ATP5F1D

Functionⁱ

Mitochondrial membrane ATP synthase (F₁F₀ ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F₁ - containing the extramembraneous catalytic core, and F₀ - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F₁ is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F₁ domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha₃beta₃ subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

GO - Molecular functionⁱ

ATPase activity
Source: UniProtKB
Non-traceable author statementⁱ
- 12539966
proton-transporting ATP synthase activity, rotational mechanism Source: InterPro
transmembrane transporter activity
Source: UniProtKB
Inferred by curatorⁱ
- 12110673
transporter activity
Source: UniProtKB
Non-traceable author statementⁱ
- 1531933

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ATP biosynthetic process Source: Reactome
ATP synthesis coupled proton transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cristae formation Source: Reactome
mitochondrial ATP synthesis coupled proton transport
Source: UniProtKB
Non-traceable author statementⁱ
- 12539966
oxidative phosphorylation
Source: UniProtKB
Non-traceable author statementⁱ
- 12539966
response to copper ion
Source: UniProtKB
Non-traceable author statementⁱ
- 12539966

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Biological process

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-163210 Formation of ATP by chemiosmotic coupling R-HSA-8949613 Cristae formation

Reactomeⁱ

R-HSA-163210 Formation of ATP by chemiosmotic coupling
R-HSA-8949613 Cristae formation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ATP synthase subunit delta, mitochondrialCurated Alternative name(s): ATP synthase F1 subunit deltaImported F-ATPase delta subunit
Gene namesⁱ	Name:ATP5F1DImported Synonyms:ATP5DImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000099624.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:837 ATP5F1D
MIMⁱ	603150 gene
neXtProtⁱ	NX_P30049

Keywords - Cellular componentⁱ

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	513
MalaCards human disease database More...MalaCardsⁱ	ATP5F1D
Open Targets More...OpenTargetsⁱ	ENSG00000099624
PharmGKBⁱ	PA25127

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB01189 Desflurane DB00228 Enflurane DB01159 Halothane DB00753 Isoflurane DB01028 Methoxyflurane DB01236 Sevoflurane

DrugBankⁱ

DB01189 Desflurane
DB00228 Enflurane
DB01159 Halothane
DB00753 Isoflurane
DB01028 Methoxyflurane
DB01236 Sevoflurane

Polymorphism and mutation databases

BioMutaⁱ	ATP5D
DMDMⁱ	584812

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 22	Mitochondrion1 PublicationAdd BLAST		22
ChainⁱPRO_0000002661	23 – 168	ATP synthase subunit delta, mitochondrialAdd BLAST		146

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	136	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	136	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	165	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	165	N6-succinyllysine; alternateBy similarity	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P30049
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P30049
PaxDbⁱ	P30049
PeptideAtlas More...PeptideAtlasⁱ	P30049
PRIDEⁱ	P30049
ProteomicsDBⁱ	54629
TopDownProteomicsⁱ	P30049

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P30049
SWISS-2DPAGEⁱ	P30049
UCD-2DPAGEⁱ	P30049

PTM databases

iPTMnetⁱ	P30049
PhosphoSitePlusⁱ	P30049

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000099624 Expressed in 233 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_ATP5D
ExpressionAtlasⁱ	P30049 baseline and differential
Genevisibleⁱ	P30049 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA002865

HPAⁱ

HPA002865

Interactionⁱ

Subunit structureⁱ

F-type ATPases have 2 components, CF₁ - the catalytic core - and CF₀ - the membrane proton channel. CF₁ has five subunits: alpha₃, beta₃, gamma₁, delta₁, epsilon₁. CF₀ seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MD and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	106998, 51 interactors
CORUMⁱ	P30049
IntActⁱ	P30049, 20 interactors
STRINGⁱ	9606.ENSP00000215375

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P30049
SMRⁱ	P30049
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ATPase epsilon chain family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1758 Eukaryota COG0355 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017576
HOGENOMⁱ	HOG000216023
HOVERGENⁱ	HBG001856
InParanoidⁱ	P30049
KEGG Orthology (KO) More...KOⁱ	K02134
OMAⁱ	AANKTFY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1AP6
PhylomeDBⁱ	P30049
TreeFamⁱ	TF313029

