UniProtKB - P30015 (LHR_ECOLI)
Protein
Probable ATP-dependent helicase lhr
Gene
lhr
Organism
Escherichia coli (strain K12)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 51 – 58 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- helicase activity Source: UniProtKB-KW
- nucleic acid binding Source: InterPro
Keywordsi
Molecular function | Helicase, Hydrolase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11548-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable ATP-dependent helicase lhr (EC:3.6.4.-)Alternative name(s): Large helicase-related protein |
Gene namesi | Name:lhr Synonyms:rhlF Ordered Locus Names:b1653, JW1645 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000102193 | 1 – 1538 | Probable ATP-dependent helicase lhrAdd BLAST | 1538 |
Proteomic databases
PaxDbi | P30015 |
PRIDEi | P30015 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260268, 108 interactors |
DIPi | DIP-10097N |
IntActi | P30015, 9 interactors |
STRINGi | 511145.b1653 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 235 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 198 | |
Domaini | 284 – 462 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 179 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 179 – 182 | DEVH box | 4 |
Sequence similaritiesi
Belongs to the helicase family.Curated
Phylogenomic databases
eggNOGi | COG1201, Bacteria |
HOGENOMi | CLU_002025_3_1_6 |
InParanoidi | P30015 |
PhylomeDBi | P30015 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR013701, DEAD/DEAH_assoc IPR011545, DEAD/DEAH_box_helicase_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF08494, DEAD_assoc, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
i Sequence
Sequence statusi: Complete.
P30015-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADNPDPSSL LPDVFSPATR DWFLRAFKQP TAVQPQTWHV AARSEHALVI
60 70 80 90 100
APTGSGKTLA AFLYALDRLF REGGEDTREA HKRKTSRILY ISPIKALGTD
110 120 130 140 150
VQRNLQIPLK GIADERRRRG ETEVNLRVGI RTGDTPAQER SKLTRNPPDI
160 170 180 190 200
LITTPESLYL MLTSRARETL RGVETVIIDE VHAVAGSKRG AHLALSLERL
210 220 230 240 250
DALLHTSAQR IGLSATVRSA SDVAAFLGGD RPVTVVNPPA MRHPQIRIVV
260 270 280 290 300
PVANMDDVSS VASGTGEDSH AGREGSIWPY IETGILDEVL RHRSTIVFTN
310 320 330 340 350
SRGLAEKLTA RLNELYAARL QRSPSIAVDA AHFESTSGAT SNRVQSSDVF
360 370 380 390 400
IARSHHGSVS KEQRAITEQA LKSGELRCVV ATSSLELGID MGAVDLVIQV
410 420 430 440 450
ATPLSVASGL QRIGRAGHQV GGVSKGLFFP RTRRDLVDSA VIVECMFAGR
460 470 480 490 500
LENLTPPHNP LDVLAQQTVA AAAMDALQVD EWYSRVRRAA PWKDLPRRVF
510 520 530 540 550
DATLDMLSGR YPSGDFSAFR PKLVWNRETG ILTARPGAQL LAVTSGGTIP
560 570 580 590 600
DRGMYSVLLP EGEEKAGSRR VGELDEEMVY ESRVNDIITL GATSWRIQQI
610 620 630 640 650
TRDQVIVTPA PGRSARLPFW RGEGNGRPAE LGEMIGDFLH LLADGAFFSG
660 670 680 690 700
TIPPWLAEEN TIANIQGLIE EQRNATGIVP GSRHLVLERC RDEIGDWRII
710 720 730 740 750
LHSPYGRRVH EPWAVAIAGR IHALWGADAS VVASDDGIVA RIPDTDGKLP
760 770 780 790 800
DAAIFLFEPE KLLQIVREAV GSSALFAARF RECAARALLM PGRTPGHRTP
