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Protein

ATP synthase subunit delta, mitochondrial

Gene

ATP5F1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • proton-transporting ATP synthase activity, rotational mechanism Source: InterPro
  • transmembrane transporter activity Source: UniProtKB
  • transporter activity Source: UniProtKB

GO - Biological processi

  • ATP biosynthetic process Source: Reactome
  • ATP synthesis coupled proton transport Source: GO_Central
  • cristae formation Source: Reactome
  • mitochondrial ATP synthesis coupled proton transport Source: UniProtKB
  • oxidative phosphorylation Source: UniProtKB
  • response to copper ion Source: UniProtKB

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-163210 Formation of ATP by chemiosmotic coupling
R-HSA-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit delta, mitochondrialCurated
Alternative name(s):
ATP synthase F1 subunit deltaImported
F-ATPase delta subunit
Gene namesi
Name:ATP5F1DImported
Synonyms:ATP5DImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000099624.7
HGNCiHGNC:837 ATP5F1D
MIMi603150 gene
neXtProtiNX_P30049

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi513
OpenTargetsiENSG00000099624
PharmGKBiPA25127

Chemistry databases

DrugBankiDB01189 Desflurane
DB00228 Enflurane
DB01159 Halothane
DB00753 Isoflurane
DB01028 Methoxyflurane
DB01236 Sevoflurane

Polymorphism and mutation databases

BioMutaiATP5D
DMDMi584812

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22Mitochondrion1 PublicationAdd BLAST22
ChainiPRO_000000266123 – 168ATP synthase subunit delta, mitochondrialAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136N6-acetyllysine; alternateBy similarity1
Modified residuei136N6-succinyllysine; alternateBy similarity1
Modified residuei165N6-acetyllysine; alternateBy similarity1
Modified residuei165N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP30049
MaxQBiP30049
PaxDbiP30049
PeptideAtlasiP30049
PRIDEiP30049
ProteomicsDBi54629
TopDownProteomicsiP30049

2D gel databases

OGPiP30049
SWISS-2DPAGEiP30049
UCD-2DPAGEiP30049

PTM databases

iPTMnetiP30049
PhosphoSitePlusiP30049

Expressioni

Gene expression databases

BgeeiENSG00000099624
CleanExiHS_ATP5D
ExpressionAtlasiP30049 baseline and differential
GenevisibleiP30049 HS

Organism-specific databases

HPAiHPA002865

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5ME, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi106998, 51 interactors
CORUMiP30049
IntActiP30049, 24 interactors
STRINGi9606.ENSP00000215375

Structurei

3D structure databases

ProteinModelPortaliP30049
SMRiP30049
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase epsilon chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1758 Eukaryota
COG0355 LUCA
GeneTreeiENSGT00390000017576
HOGENOMiHOG000216023
HOVERGENiHBG001856
InParanoidiP30049
KOiK02134
OMAiAANKTFY
OrthoDBiEOG091G1AP6
PhylomeDBiP30049
TreeFamiTF313029

Family and domain databases

CDDicd12152 F1-ATPase_delta, 1 hit
Gene3Di2.60.15.10, 1 hit
HAMAPiMF_00530 ATP_synth_epsil_bac, 1 hit
InterProiView protein in InterPro
IPR036794 ATP_F1_dsu/esu_C_sf
IPR001469 ATP_synth_F1_dsu/esu
IPR020546 ATP_synth_F1_dsu/esu_N
IPR036771 ATPsynth_dsu/esu_N
PANTHERiPTHR13822 PTHR13822, 1 hit
PfamiView protein in Pfam
PF02823 ATP-synt_DE_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000944 ATPase_F1-cplx_dsu/esu, 1 hit
SUPFAMiSSF46604 SSF46604, 1 hit
SSF51344 SSF51344, 1 hit
TIGRFAMsiTIGR01216 ATP_synt_epsi, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPAALLRRP GLGRLVRHAR AYAEAAAAPA AASGPNQMSF TFASPTQVFF
60 70 80 90 100
NGANVRQVDV PTLTGAFGIL AAHVPTLQVL RPGLVVVHAE DGTTSKYFVS
110 120 130 140 150
SGSIAVNADS SVQLLAEEAV TLDMLDLGAA KANLEKAQAE LVGTADEATR
160
AEIQIRIEAN EALVKALE
Length:168
Mass (Da):17,490
Last modified:October 1, 1994 - v2
Checksum:iB7F0D1D01ADFDFE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S87916 mRNA Translation: AAA08055.1
S87918 mRNA Translation: ABB76284.1
X63422 mRNA Translation: CAA45016.1
X63423 mRNA Translation: CAA45017.1
CR542218 mRNA Translation: CAG47014.1
AC004221 Genomic DNA Translation: AAC04304.1
CH471139 Genomic DNA Translation: EAW69532.1
CH471139 Genomic DNA Translation: EAW69533.1
CH471139 Genomic DNA Translation: EAW69534.1
BC002389 mRNA Translation: AAH02389.1
BC004426 mRNA Translation: AAH04426.1
BC018079 mRNA Translation: AAH18079.1
CCDSiCCDS12058.1
PIRiS22348
RefSeqiNP_001001975.1, NM_001001975.1
NP_001678.1, NM_001687.4
UniGeneiHs.418668

Genome annotation databases

EnsembliENST00000215375; ENSP00000215375; ENSG00000099624
ENST00000395633; ENSP00000378995; ENSG00000099624
ENST00000591660; ENSP00000464863; ENSG00000099624
GeneIDi513
KEGGihsa:513
UCSCiuc002lrn.4 human

Similar proteinsi

Entry informationi

Entry nameiATPD_HUMAN
AccessioniPrimary (citable) accession number: P30049
Secondary accession number(s): D6W5Y3, Q6FG90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 1, 1994
Last modified: July 18, 2018
This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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