UniProtKB - P30130 (FIMD_ECOLI)
Protein
Outer membrane usher protein FimD
Gene
fimD
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in the export and assembly of FimA fimbrial subunits across the outer membrane.
GO - Molecular functioni
- fimbrial usher porin activity Source: EcoCyc
GO - Biological processi
- pilus assembly Source: EcoCyc
Keywordsi
Biological process | Fimbrium biogenesis, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10311-MONOMER |
Protein family/group databases
TCDBi | 1.B.11.3.9, the outer membrane fimbrial usher porin (fup) family |
Names & Taxonomyi
Protein namesi | Recommended name: Outer membrane usher protein FimD |
Gene namesi | Name:fimD Ordered Locus Names:b4317, JW5780 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell outer membrane By similarity; Multi-pass membrane protein By similarity
GO - Cellular componenti
- cell outer membrane Source: EcoCyc
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Cell outer membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 45 | 1 PublicationAdd BLAST | 45 | |
ChainiPRO_0000009312 | 46 – 878 | Outer membrane usher protein FimDAdd BLAST | 833 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 855 ↔ 877 | Sequence analysis |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P30130 |
PRIDEi | P30130 |
Interactioni
Binary interactionsi
P30130
With | #Exp. | IntAct |
---|---|---|
fimC [P31697] | 11 | EBI-554889,EBI-1028005 |
Protein-protein interaction databases
BioGRIDi | 4262748, 186 interactors |
DIPi | DIP-9612N |
IntActi | P30130, 7 interactors |
MINTi | P30130 |
STRINGi | 511145.b4317 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P30130 |
SMRi | P30130 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P30130 |
Family & Domainsi
Sequence similaritiesi
Belongs to the fimbrial export usher family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane beta strandPhylogenomic databases
eggNOGi | COG3188, Bacteria |
HOGENOMi | CLU_009120_3_1_6 |
InParanoidi | P30130 |
PhylomeDBi | P30130 |
Family and domain databases
Gene3Di | 2.60.40.2070, 1 hit 2.60.40.2610, 1 hit 3.10.20.410, 1 hit |
InterProi | View protein in InterPro IPR000015, Fimb_usher IPR018030, Fimbrial_membr_usher_CS IPR042186, FimD_plug_dom IPR025949, PapC-like_C IPR043142, PapC-like_C_sf IPR025885, PapC_N IPR037224, PapC_N_sf |
PANTHERi | PTHR30451, PTHR30451, 1 hit |
Pfami | View protein in Pfam PF13953, PapC_C, 1 hit PF13954, PapC_N, 1 hit PF00577, Usher, 1 hit |
SUPFAMi | SSF141729, SSF141729, 1 hit |
PROSITEi | View protein in PROSITE PS01151, FIMBRIAL_USHER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P30130-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSYLNLRLYQ RNTQCLHIRK HRLAGFFVRL VVACAFAAQA PLSSADLYFN
60 70 80 90 100
PRFLADDPQA VADLSRFENG QELPPGTYRV DIYLNNGYMA TRDVTFNTGD
110 120 130 140 150
SEQGIVPCLT RAQLASMGLN TASVAGMNLL ADDACVPLTT MVQDATAHLD
160 170 180 190 200
VGQQRLNLTI PQAFMSNRAR GYIPPELWDP GINAGLLNYN FSGNSVQNRI
210 220 230 240 250
GGNSHYAYLN LQSGLNIGAW RLRDNTTWSY NSSDRSSGSK NKWQHINTWL
260 270 280 290 300
ERDIIPLRSR LTLGDGYTQG DIFDGINFRG AQLASDDNML PDSQRGFAPV
310 320 330 340 350
IHGIARGTAQ VTIKQNGYDI YNSTVPPGPF TINDIYAAGN SGDLQVTIKE
360 370 380 390 400
ADGSTQIFTV PYSSVPLLQR EGHTRYSITA GEYRSGNAQQ EKTRFFQSTL
410 420 430 440 450
LHGLPAGWTI YGGTQLADRY RAFNFGIGKN MGALGALSVD MTQANSTLPD
460 470 480 490 500
DSQHDGQSVR FLYNKSLNES GTNIQLVGYR YSTSGYFNFA DTTYSRMNGY
510 520 530 540 550
NIETQDGVIQ VKPKFTDYYN LAYNKRGKLQ LTVTQQLGRT STLYLSGSHQ
560 570 580 590 600
TYWGTSNVDE QFQAGLNTAF EDINWTLSYS LTKNAWQKGR DQMLALNVNI
610 620 630 640 650
PFSHWLRSDS KSQWRHASAS YSMSHDLNGR MTNLAGVYGT LLEDNNLSYS
660 670 680 690 700
