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UniProtKB - P30279 (CCND2_HUMAN)

Entry version 206 (23 Feb 2022)
Sequence version 1 (01 Apr 1993)
Previous versions | rss
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Protein

G1/S-specific cyclin-D2

Gene

CCND2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition (PubMed:8114739, PubMed:18827403).

Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase (PubMed:8114739, PubMed:18827403).

Hypophosphorylates RB1 in early G1 phase (PubMed:8114739, PubMed:18827403).

Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739, PubMed:18827403).

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P30279

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-69231, Cyclin D associated events in G1
R-HSA-8934593, Regulation of RUNX1 Expression and Activity
R-HSA-9661069, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P30279

SIGNOR Signaling Network Open Resource

More...SIGNORi		P30279

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G1/S-specific cyclin-D21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCND21 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1583, CCND2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		123833, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P30279

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000118971

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by megalencephaly, ventriculomegaly that may lead to hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072370280T → A in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777618EnsemblClinVar.1
Natural variantiVAR_072371280T → N in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777620EnsemblClinVar.1
Natural variantiVAR_072372281P → L in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777622EnsemblClinVar.1
Natural variantiVAR_072373281P → R in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777622EnsemblClinVar.1
Natural variantiVAR_072374284V → G in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs777786993EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		894

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		CCND2

MalaCards human disease database

More...MalaCardsi		CCND2
MIMi615938, phenotype

Open Targets

More...OpenTargetsi		ENSG00000118971

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		83473, Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26150

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P30279, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2095942
CHEMBL3301385
CHEMBL3301386

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCND2

Domain mapping of disease mutations (DMDM)

More...DMDMi		231741

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000804371 – 289G1/S-specific cyclin-D2Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei271PhosphoserineCombined sources1
Modified residuei280PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Thr-280 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex.By similarity
Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-280 phosphorylation (PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex represents the major regulator of CCND2 stability during the G1/S transition (PubMed:33854235, PubMed:33854239). Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation (PubMed:22323446).3 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P30279

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P30279

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P30279

MaxQB - The MaxQuant DataBase

More...MaxQBi		P30279

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P30279

PeptideAtlas

More...PeptideAtlasi		P30279

PRoteomics IDEntifications database

More...PRIDEi		P30279

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54647 [P30279-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P30279

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P30279

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000118971, Expressed in amniotic fluid and 254 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P30279, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P30279, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000118971, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex (PubMed:8114739, PubMed:18827403). The cyclin subunit imparts substrate specificity to the complex (PubMed:8114739, PubMed:18827403).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107334, 144 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2011, Cyclin D2-CDK4 complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P30279

Database of interacting proteins

More...DIPi		DIP-178N

Protein interaction database and analysis system

More...IntActi		P30279, 11 interactors

Molecular INTeraction database

More...MINTi		P30279

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000261254

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P30279

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P30279, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P30279

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 151Cyclin N-terminalAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni264 – 289DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi265 – 289Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155180

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_052190_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P30279

Identification of Orthologs from Complete Genome Data

More...OMAi		CLEMDTN

Database of Orthologous Groups

More...OrthoDBi		1234739at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P30279

TreeFam database of animal gene trees

More...TreeFami		TF101004

Family and domain databases

Conserved Domains Database

More...CDDi		cd00043, CYCLIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR015451, Cyclin_D
IPR006671, Cyclin_N

The PANTHER Classification System

More...PANTHERi		PTHR10177, PTHR10177, 1 hit
PTHR10177:SF66, PTHR10177:SF66, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00385, CYCLIN, 1 hit
SM01332, Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47954, SSF47954, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00292, CYCLINS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P30279-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELLCHEVDP VRRAVRDRNL LRDDRVLQNL LTIEERYLPQ CSYFKCVQKD 
        60         70         80         90        100
IQPYMRRMVA TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAG VPTPKSHLQL 
       110        120        130        140        150
LGAVCMFLAS KLKETSPLTA EKLCIYTDNS IKPQELLEWE LVVLGKLKWN 
       160        170        180        190        200
LAAVTPHDFI EHILRKLPQQ REKLSLIRKH AQTFIALCAT DFKFAMYPPS 
       210        220        230        240        250
MIATGSVGAA ICGLQQDEEV SSLTCDALTE LLAKITNTDV DCLKACQEQI 
       260        270        280 
EAVLLNSLQQ YRQDQRDGSK SEDELDQAST PTDVRDIDL
Length:289
Mass (Da):33,067
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4E5FEF476D76D90
GO
Isoform 2 (identifier: P30279-2) [UniParc]FASTAAdd to basket
Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     138-209: EWELVVLGKL...SMIATGSVGA → VMTGPFLPSF...YYVPRLRAQH
     210-289: Missing.

