UniProtKB - P30153 (2AAA_HUMAN)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
PPP2R1A
Functioni
GO - Molecular functioni
- protein antigen binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- protein phosphatase regulator activity Source: GO_Central
- protein serine/threonine phosphatase activity Source: Ensembl
GO - Biological processi
- apoptotic process Source: UniProtKB
- ceramide metabolic process Source: UniProtKB
- chromosome segregation Source: UniProtKB
- ciliary basal body-plasma membrane docking Source: Reactome
- female meiotic nuclear division Source: Ensembl
- G2/M transition of mitotic cell cycle Source: Reactome
- inactivation of MAPK activity Source: UniProtKB
- meiotic sister chromatid cohesion, centromeric Source: Ensembl
- meiotic spindle elongation Source: Ensembl
- mitotic nuclear envelope reassembly Source: Reactome
- mitotic sister chromatid separation Source: Ensembl
- negative regulation of cell growth Source: UniProtKB
- negative regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- peptidyl-serine dephosphorylation Source: Ensembl
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
- protein-containing complex assembly Source: UniProtKB
- protein dephosphorylation Source: UniProtKB
- regulation of cell adhesion Source: UniProtKB
- regulation of cell differentiation Source: UniProtKB
- regulation of DNA replication Source: UniProtKB
- regulation of G2/M transition of mitotic cell cycle Source: Reactome
- regulation of growth Source: UniProtKB
- regulation of meiotic cell cycle process involved in oocyte maturation Source: Ensembl
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of Wnt signaling pathway Source: UniProtKB
- response to organic substance Source: UniProtKB
- RNA splicing Source: UniProtKB
- second-messenger-mediated signaling Source: UniProtKB
Keywordsi
Biological process | Chromosome partition |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000105568-MONOMER |
PathwayCommonsi | P30153 |
Reactomei | R-HSA-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-1295596, Spry regulation of FGF signaling R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-163685, Integration of energy metabolism R-HSA-163767, PP2A-mediated dephosphorylation of key metabolic factors R-HSA-180024, DARPP-32 events R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-196299, Beta-catenin phosphorylation cascade R-HSA-198753, ERK/MAPK targets R-HSA-202670, ERKs are inactivated R-HSA-2465910, MASTL Facilitates Mitotic Progression R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-2995383, Initiation of Nuclear Envelope (NE) Reformation R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-389513, CTLA4 inhibitory signaling R-HSA-432142, Platelet sensitization by LDL R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-5339716, Misspliced GSK3beta mutants stabilize beta-catenin R-HSA-5358747, S33 mutants of beta-catenin aren't phosphorylated R-HSA-5358749, S37 mutants of beta-catenin aren't phosphorylated R-HSA-5358751, S45 mutants of beta-catenin aren't phosphorylated R-HSA-5358752, T41 mutants of beta-catenin aren't phosphorylated R-HSA-5467337, APC truncation mutants have impaired AXIN binding R-HSA-5467340, AXIN missense mutants destabilize the destruction complex R-HSA-5467348, Truncations of AMER1 destabilize the destruction complex R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-5663220, RHO GTPases Activate Formins R-HSA-5673000, RAF activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-6804757, Regulation of TP53 Degradation R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-68877, Mitotic Prometaphase R-HSA-69231, Cyclin D associated events in G1 R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition R-HSA-8854518, AURKA Activation by TPX2 R-HSA-9634600, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9648025, EML4 and NUDC in mitotic spindle formation R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | P30153 |
SIGNORi | P30153 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformAlternative name(s): Medium tumor antigen-associated 61 kDa protein PP2A subunit A isoform PR65-alpha PP2A subunit A isoform R1-alpha |
Gene namesi | Name:PPP2R1A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9302, PPP2R1A |
MIMi | 605983, gene |
neXtProti | NX_P30153 |
VEuPathDBi | HostDB:ENSG00000105568.17 |
Subcellular locationi
Plasma membrane
- Lateral cell membrane 1 Publication
