UniProtKB - P30039 (PBLD_HUMAN)
Protein
Phenazine biosynthesis-like domain-containing protein
Gene
PBLD
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 46 | By similarity | 1 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- isomerase activity Source: GO_Central
GO - Biological processi
- biosynthetic process Source: InterPro
- maintenance of gastrointestinal epithelium Source: UniProtKB
- negative regulation of epithelial cell migration Source: UniProtKB
- negative regulation of epithelial cell proliferation Source: UniProtKB
- negative regulation of epithelial to mesenchymal transition Source: UniProtKB
- negative regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
- negative regulation of SMAD protein signal transduction Source: UniProtKB
- negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Isomerase |
Enzyme and pathway databases
PathwayCommonsi | P30039 |
Names & Taxonomyi
Protein namesi | Recommended name: Phenazine biosynthesis-like domain-containing protein (EC:5.1.-.-)Alternative name(s): MAWD-binding protein Short name: MAWDBP Unknown protein 32 from 2D-page of liver tissue |
Gene namesi | Name:PBLD Synonyms:MAWBP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23301, PBLD |
MIMi | 612189, gene |
neXtProti | NX_P30039 |
VEuPathDBi | HostDB:ENSG00000108187.15 |
Subcellular locationi
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 64081 |
OpenTargetsi | ENSG00000108187 |
PharmGKBi | PA162398821 |
Miscellaneous databases
Pharosi | P30039, Tbio |
Genetic variation databases
BioMutai | PBLD |
DMDMi | 17380331 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000162383 | 1 – 288 | Phenazine biosynthesis-like domain-containing proteinAdd BLAST | 288 |
Proteomic databases
EPDi | P30039 |
jPOSTi | P30039 |
MassIVEi | P30039 |
MaxQBi | P30039 |
PaxDbi | P30039 |
PeptideAtlasi | P30039 |
PRIDEi | P30039 |
ProteomicsDBi | 10356 54618 [P30039-1] |
2D gel databases
SWISS-2DPAGEi | P30039 |
PTM databases
iPTMneti | P30039 |
PhosphoSitePlusi | P30039 |
Expressioni
Gene expression databases
Bgeei | ENSG00000108187, Expressed in nephron tubule and 209 other tissues |
ExpressionAtlasi | P30039, baseline and differential |
Genevisiblei | P30039, HS |
Organism-specific databases
HPAi | ENSG00000108187, Tissue enhanced (intestine, kidney, liver) |
Interactioni
Subunit structurei
Interacts with UNRIP/MAWD.
Binary interactionsi
Hide detailsP30039
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 122047, 17 interactors |
IntActi | P30039, 13 interactors |
STRINGi | 9606.ENSP00000351619 |
Miscellaneous databases
RNActi | P30039, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the PhzF family.Curated
Phylogenomic databases
eggNOGi | KOG3033, Eukaryota |
GeneTreei | ENSGT00390000017595 |
HOGENOMi | CLU_048756_2_0_1 |
InParanoidi | P30039 |
OMAi | DWALRWF |
PhylomeDBi | P30039 |
TreeFami | TF314596 |
Family and domain databases
InterProi | View protein in InterPro IPR003719, Phenazine_PhzF |
PANTHERi | PTHR13774, PTHR13774, 1 hit |
Pfami | View protein in Pfam PF02567, PhzC-PhzF, 1 hit |
PIRSFi | PIRSF016184, PhzC_PhzF, 1 hit |
TIGRFAMsi | TIGR00654, PhzF_family, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P30039-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKLPIFIADA FTARAFRGNP AAVCLLENEL DEDMHQKIAR EMNLSETAFI
60 70 80 90 100
RKLHPTDNFA QSSCFGLRWF TPASEVPLCG HATLASAAVL FHKIKNMNST
110 120 130 140 150
LTFVTLSGEL RARRAEDGIV LDLPLYPAHP QDFHEVEDLI KTAIGNTLVQ
160 170 180 190 200
DICYSPDTQK LLVRLSDVYN RSFLENLKVN TENLLQVENT GKVKGLILTL
210 220 230 240 250
KGEPGGQTQA FDFYSRYFAP WVGVAEDPVT GSAHAVLSSY WSQHLGKKEM
260 270 280
HAFQCSHRGG ELGISLRPDG RVDIRGGAAV VLEGTLTA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DFS0 | A0A0C4DFS0_HUMAN | MAWD binding protein, isoform CRA_d | PBLD MAWBP, hCG_32856 | 255 | Annotation score: | ||
V9GY00 | V9GY00_HUMAN | Phenazine biosynthesis-like domain-... | PBLD | 90 | Annotation score: |
Sequence cautioni
The sequence BAB55285 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 – 13 | TA → NV AA sequence (PubMed:1286669).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022684 | 17 | R → C1 PublicationCorresponds to variant dbSNP:rs12359690Ensembl. | 1 | |
