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Protein

Phenazine biosynthesis-like domain-containing protein

Gene

PBLD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46By similarity1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • isomerase activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Phenazine biosynthesis-like domain-containing protein (EC:5.1.-.-)
Alternative name(s):
MAWD-binding protein
Short name:
MAWDBP
Unknown protein 32 from 2D-page of liver tissue
Gene namesi
Name:PBLD
Synonyms:MAWBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000108187.15
HGNCiHGNC:23301 PBLD
MIMi612189 gene
neXtProtiNX_P30039

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi64081
OpenTargetsiENSG00000108187
PharmGKBiPA162398821

Polymorphism and mutation databases

BioMutaiPBLD
DMDMi17380331

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001623831 – 288Phenazine biosynthesis-like domain-containing proteinAdd BLAST288

Proteomic databases

EPDiP30039
MaxQBiP30039
PaxDbiP30039
PeptideAtlasiP30039
PRIDEiP30039
ProteomicsDBi54618

2D gel databases

SWISS-2DPAGEiP30039

PTM databases

iPTMnetiP30039
PhosphoSitePlusiP30039

Expressioni

Gene expression databases

BgeeiENSG00000108187 Expressed in 196 organ(s), highest expression level in nephron tubule
CleanExiHS_PBLD
ExpressionAtlasiP30039 baseline and differential
GenevisibleiP30039 HS

Organism-specific databases

HPAiHPA038035
HPA038036

Interactioni

Subunit structurei

Interacts with UNRIP/MAWD.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122047, 13 interactors
IntActiP30039, 11 interactors
STRINGi9606.ENSP00000308466

Structurei

3D structure databases

ProteinModelPortaliP30039
SMRiP30039
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PhzF family.Curated

Phylogenomic databases

eggNOGiKOG3033 Eukaryota
COG0384 LUCA
GeneTreeiENSGT00390000017595
HOGENOMiHOG000251510
HOVERGENiHBG018191
InParanoidiP30039
OMAiKKEMHAF
OrthoDBiEOG091G1768
PhylomeDBiP30039
TreeFamiTF314596

Family and domain databases

InterProiView protein in InterPro
IPR003719 Phenazine_PhzF
PANTHERiPTHR13774 PTHR13774, 1 hit
PfamiView protein in Pfam
PF02567 PhzC-PhzF, 1 hit
PIRSFiPIRSF016184 PhzC_PhzF, 1 hit
TIGRFAMsiTIGR00654 PhzF_family, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P30039-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLPIFIADA FTARAFRGNP AAVCLLENEL DEDMHQKIAR EMNLSETAFI
60 70 80 90 100
RKLHPTDNFA QSSCFGLRWF TPASEVPLCG HATLASAAVL FHKIKNMNST
110 120 130 140 150
LTFVTLSGEL RARRAEDGIV LDLPLYPAHP QDFHEVEDLI KTAIGNTLVQ
160 170 180 190 200
DICYSPDTQK LLVRLSDVYN RSFLENLKVN TENLLQVENT GKVKGLILTL
210 220 230 240 250
KGEPGGQTQA FDFYSRYFAP WVGVAEDPVT GSAHAVLSSY WSQHLGKKEM
260 270 280
HAFQCSHRGG ELGISLRPDG RVDIRGGAAV VLEGTLTA
Length:288
Mass (Da):31,785
Last modified:September 26, 2001 - v2
Checksum:iAF79ECB704E6D62F
GO
Isoform 2 (identifier: P30039-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-288: AFQCSHRGGELGISLRPDGRVDIRGGAAVVLEGTLTA → GRTALYQFLFYLPNSKLVFLLICTIPLKM

Note: Gene prediction based on EST data.
Show »
Length:280
Mass (Da):31,409
Checksum:i04C2DF7A81DF1D62
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFS0A0A0C4DFS0_HUMAN
MAWD binding protein, isoform CRA_d
PBLD MAWBP, hCG_32856
255Annotation score:
V9GY00V9GY00_HUMAN
Phenazine biosynthesis-like domain-...
PBLD
90Annotation score:

