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UniProtKB - P30044 (PRDX5_HUMAN)

Entry version 214 (02 Dec 2020)
Sequence version 4 (11 Jan 2011)
Previous versions | rss
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Protein

Peroxiredoxin-5, mitochondrial

Gene

PRDX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.4 Publications

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys Prx, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei100Cysteine sulfenic acid (-SOH) intermediate2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS05016-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.11.1.15, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P30044

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3299685, Detoxification of Reactive Oxygen Species
R-HSA-5628897, TP53 Regulates Metabolic Genes [P30044-2]

SIGNOR Signaling Network Open Resource

More...SIGNORi		P30044

Protein family/group databases

PeroxiBase, a peroxidase database

More...PeroxiBasei		4448, HsPrxV

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxiredoxin-5, mitochondrial (EC:1.11.1.241 Publication)
Alternative name(s):
Alu corepressor 1
Antioxidant enzyme B166
Short name:
AOEB166
Liver tissue 2D-page spot 71B
PLP
Peroxiredoxin V
Short name:
Prx-V
Peroxisomal antioxidant enzyme
TPx type VI
Thioredoxin peroxidase PMP20
Thioredoxin-dependent peroxiredoxin 5Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRDX5Imported
Synonyms:ACR1
ORF Names:SBBI10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000126432.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:9355, PRDX5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606583, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P30044

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi100C → S: Loss of antioxidant activity. Loss of S-palmitoylation. 2 Publications1
Mutagenesisi125C → S: No change in antioxidant activity. No change in S-palmitoylation levels. 2 Publications1
Mutagenesisi204C → S: Loss of antioxidant activity. No change in S-palmitoylation levels. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		25824

Open Targets

More...OpenTargetsi		ENSG00000126432

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33726

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P30044, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3627586

Drug and drug target database

More...DrugBanki		DB00995, Auranofin
DB03608, Diminazene
DB09221, Polaprezinc

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRDX5

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373539

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 52MitochondrionSequence analysisAdd BLAST52
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002379353 – 214Peroxiredoxin-5, mitochondrialAdd BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75N6-acetyllysineBy similarity1
Modified residuei83N6-acetyllysine; alternateCombined sources1
Modified residuei83N6-succinyllysine; alternateBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi100 ↔ 204Redox-activePROSITE-ProRule annotation2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi100S-palmitoyl cysteine1 Publication1
Modified residuei116N6-succinyllysineBy similarity1
Modified residuei171PhosphoserineBy similarity1
Modified residuei182PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

S-palmitoylated (PubMed:31740833). Palmitoylation occurs on the active site, inhibiting its reactivity; therefore PRDX5 palmitoylation status determines its antioxidant capacity (PubMed:31740833).1 Publication
S-palmitoylated (PubMed:31740833). Depalmitoylated by ABHD10 (PubMed:31740833).1 Publication

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-572

Encyclopedia of Proteome Dynamics

More...EPDi		P30044

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P30044

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P30044

MaxQB - The MaxQuant DataBase

More...MaxQBi		P30044

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P30044

PeptideAtlas

More...PeptideAtlasi		P30044

PRoteomics IDEntifications database

More...PRIDEi		P30044

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1092
54624 [P30044-1]
54625 [P30044-2]
797

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P30044-1 [P30044-1]
P30044-2 [P30044-2]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P30044

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00759663

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P30044

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P30044

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P30044

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P30044

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P30044

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P30044

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000126432, Expressed in bronchial epithelial cell and 209 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P30044, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000126432, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117352, 134 interactors

Protein interaction database and analysis system

More...IntActi		P30044, 41 interactors

Molecular INTeraction database

More...MINTi		P30044

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000265462

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P30044, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P30044

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P30044

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 214ThioredoxinPROSITE-ProRule annotationAdd BLAST159

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi212 – 214Microbody targeting signal1 Publication3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxiredoxin family. Prx5 subfamily.Curated

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0541, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018173

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_072440_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P30044

Identification of Orthologs from Complete Genome Data

More...OMAi		GYINHPK

Database of Orthologous Groups

More...OrthoDBi		1281610at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P30044

TreeFam database of animal gene trees

More...TreeFami		TF105182

Family and domain databases

Conserved Domains Database

More...CDDi		cd03013, PRX5_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037944, PRX5-like
IPR013740, Redoxin
IPR036249, Thioredoxin-like_sf
IPR013766, Thioredoxin_domain

