Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P30049 (ATPD_HUMAN)

Entry version 199 (07 Apr 2021)
Sequence version 2 (01 Oct 1994)
Previous versions | rss
Add a publicationFeedback
Protein

ATP synthase subunit delta, mitochondrial

Gene

ATP5F1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:29478781). F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (PubMed:1531933).1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS01900-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P30049

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-163210, Formation of ATP by chemiosmotic coupling
R-HSA-8949613, Cristae formation

SIGNOR Signaling Network Open Resource

More...SIGNORi		P30049

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP synthase subunit delta, mitochondrialCurated
Alternative name(s):
ATP synthase F1 subunit deltaImported
F-ATPase delta subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP5F1DImported
Synonyms:ATP5DImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:837, ATP5F1D

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603150, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P30049

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000099624.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mitochondrial complex V deficiency, nuclear type 5 (MC5DN5)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA mitochondrial disorder characterized by childhood onset of episodic metabolic decompensation featuring lactic acidosis and hyperammonemia accompanied by ketoacidosis or hypoglycemia. Chronic manifestations include developmental delay, easy fatiguability, and 3-methylglutaconic aciduria. The transmission pattern of MC5DN5 is consistent with autosomal recessive inheritance.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08145282P → L in MC5DN5; no effect on protein abundance; decreased mitochondrial proton-transporting ATP synthase complex assembly; decreased aerobic respiration in patient cells homozygous for the mutation; partial loss of function confirmed by complementation assays. 1 PublicationCorresponds to variant dbSNP:rs867410737EnsemblClinVar.1
Natural variantiVAR_081453106V → G in MC5DN5; no effect on protein abundance; decreased mitochondrial proton-transporting ATP synthase complex assembly; decreased aerobic respiration in patient cells homozygous for the mutation; partial loss of function confirmed by complementation assays. 1 PublicationCorresponds to variant dbSNP:rs1555745989EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...DisGeNETi		513

MalaCards human disease database

More...MalaCardsi		ATP5F1D
MIMi618120, phenotype

Open Targets

More...OpenTargetsi		ENSG00000099624

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25127

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P30049, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01189, Desflurane
DB00753, Isoflurane
DB13749, Magnesium gluconate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATP5D

Domain mapping of disease mutations (DMDM)

More...DMDMi		584812

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 22Mitochondrion1 PublicationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000266123 – 168ATP synthase subunit delta, mitochondrialAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei136N6-acetyllysine; alternateBy similarity1
Modified residuei136N6-succinyllysine; alternateBy similarity1
Modified residuei165N6-acetyllysine; alternateBy similarity1
Modified residuei165N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P30049

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P30049

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P30049

MaxQB - The MaxQuant DataBase

More...MaxQBi		P30049

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P30049

PeptideAtlas

More...PeptideAtlasi		P30049

PRoteomics IDEntifications database

More...PRIDEi		P30049

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54629

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P30049

2D gel databases

USC-OGP 2-DE database

More...OGPi		P30049

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P30049

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P30049

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P30049

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P30049

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000099624, Expressed in apex of heart and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P30049, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P30049, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000099624, Tissue enriched (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L).

Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106998, 112 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P30049

Protein interaction database and analysis system

More...IntActi		P30049, 60 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000215375

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P30049, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P30049

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATPase epsilon chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1758, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017576

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_084338_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P30049

Identification of Orthologs from Complete Genome Data

More...OMAi		PHQAIYK

Database of Orthologous Groups

More...OrthoDBi		1286602at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P30049

TreeFam database of animal gene trees

More...TreeFami		TF313029

Family and domain databases

Conserved Domains Database

More...CDDi		cd12152, F1-ATPase_delta, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.15.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00530, ATP_synth_epsil_bac, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036794, ATP_F1_dsu/esu_C_sf
IPR001469, ATP_synth_F1_dsu/esu
IPR020546, ATP_synth_F1_dsu/esu_N
IPR036771, ATPsynth_dsu/esu_N

The PANTHER Classification System

More...PANTHERi		PTHR13822, PTHR13822, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02823, ATP-synt_DE_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46604, SSF46604, 1 hit
SSF51344, SSF51344, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01216, ATP_synt_epsi, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P30049-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPAALLRRP GLGRLVRHAR AYAEAAAAPA AASGPNQMSF TFASPTQVFF 
        60         70         80         90        100
NGANVRQVDV PTLTGAFGIL AAHVPTLQVL RPGLVVVHAE DGTTSKYFVS 
       110        120        130        140        150
SGSIAVNADS SVQLLAEEAV TLDMLDLGAA KANLEKAQAE LVGTADEATR 
       160 
AEIQIRIEAN EALVKALE
Length:168
Mass (Da):17,490
Last modified:October 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7F0D1D01ADFDFE7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTL3A0A087WTL3_HUMAN
ATP synthase F1 subunit delta
ATP5F1D
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08145282P → L in MC5DN5; no effect on protein abundance; decreased mitochondrial proton-transporting ATP synthase complex assembly; decreased aerobic respiration in patient cells homozygous for the mutation; partial loss of function confirmed by complementation assays. 1 PublicationCorresponds to variant dbSNP:rs867410737EnsemblClinVar.1
Natural variantiVAR_081453106V → G in MC5DN5; no effect on protein abundance; decreased mitochondrial proton-transporting ATP synthase complex assembly; decreased aerobic respiration in patient cells homozygous for the mutation; partial loss of function confirmed by complementation assays. 1 PublicationCorresponds to variant dbSNP:rs1555745989EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S87916 mRNA Translation: AAA08055.1
S87918 mRNA Translation: ABB76284.1
X63422 mRNA Translation: CAA45016.1
X63423 mRNA Translation: CAA45017.1
CR542218 mRNA Translation: CAG47014.1
AC004221 Genomic DNA Translation: AAC04304.1
CH471139 Genomic DNA Translation: EAW69532.1
CH471139 Genomic DNA Translation: EAW69533.1
CH471139 Genomic DNA Translation: EAW69534.1
BC002389 mRNA Translation: AAH02389.1
BC004426 mRNA Translation: AAH04426.1
BC018079 mRNA Translation: AAH18079.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12058.1

