CCND2

Functionⁱ

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G₁/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G₁ phase. Hypophosphorylates RB1 in early G₁ phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).By similarity

GO - Molecular functionⁱ

cyclin-dependent protein serine/threonine kinase regulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8114739

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
mitotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of apoptotic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24130168
positive regulation of cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24130168
positive regulation of cyclin-dependent protein serine/threonine kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8114739
positive regulation of G1/S transition of mitotic cell cycle
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24130168
positive regulation of protein phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 8114739
protein phosphorylation Source: GOC
regulation of cyclin-dependent protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of mitotic nuclear division
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cyclin
Biological process	Cell cycle, Cell division

Enzyme and pathway databases

Reactomeⁱ	R-HSA-69231 Cyclin D associated events in G1 R-HSA-8934593 Regulation of RUNX1 Expression and Activity
SignaLinkⁱ	P30279
SIGNORⁱ	P30279

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: G1/S-specific cyclin-D2
Gene namesⁱ	Name:CCND2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000118971.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1583 CCND2
MIMⁱ	123833 gene
neXtProtⁱ	NX_P30279

Keywords - Cellular componentⁱ

Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA syndrome characterized by megalencephaly, ventriculomegaly that may lead to hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_072370	280	T → A in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777618EnsemblClinVar.	1
Natural variantⁱVAR_072371	280	T → N in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777620EnsemblClinVar.	1
Natural variantⁱVAR_072372	281	P → L in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777622EnsemblClinVar.	1
Natural variantⁱVAR_072373	281	P → R in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777622EnsemblClinVar.	1
Natural variantⁱVAR_072374	284	V → G in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs777786993EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	894
MalaCards human disease database More...MalaCardsⁱ	CCND2
MIMⁱ	615938 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000118971
Orphanetⁱ	83473 Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome
PharmGKBⁱ	PA26150

Chemistry databases

ChEMBLⁱ	CHEMBL3301386

ChEMBLⁱ

CHEMBL3301386

Polymorphism and mutation databases

BioMutaⁱ	CCND2
DMDMⁱ	231741

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080437	1 – 289	G1/S-specific cyclin-D2Add BLAST		289

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	271	PhosphoserineCombined sources		1
Modified residueⁱ	280	PhosphothreonineBy similarity		1

Post-translational modificationⁱ

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P30279
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P30279
PaxDbⁱ	P30279
PeptideAtlas More...PeptideAtlasⁱ	P30279
PRIDEⁱ	P30279
ProteomicsDBⁱ	54647

PTM databases

iPTMnetⁱ	P30279
PhosphoSitePlusⁱ	P30279

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000118971 Expressed in 240 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_CCND2
ExpressionAtlasⁱ	P30279 baseline and differential
Genevisibleⁱ	P30279 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049138 HPA054196

HPAⁱ

HPA049138
HPA054196

Interactionⁱ

Subunit structureⁱ

Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CDK4	P11802	12	EBI-748789,EBI-295644
CDK5	Q00535	13	EBI-748789,EBI-1041567
CDKN1A	P38936	14	EBI-748789,EBI-375077
CDKN1B	P46527	5	EBI-748789,EBI-519280

GO - Molecular functionⁱ

protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8114739

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107334, 91 interactors
ComplexPortalⁱ	CPX-2011 Cyclin D2-CDK4 complex
CORUMⁱ	P30279
Database of interacting proteins More...DIPⁱ	DIP-178N
IntActⁱ	P30279, 8 interactors
Molecular INTeraction database More...MINTⁱ	P30279
STRINGⁱ	9606.ENSP00000261254

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P30279
SMRⁱ	P30279
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	26 – 151	Cyclin N-terminalAdd BLAST		126

Sequence similaritiesⁱ

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0656 Eukaryota ENOG410XRKC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150931
HOGENOMⁱ	HOG000008182
HOVERGENⁱ	HBG050837
InParanoidⁱ	P30279
KEGG Orthology (KO) More...KOⁱ	K10151
OMAⁱ	VVPTKKC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0URX
PhylomeDBⁱ	P30279
TreeFamⁱ	TF101004

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR015451 Cyclin_D IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit PTHR10177:SF66 PTHR10177:SF66, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
PIRSFⁱ	PIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 1 hit SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292 CYCLINS, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P30279-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELLCHEVDP VRRAVRDRNL LRDDRVLQNL LTIEERYLPQ CSYFKCVQKD 
        60         70         80         90        100
IQPYMRRMVA TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAG VPTPKSHLQL 
       110        120        130        140        150
LGAVCMFLAS KLKETSPLTA EKLCIYTDNS IKPQELLEWE LVVLGKLKWN 
       160        170        180        190        200
LAAVTPHDFI EHILRKLPQQ REKLSLIRKH AQTFIALCAT DFKFAMYPPS 
       210        220        230        240        250
MIATGSVGAA ICGLQQDEEV SSLTCDALTE LLAKITNTDV DCLKACQEQI 
       260        270        280 
EAVLLNSLQQ YRQDQRDGSK SEDELDQAST PTDVRDIDL

