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UniProtKB - P30015 (LHR_ECOLI)

Entry version 152 (02 Jun 2021)
Sequence version 2 (01 Jun 1994)
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Protein

Probable ATP-dependent helicase lhr

Gene

lhr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi51 – 58ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG11548-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable ATP-dependent helicase lhr (EC:3.6.4.-)
Alternative name(s):
Large helicase-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lhr
Synonyms:rhlF
Ordered Locus Names:b1653, JW1645
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001021931 – 1538Probable ATP-dependent helicase lhrAdd BLAST1538

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P30015

PRoteomics IDEntifications database

More...PRIDEi		P30015

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4260268, 108 interactors

Database of interacting proteins

More...DIPi		DIP-10097N

Protein interaction database and analysis system

More...IntActi		P30015, 9 interactors

STRING: functional protein association networks

More...STRINGi		511145.b1653

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P30015

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 235Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST198
Domaini284 – 462Helicase C-terminalPROSITE-ProRule annotationAdd BLAST179

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1287 – 1312DisorderedSequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi179 – 182DEVH box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1201, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002025_3_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P30015

Database for complete collections of gene phylogenies

More...PhylomeDBi		P30015

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR013701, DEAD/DEAH_assoc
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00270, DEAD, 1 hit
PF08494, DEAD_assoc, 1 hit
PF00271, Helicase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P30015-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADNPDPSSL LPDVFSPATR DWFLRAFKQP TAVQPQTWHV AARSEHALVI 
        60         70         80         90        100
APTGSGKTLA AFLYALDRLF REGGEDTREA HKRKTSRILY ISPIKALGTD 
       110        120        130        140        150
VQRNLQIPLK GIADERRRRG ETEVNLRVGI RTGDTPAQER SKLTRNPPDI 
       160        170        180        190        200
LITTPESLYL MLTSRARETL RGVETVIIDE VHAVAGSKRG AHLALSLERL 
       210        220        230        240        250
DALLHTSAQR IGLSATVRSA SDVAAFLGGD RPVTVVNPPA MRHPQIRIVV 
       260        270        280        290        300
PVANMDDVSS VASGTGEDSH AGREGSIWPY IETGILDEVL RHRSTIVFTN 
       310        320        330        340        350
SRGLAEKLTA RLNELYAARL QRSPSIAVDA AHFESTSGAT SNRVQSSDVF 
       360        370        380        390        400
IARSHHGSVS KEQRAITEQA LKSGELRCVV ATSSLELGID MGAVDLVIQV 
       410        420        430        440        450
ATPLSVASGL QRIGRAGHQV GGVSKGLFFP RTRRDLVDSA VIVECMFAGR 
       460        470        480        490        500
LENLTPPHNP LDVLAQQTVA AAAMDALQVD EWYSRVRRAA PWKDLPRRVF 
       510        520        530        540        550
DATLDMLSGR YPSGDFSAFR PKLVWNRETG ILTARPGAQL LAVTSGGTIP 
       560        570        580        590        600
DRGMYSVLLP EGEEKAGSRR VGELDEEMVY ESRVNDIITL GATSWRIQQI 
       610        620        630        640        650
TRDQVIVTPA PGRSARLPFW RGEGNGRPAE LGEMIGDFLH LLADGAFFSG 
       660        670        680        690        700
TIPPWLAEEN TIANIQGLIE EQRNATGIVP GSRHLVLERC RDEIGDWRII 
       710        720        730        740        750
LHSPYGRRVH EPWAVAIAGR IHALWGADAS VVASDDGIVA RIPDTDGKLP 
       760        770        780        790        800
DAAIFLFEPE KLLQIVREAV GSSALFAARF RECAARALLM PGRTPGHRTP 
       810        820        830        840        850
LWQQRLRASQ LLEIAQGYPD FPVILETLRE CLQDVYDLPA LERLMRRLNG 
       860        870        880        890        900
GEIQISDVTT TTPSPFATSL LFGYVAEFMY QSDAPLAERR ASVLSLDSEL 
       910        920        930        940        950
LRNLLGQVDP GELLDPQVIR QVEEELQRLA PGRRAKGEEG LFDLLRELGP 
       960        970        980        990       1000
MTVEDLAQRH TGSSEEVASY LENLLAVKRI FPAMISGQER LACMDDAARL 
      1010       1020       1030       1040       1050
RDALGVRLPE SLPEIYLHRV SYPLRDLFLR YLRAHALVTA EQLAHEFSLG 
      1060       1070       1080       1090       1100
IAIVEEQLQQ LREQGLVMNL QQDIWVSDEV FRRLRLRSLQ AAREATRPVA 
      1110       1120       1130       1140       1150
ATTYARLLLE RQGVLPATDG SPALFASTSP GVYEGVDGVM RVIEQLAGVG 
      1160       1170       1180       1190       1200
LPASLWESQI LPARVRDYSS EMLDELLATG AVIWSGQKKL GEDDGLVALH 
      1210       1220       1230       1240       1250
LQEYAAESFT PAEADQANRS ALQQAIVAVL ADGGAWFAQQ ISQRIRDKIG 
      1260       1270       1280       1290       1300
ESVDLSALQE ALWALVWQGV ITSDIWAPLR ALTRSSSNAR TSTRRSHRAR 
      1310       1320       1330       1340       1350
RGRPVYAQPV SPRVSYNTPN LAGRWSLLQV EPLNDTERML ALAENMLDRY 
      1360       1370       1380       1390       1400
GIISRQAVIA ENIPGGFPSM QTLCRSMEDS GRIMRGRFVE GLGGAQFAER 
      1410       1420       1430       1440       1450
LTIDRLRDLA TQATQTRHYT PVALSANDPA NVWGNLLPWP AHPATLVPTR 
      1460       1470       1480       1490       1500
RAGALVVVSG GKLLLYLAQG GKKMLVWQEK EELLAPEVFH ALTTALRREP 
      1510       1520       1530 
RLRFTLTEVN DLPVRQTPMF TLLREAGFSS SPQGLDWG
Length:1,538
Mass (Da):169,381
Last modified:June 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i563172B5FE3D826E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L01622 Genomic DNA Translation: AAC37009.1
U00096 Genomic DNA Translation: AAC74725.1
AP009048 Genomic DNA Translation: BAA15419.1

Protein sequence database of the Protein Information Resource

More...PIRi		G64922

NCBI Reference Sequences

More...RefSeqi		NP_416170.1, NC_000913.3
WP_001310858.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74725; AAC74725; b1653
BAA15419; BAA15419; BAA15419

Database of genes from NCBI RefSeq genomes

More...GeneIDi		946156

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW1645
eco:b1653

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.606

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01622 Genomic DNA Translation: AAC37009.1
U00096 Genomic DNA Translation: AAC74725.1
AP009048 Genomic DNA Translation: BAA15419.1
PIRiG64922
RefSeqiNP_416170.1, NC_000913.3
WP_001310858.1, NZ_LN832404.1

3D structure databases

SMRiP30015
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4260268, 108 interactors
DIPiDIP-10097N
IntActiP30015, 9 interactors
STRINGi511145.b1653

Proteomic databases

PaxDbiP30015
PRIDEiP30015

Genome annotation databases

EnsemblBacteriaiAAC74725; AAC74725; b1653
BAA15419; BAA15419; BAA15419
GeneIDi946156
KEGGiecj:JW1645
eco:b1653
PATRICifig|1411691.4.peg.606

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1510

Phylogenomic databases

eggNOGiCOG1201, Bacteria
HOGENOMiCLU_002025_3_1_6
InParanoidiP30015
PhylomeDBiP30015

Enzyme and pathway databases

BioCyciEcoCyc:EG11548-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P30015

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR013701, DEAD/DEAH_assoc
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF08494, DEAD_assoc, 1 hit
PF00271, Helicase_C, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLHR_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30015
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: June 1, 1994
Last modified: June 2, 2021
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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