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm By similarity
- centromere 1 Publication
- dendrite 1 Publication
Note: Centromeric localization requires the presence of BUB1.1 Publication
Cytoskeleton
- microtubule cytoskeleton Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- lateral plasma membrane Source: UniProtKB-SubCell
Other locations
- chromosome, centromeric region Source: UniProtKB
- cytoplasm Source: GO_Central
- dendrite Source: UniProtKB-SubCell
- glutamatergic synapse Source: Ensembl
- membrane Source: UniProtKB
- protein phosphatase type 2A complex Source: UniProtKB
- protein serine/threonine phosphatase complex Source: GO_Central
Keywords - Cellular componenti
Cell membrane, Cell projection, Centromere, Chromosome, Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Mental retardation, autosomal dominant 36 (MRD36)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073718 | 132 | V → L in MRD36. 1 Publication | 1 | |
Natural variantiVAR_074488 | 179 | P → L in MRD36; reduces PPP2CA binding; reduces PPP2R5A binding; reduces PPP2R5C binding; does not affect PPP2R5D binding; reduces PPP2R2A binding; reduces PPP2R2B binding; does not affect PPP2R3A binding; decreases phosphatase activity of PPP2CA. 1 PublicationCorresponds to variant dbSNP:rs786205228EnsemblClinVar. | 1 | |
Natural variantiVAR_074489 | 182 | R → W in MRD36; reduces PPP2CA binding; reduces PPP2R5A binding; reduces PPP2R5C binding; does not affect PPP2R5D binding; reduces PPP2R2A binding; reduces PPP2R2B binding; reduces PPP2R3A binding; decreases phosphatase activity of PPP2CA. 1 PublicationCorresponds to variant dbSNP:rs786205227EnsemblClinVar. | 1 | |
Natural variantiVAR_074490 | 258 | R → H in MRD36; reduces PPP2CA binding; reduces PPP2R5A binding; reduces PPP2R5C binding; does not affect PPP2R5D binding; reduces PPP2R2A binding; reduces PPP2R2B binding; reduces PPP2R3A binding; does not affect phosphatase activity of PPP2CA. 1 PublicationCorresponds to variant dbSNP:rs863225094EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Mental retardationOrganism-specific databases
DisGeNETi | 5518 |
MalaCardsi | PPP2R1A |
MIMi | 616362, phenotype |
OpenTargetsi | ENSG00000105568 |
Orphaneti | 457284, Microcephaly-corpus callosum hypoplasia-intellectual disability-facial dysmorphism syndrome |
PharmGKBi | PA33666 |
Miscellaneous databases
Pharosi | P30153, Tbio |
Chemistry databases
DrugBanki | DB06905, (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid DB02506, 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid |
Genetic variation databases
BioMutai | PPP2R1A |
DMDMi | 143811355 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000071400 | 2 – 589 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformAdd BLAST | 588 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 280 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
CPTACi | CPTAC-257 CPTAC-258 |
EPDi | P30153 |
jPOSTi | P30153 |
MassIVEi | P30153 |
MaxQBi | P30153 |
PaxDbi | P30153 |
PeptideAtlasi | P30153 |
PRIDEi | P30153 |
ProteomicsDBi | 54636 |
2D gel databases
OGPi | P30153 |
REPRODUCTION-2DPAGEi | IPI00554737 |
PTM databases
iPTMneti | P30153 |
MetOSitei | P30153 |
PhosphoSitePlusi | P30153 |
SwissPalmi | P30153 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105568, Expressed in anterior cingulate cortex and 242 other tissues |
ExpressionAtlasi | P30153, baseline and differential |
Genevisiblei | P30153, HS |
Organism-specific databases
HPAi | ENSG00000105568, Low tissue specificity |
Interactioni
Subunit structurei
PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity).
Interacts with FOXO1; the interaction dephosphorylates FOXO1 on AKT-mediated phosphorylation sites (By similarity).
Interacts with IPO9 (PubMed:12670497).
Interacts with TP53 and SGO1 (PubMed:17245430, PubMed:16580887).
Interacts with PLA2G16; this interaction might decrease PP2A activity (PubMed:17374643).
Interacts with CTTNBP2NL (PubMed:18782753).
Interacts with GNA12; the interaction promotes protein phosphatase 2A activation causing dephosphorylation of MAPT (PubMed:15525651).
Interacts with CIP2A; this interaction stabilizes CIP2A (PubMed:28174209).
Interacts with PABIR1/FAM122A (PubMed:27588481).
Interacts with ADCY8; antagonizes interaction between ADCY8 and calmodulin (By similarity).
Interacts with CRTC3 (when phosphorylated at 'Ser-391') (PubMed:30611118).
Interacts with SPRY2 (PubMed:17974561).