The PANTHER Classification System

More...PANTHERi		PTHR10430, PTHR10430, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08534, Redoxin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52833, SSF52833, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51352, THIOREDOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket
Isoform Mitochondrial (identifier: P30044-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLAGVCALR RSAGYILVGG AGGQSAAAAA RRYSEGEWAS GGVRSFSRAA 
        60         70         80         90        100
AAMAPIKVGD AIPAVEVFEG EPGNKVNLAE LFKGKKGVLF GVPGAFTPGC 
       110        120        130        140        150
SKTHLPGFVE QAEALKAKGV QVVACLSVND AFVTGEWGRA HKAEGKVRLL 
       160        170        180        190        200
ADPTGAFGKE TDLLLDDSLV SIFGNRRLKR FSMVVQDGIV KALNVEPDGT 
       210 
GLTCSLAPNI ISQL
Length:214
Mass (Da):22,086
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA1DEB21120254EE
GO
Isoform Cytoplasmic+peroxisomal (identifier: P30044-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Show »
Length:162
Mass (Da):17,031
Checksum:i370DF621012F880D
GO
Isoform 3 (identifier: P30044-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-145: Missing.

Show »
Length:170
Mass (Da):17,454
Checksum:i29984B81B33F82C1
GO
Isoform 4 (identifier: P30044-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-145: Missing.

Note: Produced by alternative splicing.Curated
Show »
Length:125
Mass (Da):12,897
Checksum:iF3A1C1531E4E4A73
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF17200 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141H → T in AAF04856 (PubMed:10679306).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02504933Y → C7 PublicationsCorresponds to variant dbSNP:rs7938623Ensembl.1
Natural variantiVAR_036406157F → L in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0188291 – 52Missing in isoform Cytoplasmic+peroxisomal. 4 PublicationsAdd BLAST52
Alternative sequenceiVSP_04668257 – 145Missing in isoform 4. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_045783102 – 145Missing in isoform 3. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF231705 mRNA Translation: AAF78899.1
AF124993 mRNA Translation: AAF27531.1
AF110731 mRNA Translation: AAF03750.1
AF197952 mRNA Translation: AAF04856.1
AJ249483 mRNA Translation: CAB62210.1
AF242525 mRNA Translation: AAF99605.1
AF112212 mRNA Translation: AAF17200.1 Frameshift.
CR457203 mRNA Translation: CAG33484.1
DQ247769 Genomic DNA Translation: ABB05181.1
AP001453 Genomic DNA No translation available.
AP003774 Genomic DNA No translation available.
BC110983 mRNA Translation: AAI10984.1
BC113723 mRNA Translation: AAI13724.1
BC113725 mRNA Translation: AAI13726.1
BC143849 mRNA Translation: AAI43850.1
BC171733 mRNA Translation: AAI71733.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8069.1 [P30044-1]
CCDS8070.1 [P30044-3]
CCDS8071.1 [P30044-4]

NCBI Reference Sequences

More...RefSeqi		NP_036226.1, NM_012094.4 [P30044-1]
NP_857634.1, NM_181651.2 [P30044-3]
NP_857635.1, NM_181652.2 [P30044-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265462; ENSP00000265462; ENSG00000126432 [P30044-1]
ENST00000347941; ENSP00000335363; ENSG00000126432 [P30044-4]
ENST00000352435; ENSP00000335334; ENSG00000126432 [P30044-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25824

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25824

UCSC genome browser

More...UCSCi		uc001nzu.4, human [P30044-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231705 mRNA Translation: AAF78899.1
AF124993 mRNA Translation: AAF27531.1
AF110731 mRNA Translation: AAF03750.1
AF197952 mRNA Translation: AAF04856.1
AJ249483 mRNA Translation: CAB62210.1
AF242525 mRNA Translation: AAF99605.1
AF112212 mRNA Translation: AAF17200.1 Frameshift.
CR457203 mRNA Translation: CAG33484.1
DQ247769 Genomic DNA Translation: ABB05181.1
AP001453 Genomic DNA No translation available.
AP003774 Genomic DNA No translation available.
BC110983 mRNA Translation: AAI10984.1
BC113723 mRNA Translation: AAI13724.1
BC113725 mRNA Translation: AAI13726.1
BC143849 mRNA Translation: AAI43850.1
BC171733 mRNA Translation: AAI71733.1
CCDSiCCDS8069.1 [P30044-1]
CCDS8070.1 [P30044-3]
CCDS8071.1 [P30044-4]
RefSeqiNP_036226.1, NM_012094.4 [P30044-1]
NP_857634.1, NM_181651.2 [P30044-3]
NP_857635.1, NM_181652.2 [P30044-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H4OX-ray1.95A/B/C/D/E/F/G/H54-214[»]
1HD2X-ray1.50A54-214[»]
1OC3X-ray2.00A/B/C54-214[»]
1URMX-ray1.70A54-214[»]
2VL2X-ray1.92A/B/C54-214[»]
2VL3X-ray1.83A/B/C54-214[»]
2VL9X-ray2.70A/B/C/D54-214[»]
3MNGX-ray1.45A54-214[»]
4K7IX-ray2.25A/B/C54-214[»]
4K7NX-ray2.30A/B/C54-214[»]
4K7OX-ray1.98A/B/C54-214[»]
4MMMX-ray1.47A/C/E/G54-214[»]
SMRiP30044
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117352, 134 interactors
IntActiP30044, 41 interactors
MINTiP30044
STRINGi9606.ENSP00000265462