Sequence cautioni

The sequence BAB55285 differs from that shown. Reason: Frameshift at position 232.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12 – 13TA → NV AA sequence (PubMed:1286669).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02268417R → C1 PublicationCorresponds to variant dbSNP:rs12359690Ensembl.1
Natural variantiVAR_07240362S → I1 PublicationCorresponds to variant dbSNP:rs756247151Ensembl.1
Natural variantiVAR_022685257H → R1 PublicationCorresponds to variant dbSNP:rs4142048Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053822252 – 288AFQCS…GTLTA → GRTALYQFLFYLPNSKLVFL LICTIPLKM in isoform 2. CuratedAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027673 mRNA Translation: BAB55285.1 Frameshift.
AC016395 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54274.1
CH471083 Genomic DNA Translation: EAW54273.1
BC009738 mRNA Translation: AAH09738.1
AB049758 mRNA Translation: BAB16606.1
CCDSiCCDS44413.1 [P30039-2]
CCDS7277.2 [P30039-1]
RefSeqiNP_001028255.1, NM_001033083.1 [P30039-2]
NP_071412.2, NM_022129.3 [P30039-1]
XP_005270085.1, XM_005270028.3 [P30039-1]
UniGeneiHs.198158

Genome annotation databases

EnsembliENST00000309049; ENSP00000308466; ENSG00000108187 [P30039-1]
ENST00000358769; ENSP00000351619; ENSG00000108187 [P30039-1]
ENST00000495025; ENSP00000476306; ENSG00000108187 [P30039-2]
GeneIDi64081
KEGGihsa:64081
UCSCiuc001jnr.1 human [P30039-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027673 mRNA Translation: BAB55285.1 Frameshift.
AC016395 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54274.1
CH471083 Genomic DNA Translation: EAW54273.1
BC009738 mRNA Translation: AAH09738.1
AB049758 mRNA Translation: BAB16606.1
CCDSiCCDS44413.1 [P30039-2]
CCDS7277.2 [P30039-1]
RefSeqiNP_001028255.1, NM_001033083.1 [P30039-2]
NP_071412.2, NM_022129.3 [P30039-1]
XP_005270085.1, XM_005270028.3 [P30039-1]
UniGeneiHs.198158

3D structure databases

ProteinModelPortaliP30039
SMRiP30039
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122047, 13 interactors
IntActiP30039, 11 interactors
STRINGi9606.ENSP00000308466

PTM databases

iPTMnetiP30039
PhosphoSitePlusiP30039

Polymorphism and mutation databases

BioMutaiPBLD
DMDMi17380331

2D gel databases

SWISS-2DPAGEiP30039

Proteomic databases

EPDiP30039
MaxQBiP30039
PaxDbiP30039
PeptideAtlasiP30039
PRIDEiP30039
ProteomicsDBi54618

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309049; ENSP00000308466; ENSG00000108187 [P30039-1]
ENST00000358769; ENSP00000351619; ENSG00000108187 [P30039-1]
ENST00000495025; ENSP00000476306; ENSG00000108187 [P30039-2]
GeneIDi64081
KEGGihsa:64081
UCSCiuc001jnr.1 human [P30039-1]

Organism-specific databases

CTDi64081
DisGeNETi64081
EuPathDBiHostDB:ENSG00000108187.15
GeneCardsiPBLD
HGNCiHGNC:23301 PBLD
HPAiHPA038035
HPA038036
MIMi612189 gene
neXtProtiNX_P30039
OpenTargetsiENSG00000108187
PharmGKBiPA162398821
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3033 Eukaryota
COG0384 LUCA
GeneTreeiENSGT00390000017595
HOGENOMiHOG000251510
HOVERGENiHBG018191
InParanoidiP30039
OMAiKKEMHAF
OrthoDBiEOG091G1768
PhylomeDBiP30039
TreeFamiTF314596

Miscellaneous databases

ChiTaRSiPBLD human
GenomeRNAii64081
PROiPR:P30039
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108187 Expressed in 196 organ(s), highest expression level in nephron tubule
CleanExiHS_PBLD
ExpressionAtlasiP30039 baseline and differential
GenevisibleiP30039 HS

Family and domain databases

InterProiView protein in InterPro
IPR003719 Phenazine_PhzF
PANTHERiPTHR13774 PTHR13774, 1 hit
PfamiView protein in Pfam
PF02567 PhzC-PhzF, 1 hit
PIRSFiPIRSF016184 PhzC_PhzF, 1 hit
TIGRFAMsiTIGR00654 PhzF_family, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPBLD_HUMAN
AccessioniPrimary (citable) accession number: P30039
Secondary accession number(s): A8MZJ3, C9JIM0, Q9HCC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: September 26, 2001
Last modified: September 12, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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