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Entry version 128 (11 Dec 2019)
Sequence version 1 (01 Apr 1993)
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Protein

DNA polymerase delta subunit 3

Gene

cdc27

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processCell cycle, Cell division, DNA replication, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-110314 Recognition of DNA damage by PCNA-containing replication complex
R-SPO-174411 Polymerase switching on the C-strand of the telomere
R-SPO-174414 Processive synthesis on the C-strand of the telomere
R-SPO-174417 Telomere C-strand (Lagging Strand) Synthesis
R-SPO-174437 Removal of the Flap Intermediate from the C-strand
R-SPO-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-SPO-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-SPO-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-SPO-5656169 Termination of translesion DNA synthesis
R-SPO-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-SPO-5696400 Dual Incision in GG-NER
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SPO-69091 Polymerase switching
R-SPO-69166 Removal of the Flap Intermediate
R-SPO-69183 Processive synthesis on the lagging strand

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase delta subunit 3
Alternative name(s):
Cell division control protein 27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cdc27
ORF Names:SPBC1734.02c, SPBC337.18c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPBC1734.02c

Schizosaccharomyces pombe database

More...
PomBasei
SPBC1734.02c cdc27

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi57G → E: Cell cycle arrest at 35 degrees Celsius. 1
Mutagenesisi57G → R: Cell cycle arrest at 35 degrees Celsius. 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001860491 – 372DNA polymerase delta subunit 3Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei163Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P30261

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30261

PRoteomics IDEntifications database

More...
PRIDEi
P30261

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30261

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer that consist of the pol3, cdc1, cdc27 and cdm1 subunits. Cdc27 interacts with cdc1 and is required for dimerization of the tetramer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
276184, 20 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2100 DNA polymerase delta heterotetramer

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P30261

Protein interaction database and analysis system

More...
IntActi
P30261, 2 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC1734.02c.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P30261

KEGG Orthology (KO)

More...
KOi
K03504

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFIHNEN

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1300, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019038 POLD3
IPR041913 POLD3_sf

The PANTHER Classification System

More...
PANTHERi
PTHR17598 PTHR17598, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09507 CDC27, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P30261-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEWRNFLDI KVINESSLVT VDNLSLQLDI SSEKAQEYLN MFYQGNDFLY
60 70 80 90 100
PIYLIHGQPI DDEINLEIDE ESQPISNFPV LQYILCDKSS LQEKQSRLKS
110 120 130 140 150
GYKTVIFALS SAPLSDFDEL LPAVYEIREK DVLYKKEDAD KYGFIFNENS
160 170 180 190 200
VPRVLKKAPS THSPQLSVPS KTSTIDKTDT RSTEKTKGKD IFSNARNQKG
210 220 230 240 250
NSSRKNKKAP LENHKEKEPL LPKEEKLSEQ AKRERDDLKN IMQLEDESVS
260 270 280 290 300
TTSVHDSEDD NLDSNNFQLE IGTEAKSAAP DEPQEIIKSV SGGKRRGKRK
310 320 330 340 350
VKKYATTKDE EGFLVTKEEE VWESFSEDEN ISTGTSNVVR NKPTTVNIAT
360 370
KKKNTAQSKP QQKSIMSFFG KK
Length:372
Mass (Da):42,350
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E6F9AD407B17673
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M74062 Genomic DNA Translation: AAA35295.1
M83307 mRNA Translation: AAA35296.1
CU329671 Genomic DNA Translation: CAA21288.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T39649

NCBI Reference Sequences

More...
RefSeqi
NP_595419.1, NM_001021326.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC1734.02c.1; SPBC1734.02c.1:pep; SPBC1734.02c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539627

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC1734.02c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74062 Genomic DNA Translation: AAA35295.1
M83307 mRNA Translation: AAA35296.1
CU329671 Genomic DNA Translation: CAA21288.1
PIRiT39649
RefSeqiNP_595419.1, NM_001021326.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi276184, 20 interactors
ComplexPortaliCPX-2100 DNA polymerase delta heterotetramer
ELMiP30261
IntActiP30261, 2 interactors
STRINGi4896.SPBC1734.02c.1

PTM databases

iPTMnetiP30261

Proteomic databases

MaxQBiP30261
PaxDbiP30261
PRIDEiP30261

Genome annotation databases

EnsemblFungiiSPBC1734.02c.1; SPBC1734.02c.1:pep; SPBC1734.02c
GeneIDi2539627
KEGGispo:SPBC1734.02c

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.02c
PomBaseiSPBC1734.02c cdc27

Phylogenomic databases

InParanoidiP30261
KOiK03504
OMAiGFIHNEN

Enzyme and pathway databases

ReactomeiR-SPO-110314 Recognition of DNA damage by PCNA-containing replication complex
R-SPO-174411 Polymerase switching on the C-strand of the telomere
R-SPO-174414 Processive synthesis on the C-strand of the telomere
R-SPO-174417 Telomere C-strand (Lagging Strand) Synthesis
R-SPO-174437 Removal of the Flap Intermediate from the C-strand
R-SPO-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-SPO-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-SPO-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-SPO-5656169 Termination of translesion DNA synthesis
R-SPO-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-SPO-5696400 Dual Incision in GG-NER
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SPO-69091 Polymerase switching
R-SPO-69166 Removal of the Flap Intermediate
R-SPO-69183 Processive synthesis on the lagging strand

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P30261

Family and domain databases

Gene3Di1.10.10.1300, 1 hit
InterProiView protein in InterPro
IPR019038 POLD3
IPR041913 POLD3_sf
PANTHERiPTHR17598 PTHR17598, 2 hits
PfamiView protein in Pfam
PF09507 CDC27, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOD3_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30261
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: December 11, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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