific cyclin-D3
CCND3
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8M4H0Y8M4_HUMAN
G1/S-specific cyclin-D3
CCND3
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RI00D6RI00_HUMAN
G1/S-specific cyclin-D3
CCND3
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIX2D6RIX2_HUMAN
G1/S-specific cyclin-D3
CCND3
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDL3D6RDL3_HUMAN
G1/S-specific cyclin-D3
CCND3
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDF8D6RDF8_HUMAN
G1/S-specific cyclin-D3
CCND3
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMS0A0A1D5RMS0_HUMAN
G1/S-specific cyclin-D3
CCND3
10Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020412134P → S. Corresponds to variant dbSNP:rs3218089Ensembl.1
Natural variantiVAR_033726253E → D. Corresponds to variant dbSNP:rs33966734Ensembl.1
Natural variantiVAR_014205259S → A6 PublicationsCorresponds to variant dbSNP:rs1051130Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0462661 – 196Missing in isoform 4. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_0426491 – 81Missing in isoform 2. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_04626767 – 138Missing in isoform 3. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M90814 mRNA Translation: AAA51927.1
M92287 mRNA Translation: AAA52137.1
AF517525 Genomic DNA Translation: AAM51826.1
BX400719 mRNA No translation available.
AK057206 mRNA Translation: BAG51884.1
AK097856 mRNA No translation available.
AK315421 mRNA Translation: BAG37810.1
CR542246 mRNA Translation: CAG47042.1
AL160163 Genomic DNA No translation available.
AL513008 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04071.1
BC011616 mRNA Translation: AAH11616.1
M88087
, M88084, M88085, M88086 Genomic DNA Translation: AAA51929.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47425.1 [P30281-3]
CCDS47426.1 [P30281-2]
CCDS47427.1 [P30281-4]
CCDS4863.1 [P30281-1]

Protein sequence database of the Protein Information Resource

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PIRi
B42822

NCBI Reference Sequences

More...
RefSeqi
NP_001129489.1, NM_001136017.3 [P30281-2]
NP_001129597.1, NM_001136125.2 [P30281-3]
NP_001129598.1, NM_001136126.2 [P30281-4]
NP_001274356.1, NM_001287427.1
NP_001274363.1, NM_001287434.1 [P30281-4]
NP_001751.1, NM_001760.4 [P30281-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.534307

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000372988; ENSP00000362079; ENSG00000112576 [P30281-2]
ENST00000372991; ENSP00000362082; ENSG00000112576 [P30281-1]
ENST00000414200; ENSP00000397545; ENSG00000112576 [P30281-3]
ENST00000415497; ENSP00000401595; ENSG00000112576 [P30281-4]
ENST00000511642; ENSP00000426212; ENSG00000112576 [P30281-2]
ENST00000616010; ENSP00000484424; ENSG00000112576 [P30281-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
896

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:896

UCSC genome browser

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UCSCi
uc003orn.4 human [P30281-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90814 mRNA Translation: AAA51927.1
M92287 mRNA Translation: AAA52137.1
AF517525 Genomic DNA Translation: AAM51826.1
BX400719 mRNA No translation available.
AK057206 mRNA Translation: BAG51884.1
AK097856 mRNA No translation available.
AK315421 mRNA Translation: BAG37810.1
CR542246 mRNA Translation: CAG47042.1
AL160163 Genomic DNA No translation available.
AL513008 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04071.1
BC011616 mRNA Translation: AAH11616.1
M88087
, M88084, M88085, M88086 Genomic DNA Translation: AAA51929.1
CCDSiCCDS47425.1 [P30281-3]
CCDS47426.1 [P30281-2]
CCDS47427.1 [P30281-4]
CCDS4863.1 [P30281-1]
PIRiB42822
RefSeqiNP_001129489.1, NM_001136017.3 [P30281-2]
NP_001129597.1, NM_001136125.2 [P30281-3]
NP_001129598.1, NM_001136126.2 [P30281-4]
NP_001274356.1, NM_001287427.1
NP_001274363.1, NM_001287434.1 [P30281-4]
NP_001751.1, NM_001760.4 [P30281-1]
UniGeneiHs.534307

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3G33X-ray3.00B/D1-292[»]
ProteinModelPortaliP30281
SMRiP30281
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107336, 52 interactors
ComplexPortaliCPX-2012 Cyclin D3-CDK4 complex
CPX-2013 Cyclin D3-CDK6 complex
CORUMiP30281
DIPiDIP-31734N
IntActiP30281, 36 interactors
MINTiP30281
STRINGi9606.ENSP00000362082

Chemistry databases

BindingDBiP30281
ChEMBLiCHEMBL2422

PTM databases

iPTMnetiP30281
PhosphoSitePlusiP30281

Polymorphism and mutation databases

BioMutaiCCND3
DMDMi20981685

Proteomic databases

EPDiP30281
MaxQBiP30281
PaxDbiP30281
PeptideAtlasiP30281
PRIDEiP30281
ProteomicsDBi54648
54649 [P30281-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
896
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372988; ENSP00000362079; ENSG00000112576 [P30281-2]
ENST00000372991; ENSP00000362082; ENSG00000112576 [P30281-1]
ENST00000414200; ENSP00000397545; ENSG00000112576 [P30281-3]
ENST00000415497; ENSP00000401595; ENSG00000112576 [P30281-4]
ENST00000511642; ENSP00000426212; ENSG00000112576 [P30281-2]
ENST00000616010; ENSP00000484424; ENSG00000112576 [P30281-4]
GeneIDi896
KEGGihsa:896
UCSCiuc003orn.4 human [P30281-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
896
DisGeNETi896
EuPathDBiHostDB:ENSG00000112576.12

GeneCards: human genes, protein and diseases

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GeneCardsi
CCND3
HGNCiHGNC:1585 CCND3
HPAiCAB000116
MIMi123834 gene
neXtProtiNX_P30281
OpenTargetsiENSG00000112576
PharmGKBiPA26152

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0656 Eukaryota
ENOG410XRKC LUCA
GeneTreeiENSGT00940000160743
HOGENOMiHOG000008182
HOVERGENiHBG050837
InParanoidiP30281
KOiK10152
OMAiWMHEVCE
OrthoDBiEOG091G0URX
PhylomeDBiP30281
TreeFamiTF101004

Enzyme and pathway databases

ReactomeiR-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-69231 Cyclin D associated events in G1
R-HSA-8934593 Regulation of RUNX1 Expression and Activity
SignaLinkiP30281
SIGNORiP30281

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CCND3 human
EvolutionaryTraceiP30281

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Cyclin_D3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
896

Protein Ontology

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PROi
PR:P30281

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112576 Expressed in 225 organ(s), highest expression level in blood
CleanExiHS_CCND3
ExpressionAtlasiP30281 baseline and differential
GenevisibleiP30281 HS

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR015451 Cyclin_D
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF65 PTHR10177:SF65, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCND3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30281
Secondary accession number(s): B2RD63
, B3KQ22, E9PAS4, E9PB36, Q5T8J0, Q6FG62, Q96F49
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 15, 2002
Last modified: December 5, 2018
This is version 191 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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