Length:289

Mass (Da):33,067

Last modified:April 1, 1993 - v1

Checksum:ⁱE4E5FEF476D76D90

GO

Isoform 2 (identifier: P30279-2) [UniParc]FASTA Add to basket

Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
138-209: EWELVVLGKL...SMIATGSVGA → VMTGPFLPSF...YYVPRLRAQH
210-289: Missing.

« Hide

        10         20         30         40         50
MELLCHEVDP VRRAVRDRNL LRDDRVLQNL LTIEERYLPQ CSYFKCVQKD 
        60         70         80         90        100
IQPYMRRMVA TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAG VPTPKSHLQL 
       110        120        130        140        150
LGAVCMFLAS KLKETSPLTA EKLCIYTDNS IKPQELLVMT GPFLPSFLRF 
       160        170        180        190        200
PLSPGQQYAF YHHCQSKFLG SRMTPPIEFT HLWAIAHLIG NHCLFFVCSY 

YVPRLRAQH

Note: Acts as proto-oncogene. Retains ability to bind CDK4, but unable to catalyze efficiently RB phosphorylation and inactivation.1 Publication

Show »

Length:209

Mass (Da):24,461

Checksum:ⁱ35CABC2E9A5BF46E

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0YGD4	H0YGD4_HUMAN		G1/S-specific cyclin-D2 G1/S-specific cyclin-D2	CCND2	170	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	166 – 167	KL → NV in AAA51928 (PubMed:1386335).Curated		2
Sequence conflictⁱ	224	T → H in AAA51928 (PubMed:1386335).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018820	268	G → R1 PublicationCorresponds to variant dbSNP:rs3217921Ensembl.	1
Natural variantⁱVAR_072370	280	T → A in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777618EnsemblClinVar.	1
Natural variantⁱVAR_072371	280	T → N in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777620EnsemblClinVar.	1
Natural variantⁱVAR_072372	281	P → L in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777622EnsemblClinVar.	1
Natural variantⁱVAR_072373	281	P → R in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777622EnsemblClinVar.	1
Natural variantⁱVAR_072374	284	V → G in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs777786993EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_057295	138 – 209	EWELV…GSVGA → VMTGPFLPSFLRFPLSPGQQ YAFYHHCQSKFLGSRMTPPI EFTHLWAIAHLIGNHCLFFV CSYYVPRLRAQH in isoform 2. 1 PublicationAdd BLAST		72
Alternative sequenceⁱVSP_057296	210 – 289	Missing in isoform 2. 1 PublicationAdd BLAST		80

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M90813 mRNA Translation: AAA51926.1 X68452 mRNA Translation: CAA48493.1 D13639 mRNA Translation: BAA02802.1 BT019847 mRNA Translation: AAV38650.1 AF518005 Genomic DNA Translation: AAM54041.1 AK291146 mRNA Translation: BAF83835.1 AC006122 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88851.1 BC010958 mRNA Translation: AAH10958.1 BC089384 mRNA Translation: AAH89384.1 M88083 , M88080, M88081, M88082 Genomic DNA Translation: AAA51928.1 AI146555 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8524.1 [P30279-1]
PIRⁱ	A42822
NCBI Reference Sequences More...RefSeqⁱ	NP_001750.1, NM_001759.3 [P30279-1]
UniGeneⁱ	Hs.376071

Genome annotation databases

Ensemblⁱ	ENST00000261254; ENSP00000261254; ENSG00000118971 [P30279-1]
GeneIDⁱ	894
KEGGⁱ	hsa:894
UCSC genome browser More...UCSCⁱ	uc001qmo.4 human [P30279-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P30279	CCND2 isoform 1		PANTR		289	UniRef100_P30279
Uncharacterized protein		PANPA		289
Cyclin D2		GORGO		289

Protein	Similar proteins		Species	Score	Length	Source
P30279	G1/S-specific cyclin-D2		BOVIN		289	UniRef90_P30279
G1/S-specific cyclin-D2		MOUSE		289
G1/S-specific cyclin-D2		PIG		288
G1/S-specific cyclin-D2		RAT		288
CCND2 isoform 1		PANTR		289
+99

