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Protein

Peroxiredoxin-5, mitochondrial

Gene

PRDX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.3 Publications

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys Prx, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei100Cysteine sulfenic acid (-SOH) intermediate2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.11.1.15 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-5628897 TP53 Regulates Metabolic Genes

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P30044

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
4448 HsPrxV

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxiredoxin-5, mitochondrial (EC:1.11.1.151 Publication)
Alternative name(s):
Alu corepressor 1
Antioxidant enzyme B166
Short name:
AOEB166
Liver tissue 2D-page spot 71B
PLP
Peroxiredoxin V
Short name:
Prx-V
Peroxisomal antioxidant enzyme
TPx type VI
Thioredoxin peroxidase PMP20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRDX5
Synonyms:ACR1
ORF Names:SBBI10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000126432.13

Human Gene Nomenclature Database

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HGNCi
HGNC:9355 PRDX5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606583 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P30044

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi100C → S: Complete loss of activity. 1 Publication1
Mutagenesisi125C → S: No change in activity. 1 Publication1
Mutagenesisi204C → S: Complete loss of activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
25824

Open Targets

More...
OpenTargetsi
ENSG00000126432

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33726

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3627586

Drug and drug target database

More...
DrugBanki
DB00995 Auranofin
DB03793 Benzoic Acid
DB03608 Diminazene

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRDX5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373539

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 52MitochondrionSequence analysisAdd BLAST52
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002379353 – 214Peroxiredoxin-5, mitochondrialAdd BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75N6-acetyllysineBy similarity1
Modified residuei83N6-acetyllysine; alternateCombined sources1
Modified residuei83N6-succinyllysine; alternateBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi100 ↔ 204Redox-activePROSITE-ProRule annotation2 Publications
Modified residuei116N6-succinyllysineBy similarity1
Modified residuei171PhosphoserineBy similarity1
Modified residuei182PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P30044

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P30044

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30044

PeptideAtlas

More...
PeptideAtlasi
P30044

PRoteomics IDEntifications database

More...
PRIDEi
P30044

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54624
54625 [P30044-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P30044-1 [P30044-1]
P30044-2 [P30044-2]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P30044

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00759663

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P30044

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P30044

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30044

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P30044

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P30044

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126432 Expressed in 191 organ(s), highest expression level in bronchial epithelial cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_PRDX5

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P30044 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB008661
HPA037915
HPA037916

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SOD1P0044110EBI-722161,EBI-990792

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117352, 80 interactors

Protein interaction database and analysis system

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IntActi
P30044, 33 interactors

Molecular INTeraction database

More...
MINTi
P30044

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265462

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P30044

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P30044

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P30044

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 214ThioredoxinPROSITE-ProRule annotationAdd BLAST159

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi212 – 214Microbody targeting signal1 Publication3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxiredoxin family. Prx5 subfamily.Curated

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0541 Eukaryota
COG0678 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018173

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000255884

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053675

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P30044

KEGG Orthology (KO)

More...
KOi
K11187

Identification of Orthologs from Complete Genome Data

More...
OMAi
QRYAMVV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0OSA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P30044

TreeFam database of animal gene trees

More...
TreeFami
TF105182

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03013 PRX5_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037944 PRX5-like
IPR013740 Redoxin
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10430 PTHR10430, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08534 Redoxin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833 SSF52833, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51352 THIOREDOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket
Isoform Mitochondrial (identifier: P30044-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLAGVCALR RSAGYILVGG AGGQSAAAAA RRYSEGEWAS GGVRSFSRAA
60 70 80 90 100
AAMAPIKVGD AIPAVEVFEG EPGNKVNLAE LFKGKKGVLF GVPGAFTPGC
110 120 130 140 150
SKTHLPGFVE QAEALKAKGV QVVACLSVND AFVTGEWGRA HKAEGKVRLL
160 170 180 190 200
ADPTGAFGKE TDLLLDDSLV SIFGNRRLKR FSMVVQDGIV KALNVEPDGT
210
GLTCSLAPNI ISQL
Length:214
Mass (Da):22,086
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA1DEB21120254EE
GO
Isoform Cytoplasmic+peroxisomal (identifier: P30044-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Show »
Length:162
Mass (Da):17,031
Checksum:i370DF621012F880D
GO
Isoform 3 (identifier: P30044-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-145: Missing.