Chemistry databases

ChEMBLiCHEMBL3627586
DrugBankiDB00995, Auranofin
DB03608, Diminazene
DB09221, Polaprezinc

Protein family/group databases

PeroxiBasei4448, HsPrxV

PTM databases

iPTMnetiP30044
MetOSiteiP30044
PhosphoSitePlusiP30044
SwissPalmiP30044

Polymorphism and mutation databases

BioMutaiPRDX5
DMDMi317373539

2D gel databases

OGPiP30044
REPRODUCTION-2DPAGEiIPI00759663
SWISS-2DPAGEiP30044
UCD-2DPAGEiP30044

Proteomic databases

CPTACiCPTAC-572
EPDiP30044
jPOSTiP30044
MassIVEiP30044
MaxQBiP30044
PaxDbiP30044
PeptideAtlasiP30044
PRIDEiP30044
ProteomicsDBi1092
54624 [P30044-1]
54625 [P30044-2]
797
TopDownProteomicsiP30044-1 [P30044-1]
P30044-2 [P30044-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3276, 423 antibodies

The DNASU plasmid repository

More...DNASUi		25824

Genome annotation databases

EnsembliENST00000265462; ENSP00000265462; ENSG00000126432 [P30044-1]
ENST00000347941; ENSP00000335363; ENSG00000126432 [P30044-4]
ENST00000352435; ENSP00000335334; ENSG00000126432 [P30044-3]
GeneIDi25824
KEGGihsa:25824
UCSCiuc001nzu.4, human [P30044-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25824
DisGeNETi25824
EuPathDBiHostDB:ENSG00000126432.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRDX5
HGNCiHGNC:9355, PRDX5
HPAiENSG00000126432, Low tissue specificity
MIMi606583, gene
neXtProtiNX_P30044
OpenTargetsiENSG00000126432
PharmGKBiPA33726

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0541, Eukaryota
GeneTreeiENSGT00390000018173
HOGENOMiCLU_072440_3_1_1
InParanoidiP30044
OMAiGYINHPK
OrthoDBi1281610at2759
PhylomeDBiP30044
TreeFamiTF105182

Enzyme and pathway databases

BioCyciMetaCyc:HS05016-MONOMER
BRENDAi1.11.1.15, 2681
PathwayCommonsiP30044
ReactomeiR-HSA-3299685, Detoxification of Reactive Oxygen Species
R-HSA-5628897, TP53 Regulates Metabolic Genes [P30044-2]
SIGNORiP30044

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		25824, 9 hits in 850 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRDX5, human
EvolutionaryTraceiP30044

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PRDX5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25824
PharosiP30044, Tbio

Protein Ontology

More...PROi		PR:P30044
RNActiP30044, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000126432, Expressed in bronchial epithelial cell and 209 other tissues
GenevisibleiP30044, HS

Family and domain databases

CDDicd03013, PRX5_like, 1 hit
Gene3Di3.40.30.10, 1 hit
InterProiView protein in InterPro
IPR037944, PRX5-like
IPR013740, Redoxin
IPR036249, Thioredoxin-like_sf
IPR013766, Thioredoxin_domain
PANTHERiPTHR10430, PTHR10430, 1 hit
PfamiView protein in Pfam
PF08534, Redoxin, 1 hit
SUPFAMiSSF52833, SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51352, THIOREDOXIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRDX5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30044
Secondary accession number(s): A6NC19
, A6NG06, B7ZLJ4, B7ZVW3, Q14CK0, Q6IAF2, Q9UBU5, Q9UJU4, Q9UKX4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 11, 2011
Last modified: December 2, 2020
This is version 214 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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