UniProtKB - P30280 (CCND2_MOUSE)
G1/S-specific cyclin-D2
Ccnd2
Functioni
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
By similarityGO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
- protein kinase binding Source: MGI
GO - Biological processi
- adult locomotory behavior Source: MGI
- cell division Source: UniProtKB-KW
- cellular response to X-ray Source: MGI
- G1/S transition of mitotic cell cycle Source: MGI
- long-term memory Source: MGI
- mitotic cell cycle phase transition Source: GO_Central
- negative regulation of apoptotic process Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
- positive regulation of epithelial cell proliferation Source: MGI
- positive regulation of G1/S transition of mitotic cell cycle Source: MGI
- positive regulation of protein phosphorylation Source: MGI
- regulation of cell cycle Source: MGI
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
Reactomei | R-MMU-69231, Cyclin D associated events in G1 R-MMU-8934593, Regulation of RUNX1 Expression and Activity |
Names & Taxonomyi
Protein namesi | Recommended name: G1/S-specific cyclin-D2 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88314, Ccnd2 |
VEuPathDBi | HostDB:ENSMUSG00000000184 |
Subcellular locationi
Nucleus
- Nucleus By similarity
- Nucleus membrane By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Note: Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nuclear membrane Source: MGI
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- chromatin Source: MGI
- cyclin D2-CDK4 complex Source: MGI
- cyclin-dependent protein kinase holoenzyme complex Source: MGI
- cytoplasm Source: MGI
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080438 | 1 – 289 | G1/S-specific cyclin-D2Add BLAST | 289 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 271 | PhosphoserineBy similarity | 1 | |
Modified residuei | 280 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P30280 |
PaxDbi | P30280 |
PeptideAtlasi | P30280 |
PRIDEi | P30280 |
ProteomicsDBi | 265616 |
PTM databases
iPTMneti | P30280 |
PhosphoSitePlusi | P30280 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000000184, Expressed in rostral migratory stream and 383 other tissues |
ExpressionAtlasi | P30280, baseline and differential |
Genevisiblei | P30280, MM |
Interactioni
Subunit structurei
Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
By similarityGO - Molecular functioni
- protein kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198549, 5 interactors |
ComplexPortali | CPX-2074, Cyclin D2-CDK4 complex |
CORUMi | P30280 |
DIPi | DIP-24177N |
IntActi | P30280, 4 interactors |
STRINGi | 10090.ENSMUSP00000000188 |
Miscellaneous databases
RNActi | P30280, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 151 | Cyclin N-terminalAdd BLAST | 126 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 264 – 289 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 264 – 278 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0656, Eukaryota |
GeneTreei | ENSGT00940000155180 |
InParanoidi | P30280 |
OMAi | CLEMDTN |
OrthoDBi | 1234739at2759 |
PhylomeDBi | P30280 |
TreeFami | TF101004 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR015451, Cyclin_D IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF66, PTHR10177:SF66, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MELLCCEVDP VRRAVPDRNL LEDRVLQNLL TIEERYLPQC SYFKCVQKDI
60 70 80 90 100
QPYMRRMVAT WMLEVCEEQK CEEEVFPLAM NYLDRFLAGV PTPKTHLQLL
110 120 130 140 150
GAVCMFLASK LKETIPLTAE KLCIYTDNSV KPQELLEWEL VVLGKLKWNL
160 170 180 190 200
AAVTPHDFIE HILRKLPQQK EKLSLIRKHA QTFIALCATD FKFAMYPPSM
210 220 230 240 250
IATGSVGAAI CGLQQDDEVN TLTCDALTEL LAKITHTDVD CLKACQEQIE
260 270 280
ALLLNSLQQF RQEQHNAGSK SVEDPDQATT PTDVRDVDL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YU51 | A0A0J9YU51_MOUSE | G1/S-specific cyclin-D2 | Ccnd2 | 189 | Annotation score: | ||
Q9D8L9 | Q9D8L9_MOUSE | G1/S-specific cyclin-D2 | Ccnd2 | 156 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83749 mRNA Translation: AAA37519.1 M86182 mRNA Translation: AAA37503.1 BC049086 mRNA Translation: AAH49086.1 |
CCDSi | CCDS20564.1 |
PIRi | A41984 |
RefSeqi | NP_033959.1, NM_009829.3 XP_006505522.1, XM_006505459.2 XP_006505523.1, XM_006505460.1 |
Genome annotation databases
Ensembli | ENSMUST00000000188; ENSMUSP00000000188; ENSMUSG00000000184 |
GeneIDi | 12444 |
KEGGi | mmu:12444 |
UCSCi | uc009dvr.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83749 mRNA Translation: AAA37519.1 M86182 mRNA Translation: AAA37503.1 BC049086 mRNA Translation: AAH49086.1 |
CCDSi | CCDS20564.1 |
PIRi | A41984 |
RefSeqi | NP_033959.1, NM_009829.3 XP_006505522.1, XM_006505459.2 XP_006505523.1, XM_006505460.1 |
3D structure databases
SMRi | P30280 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198549, 5 interactors |
ComplexPortali | CPX-2074, Cyclin D2-CDK4 complex |
CORUMi | P30280 |
DIPi | DIP-24177N |
IntActi | P30280, 4 interactors |
STRINGi | 10090.ENSMUSP00000000188 |
PTM databases
iPTMneti | P30280 |
PhosphoSitePlusi | P30280 |
Proteomic databases
EPDi | P30280 |
PaxDbi | P30280 |
PeptideAtlasi | P30280 |
PRIDEi | P30280 |
ProteomicsDBi | 265616 |
Protocols and materials databases
DNASUi | 12444 |
Genome annotation databases
Ensembli | ENSMUST00000000188; ENSMUSP00000000188; ENSMUSG00000000184 |
GeneIDi | 12444 |
KEGGi | mmu:12444 |
UCSCi | uc009dvr.1, mouse |
Organism-specific databases
CTDi | 894 |
MGIi | MGI:88314, Ccnd2 |
VEuPathDBi | HostDB:ENSMUSG00000000184 |
Phylogenomic databases
eggNOGi | KOG0656, Eukaryota |
GeneTreei | ENSGT00940000155180 |
InParanoidi | P30280 |
OMAi | CLEMDTN |
OrthoDBi | 1234739at2759 |
PhylomeDBi | P30280 |
TreeFami | TF101004 |
Enzyme and pathway databases
Reactomei | R-MMU-69231, Cyclin D associated events in G1 R-MMU-8934593, Regulation of RUNX1 Expression and Activity |
Miscellaneous databases
BioGRID-ORCSi | 12444, 2 hits in 63 CRISPR screens |
ChiTaRSi | Ccnd2, mouse |
PROi | PR:P30280 |
RNActi | P30280, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000184, Expressed in rostral migratory stream and 383 other tissues |
ExpressionAtlasi | P30280, baseline and differential |
Genevisiblei | P30280, MM |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR015451, Cyclin_D IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF66, PTHR10177:SF66, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCND2_MOUSE | |
Accessioni | P30280Primary (citable) accession number: P30280 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families