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Protein

Myristoylated alanine-rich C-kinase substrate

Gene

Marcks

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • calmodulin binding Source: UniProtKB-KW
  • phosphatidylserine binding Source: RGD
  • phospholipid binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myristoylated alanine-rich C-kinase substrate
Short name:
MARCKS
Alternative name(s):
Protein kinase C substrate 80 kDa protein
Gene namesi
Name:Marcks
Synonyms:Macs
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3028 Marcks

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001571502 – 309Myristoylated alanine-rich C-kinase substrateAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei26PhosphoserineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei29PhosphoserineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei79PhosphothreonineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei128PhosphoserineBy similarity1
Modified residuei138PhosphoserineCombined sources1
Modified residuei140PhosphoserineBy similarity1
Modified residuei141PhosphoserineBy similarity1
Modified residuei143PhosphothreonineCombined sources1
Modified residuei152Phosphoserine; by PKC1 Publication1
Modified residuei156Phosphoserine; by PKCCombined sources1 Publication1
Modified residuei160PhosphoserineCombined sources1
Modified residuei163Phosphoserine; by PKCCombined sources1 Publication1
Modified residuei218PhosphoserineCombined sources1
Modified residuei246PhosphoserineBy similarity1
Modified residuei291PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiP30009
PRIDEiP30009

PTM databases

iPTMnetiP30009
PhosphoSitePlusiP30009

Expressioni

Tissue specificityi

Highest levels found in spleen and brain. Intermediate levels seen in thymus, ovary, lung and heart. Very low levels seen in kidney, skeletal muscle and liver.1 Publication

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000707

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 169Calmodulin-binding (PSD)Add BLAST25

Sequence similaritiesi

Belongs to the MARCKS family.Curated

Phylogenomic databases

eggNOGiENOG410J04K Eukaryota
ENOG4111SZ0 LUCA
HOGENOMiHOG000113482
InParanoidiP30009

Family and domain databases

InterProiView protein in InterPro
IPR002101 MARCKS
PANTHERiPTHR14353 PTHR14353, 1 hit
PfamiView protein in Pfam
PF02063 MARCKS, 1 hit
PRINTSiPR00963 MARCKS
PROSITEiView protein in PROSITE
PS00826 MARCKS_1, 1 hit
PS00827 MARCKS_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P30009-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAQFSKTAA KGEAAAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA
60 70 80 90 100
EPGAKEELQA NGSAPAADKE EPASGGAATP AAADKDEAAA APEPGAATAD
110 120 130 140 150
KEAAEAEPAE PGSPSAETEG ASASSTSSPK AEDGAAPSPS SETPKKKKKR
160 170 180 190 200
FSFKKSFKLS GFSFKKSKKE AGEGAEAEGA TADGAKDEAA AAAGGDAAAA
210 220 230 240 250
PGEQAGGAGA EGAEGGESRE AEAAEPEQPE QPEQPAAEEP RAEEPSEAVG
260 270 280 290 300
EKAEEPAPGA TADDAPSAAG PEQEAPAATD EPAASAAPSA SPEPQPECSP

EAPPAPVAE
Length:309
Mass (Da):29,795
Last modified:January 23, 2007 - v2
Checksum:i9957F2037F203316
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LMW7F1LMW7_RAT
Myristoylated alanine-rich C-kinase...
Marcks
309Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29S → G AA sequence (PubMed:2676596).Curated1
Sequence conflicti183D → E (PubMed:1396720).Curated1
Sequence conflicti216G → E AA sequence (PubMed:2676596).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59859 mRNA No translation available.
PIRiA39773
UniGeneiRn.9560

Genome annotation databases

UCSCiRGD:3028 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59859 mRNA No translation available.
PIRiA39773
UniGeneiRn.9560

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000707

PTM databases

iPTMnetiP30009
PhosphoSitePlusiP30009

Proteomic databases

PaxDbiP30009
PRIDEiP30009

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3028 rat

Organism-specific databases

RGDi3028 Marcks

Phylogenomic databases

eggNOGiENOG410J04K Eukaryota
ENOG4111SZ0 LUCA
HOGENOMiHOG000113482
InParanoidiP30009

Miscellaneous databases

PROiPR:P30009

Family and domain databases

InterProiView protein in InterPro
IPR002101 MARCKS
PANTHERiPTHR14353 PTHR14353, 1 hit
PfamiView protein in Pfam
PF02063 MARCKS, 1 hit
PRINTSiPR00963 MARCKS
PROSITEiView protein in PROSITE
PS00826 MARCKS_1, 1 hit
PS00827 MARCKS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMARCS_RAT
AccessioniPrimary (citable) accession number: P30009
Secondary accession number(s): P20468
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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