By similarity11 PublicationsBinary interactionsi
Hide detailsP30153
GO - Molecular functioni
- protein antigen binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111510, 455 interactors |
CORUMi | P30153 |
DIPi | DIP-29394N |
IntActi | P30153, 252 interactors |
MINTi | P30153 |
STRINGi | 9606.ENSP00000324804 |
Miscellaneous databases
RNActi | P30153, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P30153 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P30153 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 8 – 46 | HEAT 1Add BLAST | 39 | |
Repeati | 47 – 84 | HEAT 2Add BLAST | 38 | |
Repeati | 85 – 123 | HEAT 3Add BLAST | 39 | |
Repeati | 124 – 161 | HEAT 4Add BLAST | 38 | |
Repeati | 162 – 200 | HEAT 5Add BLAST | 39 | |
Repeati | 201 – 239 | HEAT 6Add BLAST | 39 | |
Repeati | 240 – 278 | HEAT 7Add BLAST | 39 | |
Repeati | 279 – 321 | HEAT 8Add BLAST | 43 | |
Repeati | 322 – 360 | HEAT 9Add BLAST | 39 | |
Repeati | 361 – 399 | HEAT 10Add BLAST | 39 | |
Repeati | 400 – 438 | HEAT 11Add BLAST | 39 | |
Repeati | 439 – 477 | HEAT 12Add BLAST | 39 | |
Repeati | 478 – 516 | HEAT 13Add BLAST | 39 | |
Repeati | 517 – 555 | HEAT 14Add BLAST | 39 | |
Repeati | 556 – 589 | HEAT 15Add BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 8 – 399 | PP2A subunit B bindingAdd BLAST | 392 | |
Regioni | 47 – 321 | Polyoma small and medium T antigens BindingAdd BLAST | 275 | |
Regioni | 85 – 239 | SV40 small T antigen bindingAdd BLAST | 155 | |
Regioni | 400 – 589 | PP2A subunit C bindingAdd BLAST | 190 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0211, Eukaryota |
GeneTreei | ENSGT00950000183066 |
HOGENOMi | CLU_015533_2_1_1 |
InParanoidi | P30153 |
OMAi | VKFFATR |
OrthoDBi | 447572at2759 |
PhylomeDBi | P30153 |
TreeFami | TF105552 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000357, HEAT IPR021133, HEAT_type_2 IPR031090, PP2A_A_meta |
PANTHERi | PTHR10648:SF2, PTHR10648:SF2, 1 hit |
Pfami | View protein in Pfam PF02985, HEAT, 3 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50077, HEAT_REPEAT, 11 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAAADGDDSL YPIAVLIDEL RNEDVQLRLN SIKKLSTIAL ALGVERTRSE
60 70 80 90 100
LLPFLTDTIY DEDEVLLALA EQLGTFTTLV GGPEYVHCLL PPLESLATVE
110 120 130 140 150
ETVVRDKAVE SLRAISHEHS PSDLEAHFVP LVKRLAGGDW FTSRTSACGL
160 170 180 190 200
FSVCYPRVSS AVKAELRQYF RNLCSDDTPM VRRAAASKLG EFAKVLELDN
210 220 230 240 250
VKSEIIPMFS NLASDEQDSV RLLAVEACVN IAQLLPQEDL EALVMPTLRQ
260 270 280 290 300
AAEDKSWRVR YMVADKFTEL QKAVGPEITK TDLVPAFQNL MKDCEAEVRA
310 320 330 340 350
AASHKVKEFC ENLSADCREN VIMSQILPCI KELVSDANQH VKSALASVIM
360 370 380 390 400
GLSPILGKDN TIEHLLPLFL AQLKDECPEV RLNIISNLDC VNEVIGIRQL
410 420 430 440 450
SQSLLPAIVE LAEDAKWRVR LAIIEYMPLL AGQLGVEFFD EKLNSLCMAW
460 470 480 490 500
LVDHVYAIRE AATSNLKKLV EKFGKEWAHA TIIPKVLAMS GDPNYLHRMT
510 520 530 540 550
TLFCINVLSE VCGQDITTKH MLPTVLRMAG DPVANVRFNV AKSLQKIGPI
560 570 580
LDNSTLQSEV KPILEKLTQD QDVDVKYFAQ EALTVLSLA
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J9C1 | C9J9C1_HUMAN | Serine/threonine-protein phosphatas... | PPP2R1A | 395 | Annotation score: | ||
B3KQV6 | B3KQV6_HUMAN | Serine/threonine-protein phosphatas... | PPP2R1A | 410 | Annotation score: | ||
E9PH38 | E9PH38_HUMAN | Serine/threonine-protein phosphatas... | PPP2R1A | 132 | Annotation score: | ||
M0R0K6 | M0R0K6_HUMAN | Serine/threonine-protein phosphatas... | PPP2R1A | 66 | Annotation score: | ||
M0QXG4 | M0QXG4_HUMAN | Serine/threonine-protein phosphatas... | PPP2R1A | 38 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 130 | P → A in AAA35531 (PubMed:2554323).Curated | 1 | |
Sequence conflicti | 258 | R → A in AAA36399 (PubMed:2159327).Curated | 1 | |
Sequence conflicti | 272 | K → R AA sequence (PubMed:8694763).Curated | 1 | |
