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Protein

Macrophage scavenger receptor types I and II

Gene

Msr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).By similarity

GO - Molecular functioni

  • amyloid-beta binding Source: ARUK-UCL
  • low-density lipoprotein particle binding Source: BHF-UCL
  • scavenger receptor activity Source: InterPro

GO - Biological processi

  • amyloid-beta clearance Source: ARUK-UCL
  • cholesterol transport Source: BHF-UCL
  • lipoprotein transport Source: MGI
  • negative regulation of gene expression Source: ARUK-UCL
  • phagocytosis, engulfment Source: ARUK-UCL
  • plasma lipoprotein particle clearance Source: BHF-UCL
  • positive regulation of cholesterol storage Source: BHF-UCL
  • positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL

Keywordsi

Molecular functionReceptor
Biological processEndocytosis

Enzyme and pathway databases

ReactomeiR-MMU-3000480 Scavenging by Class A Receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage scavenger receptor types I and II
Alternative name(s):
Macrophage acetylated LDL receptor I and II
Scavenger receptor type A
Short name:
SR-A
CD_antigen: CD204
Gene namesi
Name:Msr1
Synonyms:Scvr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:98257 Msr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55CytoplasmicSequence analysisAdd BLAST55
Transmembranei56 – 78Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini79 – 458ExtracellularSequence analysisAdd BLAST380

Keywords - Cellular componenti

LDL, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4399

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001816281 – 458Macrophage scavenger receptor types I and IIAdd BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi382 ↔ 446PROSITE-ProRule annotation
Disulfide bondi395 ↔ 456PROSITE-ProRule annotation
Disulfide bondi426 ↔ 436PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP30204
PaxDbiP30204
PeptideAtlasiP30204
PRIDEiP30204

PTM databases

iPTMnetiP30204
PhosphoSitePlusiP30204

Expressioni

Gene expression databases

BgeeiENSMUSG00000025044
CleanExiMM_MSR1
ExpressionAtlasiP30204 baseline and differential
GenevisibleiP30204 MM

Interactioni

Subunit structurei

Homotrimer (PubMed:8394868). Interacts with MYO18A (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActiP30204, 1 interactor
STRINGi10090.ENSMUSP00000026021

Chemistry databases

BindingDBiP30204

Structurei

3D structure databases

ProteinModelPortaliP30204
SMRiP30204
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 350Collagen-likeAdd BLAST74
Domaini357 – 457SRCRPROSITE-ProRule annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 114SpacerCuratedAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili209 – 259Sequence analysisAdd BLAST51

Keywords - Domaini

Coiled coil, Collagen, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK8A Eukaryota
ENOG410YQBT LUCA
GeneTreeiENSGT00900000140830
HOGENOMiHOG000085659
HOVERGENiHBG002473
InParanoidiP30204
KOiK06558
OMAiFCFGRES
OrthoDBiEOG091G02XD
TreeFamiTF330855

Family and domain databases

Gene3Di3.10.250.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR003543 Macro_scav_rcpt
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
PANTHERiPTHR45402 PTHR45402, 1 hit
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF03523 Macscav_rec, 1 hit
PF00530 SRCR, 1 hit
PRINTSiPR01408 MACSCAVRCPTR
PR00258 SPERACTRCPTR
SMARTiView protein in SMART
SM00202 SR, 1 hit
SUPFAMiSSF56487 SSF56487, 1 hit
PROSITEiView protein in PROSITE
PS00420 SRCR_1, 1 hit
PS50287 SRCR_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform I (identifier: P30204-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKEMTENQR LCPHEQEDAD CSSESVKFDA RSMTASLPHS TKNGPSLQEK
60 70 80 90 100
LKSFKAALIA LYLLVFAVLI PVVGIVTAQL LNWEMKNCLV CSLNTSDTSQ
110 120 130 140 150
GPMEKENTSK VEMRFTIIME HMKDMEERIE SISNSKADLI DTERFQNFSM
160 170 180 190 200
ATDQRLNDIL LQLNSLISSV QEHGNSLDAI SKSLQSLNMT LLDVQLHTET
210 220 230 240 250
LNVRVRESTA KQQEDISKLE ERVYKVSAEV QSVKEEQAHV EQEVKQEVRV
260 270 280 290 300
LNNITNDLRL KDWEHSQTLK NITFIQGPPG PQGEKGDRGL TGQTGPPGAP
310 320 330 340 350
GIRGIPGVKG DRGQIGFPGG RGNPGAPGKP GRSGSPGPKG QKGEKGSVGG
360 370 380 390 400
STPLKTVRLV GGSGAHEGRV EIFHQGQWGT ICDDRWDIRA GQVVCRSLGY
410 420 430 440 450
QEVLAVHKRA HFGQGTGPIW LNEVMCFGRE SSIENCKINQ WGVLSCSHSE