810 820 830 840 850
LWQQRLRASQ LLEIAQGYPD FPVILETLRE CLQDVYDLPA LERLMRRLNG
860 870 880 890 900
GEIQISDVTT TTPSPFATSL LFGYVAEFMY QSDAPLAERR ASVLSLDSEL
910 920 930 940 950
LRNLLGQVDP GELLDPQVIR QVEEELQRLA PGRRAKGEEG LFDLLRELGP
960 970 980 990 1000
MTVEDLAQRH TGSSEEVASY LENLLAVKRI FPAMISGQER LACMDDAARL
1010 1020 1030 1040 1050
RDALGVRLPE SLPEIYLHRV SYPLRDLFLR YLRAHALVTA EQLAHEFSLG
1060 1070 1080 1090 1100
IAIVEEQLQQ LREQGLVMNL QQDIWVSDEV FRRLRLRSLQ AAREATRPVA
1110 1120 1130 1140 1150
ATTYARLLLE RQGVLPATDG SPALFASTSP GVYEGVDGVM RVIEQLAGVG
1160 1170 1180 1190 1200
LPASLWESQI LPARVRDYSS EMLDELLATG AVIWSGQKKL GEDDGLVALH
1210 1220 1230 1240 1250
LQEYAAESFT PAEADQANRS ALQQAIVAVL ADGGAWFAQQ ISQRIRDKIG
1260 1270 1280 1290 1300
ESVDLSALQE ALWALVWQGV ITSDIWAPLR ALTRSSSNAR TSTRRSHRAR
1310 1320 1330 1340 1350
RGRPVYAQPV SPRVSYNTPN LAGRWSLLQV EPLNDTERML ALAENMLDRY
1360 1370 1380 1390 1400
GIISRQAVIA ENIPGGFPSM QTLCRSMEDS GRIMRGRFVE GLGGAQFAER
1410 1420 1430 1440 1450
LTIDRLRDLA TQATQTRHYT PVALSANDPA NVWGNLLPWP AHPATLVPTR
1460 1470 1480 1490 1500
RAGALVVVSG GKLLLYLAQG GKKMLVWQEK EELLAPEVFH ALTTALRREP
1510 1520 1530
RLRFTLTEVN DLPVRQTPMF TLLREAGFSS SPQGLDWG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01622 Genomic DNA Translation: AAC37009.1 U00096 Genomic DNA Translation: AAC74725.1 AP009048 Genomic DNA Translation: BAA15419.1 |
PIRi | G64922 |
RefSeqi | NP_416170.1, NC_000913.3 WP_001310858.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC74725; AAC74725; b1653 BAA15419; BAA15419; BAA15419 |
GeneIDi | 946156 |
KEGGi | ecj:JW1645 eco:b1653 |
PATRICi | fig|1411691.4.peg.606 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01622 Genomic DNA Translation: AAC37009.1 U00096 Genomic DNA Translation: AAC74725.1 AP009048 Genomic DNA Translation: BAA15419.1 |
PIRi | G64922 |
RefSeqi | NP_416170.1, NC_000913.3 WP_001310858.1, NZ_LN832404.1 |
3D structure databases
SMRi | P30015 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260268, 108 interactors |
DIPi | DIP-10097N |
IntActi | P30015, 9 interactors |
STRINGi | 511145.b1653 |
Proteomic databases
PaxDbi | P30015 |
PRIDEi | P30015 |
Genome annotation databases
EnsemblBacteriai | AAC74725; AAC74725; b1653 BAA15419; BAA15419; BAA15419 |
GeneIDi | 946156 |
KEGGi | ecj:JW1645 eco:b1653 |
PATRICi | fig|1411691.4.peg.606 |
Organism-specific databases
EchoBASEi | EB1510 |
Phylogenomic databases
eggNOGi | COG1201, Bacteria |
HOGENOMi | CLU_002025_3_1_6 |
InParanoidi | P30015 |
PhylomeDBi | P30015 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11548-MONOMER |
Miscellaneous databases
PROi | PR:P30015 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR013701, DEAD/DEAH_assoc IPR011545, DEAD/DEAH_box_helicase_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF08494, DEAD_assoc, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LHR_ECOLI | |
Accessioni | P30015Primary (citable) accession number: P30015 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families