Sequence conflicti | 551 | L → P in CAG29336 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073718 | 132 | V → L in MRD36. 1 Publication | 1 | |
Natural variantiVAR_074488 | 179 | P → L in MRD36; reduces PPP2CA binding; reduces PPP2R5A binding; reduces PPP2R5C binding; does not affect PPP2R5D binding; reduces PPP2R2A binding; reduces PPP2R2B binding; does not affect PPP2R3A binding; decreases phosphatase activity of PPP2CA. 1 PublicationCorresponds to variant dbSNP:rs786205228EnsemblClinVar. | 1 | |
Natural variantiVAR_074489 | 182 | R → W in MRD36; reduces PPP2CA binding; reduces PPP2R5A binding; reduces PPP2R5C binding; does not affect PPP2R5D binding; reduces PPP2R2A binding; reduces PPP2R2B binding; reduces PPP2R3A binding; decreases phosphatase activity of PPP2CA. 1 PublicationCorresponds to variant dbSNP:rs786205227EnsemblClinVar. | 1 | |
Natural variantiVAR_074490 | 258 | R → H in MRD36; reduces PPP2CA binding; reduces PPP2R5A binding; reduces PPP2R5C binding; does not affect PPP2R5D binding; reduces PPP2R2A binding; reduces PPP2R2B binding; reduces PPP2R3A binding; does not affect phosphatase activity of PPP2CA. 1 PublicationCorresponds to variant dbSNP:rs863225094EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31786 mRNA Translation: AAA35531.1 J02902 mRNA Translation: AAA36399.1 CR450340 mRNA Translation: CAG29336.1 BC001537 mRNA Translation: AAH01537.1 |
CCDSi | CCDS12849.1 |
PIRi | A34541 |
RefSeqi | NP_055040.2, NM_014225.5 |
Genome annotation databases
Ensembli | ENST00000322088; ENSP00000324804; ENSG00000105568 |
GeneIDi | 5518 |
KEGGi | hsa:5518 |
UCSCi | uc002pyp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31786 mRNA Translation: AAA35531.1 J02902 mRNA Translation: AAA36399.1 CR450340 mRNA Translation: CAG29336.1 BC001537 mRNA Translation: AAH01537.1 |
CCDSi | CCDS12849.1 |
PIRi | A34541 |
RefSeqi | NP_055040.2, NM_014225.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B3U | X-ray | 2.30 | A/B | 2-589 | [»] | |
2IE3 | X-ray | 2.80 | A | 1-589 | [»] | |
2IE4 | X-ray | 2.60 | A | 1-589 | [»] | |
2NPP | X-ray | 3.30 | A/D | 1-589 | [»] | |
2NYL | X-ray | 3.80 | A/D | 8-589 | [»] | |
2NYM | X-ray | 3.60 | A/D | 8-589 | [»] | |
2PKG | X-ray | 3.30 | A/B | 10-589 | [»] | |
3C5W | X-ray | 2.80 | A | 9-46 | [»] | |
A | 400-589 | [»] | ||||
3DW8 | X-ray | 2.85 | A/D | 9-589 | [»] | |
3K7V | X-ray | 2.85 | A | 1-589 | [»] | |
3K7W | X-ray | 2.96 | A | 1-589 | [»] | |
4I5L | X-ray | 2.43 | A/D | 6-589 | [»] | |
4I5N | X-ray | 2.80 | A/D | 6-589 | [»] | |
4LAC | X-ray | 2.82 | A | 404-589 | [»] | |
5W0W | X-ray | 3.80 | A/D/G/J | 9-589 | [»] | |
6IUR | X-ray | 3.33 | A/B/E/F | 8-589 | [»] | |
6NTS | electron microscopy | 3.63 | A | 1-589 | [»] | |
SMRi | P30153 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111510, 455 interactors |
CORUMi | P30153 |
DIPi | DIP-29394N |
IntActi | P30153, 252 interactors |
MINTi | P30153 |
STRINGi | 9606.ENSP00000324804 |
Chemistry databases
DrugBanki | DB06905, (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid DB02506, 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid |
PTM databases
iPTMneti | P30153 |
MetOSitei | P30153 |
PhosphoSitePlusi | P30153 |
SwissPalmi | P30153 |
Genetic variation databases
BioMutai | PPP2R1A |
DMDMi | 143811355 |
2D gel databases
OGPi | P30153 |
REPRODUCTION-2DPAGEi | IPI00554737 |
Proteomic databases
CPTACi | CPTAC-257 CPTAC-258 |
EPDi | P30153 |
jPOSTi | P30153 |
MassIVEi | P30153 |
MaxQBi | P30153 |
PaxDbi | P30153 |
PeptideAtlasi | P30153 |
PRIDEi | P30153 |
ProteomicsDBi | 54636 |
Protocols and materials databases
Antibodypediai | 4348, 374 antibodies |
DNASUi | 5518 |
Genome annotation databases
Ensembli | ENST00000322088; ENSP00000324804; ENSG00000105568 |
GeneIDi | 5518 |
KEGGi | hsa:5518 |
UCSCi | uc002pyp.4, human |
Organism-specific databases
CTDi | 5518 |
DisGeNETi | 5518 |
