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Entry version 154 (12 Aug 2020)
Sequence version 2 (01 Jun 1994)
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Protein

Transcription elongation factor GreB

Gene

greB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.UniRule annotation1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG11578-MONOMER
ECOL316407:JW3369-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription elongation factor GreBUniRule annotation
Alternative name(s):
Transcript cleavage factor GreBUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:greBUniRule annotation
Ordered Locus Names:b3406, JW3369
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001769221 – 158Transcription elongation factor GreBAdd BLAST158

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P30128

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P30128

PRoteomics IDEntifications database

More...
PRIDEi
P30128

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4261264, 21 interactors

Database of interacting proteins

More...
DIPi
DIP-9834N

Protein interaction database and analysis system

More...
IntActi
P30128, 24 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b3406

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P30128

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P30128

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GreA/GreB family. GreB subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0782, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_101379_3_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P30128

KEGG Orthology (KO)

More...
KOi
K04760

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P30128

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.180, 1 hit
3.10.50.30, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00105, GreA_GreB, 1 hit
MF_00930, GreB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036953, GreA/GreB_C_sf
IPR018151, TF_GreA/GreB_CS
IPR028624, Tscrpt_elong_fac_GreA/B
IPR001437, Tscrpt_elong_fac_GreA/B_C
IPR023459, Tscrpt_elong_fac_GreA/B_fam
IPR022691, Tscrpt_elong_fac_GreA/B_N
IPR036805, Tscrpt_elong_fac_GreA/B_N_sf
IPR006358, Tscrpt_elong_fac_GreB

The PANTHER Classification System

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PANTHERi
PTHR30437, PTHR30437, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01272, GreA_GreB, 1 hit
PF03449, GreA_GreB_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006092, GreA_GreB, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46557, SSF46557, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01461, greB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00829, GREAB_1, 1 hit
PS00830, GREAB_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P30128-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTPLVTREG YEKLKQELNY LWREERPEVT KKVTWAASLG DRSENADYQY
60 70 80 90 100
NKKRLREIDR RVRYLTKCLE NLKIVDYSPQ QEGKVFFGAW VEIENDDGVT
110 120 130 140 150
HRFRIVGYDE IFGRKDYISI DSPMARALLK KEVGDLAVVN TPAGEASWYV

NAIEYVKP
Length:158
Mass (Da):18,527
Last modified:June 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28B46455FABA59CF
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA58203 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U81522 Genomic DNA Translation: AAB39763.1
U18997 Genomic DNA Translation: AAA58203.1 Different initiation.
U00096 Genomic DNA Translation: AAC76431.2
AP009048 Genomic DNA Translation: BAE77885.1

Protein sequence database of the Protein Information Resource

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PIRi
A65136

NCBI Reference Sequences

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RefSeqi
YP_026216.2, NC_000913.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76431; AAC76431; b3406
BAE77885; BAE77885; BAE77885

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2847706

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW3369
eco:b3406

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3323

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81522 Genomic DNA Translation: AAB39763.1
U18997 Genomic DNA Translation: AAA58203.1 Different initiation.
U00096 Genomic DNA Translation: AAC76431.2
AP009048 Genomic DNA Translation: BAE77885.1
PIRiA65136
RefSeqiYP_026216.2, NC_000913.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P4VX-ray2.60A/B/C/D/E/F1-158[»]
6RI7electron microscopy3.90F/G1-158[»]
6RINelectron microscopy3.70F1-158[»]
SMRiP30128
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4261264, 21 interactors
DIPiDIP-9834N
IntActiP30128, 24 interactors
STRINGi511145.b3406

Proteomic databases

jPOSTiP30128
PaxDbiP30128
PRIDEiP30128

Genome annotation databases

EnsemblBacteriaiAAC76431; AAC76431; b3406
BAE77885; BAE77885; BAE77885
GeneIDi2847706
KEGGiecj:JW3369
eco:b3406
PATRICifig|1411691.4.peg.3323

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1538

Phylogenomic databases

eggNOGiCOG0782, Bacteria
HOGENOMiCLU_101379_3_0_6
InParanoidiP30128
KOiK04760
PhylomeDBiP30128

Enzyme and pathway databases

BioCyciEcoCyc:EG11578-MONOMER
ECOL316407:JW3369-MONOMER

Miscellaneous databases

EvolutionaryTraceiP30128

Protein Ontology

More...
PROi
PR:P30128

Family and domain databases

Gene3Di1.10.287.180, 1 hit
3.10.50.30, 1 hit
HAMAPiMF_00105, GreA_GreB, 1 hit
MF_00930, GreB, 1 hit
InterProiView protein in InterPro
IPR036953, GreA/GreB_C_sf
IPR018151, TF_GreA/GreB_CS
IPR028624, Tscrpt_elong_fac_GreA/B
IPR001437, Tscrpt_elong_fac_GreA/B_C
IPR023459, Tscrpt_elong_fac_GreA/B_fam
IPR022691, Tscrpt_elong_fac_GreA/B_N
IPR036805, Tscrpt_elong_fac_GreA/B_N_sf
IPR006358, Tscrpt_elong_fac_GreB
PANTHERiPTHR30437, PTHR30437, 1 hit
PfamiView protein in Pfam
PF01272, GreA_GreB, 1 hit
PF03449, GreA_GreB_N, 1 hit
PIRSFiPIRSF006092, GreA_GreB, 1 hit
SUPFAMiSSF46557, SSF46557, 1 hit
TIGRFAMsiTIGR01461, greB, 1 hit
PROSITEiView protein in PROSITE
PS00829, GREAB_1, 1 hit
PS00830, GREAB_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGREB_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30128
Secondary accession number(s): P78114, Q2M771
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: June 1, 1994
Last modified: August 12, 2020
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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