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12152 F1-ATPase_delta, 1 hit
Gene3Dⁱ	2.60.15.10, 1 hit
HAMAPⁱ	MF_00530 ATP_synth_epsil_bac, 1 hit
InterProⁱ	View protein in InterPro IPR036794 ATP_F1_dsu/esu_C_sf IPR001469 ATP_synth_F1_dsu/esu IPR020546 ATP_synth_F1_dsu/esu_N IPR036771 ATPsynth_dsu/esu_N
PANTHERⁱ	PTHR13822 PTHR13822, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02823 ATP-synt_DE_N, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD000944 ATPase_F1-cplx_dsu/esu, 1 hit
SUPFAMⁱ	SSF46604 SSF46604, 1 hit SSF51344 SSF51344, 1 hit
TIGRFAMsⁱ	TIGR01216 ATP_synt_epsi, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P30049-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLPAALLRRP GLGRLVRHAR AYAEAAAAPA AASGPNQMSF TFASPTQVFF 
        60         70         80         90        100
NGANVRQVDV PTLTGAFGIL AAHVPTLQVL RPGLVVVHAE DGTTSKYFVS 
       110        120        130        140        150
SGSIAVNADS SVQLLAEEAV TLDMLDLGAA KANLEKAQAE LVGTADEATR 
       160 
AEIQIRIEAN EALVKALE

Length:168

Mass (Da):17,490

Last modified:October 1, 1994 - v2

Checksum:ⁱB7F0D1D01ADFDFE7

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087WTL3	A0A087WTL3_HUMAN		ATP synthase subunit delta, mitocho... ATP synthase subunit delta, mitochondrial	ATP5F1D	99	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S87916 mRNA Translation: AAA08055.1 S87918 mRNA Translation: ABB76284.1 X63422 mRNA Translation: CAA45016.1 X63423 mRNA Translation: CAA45017.1 CR542218 mRNA Translation: CAG47014.1 AC004221 Genomic DNA Translation: AAC04304.1 CH471139 Genomic DNA Translation: EAW69532.1 CH471139 Genomic DNA Translation: EAW69533.1 CH471139 Genomic DNA Translation: EAW69534.1 BC002389 mRNA Translation: AAH02389.1 BC004426 mRNA Translation: AAH04426.1 BC018079 mRNA Translation: AAH18079.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12058.1
PIRⁱ	S22348
NCBI Reference Sequences More...RefSeqⁱ	NP_001001975.1, NM_001001975.1 NP_001678.1, NM_001687.4
UniGeneⁱ	Hs.418668

Genome annotation databases

Ensemblⁱ	ENST00000215375; ENSP00000215375; ENSG00000099624 ENST00000395633; ENSP00000378995; ENSG00000099624 ENST00000591660; ENSP00000464863; ENSG00000099624
GeneIDⁱ	513
KEGGⁱ	hsa:513
UCSC genome browser More...UCSCⁱ	uc002lrn.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P30049	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit		PANTR		168	UniRef100_P30049

Protein	Similar proteins		Species	Score	Length	Source
P30049	ATP synthase subunit delta, mitochondrial		RAT		168	UniRef90_P35434
ATP synthase subunit delta, mitochondrial	)	BOVIN		168
ATP synthase subunit delta, mitochondrial		MESAU		170
ATP synthase subunit delta, mitochondrial (Fragment)		wild yak		169
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit		PANTR		168
+70

Protein	Similar proteins		Species	Score	Length	Source
P30049	ATP synthase subunit delta, mitochondrial		RAT		168	UniRef50_P35434
ATP synthase subunit delta, mitochondrial	)	BOVIN		168
ATP synthase subunit delta, mitochondrial		MESAU		170
ATP synthase subunit delta, mitochondrial (Fragment)		wild yak		169
ATP synthase subunit delta, mitochondrial		Enhydra lutris kenyoni		168
+182

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S87916 mRNA Translation: AAA08055.1 S87918 mRNA Translation: ABB76284.1 X63422 mRNA Translation: CAA45016.1 X63423 mRNA Translation: CAA45017.1 CR542218 mRNA Translation: CAG47014.1 AC004221 Genomic DNA Translation: AAC04304.1 CH471139 Genomic DNA Translation: EAW69532.1 CH471139 Genomic DNA Translation: EAW69533.1 CH471139 Genomic DNA Translation: EAW69534.1 BC002389 mRNA Translation: AAH02389.1 BC004426 mRNA Translation: AAH04426.1 BC018079 mRNA Translation: AAH18079.1
CCDSⁱ	CCDS12058.1
PIRⁱ	S22348
RefSeqⁱ	NP_001001975.1, NM_001001975.1 NP_001678.1, NM_001687.4
UniGeneⁱ	Hs.418668