Protein	Similar proteins		Species	Score	Length	Source
P30279	G1/S-specific cyclin-D2		MOUSE		289	UniRef50_P30279
G1/S-specific cyclin-D2		BOVIN		289
G1/S-specific cyclin-D2		PIG		288
G1/S-specific cyclin-D2		RAT		288
CCND2 isoform 1		PANTR		289
+171
P30279-2	CCND2 (Fragment)		blackstripe livebearer		211	UniRef50_P30279-2
Uncharacterized protein		ONCMY		208
G1/S-specific cyclin-D1		wild yak		257
G1/S-specific cyclin-D1		FUNHE		214
UPI0003C164FF		PANHO		228
+2

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M90813 mRNA Translation: AAA51926.1 X68452 mRNA Translation: CAA48493.1 D13639 mRNA Translation: BAA02802.1 BT019847 mRNA Translation: AAV38650.1 AF518005 Genomic DNA Translation: AAM54041.1 AK291146 mRNA Translation: BAF83835.1 AC006122 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88851.1 BC010958 mRNA Translation: AAH10958.1 BC089384 mRNA Translation: AAH89384.1 M88083 , M88080, M88081, M88082 Genomic DNA Translation: AAA51928.1 AI146555 mRNA No translation available.
CCDSⁱ	CCDS8524.1 [P30279-1]
PIRⁱ	A42822
RefSeqⁱ	NP_001750.1, NM_001759.3 [P30279-1]
UniGeneⁱ	Hs.376071

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6EI2	X-ray	1.61	C	114-123	[»]
ProteinModelPortalⁱ	P30279
SMRⁱ	P30279
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107334, 91 interactors
ComplexPortalⁱ	CPX-2011 Cyclin D2-CDK4 complex
CORUMⁱ	P30279
DIPⁱ	DIP-178N
IntActⁱ	P30279, 8 interactors
MINTⁱ	P30279
STRINGⁱ	9606.ENSP00000261254

Chemistry databases

ChEMBLⁱ	CHEMBL3301386

ChEMBLⁱ

CHEMBL3301386

PTM databases

iPTMnetⁱ	P30279
PhosphoSitePlusⁱ	P30279

Polymorphism and mutation databases

BioMutaⁱ	CCND2
DMDMⁱ	231741

Proteomic databases

EPDⁱ	P30279
MaxQBⁱ	P30279
PaxDbⁱ	P30279
PeptideAtlasⁱ	P30279
PRIDEⁱ	P30279
ProteomicsDBⁱ	54647

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	894
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000261254; ENSP00000261254; ENSG00000118971 [P30279-1]
GeneIDⁱ	894
KEGGⁱ	hsa:894
UCSCⁱ	uc001qmo.4 human [P30279-1]

Organism-specific databases

CTDⁱ	894
DisGeNETⁱ	894
EuPathDBⁱ	HostDB:ENSG00000118971.7
GeneCardsⁱ	CCND2
HGNCⁱ	HGNC:1583 CCND2
HPAⁱ	HPA049138 HPA054196
MalaCardsⁱ	CCND2
MIMⁱ	123833 gene 615938 phenotype
neXtProtⁱ	NX_P30279
OpenTargetsⁱ	ENSG00000118971
Orphanetⁱ	83473 Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome
PharmGKBⁱ	PA26150
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0656 Eukaryota ENOG410XRKC LUCA
GeneTreeⁱ	ENSGT00930000150931
HOGENOMⁱ	HOG000008182
HOVERGENⁱ	HBG050837
InParanoidⁱ	P30279
KOⁱ	K10151
OMAⁱ	VVPTKKC
OrthoDBⁱ	EOG091G0URX
PhylomeDBⁱ	P30279
TreeFamⁱ	TF101004

Enzyme and pathway databases

Reactomeⁱ	R-HSA-69231 Cyclin D associated events in G1 R-HSA-8934593 Regulation of RUNX1 Expression and Activity
SignaLinkⁱ	P30279
SIGNORⁱ	P30279

Miscellaneous databases

ChiTaRSⁱ	CCND2 human
GeneWikiⁱ	Cyclin_D2
GenomeRNAiⁱ	894
Protein Ontology More...PROⁱ	PR:P30279
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000118971 Expressed in 240 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_CCND2
ExpressionAtlasⁱ	P30279 baseline and differential
Genevisibleⁱ	P30279 HS

Family and domain databases

CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR015451 Cyclin_D IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit PTHR10177:SF66 PTHR10177:SF66, 1 hit
Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
PIRSFⁱ	PIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 1 hit SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292 CYCLINS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCND2_HUMAN
Accessionⁱ	P30279Primary (citable) accession number: P30279 Secondary accession number(s): A8K531, Q13955, Q5U035
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	April 1, 1993
	Last modified:	November 7, 2018
	This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - P30279 (CCND2_HUMAN)

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G1/S-specific cyclin-D2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