Note: No experimental confirmation available.
Show »
Length:170
Mass (Da):17,454
Checksum:i29984B81B33F82C1
GO
Isoform 4 (identifier: P30044-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-145: Missing.

Note: Produced by alternative splicing.
Show »
Length:125
Mass (Da):12,897
Checksum:iF3A1C1531E4E4A73
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF17200 differs from that shown. Reason: Frameshift at positions 14 and 30.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141H → T in AAF04856 (PubMed:10679306).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02504933Y → C7 PublicationsCorresponds to variant dbSNP:rs7938623Ensembl.1
Natural variantiVAR_036406157F → L in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0188291 – 52Missing in isoform Cytoplasmic+peroxisomal. 4 PublicationsAdd BLAST52
Alternative sequenceiVSP_04668257 – 145Missing in isoform 4. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_045783102 – 145Missing in isoform 3. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF231705 mRNA Translation: AAF78899.1
AF124993 mRNA Translation: AAF27531.1
AF110731 mRNA Translation: AAF03750.1
AF197952 mRNA Translation: AAF04856.1
AJ249483 mRNA Translation: CAB62210.1
AF242525 mRNA Translation: AAF99605.1
AF112212 mRNA Translation: AAF17200.1 Frameshift.
CR457203 mRNA Translation: CAG33484.1
DQ247769 Genomic DNA Translation: ABB05181.1
AP001453 Genomic DNA No translation available.
AP003774 Genomic DNA No translation available.
BC110983 mRNA Translation: AAI10984.1
BC113723 mRNA Translation: AAI13724.1
BC113725 mRNA Translation: AAI13726.1
BC143849 mRNA Translation: AAI43850.1
BC171733 mRNA Translation: AAI71733.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8069.1 [P30044-1]
CCDS8070.1 [P30044-3]
CCDS8071.1 [P30044-4]

NCBI Reference Sequences

More...
RefSeqi
NP_036226.1, NM_012094.4
NP_857634.1, NM_181651.2
NP_857635.1, NM_181652.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.502823

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265462; ENSP00000265462; ENSG00000126432 [P30044-1]
ENST00000347941; ENSP00000335363; ENSG00000126432 [P30044-4]
ENST00000352435; ENSP00000335334; ENSG00000126432 [P30044-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25824

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:25824

UCSC genome browser

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UCSCi
uc001nzu.4 human [P30044-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231705 mRNA Translation: AAF78899.1
AF124993 mRNA Translation: AAF27531.1
AF110731 mRNA Translation: AAF03750.1
AF197952 mRNA Translation: AAF04856.1
AJ249483 mRNA Translation: CAB62210.1
AF242525 mRNA Translation: AAF99605.1
AF112212 mRNA Translation: AAF17200.1 Frameshift.
CR457203 mRNA Translation: CAG33484.1
DQ247769 Genomic DNA Translation: ABB05181.1
AP001453 Genomic DNA No translation available.
AP003774 Genomic DNA No translation available.
BC110983 mRNA Translation: AAI10984.1
BC113723 mRNA Translation: AAI13724.1
BC113725 mRNA Translation: AAI13726.1
BC143849 mRNA Translation: AAI43850.1
BC171733 mRNA Translation: AAI71733.1
CCDSiCCDS8069.1 [P30044-1]
CCDS8070.1 [P30044-3]
CCDS8071.1 [P30044-4]
RefSeqiNP_036226.1, NM_012094.4
NP_857634.1, NM_181651.2
NP_857635.1, NM_181652.2
UniGeneiHs.502823

