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Protein

Glucagon receptor

Gene

Gcgr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.1 Publication

GO - Molecular functioni

  • glucagon receptor activity Source: RGD
  • peptide hormone binding Source: RGD

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  • cell surface receptor signaling pathway Source: InterPro
  • exocytosis Source: RGD
  • glucose homeostasis Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: RGD
  • hormone-mediated signaling pathway Source: RGD
  • regulation of glycogen metabolic process Source: UniProtKB
  • response to starvation Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-163359 Glucagon signaling in metabolic regulation
R-RNO-416476 G alpha (q) signalling events
R-RNO-418555 G alpha (s) signalling events
R-RNO-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon receptor
Short name:
GL-R
Gene namesi
Name:Gcgr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2669 Gcgr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 137ExtracellularBy similarityAdd BLAST111
Transmembranei138 – 162Helical; Name=1By similarityAdd BLAST25
Topological domaini163 – 174CytoplasmicBy similarityAdd BLAST12
Transmembranei175 – 199Helical; Name=2By similarityAdd BLAST25
Topological domaini200 – 226ExtracellularBy similarityAdd BLAST27
Transmembranei227 – 250Helical; Name=3By similarityAdd BLAST24
Topological domaini251 – 264CytoplasmicBy similarityAdd BLAST14
Transmembranei265 – 286Helical; Name=4By similarityAdd BLAST22
Topological domaini287 – 304ExtracellularBy similarityAdd BLAST18
Transmembranei305 – 327Helical; Name=5By similarityAdd BLAST23
Topological domaini328 – 351CytoplasmicBy similarityAdd BLAST24
Transmembranei352 – 370Helical; Name=6By similarityAdd BLAST19
Topological domaini371 – 382ExtracellularBy similarityAdd BLAST12
Transmembranei383 – 403Helical; Name=7By similarityAdd BLAST21
Topological domaini404 – 485CytoplasmicBy similarityAdd BLAST82

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4720
GuidetoPHARMACOLOGYi251

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001283427 – 485Glucagon receptorAdd BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 68By similarity
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi59 ↔ 101By similarity
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi82 ↔ 122By similarity
Disulfide bondi225 ↔ 295By similarity
Modified residuei460PhosphoserineBy similarity1
Modified residuei476PhosphoserineCombined sources1

Post-translational modificationi

Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP30082
PRIDEiP30082

PTM databases

iPTMnetiP30082
PhosphoSitePlusiP30082

Expressioni

Gene expression databases

BgeeiENSRNOG00000036692
ExpressionAtlasiP30082 baseline and differential
GenevisibleiP30082 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051845

Chemistry databases

BindingDBiP30082

Structurei

3D structure databases

ProteinModelPortaliP30082
SMRiP30082
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni351 – 354Allosteric inhibitor bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008250
HOVERGENiHBG008318
InParanoidiP30082
KOiK04583
OMAiTELVCNR
PhylomeDBiP30082
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003290 GPCR_2_GLP1/glucagon_rcpt
IPR003291 GPCR_2_glucagon_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01353 GLUCAGNFAMLY
PR01354 GLUCAGONR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLTQLHCPY LLLLLVVLSC LPKAPSAQVM DFLFEKWKLY SDQCHHNLSL
60 70 80 90 100
LPPPTELVCN RTFDKYSCWP DTPPNTTANI SCPWYLPWYH KVQHRLVFKR
110 120 130 140 150
CGPDGQWVRG PRGQSWRDAS QCQMDDDEIE VQKGVAKMYS SYQVMYTVGY
160 170 180 190 200
SLSLGALLLA LVILLGLRKL HCTRNYIHGN LFASFVLKAG SVLVIDWLLK
210 220 230 240 250
TRYSQKIGDD LSVSVWLSDG AVAGCRVATV IMQYGIIANY CWLLVEGVYL
260 270 280 290 300
YSLLSITTFS EKSFFSLYLC IGWGSPLLFV IPWVVVKCLF ENVQCWTSND
310 320 330 340 350
NMGFWWILRI PVLLAILINF FIFVRIIHLL VAKLRAHQMH YADYKFRLAR
360 370 380 390 400
STLTLIPLLG VHEVVFAFVT DEHAQGTLRS TKLFFDLFFS SFQGLLVAVL
410 420 430 440 450
YCFLNKEVQA ELLRRWRRWQ EGKALQEERM ASSHGSHMAP AGTCHGDPCE
460 470 480
KLQLMSAGSS SGTGCEPSAK TSLASSLPRL ADSPT
Length:485
Mass (Da):55,038
Last modified:February 1, 1996 - v2
Checksum:i91AC67D7A4F5090E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216W → C (PubMed:8384842).Curated1
Sequence conflicti324V → A (PubMed:8384842).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04796 mRNA Translation: AAA16439.1
X68692 mRNA Translation: CAA48651.1
M96674 mRNA Translation: AAA02992.1
U63021 Genomic DNA Translation: AAB16800.1
PIRiJQ1957
RefSeqiNP_742088.1, NM_172091.2
NP_742089.1, NM_172092.2
XP_006247938.1, XM_006247876.3
UniGeneiRn.11225

Genome annotation databases

EnsembliENSRNOT00000054962; ENSRNOP00000051845; ENSRNOG00000036692
ENSRNOT00000083601; ENSRNOP00000074929; ENSRNOG00000036692
GeneIDi24953
KEGGirno:24953

Similar proteinsi

Entry informationi

Entry nameiGLR_RAT
AccessioniPrimary (citable) accession number: P30082
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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