Protein sequence database of the Protein Information Resource

More...PIRi		S22348

NCBI Reference Sequences

More...RefSeqi		NP_001001975.1, NM_001001975.1
NP_001678.1, NM_001687.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000215375; ENSP00000215375; ENSG00000099624
ENST00000395633; ENSP00000378995; ENSG00000099624
ENST00000591660; ENSP00000464863; ENSG00000099624

Database of genes from NCBI RefSeq genomes

More...GeneIDi		513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:513

UCSC genome browser

More...UCSCi		uc002lrn.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S87916 mRNA Translation: AAA08055.1
S87918 mRNA Translation: ABB76284.1
X63422 mRNA Translation: CAA45016.1
X63423 mRNA Translation: CAA45017.1
CR542218 mRNA Translation: CAG47014.1
AC004221 Genomic DNA Translation: AAC04304.1
CH471139 Genomic DNA Translation: EAW69532.1
CH471139 Genomic DNA Translation: EAW69533.1
CH471139 Genomic DNA Translation: EAW69534.1
BC002389 mRNA Translation: AAH02389.1
BC004426 mRNA Translation: AAH04426.1
BC018079 mRNA Translation: AAH18079.1
CCDSiCCDS12058.1
PIRiS22348
RefSeqiNP_001001975.1, NM_001001975.1
NP_001678.1, NM_001687.4

3D structure databases

SMRiP30049
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106998, 112 interactors
CORUMiP30049
IntActiP30049, 60 interactors
STRINGi9606.ENSP00000215375

Chemistry databases

DrugBankiDB01189, Desflurane
DB00753, Isoflurane
DB13749, Magnesium gluconate

PTM databases

iPTMnetiP30049
PhosphoSitePlusiP30049

Genetic variation databases

BioMutaiATP5D
DMDMi584812

2D gel databases

OGPiP30049
SWISS-2DPAGEiP30049
UCD-2DPAGEiP30049

Proteomic databases

EPDiP30049
jPOSTiP30049
MassIVEiP30049
MaxQBiP30049
PaxDbiP30049
PeptideAtlasiP30049
PRIDEiP30049
ProteomicsDBi54629
TopDownProteomicsiP30049

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1258, 303 antibodies

Genome annotation databases

EnsembliENST00000215375; ENSP00000215375; ENSG00000099624
ENST00000395633; ENSP00000378995; ENSG00000099624
ENST00000591660; ENSP00000464863; ENSG00000099624
GeneIDi513
KEGGihsa:513
UCSCiuc002lrn.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		513
DisGeNETi513

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATP5F1D
HGNCiHGNC:837, ATP5F1D
HPAiENSG00000099624, Tissue enriched (skeletal)
MalaCardsiATP5F1D
MIMi603150, gene
618120, phenotype
neXtProtiNX_P30049
OpenTargetsiENSG00000099624
PharmGKBiPA25127
VEuPathDBiHostDB:ENSG00000099624.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1758, Eukaryota
GeneTreeiENSGT00390000017576
HOGENOMiCLU_084338_0_1_1
InParanoidiP30049
OMAiPHQAIYK
OrthoDBi1286602at2759
PhylomeDBiP30049
TreeFamiTF313029

Enzyme and pathway databases

BioCyciMetaCyc:HS01900-MONOMER
PathwayCommonsiP30049
ReactomeiR-HSA-163210, Formation of ATP by chemiosmotic coupling
R-HSA-8949613, Cristae formation
SIGNORiP30049

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		513, 621 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATP5D, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ATP5D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		513
PharosiP30049, Tbio

Protein Ontology

More...PROi		PR:P30049
RNActiP30049, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000099624, Expressed in apex of heart and 244 other tissues
ExpressionAtlasiP30049, baseline and differential
GenevisibleiP30049, HS

Family and domain databases

CDDicd12152, F1-ATPase_delta, 1 hit
Gene3Di2.60.15.10, 1 hit
HAMAPiMF_00530, ATP_synth_epsil_bac, 1 hit
InterProiView protein in InterPro
IPR036794, ATP_F1_dsu/esu_C_sf
IPR001469, ATP_synth_F1_dsu/esu
IPR020546, ATP_synth_F1_dsu/esu_N
IPR036771, ATPsynth_dsu/esu_N
PANTHERiPTHR13822, PTHR13822, 1 hit
PfamiView protein in Pfam
PF02823, ATP-synt_DE_N, 1 hit
SUPFAMiSSF46604, SSF46604, 1 hit
SSF51344, SSF51344, 1 hit
TIGRFAMsiTIGR01216, ATP_synt_epsi, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATPD_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30049
Secondary accession number(s): D6W5Y3, Q6FG90
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 1, 1994
Last modified: April 7, 2021
This is version 199 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again