VQTGYAGGGD GNSGSTGYAT LNYRGGYGNA NIGYSHSDDI KQLYYGVSGG
710 720 730 740 750
VLAHANGVTL GQPLNDTVVL VKAPGAKDAK VENQTGVRTD WRGYAVLPYA
760 770 780 790 800
TEYRENRVAL DTNTLADNVD LDNAVANVVP TRGAIVRAEF KARVGIKLLM
810 820 830 840 850
TLTHNNKPLP FGAMVTSESS QSSGIVADNG QVYLSGMPLA GKVQVKWGEE
860 870
ENAHCVANYQ LPPESQQQLL TQLSAECR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 143 – 148 | QDATAH → RTLLRT in CAA35968 (PubMed:1970114).Curated | 6 | |
Sequence conflicti | 352 – 402 | DGSTQ…STLLH → VLAARRFLPYPIRTFPLLNV KAYSLFHYGRRIPYESRSRK KPAFSRVHYSN (PubMed:1970114).CuratedAdd BLAST | 51 | |
Sequence conflicti | 658 – 670 | GGDGN…TGYAT → EAMEIAEVQATP (PubMed:1970114).CuratedAdd BLAST | 13 | |
Sequence conflicti | 723 – 742 | APGAK…RTDWR → RLAQKMQKSKTRRGAYRLA in CAA35968 (PubMed:1970114).CuratedAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51655 Genomic DNA Translation: CAA35968.1 U14003 Genomic DNA Translation: AAA97213.1 U00096 Genomic DNA Translation: AAC77273.1 AP009048 Genomic DNA Translation: BAE78310.1 |
PIRi | S56542 |
RefSeqi | NP_418737.1, NC_000913.3 WP_000121005.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC77273; AAC77273; b4317 BAE78310; BAE78310; BAE78310 |
GeneIDi | 948844 |
KEGGi | ecj:JW5780 eco:b4317 |
PATRICi | fig|1411691.4.peg.2375 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51655 Genomic DNA Translation: CAA35968.1 U14003 Genomic DNA Translation: AAA97213.1 U00096 Genomic DNA Translation: AAC77273.1 AP009048 Genomic DNA Translation: BAE78310.1 |
PIRi | S56542 |
RefSeqi | NP_418737.1, NC_000913.3 WP_000121005.1, NZ_LN832404.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ZDV | NMR | - | A | 70-184 | [»] | |
1ZDX | NMR | - | A | 70-170 | [»] | |
1ZE3 | X-ray | 1.84 | D | 46-170 | [»] | |
3BWU | X-ray | 1.76 | D | 46-170 | [»] | |
3OHN | X-ray | 3.01 | A/B | 169-708 | [»] | |
3RFZ | X-ray | 2.80 | B/E | 46-878 | [»] | |
4J3O | X-ray | 3.80 | D | 46-878 | [»] | |
6E14 | electron microscopy | 4.00 | D | 1-878 | [»] | |
6E15 | electron microscopy | 6.20 | D | 1-878 | [»] | |
BMRBi | P30130 | |||||
SMRi | P30130 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262748, 186 interactors |
DIPi | DIP-9612N |
IntActi | P30130, 7 interactors |
MINTi | P30130 |
STRINGi | 511145.b4317 |
Protein family/group databases
TCDBi | 1.B.11.3.9, the outer membrane fimbrial usher porin (fup) family |
Proteomic databases
PaxDbi | P30130 |
PRIDEi | P30130 |
Genome annotation databases
EnsemblBacteriai | AAC77273; AAC77273; b4317 BAE78310; BAE78310; BAE78310 |
GeneIDi | 948844 |
KEGGi | ecj:JW5780 eco:b4317 |
PATRICi | fig|1411691.4.peg.2375 |
Organism-specific databases
EchoBASEi | EB0307 |
Phylogenomic databases
eggNOGi | COG3188, Bacteria |
HOGENOMi | CLU_009120_3_1_6 |
InParanoidi | P30130 |
PhylomeDBi | P30130 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10311-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P30130 |
PROi | PR:P30130 |
Family and domain databases
Gene3Di | 2.60.40.2070, 1 hit 2.60.40.2610, 1 hit 3.10.20.410, 1 hit |
InterProi | View protein in InterPro IPR000015, Fimb_usher IPR018030, Fimbrial_membr_usher_CS IPR042186, FimD_plug_dom IPR025949, PapC-like_C IPR043142, PapC-like_C_sf IPR025885, PapC_N IPR037224, PapC_N_sf |
PANTHERi | PTHR30451, PTHR30451, 1 hit |
Pfami | View protein in Pfam PF13953, PapC_C, 1 hit PF13954, PapC_N, 1 hit PF00577, Usher, 1 hit |
SUPFAMi | SSF141729, SSF141729, 1 hit |
PROSITEi | View protein in PROSITE PS01151, FIMBRIAL_USHER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FIMD_ECOLI | |
Accessioni | P30130Primary (citable) accession number: P30130 Secondary accession number(s): Q2M5Z6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families