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Entry version 167 (17 Jun 2020)
Sequence version 1 (01 Apr 1993)
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Protein

G2/mitotic-specific cyclin-B1

Gene

Ccnb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-RNO-176408 Regulation of APC/C activators between G1/S and early anaphase
R-RNO-176412 Phosphorylation of the APC/C
R-RNO-176417 Phosphorylation of Emi1
R-RNO-2299718 Condensation of Prophase Chromosomes
R-RNO-2500257 Resolution of Sister Chromatid Cohesion
R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
R-RNO-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-RNO-3301854 Nuclear Pore Complex (NPC) Disassembly
R-RNO-4419969 Depolymerisation of the Nuclear Lamina
R-RNO-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-RNO-68875 Mitotic Prophase
R-RNO-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-RNO-69478 G2/M DNA replication checkpoint
R-RNO-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-RNO-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-RNO-8878166 Transcriptional regulation by RUNX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccnb1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Rat genome database

More...
RGDi
2291 Ccnb1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2093

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000803531 – 423G2/mitotic-specific cyclin-B1Add BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei116Phosphoserine; by CDK1By similarity1
Modified residuei118PhosphoserineBy similarity1
Modified residuei123Phosphoserine; by PLK1By similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei311PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases (By similarity).By similarity
Phosphorylated by PLK1 at Ser-123 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-137 was also reported to be mediated by PLK1 but Ser-123 seems to be the primary phosphorylation site (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30277

PRoteomics IDEntifications database

More...
PRIDEi
P30277

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30277

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P30277

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000058539 Expressed in testis and 8 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P30277 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10.

Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase.

Interacts with CCNF; interaction is required for nuclear localization.

Interacts with CDK5RAP3.

Interacts with RFPL4A and UBE2A.

Interacts with INCA1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2072 Cyclin B1-CDK1 complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P30277

Protein interaction database and analysis system

More...
IntActi
P30277, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000025297

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P30277

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P30277

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni159 – 167Interaction with CDK2By similarity9
Regioni248 – 251Interaction with CDK2By similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi50 – 82Lys-richAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0653 Eukaryota
COG5024 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154586

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020695_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P30277

KEGG Orthology (KO)

More...
KOi
K05868

Identification of Orthologs from Complete Genome Data

More...
OMAi
YLVGQEV

Database of Orthologous Groups

More...
OrthoDBi
993640at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P30277

TreeFam database of animal gene trees

More...
TreeFami
TF101001

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00043 CYCLIN, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N

The PANTHER Classification System

More...
PANTHERi
PTHR10177 PTHR10177, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001771 Cyclin_A_B_D_E, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954 SSF47954, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00292 CYCLINS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P30277-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRVTRNTK INTENKAKVS MAGAKRVPVA VAASKPLLRS RTALGDIGNK
60 70 80 90 100
VSEQSRIPLK KETKKLGSGT VTVKALPKPV DKVPVCEPEV ELDEPEPEPV
110 120 130 140 150
MEVKHSPEPI LVDTPSPSPM ETSGCAPAEE YLCQAFSDVI LAVSDVDADD
160 170 180 190 200
GGDPNLCSEY VKDIYAYLRQ LEEEQSVRPK YLLGREVTGN MRAILIDWLI
210 220 230 240 250
QVQMKFRLLQ ETMYMTVSII DRFMQDSCVP KKMLQLVGVT AMFIASKYEE
260 270 280 290 300
MYPPEIGDFA FVTNNTYTKH QIRQMEMKIL RVLNFSLGRP LPLHFLRRAS
310 320 330 340 350
KIGEVDVEQH TLAKYLMELS MLDYDMVHFA PSQIAAGAFC LALKILDNGE
360 370 380 390 400
WTPTLQHYLS HTEESLLPVM QHLAKNIVMV NRGLTKHMTI KNKYATSKHA
410 420
KISTLAQLNC TLVQNLSKAV TKA
Length:423
Mass (Da):47,391
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4223CF71F144B279
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X60768 mRNA Translation: CAA43178.1
X64589 mRNA Translation: CAA45877.1
L11995 mRNA Translation: AAC00032.1
BC059113 mRNA Translation: AAH59113.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S34226

NCBI Reference Sequences

More...
RefSeqi
NP_741988.1, NM_171991.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000082846; ENSRNOP00000075114; ENSRNOG00000058539

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25203

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:25203

UCSC genome browser

More...
UCSCi
RGD:2291 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60768 mRNA Translation: CAA43178.1
X64589 mRNA Translation: CAA45877.1
L11995 mRNA Translation: AAC00032.1
BC059113 mRNA Translation: AAH59113.1
PIRiS34226
RefSeqiNP_741988.1, NM_171991.3

3D structure databases

SMRiP30277
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2072 Cyclin B1-CDK1 complex
CORUMiP30277
IntActiP30277, 1 interactor
STRINGi10116.ENSRNOP00000025297

Chemistry databases

BindingDBiP30277
ChEMBLiCHEMBL2093

PTM databases

iPTMnetiP30277
PhosphoSitePlusiP30277

Proteomic databases

PaxDbiP30277
PRIDEiP30277

Genome annotation databases

EnsembliENSRNOT00000082846; ENSRNOP00000075114; ENSRNOG00000058539
GeneIDi25203
KEGGirno:25203
UCSCiRGD:2291 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
891
RGDi2291 Ccnb1

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00940000154586
HOGENOMiCLU_020695_2_1_1
InParanoidiP30277
KOiK05868
OMAiYLVGQEV
OrthoDBi993640at2759
PhylomeDBiP30277
TreeFamiTF101001

Enzyme and pathway databases

ReactomeiR-RNO-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-RNO-176408 Regulation of APC/C activators between G1/S and early anaphase
R-RNO-176412 Phosphorylation of the APC/C
R-RNO-176417 Phosphorylation of Emi1
R-RNO-2299718 Condensation of Prophase Chromosomes
R-RNO-2500257 Resolution of Sister Chromatid Cohesion
R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
R-RNO-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-RNO-3301854 Nuclear Pore Complex (NPC) Disassembly
R-RNO-4419969 Depolymerisation of the Nuclear Lamina
R-RNO-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-RNO-68875 Mitotic Prophase
R-RNO-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-RNO-69478 G2/M DNA replication checkpoint
R-RNO-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-RNO-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-RNO-8878166 Transcriptional regulation by RUNX2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P30277

Gene expression databases

BgeeiENSRNOG00000058539 Expressed in testis and 8 other tissues
GenevisibleiP30277 RN

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNB1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30277
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 17, 2020
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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