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Protein

Glutathione S-transferase 1-1

Gene

GstD1

Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1-1 (EC:2.5.1.18, EC:4.5.1.1)
Alternative name(s):
DDT-dehydrochlorinase
GST class-theta
Gene namesi
Name:GstD1
Synonyms:GST, Gst1
ORF Names:GM26019
OrganismiDrosophila sechellia (Fruit fly)
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001292 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012785 Dsec\GstD1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859501 – 209Glutathione S-transferase 1-1Add BLAST209

Proteomic databases

PRIDEiP30106

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP30106
SMRiP30106
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 81GST N-terminalAdd BLAST81
Domaini87 – 209GST C-terminalAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 53Glutathione bindingBy similarity3
Regioni65 – 67Glutathione bindingBy similarity3

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

KOiK00799
OMAiANWCWVR
OrthoDBiEOG091G0MS3
PhylomeDBiP30106

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P30106-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADFYYLPGS SPCRSVIMTA KAVGVELNKK LLNLRAGEHL KPEFLKINPQ
60 70 80 90 100
HTIPTLVDNG FALWESRAIQ VYLVEKYGKT DSLYPKCPKK RAVINQRLYF
110 120 130 140 150
DMGTLYQSFA NYYYPQVFAK APADPEAFKK IESAFEFLNT FLEGQEYAAG
160 170 180 190 200
DSLTVADIAL VASVSTFEVA GFEISKYANV NKWYENAKKV TPGWEENWAG

CLEFKKFFE
Length:209
Mass (Da):23,767
Last modified:February 22, 2012 - v2
Checksum:iCD023FF2D076F716
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195E → S in M84578 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480815 Genomic DNA Translation: EDW42478.1
M84578 Genomic DNA No translation available.
RefSeqiXP_002031492.1, XM_002031456.1

Genome annotation databases

EnsemblMetazoaiFBtr0209004; FBpp0207496; FBgn0012785
GeneIDi6606692
KEGGidse:Dsec_GM26019

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480815 Genomic DNA Translation: EDW42478.1
M84578 Genomic DNA No translation available.
RefSeqiXP_002031492.1, XM_002031456.1

3D structure databases

ProteinModelPortaliP30106
SMRiP30106
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP30106

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0209004; FBpp0207496; FBgn0012785
GeneIDi6606692
KEGGidse:Dsec_GM26019

Organism-specific databases

FlyBaseiFBgn0012785 Dsec\GstD1

Phylogenomic databases

KOiK00799
OMAiANWCWVR
OrthoDBiEOG091G0MS3
PhylomeDBiP30106

Miscellaneous databases

ChiTaRSiGstS1 fly

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGSTT1_DROSE
AccessioniPrimary (citable) accession number: P30106
Secondary accession number(s): B4HHD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 22, 2012
Last modified: October 25, 2017
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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