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H4OX-ray1.95A/B/C/D/E/F/G/H54-214[»]
1HD2X-ray1.50A54-214[»]
1OC3X-ray2.00A/B/C54-214[»]
1URMX-ray1.70A54-214[»]
2VL2X-ray1.92A/B/C54-214[»]
2VL3X-ray1.83A/B/C54-214[»]
2VL9X-ray2.70A/B/C/D54-214[»]
3MNGX-ray1.45A54-214[»]
4K7IX-ray2.25A/B/C54-214[»]
4K7NX-ray2.30A/B/C54-214[»]
4K7OX-ray1.98A/B/C54-214[»]
4MMMX-ray1.47A/C/E/G54-214[»]
ProteinModelPortaliP30044
SMRiP30044
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117352, 80 interactors
IntActiP30044, 33 interactors
MINTiP30044
STRINGi9606.ENSP00000265462

Chemistry databases

ChEMBLiCHEMBL3627586
DrugBankiDB00995 Auranofin
DB03793 Benzoic Acid
DB03608 Diminazene

Protein family/group databases

PeroxiBasei4448 HsPrxV

PTM databases

iPTMnetiP30044
PhosphoSitePlusiP30044
SwissPalmiP30044

Polymorphism and mutation databases

BioMutaiPRDX5
DMDMi317373539

2D gel databases

OGPiP30044
REPRODUCTION-2DPAGEiIPI00759663
SWISS-2DPAGEiP30044
UCD-2DPAGEiP30044

Proteomic databases

EPDiP30044
MaxQBiP30044
PaxDbiP30044
PeptideAtlasiP30044
PRIDEiP30044
ProteomicsDBi54624
54625 [P30044-2]
TopDownProteomicsiP30044-1 [P30044-1]
P30044-2 [P30044-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
25824
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265462; ENSP00000265462; ENSG00000126432 [P30044-1]
ENST00000347941; ENSP00000335363; ENSG00000126432 [P30044-4]
ENST00000352435; ENSP00000335334; ENSG00000126432 [P30044-3]
GeneIDi25824
KEGGihsa:25824
UCSCiuc001nzu.4 human [P30044-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25824
DisGeNETi25824
EuPathDBiHostDB:ENSG00000126432.13

GeneCards: human genes, protein and diseases

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GeneCardsi
PRDX5
HGNCiHGNC:9355 PRDX5
HPAiCAB008661
HPA037915
HPA037916
MIMi606583 gene
neXtProtiNX_P30044
OpenTargetsiENSG00000126432
PharmGKBiPA33726

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0541 Eukaryota
COG0678 LUCA
GeneTreeiENSGT00390000018173
HOGENOMiHOG000255884
HOVERGENiHBG053675
InParanoidiP30044
KOiK11187
OMAiQRYAMVV
OrthoDBiEOG091G0OSA
PhylomeDBiP30044
TreeFamiTF105182

Enzyme and pathway databases

BRENDAi1.11.1.15 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-5628897 TP53 Regulates Metabolic Genes
SIGNORiP30044

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PRDX5 human
EvolutionaryTraceiP30044

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PRDX5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25824

Protein Ontology

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PROi
PR:P30044

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126432 Expressed in 191 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_PRDX5
GenevisibleiP30044 HS

Family and domain databases

CDDicd03013 PRX5_like, 1 hit
InterProiView protein in InterPro
IPR037944 PRX5-like
IPR013740 Redoxin
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PANTHERiPTHR10430 PTHR10430, 1 hit
PfamiView protein in Pfam
PF08534 Redoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51352 THIOREDOXIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRDX5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30044
Secondary accession number(s): A6NC19
, A6NG06, B7ZLJ4, B7ZVW3, Q14CK0, Q6IAF2, Q9UBU5, Q9UJU4, Q9UKX4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 11, 2011
Last modified: December 5, 2018
This is version 198 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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