Natural variantiVAR_072403 | 62 | S → I1 PublicationCorresponds to variant dbSNP:rs756247151Ensembl. | 1 | |
Natural variantiVAR_022685 | 257 | H → R1 PublicationCorresponds to variant dbSNP:rs4142048Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053822 | 252 – 288 | AFQCS…GTLTA → GRTALYQFLFYLPNSKLVFL LICTIPLKM in isoform 2. CuratedAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027673 mRNA Translation: BAB55285.1 Frameshift. AC016395 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54274.1 CH471083 Genomic DNA Translation: EAW54273.1 BC009738 mRNA Translation: AAH09738.1 AB049758 mRNA Translation: BAB16606.1 |
CCDSi | CCDS44413.1 [P30039-2] CCDS7277.2 [P30039-1] |
RefSeqi | NP_001028255.1, NM_001033083.1 [P30039-2] NP_071412.2, NM_022129.3 [P30039-1] XP_005270085.1, XM_005270028.3 [P30039-1] |
Genome annotation databases
Ensembli | ENST00000309049; ENSP00000308466; ENSG00000108187 [P30039-1] ENST00000358769; ENSP00000351619; ENSG00000108187 [P30039-1] ENST00000495025; ENSP00000476306; ENSG00000108187 [P30039-2] |
GeneIDi | 64081 |
KEGGi | hsa:64081 |
UCSCi | uc001jnr.1, human [P30039-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027673 mRNA Translation: BAB55285.1 Frameshift. AC016395 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54274.1 CH471083 Genomic DNA Translation: EAW54273.1 BC009738 mRNA Translation: AAH09738.1 AB049758 mRNA Translation: BAB16606.1 |
CCDSi | CCDS44413.1 [P30039-2] CCDS7277.2 [P30039-1] |
RefSeqi | NP_001028255.1, NM_001033083.1 [P30039-2] NP_071412.2, NM_022129.3 [P30039-1] XP_005270085.1, XM_005270028.3 [P30039-1] |
3D structure databases
SMRi | P30039 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122047, 17 interactors |
IntActi | P30039, 13 interactors |
STRINGi | 9606.ENSP00000351619 |
PTM databases
iPTMneti | P30039 |
PhosphoSitePlusi | P30039 |
Genetic variation databases
BioMutai | PBLD |
DMDMi | 17380331 |
2D gel databases
SWISS-2DPAGEi | P30039 |
Proteomic databases
EPDi | P30039 |
jPOSTi | P30039 |
MassIVEi | P30039 |
MaxQBi | P30039 |
PaxDbi | P30039 |
PeptideAtlasi | P30039 |
PRIDEi | P30039 |
ProteomicsDBi | 10356 54618 [P30039-1] |
Protocols and materials databases
Antibodypediai | 28440, 239 antibodies |
Genome annotation databases
Ensembli | ENST00000309049; ENSP00000308466; ENSG00000108187 [P30039-1] ENST00000358769; ENSP00000351619; ENSG00000108187 [P30039-1] ENST00000495025; ENSP00000476306; ENSG00000108187 [P30039-2] |
GeneIDi | 64081 |
KEGGi | hsa:64081 |
UCSCi | uc001jnr.1, human [P30039-1] |
Organism-specific databases
CTDi | 64081 |
DisGeNETi | 64081 |
GeneCardsi | PBLD |
HGNCi | HGNC:23301, PBLD |
HPAi | ENSG00000108187, Tissue enhanced (intestine, kidney, liver) |
MIMi | 612189, gene |
neXtProti | NX_P30039 |
OpenTargetsi | ENSG00000108187 |
PharmGKBi | PA162398821 |
VEuPathDBi | HostDB:ENSG00000108187.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3033, Eukaryota |
GeneTreei | ENSGT00390000017595 |
HOGENOMi | CLU_048756_2_0_1 |
InParanoidi | P30039 |
OMAi | DWALRWF |
PhylomeDBi | P30039 |
TreeFami | TF314596 |
Enzyme and pathway databases
PathwayCommonsi | P30039 |
Miscellaneous databases
BioGRID-ORCSi | 64081, 7 hits in 873 CRISPR screens |
ChiTaRSi | PBLD, human |
GenomeRNAii | 64081 |
Pharosi | P30039, Tbio |
PROi | PR:P30039 |
RNActi | P30039, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108187, Expressed in nephron tubule and 209 other tissues |
ExpressionAtlasi | P30039, baseline and differential |
Genevisiblei | P30039, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003719, Phenazine_PhzF |
PANTHERi | PTHR13774, PTHR13774, 1 hit |
Pfami | View protein in Pfam PF02567, PhzC-PhzF, 1 hit |
PIRSFi | PIRSF016184, PhzC_PhzF, 1 hit |
TIGRFAMsi | TIGR00654, PhzF_family, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PBLD_HUMAN | |
Accessioni | P30039Primary (citable) accession number: P30039 Secondary accession number(s): A8MZJ3, C9JIM0, Q9HCC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | September 26, 2001 | |
Last modified: | February 10, 2021 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants