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Protein

High affinity immunoglobulin epsilon receptor subunit gamma

Gene

FCER1G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation.By similarity

GO - Molecular functioni

  • IgE binding Source: GO_Central
  • IgE receptor activity Source: GO_Central
  • IgG binding Source: GO_Central
  • protein homodimerization activity Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionIgE-binding protein, Receptor
Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-114604 GPVI-mediated activation cascade
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5621480 Dectin-2 family
R-HSA-6798695 Neutrophil degranulation
R-HSA-75892 Platelet Adhesion to exposed collagen
SIGNORiP30273

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit gamma
Alternative name(s):
Fc receptor gamma-chain
Short name:
FcRgamma
Fc-epsilon RI-gamma
IgE Fc receptor subunit gamma
Short name:
FceRI gamma
Gene namesi
Name:FCER1G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158869.10
HGNCiHGNC:3611 FCER1G
MIMi147139 gene
neXtProtiNX_P30273

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 23ExtracellularSequence analysis5
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 86CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2207
OpenTargetsiENSG00000158869
PharmGKBiPA28057

Chemistry databases

DrugBankiDB00895 Benzylpenicilloyl Polylysine

Polymorphism and mutation databases

BioMutaiFCER1G
DMDMi232085

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001650119 – 86High affinity immunoglobulin epsilon receptor subunit gammaAdd BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25InterchainBy similarity
Modified residuei65PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei69PhosphoserineCombined sources1
Modified residuei76PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei78PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiP30273
PaxDbiP30273
PeptideAtlasiP30273
PRIDEiP30273
ProteomicsDBi54646
TopDownProteomicsiP30273

PTM databases

iPTMnetiP30273
PhosphoSitePlusiP30273

Expressioni

Gene expression databases

BgeeiENSG00000158869 Expressed in 197 organ(s), highest expression level in blood
CleanExiHS_FCER1G
ExpressionAtlasiP30273 baseline and differential
GenevisibleiP30273 HS

Organism-specific databases

HPAiCAB022108
HPA026872

Interactioni

Subunit structurei

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide-linked gamma chains. Associates with FCGR1A; forms a functional signaling complex (PubMed:8611682). Associated with CLEC6A (By similarity). Interacts with CLEC4E (PubMed:18776906). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CSF2RB and recruits SYK in response to IL3 stimulation; this interaction is direct (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with TARM1 (PubMed:26311901).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SYKP434052EBI-515289,EBI-78302

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108501, 4 interactors
DIPiDIP-29514N
ELMiP30273
IntActiP30273, 7 interactors
MINTiP30273
STRINGi9606.ENSP00000289902

Structurei

3D structure databases

DisProtiDP00509
ProteinModelPortaliP30273
SMRiP30273
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 82ITAMPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the CD3Z/FCER1G family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J5TQ Eukaryota
ENOG410Z3W0 LUCA
GeneTreeiENSGT00390000003894
HOGENOMiHOG000293158
HOVERGENiHBG051601
InParanoidiP30273
KOiK07983
OMAiYCRLKLQ
PhylomeDBiP30273
TreeFamiTF330937

Family and domain databases

InterProiView protein in InterPro
IPR021663 CD3_zeta/IgE_Fc_rcpt_gamma
IPR003110 Phos_immunorcpt_sig_ITAM
PfamiView protein in Pfam
PF02189 ITAM, 1 hit
PF11628 TCR_zetazeta, 1 hit
SMARTiView protein in SMART
SM00077 ITAM, 1 hit
PROSITEiView protein in PROSITE
PS51055 ITAM_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P30273-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV
60 70 80
RKAAITSYEK SDGVYTGLST RNQETYETLK HEKPPQ
Length:86
Mass (Da):9,667
Last modified:April 1, 1993 - v1
Checksum:i2F2C7536513D6165
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NCQ8A6NCQ8_HUMAN
High affinity immunoglobulin epsilo...
FCER1G
112Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33195 mRNA Translation: AAA35828.1
M33196 Genomic DNA No translation available.
AL590714 Genomic DNA No translation available.
CCDSiCCDS1225.1
PIRiA35241
RefSeqiNP_004097.1, NM_004106.1
UniGeneiHs.433300

Genome annotation databases

EnsembliENST00000289902; ENSP00000289902; ENSG00000158869
GeneIDi2207
KEGGihsa:2207
UCSCiuc001fyz.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33195 mRNA Translation: AAA35828.1
M33196 Genomic DNA No translation available.
AL590714 Genomic DNA No translation available.
CCDSiCCDS1225.1
PIRiA35241
RefSeqiNP_004097.1, NM_004106.1
UniGeneiHs.433300

3D structure databases

DisProtiDP00509
ProteinModelPortaliP30273
SMRiP30273
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108501, 4 interactors
DIPiDIP-29514N
ELMiP30273
IntActiP30273, 7 interactors
MINTiP30273
STRINGi9606.ENSP00000289902

Chemistry databases

DrugBankiDB00895 Benzylpenicilloyl Polylysine

PTM databases

iPTMnetiP30273
PhosphoSitePlusiP30273

Polymorphism and mutation databases

BioMutaiFCER1G
DMDMi232085

Proteomic databases

EPDiP30273
PaxDbiP30273
PeptideAtlasiP30273
PRIDEiP30273
ProteomicsDBi54646
TopDownProteomicsiP30273

Protocols and materials databases

DNASUi2207
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289902; ENSP00000289902; ENSG00000158869
GeneIDi2207
KEGGihsa:2207
UCSCiuc001fyz.1 human

Organism-specific databases

CTDi2207
DisGeNETi2207
EuPathDBiHostDB:ENSG00000158869.10
GeneCardsiFCER1G
HGNCiHGNC:3611 FCER1G
HPAiCAB022108
HPA026872
MIMi147139 gene
neXtProtiNX_P30273
OpenTargetsiENSG00000158869
PharmGKBiPA28057
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J5TQ Eukaryota
ENOG410Z3W0 LUCA
GeneTreeiENSGT00390000003894
HOGENOMiHOG000293158
HOVERGENiHBG051601
InParanoidiP30273
KOiK07983
OMAiYCRLKLQ
PhylomeDBiP30273
TreeFamiTF330937

Enzyme and pathway databases

ReactomeiR-HSA-114604 GPVI-mediated activation cascade
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5621480 Dectin-2 family
R-HSA-6798695 Neutrophil degranulation
R-HSA-75892 Platelet Adhesion to exposed collagen
SIGNORiP30273

Miscellaneous databases

ChiTaRSiFCER1G human
GenomeRNAii2207
PROiPR:P30273
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158869 Expressed in 197 organ(s), highest expression level in blood
CleanExiHS_FCER1G
ExpressionAtlasiP30273 baseline and differential
GenevisibleiP30273 HS

Family and domain databases

InterProiView protein in InterPro
IPR021663 CD3_zeta/IgE_Fc_rcpt_gamma
IPR003110 Phos_immunorcpt_sig_ITAM
PfamiView protein in Pfam
PF02189 ITAM, 1 hit
PF11628 TCR_zetazeta, 1 hit
SMARTiView protein in SMART
SM00077 ITAM, 1 hit
PROSITEiView protein in PROSITE
PS51055 ITAM_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCERG_HUMAN
AccessioniPrimary (citable) accession number: P30273
Secondary accession number(s): Q5VTW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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