3D structure databases

ProteinModelPortalⁱ	P30049
SMRⁱ	P30049
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106998, 51 interactors
CORUMⁱ	P30049
IntActⁱ	P30049, 20 interactors
STRINGⁱ	9606.ENSP00000215375

Chemistry databases

DrugBankⁱ	DB01189 Desflurane DB00228 Enflurane DB01159 Halothane DB00753 Isoflurane DB01028 Methoxyflurane DB01236 Sevoflurane

DrugBankⁱ

DB01189 Desflurane
DB00228 Enflurane
DB01159 Halothane
DB00753 Isoflurane
DB01028 Methoxyflurane
DB01236 Sevoflurane

PTM databases

iPTMnetⁱ	P30049
PhosphoSitePlusⁱ	P30049

Polymorphism and mutation databases

BioMutaⁱ	ATP5D
DMDMⁱ	584812

2D gel databases

OGPⁱ	P30049
SWISS-2DPAGEⁱ	P30049
UCD-2DPAGEⁱ	P30049

Proteomic databases

EPDⁱ	P30049
MaxQBⁱ	P30049
PaxDbⁱ	P30049
PeptideAtlasⁱ	P30049
PRIDEⁱ	P30049
ProteomicsDBⁱ	54629
TopDownProteomicsⁱ	P30049

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000215375; ENSP00000215375; ENSG00000099624 ENST00000395633; ENSP00000378995; ENSG00000099624 ENST00000591660; ENSP00000464863; ENSG00000099624
GeneIDⁱ	513
KEGGⁱ	hsa:513
UCSCⁱ	uc002lrn.4 human

Organism-specific databases

CTDⁱ	513
DisGeNETⁱ	513
EuPathDBⁱ	HostDB:ENSG00000099624.7
GeneCardsⁱ	ATP5F1D
HGNCⁱ	HGNC:837 ATP5F1D
HPAⁱ	HPA002865
MalaCardsⁱ	ATP5F1D
MIMⁱ	603150 gene
neXtProtⁱ	NX_P30049
OpenTargetsⁱ	ENSG00000099624
PharmGKBⁱ	PA25127
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1758 Eukaryota COG0355 LUCA
GeneTreeⁱ	ENSGT00390000017576
HOGENOMⁱ	HOG000216023
HOVERGENⁱ	HBG001856
InParanoidⁱ	P30049
KOⁱ	K02134
OMAⁱ	AANKTFY
OrthoDBⁱ	EOG091G1AP6
PhylomeDBⁱ	P30049
TreeFamⁱ	TF313029

Enzyme and pathway databases

Reactomeⁱ	R-HSA-163210 Formation of ATP by chemiosmotic coupling R-HSA-8949613 Cristae formation

Reactomeⁱ

R-HSA-163210 Formation of ATP by chemiosmotic coupling
R-HSA-8949613 Cristae formation

Miscellaneous databases

ChiTaRSⁱ	ATP5D human
GeneWikiⁱ	ATP5D
GenomeRNAiⁱ	513
Protein Ontology More...PROⁱ	PR:P30049
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000099624 Expressed in 233 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_ATP5D
ExpressionAtlasⁱ	P30049 baseline and differential
Genevisibleⁱ	P30049 HS

Family and domain databases

CDDⁱ	cd12152 F1-ATPase_delta, 1 hit
Gene3Dⁱ	2.60.15.10, 1 hit
HAMAPⁱ	MF_00530 ATP_synth_epsil_bac, 1 hit
InterProⁱ	View protein in InterPro IPR036794 ATP_F1_dsu/esu_C_sf IPR001469 ATP_synth_F1_dsu/esu IPR020546 ATP_synth_F1_dsu/esu_N IPR036771 ATPsynth_dsu/esu_N
PANTHERⁱ	PTHR13822 PTHR13822, 1 hit
Pfamⁱ	View protein in Pfam PF02823 ATP-synt_DE_N, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD000944 ATPase_F1-cplx_dsu/esu, 1 hit
SUPFAMⁱ	SSF46604 SSF46604, 1 hit SSF51344 SSF51344, 1 hit
TIGRFAMsⁱ	TIGR01216 ATP_synt_epsi, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ATPD_HUMAN
Accessionⁱ	P30049Primary (citable) accession number: P30049 Secondary accession number(s): D6W5Y3, Q6FG90
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	October 1, 1994
	Last modified:	November 7, 2018
	This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - P30049 (ATPD_HUMAN)

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ATP synthase subunit delta, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