DAGVTCTS
Length:458
Mass (Da):50,170
Last modified:July 27, 2011 - v3
Checksum:iDA069B90A6B59EB5
GO
Isoform II (identifier: P30204-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     352-354: TPL → RSV
     355-458: Missing.

Show »
Length:354
Mass (Da):38,773
Checksum:i348E084D2D8B644B
GO

Sequence cautioni

The sequence AAA39747 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA39748 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16Q → R in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti16Q → R in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti16Q → R in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti16Q → R in AAF14001 (Ref. 3) Curated1
Sequence conflicti16Q → R in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti16Q → R in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti47L → V in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti47L → V in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti47L → V in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti47L → V in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti47L → V in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti93L → R in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti93L → R in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti93L → R in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti93L → R in AAF14001 (Ref. 3) Curated1
Sequence conflicti93L → R in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti93L → R in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti110K → N in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti110K → N in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti110K → N in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti110K → N in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti110K → N in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti120E → A in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti120E → A in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti120E → A in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti120E → A in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti120E → A in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti130E → Q in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti130E → Q in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti130E → Q in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti130E → Q in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti130E → Q in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti143E → G in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti143E → G in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti143E → G in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti143E → G in AAF14001 (Ref. 3) Curated1
Sequence conflicti143E → G in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti143E → G in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti168S → L in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti168S → L in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti168S → L in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti168S → L in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti168S → L in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti202N → H in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti202N → H in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti202N → H in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti202N → H in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti202N → H in AAH03814 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006231352 – 354TPL → RSV in isoform II. 4 Publications3
Alternative sequenceiVSP_006232355 – 458Missing in isoform II. 4 PublicationsAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04274 mRNA Translation: AAA39747.1 Different initiation.
L04275 mRNA Translation: AAA39748.1 Different initiation.
D13382 mRNA Translation: BAA02650.1
AF203781 mRNA Translation: AAF14001.1
M59445 mRNA Translation: AAA37464.1
M59446 mRNA Translation: AAA37465.1
U13873 Genomic DNA Translation: AAC13774.1
AK089178 mRNA Translation: BAC40779.1
AC111028 Genomic DNA No translation available.
BC003814 mRNA Translation: AAH03814.1
CCDSiCCDS52542.1 [P30204-1]
CCDS52543.1 [P30204-2]
PIRiB44407
I73338
RefSeqiNP_001106797.1, NM_001113326.1 [P30204-1]
UniGeneiMm.239291

Genome annotation databases

EnsembliENSMUST00000026021; ENSMUSP00000026021; ENSMUSG00000025044 [P30204-1]
ENSMUST00000170091; ENSMUSP00000132535; ENSMUSG00000025044 [P30204-2]
GeneIDi20288
KEGGimmu:20288
UCSCiuc012gcm.1 mouse [P30204-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMSRE_MOUSE
AccessioniPrimary (citable) accession number: P30204
Secondary accession number(s): E9QNQ5, Q923G0, Q9QZ56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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