Note: Acts as proto-oncogene. Retains ability to bind CDK4, but unable to catalyze efficiently RB phosphorylation and inactivation.1 Publication
Show »
Length:209
Mass (Da):24,461
Checksum:i35CABC2E9A5BF46E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6Q8PGZ3A0A6Q8PGZ3_HUMAN
G1/S-specific cyclin-D2
CCND2
303Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti166 – 167KL → NV in AAA51928 (PubMed:1386335).Curated2
Sequence conflicti224T → H in AAA51928 (PubMed:1386335).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018820268G → R1 PublicationCorresponds to variant dbSNP:rs3217921Ensembl.1
Natural variantiVAR_072370280T → A in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777618EnsemblClinVar.1
Natural variantiVAR_072371280T → N in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777620EnsemblClinVar.1
Natural variantiVAR_072372281P → L in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777622EnsemblClinVar.1
Natural variantiVAR_072373281P → R in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs587777622EnsemblClinVar.1
Natural variantiVAR_072374284V → G in MPPH3. 1 PublicationCorresponds to variant dbSNP:rs777786993EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_057295138 – 209EWELV…GSVGA → VMTGPFLPSFLRFPLSPGQQ YAFYHHCQSKFLGSRMTPPI EFTHLWAIAHLIGNHCLFFV CSYYVPRLRAQH in isoform 2. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_057296210 – 289Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M90813 mRNA Translation: AAA51926.1
X68452 mRNA Translation: CAA48493.1
D13639 mRNA Translation: BAA02802.1
BT019847 mRNA Translation: AAV38650.1
AF518005 Genomic DNA Translation: AAM54041.1
AK291146 mRNA Translation: BAF83835.1
AC006122 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88851.1
BC010958 mRNA Translation: AAH10958.1
BC089384 mRNA Translation: AAH89384.1
M88083 M88082 Genomic DNA Translation: AAA51928.1
AI146555 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8524.1 [P30279-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A42822

NCBI Reference Sequences

More...RefSeqi		NP_001750.1, NM_001759.3 [P30279-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261254; ENSP00000261254; ENSG00000118971
ENST00000676279; ENSP00000502597; ENSG00000118971
ENST00000676411; ENSP00000502654; ENSG00000118971

Database of genes from NCBI RefSeq genomes

More...GeneIDi		894

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:894

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000261254.8; ENSP00000261254.3; NM_001759.4; NP_001750.1

UCSC genome browser

More...UCSCi		uc001qmo.4, human [P30279-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90813 mRNA Translation: AAA51926.1
X68452 mRNA Translation: CAA48493.1
D13639 mRNA Translation: BAA02802.1
BT019847 mRNA Translation: AAV38650.1
AF518005 Genomic DNA Translation: AAM54041.1
AK291146 mRNA Translation: BAF83835.1
AC006122 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88851.1
BC010958 mRNA Translation: AAH10958.1
BC089384 mRNA Translation: AAH89384.1
M88083 M88082 Genomic DNA Translation: AAA51928.1
AI146555 mRNA No translation available.
CCDSiCCDS8524.1 [P30279-1]
PIRiA42822
RefSeqiNP_001750.1, NM_001759.3 [P30279-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EI2X-ray1.61C114-123[»]
SMRiP30279
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107334, 144 interactors
ComplexPortaliCPX-2011, Cyclin D2-CDK4 complex
CORUMiP30279
DIPiDIP-178N
IntActiP30279, 11 interactors
MINTiP30279
STRINGi9606.ENSP00000261254

Chemistry databases

BindingDBiP30279
ChEMBLiCHEMBL2095942
CHEMBL3301385
CHEMBL3301386

PTM databases

iPTMnetiP30279
PhosphoSitePlusiP30279

Genetic variation databases

BioMutaiCCND2
DMDMi231741

Proteomic databases

EPDiP30279
jPOSTiP30279
MassIVEiP30279
MaxQBiP30279
PaxDbiP30279
PeptideAtlasiP30279
PRIDEiP30279
ProteomicsDBi54647 [P30279-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10540, 820 antibodies from 38 providers

The DNASU plasmid repository

More...DNASUi		894

Genome annotation databases

EnsembliENST00000261254; ENSP00000261254; ENSG00000118971
ENST00000676279; ENSP00000502597; ENSG00000118971
ENST00000676411; ENSP00000502654; ENSG00000118971
GeneIDi894
KEGGihsa:894
MANE-SelectiENST00000261254.8; ENSP00000261254.3; NM_001759.4; NP_001750.1
UCSCiuc001qmo.4, human [P30279-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		894
DisGeNETi894

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCND2
GeneReviewsiCCND2
HGNCiHGNC:1583, CCND2
HPAiENSG00000118971, Low tissue specificity
MalaCardsiCCND2
MIMi123833, gene
615938, phenotype
neXtProtiNX_P30279
OpenTargetsiENSG00000118971
Orphaneti83473, Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome
PharmGKBiPA26150
VEuPathDBiHostDB:ENSG00000118971

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0656, Eukaryota
GeneTreeiENSGT00940000155180
HOGENOMiCLU_052190_0_0_1
InParanoidiP30279
OMAiCLEMDTN
OrthoDBi1234739at2759
PhylomeDBiP30279
TreeFamiTF101004

Enzyme and pathway databases

PathwayCommonsiP30279
ReactomeiR-HSA-69231, Cyclin D associated events in G1
R-HSA-8934593, Regulation of RUNX1 Expression and Activity
R-HSA-9661069, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
SignaLinkiP30279
SIGNORiP30279

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		894, 46 hits in 1064 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCND2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Cyclin_D2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		894
PharosiP30279, Tbio

Protein Ontology

More...PROi		PR:P30279
RNActiP30279, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000118971, Expressed in amniotic fluid and 254 other tissues
ExpressionAtlasiP30279, baseline and differential
GenevisibleiP30279, HS

Family and domain databases

CDDicd00043, CYCLIN, 1 hit
InterProiView protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR015451, Cyclin_D
IPR006671, Cyclin_N
PANTHERiPTHR10177, PTHR10177, 1 hit
PTHR10177:SF66, PTHR10177:SF66, 1 hit
PfamiView protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 1 hit
SM01332, Cyclin_C, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292, CYCLINS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCND2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30279
Secondary accession number(s): A8K531, Q13955, Q5U035
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 23, 2022
This is version 206 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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