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Protein

60S ribosomal protein L12

Gene

RPL12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds directly to 26S ribosomal RNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP30050

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L12
Alternative name(s):
Large ribosomal subunit protein uL111 Publication
Gene namesi
Name:RPL12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000197958.12
HGNCiHGNC:10302 RPL12
MIMi180475 gene
neXtProtiNX_P30050

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6136
OpenTargetsiENSG00000197958
PharmGKBiPA34665

Polymorphism and mutation databases

BioMutaiRPL12
DMDMi266921

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001044561 – 16560S ribosomal protein L12Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei54N6-acetyllysineCombined sources1
Modified residuei165PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP30050
MaxQBiP30050
PaxDbiP30050
PeptideAtlasiP30050
PRIDEiP30050
ProteomicsDBi54630
54631 [P30050-2]

2D gel databases

SWISS-2DPAGEiP30050

PTM databases

iPTMnetiP30050
PhosphoSitePlusiP30050
SwissPalmiP30050

Expressioni

Gene expression databases

BgeeiENSG00000197958
CleanExiHS_RPL12
GenevisibleiP30050 HS

Organism-specific databases

HPAiHPA003403

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CANXP278243EBI-352743,EBI-355947

Protein-protein interaction databases

BioGridi112056, 166 interactors
CORUMiP30050
IntActiP30050, 48 interactors
MINTiP30050
STRINGi9606.ENSP00000354739

Structurei

3D structure databases

ProteinModelPortaliP30050
SMRiP30050
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0886 Eukaryota
COG0080 LUCA
GeneTreeiENSGT00390000006922
HOVERGENiHBG007231
InParanoidiP30050
KOiK02870
OMAiIKHNGNL
OrthoDBiEOG091G0PW6
PhylomeDBiP30050
TreeFamiTF300123

Family and domain databases

CDDicd00349 Ribosomal_L11, 1 hit
Gene3Di1.10.10.250, 1 hit
3.30.1550.10, 1 hit
HAMAPiMF_00736 Ribosomal_L11, 1 hit
InterProiView protein in InterPro
IPR000911 Ribosomal_L11/L12
IPR036796 Ribosomal_L11/L12_N_sf
IPR020783 Ribosomal_L11_C
IPR036769 Ribosomal_L11_C_sf
IPR020785 Ribosomal_L11_CS
IPR020784 Ribosomal_L11_N
PANTHERiPTHR11661 PTHR11661, 1 hit
PfamiView protein in Pfam
PF00298 Ribosomal_L11, 1 hit
PF03946 Ribosomal_L11_N, 1 hit
SMARTiView protein in SMART
SM00649 RL11, 1 hit
SUPFAMiSSF46906 SSF46906, 1 hit
SSF54747 SSF54747, 1 hit
PROSITEiView protein in PROSITE
PS00359 RIBOSOMAL_L11, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30050-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPKFDPNEI KVVYLRCTGG EVGATSALAP KIGPLGLSPK KVGDDIAKAT
60 70 80 90 100
GDWKGLRITV KLTIQNRQAQ IEVVPSASAL IIKALKEPPR DRKKQKNIKH
110 120 130 140 150
SGNITFDEIV NIARQMRHRS LARELSGTIK EILGTAQSVG CNVDGRHPHD
160
IIDDINSGAV ECPAS
Length:165
Mass (Da):17,819
Last modified:April 1, 1993 - v1
Checksum:i7EFD783A8ED350F9
GO
Isoform 2 (identifier: P30050-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-70: Missing.

Note: No experimental confirmation available.
Show »
Length:132
Mass (Da):14,199
Checksum:i1FDF4BEF878AD5D5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03469538 – 70Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06505 mRNA Translation: AAA36157.1
AL445222 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87669.1
BC050644 mRNA Translation: AAH50644.1
BC059950 mRNA Translation: AAH59950.1
BC094831 mRNA Translation: AAH94831.1
BC105603 mRNA Translation: AAI05604.1
CCDSiCCDS6872.1 [P30050-1]
PIRiS35531
RefSeqiNP_000967.1, NM_000976.3 [P30050-1]
UniGeneiHs.408054

Genome annotation databases

EnsembliENST00000361436; ENSP00000354739; ENSG00000197958 [P30050-1]
ENST00000536368; ENSP00000441179; ENSG00000197958 [P30050-2]
GeneIDi6136
KEGGihsa:6136
UCSCiuc004bqy.3 human [P30050-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRL12_HUMAN
AccessioniPrimary (citable) accession number: P30050
Secondary accession number(s): Q5VVV2, Q6PB27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 18, 2018
This is version 181 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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