GeneCardsi | PPP2R1A |
HGNCi | HGNC:9302, PPP2R1A |
HPAi | ENSG00000105568, Low tissue specificity |
MalaCardsi | PPP2R1A |
MIMi | 605983, gene 616362, phenotype |
neXtProti | NX_P30153 |
OpenTargetsi | ENSG00000105568 |
Orphaneti | 457284, Microcephaly-corpus callosum hypoplasia-intellectual disability-facial dysmorphism syndrome |
PharmGKBi | PA33666 |
VEuPathDBi | HostDB:ENSG00000105568.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0211, Eukaryota |
GeneTreei | ENSGT00950000183066 |
HOGENOMi | CLU_015533_2_1_1 |
InParanoidi | P30153 |
OMAi | VKFFATR |
OrthoDBi | 447572at2759 |
PhylomeDBi | P30153 |
TreeFami | TF105552 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000105568-MONOMER |
PathwayCommonsi | P30153 |
Reactomei | R-HSA-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-1295596, Spry regulation of FGF signaling R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-163685, Integration of energy metabolism R-HSA-163767, PP2A-mediated dephosphorylation of key metabolic factors R-HSA-180024, DARPP-32 events R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-196299, Beta-catenin phosphorylation cascade R-HSA-198753, ERK/MAPK targets R-HSA-202670, ERKs are inactivated R-HSA-2465910, MASTL Facilitates Mitotic Progression R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-2995383, Initiation of Nuclear Envelope (NE) Reformation R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-389513, CTLA4 inhibitory signaling R-HSA-432142, Platelet sensitization by LDL R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-5339716, Misspliced GSK3beta mutants stabilize beta-catenin R-HSA-5358747, S33 mutants of beta-catenin aren't phosphorylated R-HSA-5358749, S37 mutants of beta-catenin aren't phosphorylated R-HSA-5358751, S45 mutants of beta-catenin aren't phosphorylated R-HSA-5358752, T41 mutants of beta-catenin aren't phosphorylated R-HSA-5467337, APC truncation mutants have impaired AXIN binding R-HSA-5467340, AXIN missense mutants destabilize the destruction complex R-HSA-5467348, Truncations of AMER1 destabilize the destruction complex R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-5663220, RHO GTPases Activate Formins R-HSA-5673000, RAF activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-6804757, Regulation of TP53 Degradation R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-68877, Mitotic Prometaphase R-HSA-69231, Cyclin D associated events in G1 R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition R-HSA-8854518, AURKA Activation by TPX2 R-HSA-9634600, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9648025, EML4 and NUDC in mitotic spindle formation R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | P30153 |
SIGNORi | P30153 |
Miscellaneous databases
BioGRID-ORCSi | 5518, 652 hits in 886 CRISPR screens |
ChiTaRSi | PPP2R1A, human |
EvolutionaryTracei | P30153 |
GeneWikii | PPP2R1A |
GenomeRNAii | 5518 |
Pharosi | P30153, Tbio |
PROi | PR:P30153 |
RNActi | P30153, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105568, Expressed in anterior cingulate cortex and 242 other tissues |
ExpressionAtlasi | P30153, baseline and differential |
Genevisiblei | P30153, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000357, HEAT IPR021133, HEAT_type_2 IPR031090, PP2A_A_meta |
PANTHERi | PTHR10648:SF2, PTHR10648:SF2, 1 hit |
Pfami | View protein in Pfam PF02985, HEAT, 3 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50077, HEAT_REPEAT, 11 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 2AAA_HUMAN | |
Accessioni | P30153Primary (citable) accession number: P30153 Secondary accession number(s): Q13773, Q6ICQ3, Q96DH3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 3, 2007 | |
Last modified: | February 10, 2021 | |
This is version 215 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants