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Entry version 159 (22 Apr 2020)
Sequence version 1 (01 Apr 1993)
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Protein

Inositol 1,4,5-trisphosphate receptor type 2

Gene

Itpr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-114508 Effects of PIP2 hydrolysis
R-RNO-139853 Elevation of cytosolic Ca2+ levels
R-RNO-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-RNO-5578775 Ion homeostasis
R-RNO-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.3.2.1 the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 2
Alternative name(s):
IP3 receptor isoform 2
Short name:
IP3R 2
Short name:
InsP3R2
Type 2 inositol 1,4,5-trisphosphate receptor
Short name:
Type 2 InsP3 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Itpr2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
69649 Itpr2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 2227CytoplasmicSequence analysisAdd BLAST2227
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2228 – 2248HelicalSequence analysisAdd BLAST21
Topological domaini2249 – 2260ExtracellularSequence analysisAdd BLAST12
Transmembranei2261 – 2281HelicalSequence analysisAdd BLAST21
Topological domaini2282 – 2284CytoplasmicSequence analysis3
Transmembranei2285 – 2305HelicalSequence analysisAdd BLAST21
Topological domaini2306 – 2307ExtracellularSequence analysis2
Transmembranei2308 – 2328HelicalSequence analysisAdd BLAST21
Topological domaini2329 – 2351CytoplasmicSequence analysisAdd BLAST23
Transmembranei2352 – 2372HelicalSequence analysisAdd BLAST21
Topological domaini2373 – 2394ExtracellularSequence analysisAdd BLAST22
Transmembranei2395 – 2415HelicalSequence analysisAdd BLAST21
Topological domaini2416 – 2521CytoplasmicSequence analysisAdd BLAST106
Transmembranei2522 – 2542HelicalSequence analysisAdd BLAST21
Topological domaini2543 – 2701ExtracellularSequence analysisAdd BLAST159

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001539261 – 2701Inositol 1,4,5-trisphosphate receptor type 2Add BLAST2701

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei937Phosphoserine; by PKABy similarity1
Modified residuei1160PhosphoserineBy similarity1
Modified residuei1709PhosphoserineBy similarity1
Modified residuei2607PhosphotyrosineSequence analysis1
Modified residuei2633PhosphoserineBy similarity1
Modified residuei2636PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P29995

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29995

PRoteomics IDEntifications database

More...
PRIDEi
P29995

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29995

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P29995

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

Interacts with CABP1 (PubMed:12032348).

Interacts with BOK; regulates ITPR2 expression.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
249575, 2 interactors

Protein interaction database and analysis system

More...
IntActi
P29995, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000047905

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P29995

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 166MIR 1PROSITE-ProRule annotationAdd BLAST55
Domaini173 – 223MIR 2PROSITE-ProRule annotationAdd BLAST51
Domaini231 – 287MIR 3PROSITE-ProRule annotationAdd BLAST57
Domaini294 – 357MIR 4PROSITE-ProRule annotationAdd BLAST64
Domaini378 – 434MIR 5PROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni265 – 269Inositol 1,4,5-trisphosphate bindingBy similarity5
Regioni507 – 510Inositol 1,4,5-trisphosphate bindingBy similarity4
Regioni567 – 569Inositol 1,4,5-trisphosphate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the InsP3 receptor family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3533 Eukaryota
ENOG410XR97 LUCA

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P29995

KEGG Orthology (KO)

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KOi
K04959

Database of Orthologous Groups

More...
OrthoDBi
94996at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P29995

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR035910 RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00779 INSP3RECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472 MIR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 2 hits
SSF48371 SSF48371, 1 hit
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P29995-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLTNPP
60 70 80 90 100
KKFRDCLFKV CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ
110 120 130 140 150
KQNESENRKL LGEIVKYSKV IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS
160 170 180 190 200
LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD KVVLMPVNAG QPLHASNVEL
210 220 230 240 250
LDNPGCKEVN AVNCNTSWKI TLFMKFSSYR EDVLKGGDVV RLFHAEQEKF
260 270 280 290 300
LTCDDYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN
310 320 330 340 350
SLFRFKHLAT GNYLAAELNP DYRDAQNEGK TVRDGELPTS KKKHQAGEKI
360 370 380 390 400
MYTLVSVPHG NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS
410 420 430 440 450
TSIPIDTEEE RPVMLKIGTC QTKEDKEAFA IVCVPLSEVR DLDFANDANK
460 470 480 490 500
VLATTVKKLE NGSITQNERR FVTKLLEDLI FFVADVTNNG QDVLDVVITK
510 520 530 540 550
PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED LGDQRYAPYK
560 570 580 590 600
YVLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH
610 620 630 640 650
NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NSTAIPVTQE
660 670 680 690 700
LICKFMLSPG NADILIQTKL VSMQVENPME SSILPDDIDD EEVWLYWIDS
710 720 730 740 750
NKEPHGKAIR HLAQEAREGT KADLEVLTYY RYQLNLFARM CLDRQYLAIN
760 770 780 790 800
QISTQLSVDL ILRCVSDESL PFDLRASFCR LMLHMHVDRD PQESVVPVRY
810 820 830 840 850
ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE YLKEVVNQPF
860 870 880 890 900
PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM
910 920 930 940 950
SSYFERLSKF QDGSNNVMRT IHGVGEMMTQ MVLSRGSIFP VSWPDAQPSV
960 970 980 990 1000
HPSKQASPGE QEDVTVMDTK LKVIEILQFI LSVRLDYRIS YMLSIYKKEF
1010 1020 1030 1040 1050
GENDGNGDPS ASGTPETLLP SALVPDIDEI AAQAETMFAG RKEKTPVQLD
1060 1070 1080 1090 1100
DEGGRTFLRV LIHLIMHDYA PLLSGALQLL FKHFSQRAEV LQAFKQVQLL
1110 1120 1130 1140 1150
VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSGSYENGD MGEGQAKGGE
1160 1170 1180 1190 1200
EANEESNLLS PVQDGAKTPQ IDSNKGNNYR IVKEILIRLS KLCVQNKKCR
1210 1220 1230 1240 1250
NQHQRLLKNM GAHSVVLDLL QIPYEKTDEK MNEVMDLAHT FLQNFCRGNP
1260 1270 1280 1290 1300
QNQVLLHKHL NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI
1310 1320 1330 1340 1350
ETHGRHVEYL RFLQTIVKAD GKYVKKCQDM VMTELINGGE DVLIFYNDRA
1360 1370 1380 1390 1400
SFPILLNMMC SERARGDESG PLAYHITLVE LLAACTEGKN VYTEIKCNSL
1410 1420 1430 1440 1450
LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE IYTSNHIWKL
1460 1470 1480 1490 1500
FENFLVDMAR VCNTTTDRKH ADTFLERCVT ESVMNIVSGF FNSPFSDNST
1510 1520 1530 1540 1550
SLQTHQPVFI QLLQSAFRIY NCTWPNPAQK ASVESCIRAL AEVAKNRGIA
1560 1570 1580 1590 1600
IPVDLDSQVN TLFMKNHSST VQRAAMGWRL SARSGPRFKE ALGGPAWDYR
1610 1620 1630 1640 1650
NIIEKLQDVV ASLEQQFSPM MQAEFSVLVD VLYSPELLFP EGSDARIRCG
1660 1670 1680 1690 1700
AFMSKLINHT KKLMEKEEKL CIKILQTLRE MLEKKDSFME ESSTLRKILL
1710 1720 1730 1740 1750
NRYFKGDHSV GVNGPLSGAY AKTAQVGGGF TGQDADKTGI SMSDIQCLLD
1760 1770 1780 1790 1800
KEGASELVID VIVNTKNDRI FSEGILLGIA LLEGGNTQTQ NSFYQQLHEQ
1810 1820 1830 1840 1850
KKSEKFFKVL YDRMKAAQKE IRSTVTVNTI DLGSKKREED SDLMALGPRM
1860 1870 1880 1890 1900
RVRDSSLHLK EGMKGQLTEA SSATSKAYCV YRREMDPDID TMCPGQEAGS
1910 1920 1930 1940 1950
AEEKSAEEVT MSPAITIMRP ILRFLQLLCE NHNRELQNFL RNQNNKTNYN
1960 1970 1980 1990 2000
LVCETLQFLD CICGSTTGGL GLLGLYINEK NVALVNQTLE SLTEYCQGPC
2010 2020 2030 2040 2050
HENQTCIATH ESNGIDIIIA LILSDINPLG KYRMDLVLQL KNNASKLLLA
2060 2070 2080 2090 2100
IMESRHDSEN AERILFNMRP KELVDVMKNA YNQGLECNHG DEEGGDDGVS
2110 2120 2130 2140 2150
PKDVGHNIYI LAHQLARHNK LLQQMLKPGS DPEEGDEALK YYANHTAQIE
2160 2170 2180 2190 2200
IVRHDRTMEQ IVFPVPNICE FLTRESKYRV FNTTERDEQG SKVNDFFQQT
2210 2220 2230 2240 2250
EDLYNEMKWQ KKIRNNPALF WFSRHISLWG SISFNLAVFI NLAVALFYPF
2260 2270 2280 2290 2300
GDDGDEGTLS PLFSALLWVA VAICTSMLFF FSKPVGIRPF LVSIMLRSIY
2310 2320 2330 2340 2350
TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV ILDMAFLYHV
2360 2370 2380 2390 2400
AYVLVCMLGL FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV
2410 2420 2430 2440 2450
LALILVYLFS IIGFLFLKDD FTMEVDRLKN RTPVTGNDGV PTMTLTSMLG
2460 2470 2480 2490 2500
TCPKENCSPT IPSSNAAGEG GEDGIERTCD TLLMCIVTVL NQGLRNGGGV
2510 2520 2530 2540 2550
GDVLRRPSKD EPLFAARVVY DLLFFFIVII IVLNLIFGVI IDTFADLRSE
2560 2570 2580 2590 2600
KQKKEKILKT TCFICGLERD KFDNKTVSFE EHIKSEHNMW HYLYFIVLVK
2610 2620 2630 2640 2650
VKDPTEYTGP ESYVAQMITE KNLDWFPRMR AMSLVSNEGD SEQNEIRNLQ
2660 2670 2680 2690 2700
EKLESTMSLV KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN TPHENHHMPP

H
Length:2,701
Mass (Da):307,058
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42BF7F1024335984
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LQR8F1LQR8_RAT
Inositol 1,4,5-trisphosphate recept...
Itpr2
2,058Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119K → N in AAK11622 (Ref. 2) Curated1
Sequence conflicti344H → R in AAK11622 (Ref. 2) Curated1
Sequence conflicti943W → V in AAK11622 (Ref. 2) Curated1
Sequence conflicti1692S → G in AAK11622 (Ref. 2) Curated1
Sequence conflicti2556K → E in AAK11622 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti689D → H. 1
Natural varianti1013G → C. 1
Natural varianti1256L → P. 1
Natural varianti2384V → I. 1
Natural varianti2694E → V. 1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X61677 mRNA Translation: CAA43852.1
AF329470 mRNA Translation: AAK11622.1

Protein sequence database of the Protein Information Resource

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PIRi
S17796

NCBI Reference Sequences

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RefSeqi
NP_112308.1, NM_031046.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
81678

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:81678

UCSC genome browser

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UCSCi
RGD:69649 rat

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61677 mRNA Translation: CAA43852.1
AF329470 mRNA Translation: AAK11622.1
PIRiS17796
RefSeqiNP_112308.1, NM_031046.3

3D structure databases

SMRiP29995
ModBaseiSearch...

Protein-protein interaction databases

BioGridi249575, 2 interactors
IntActiP29995, 2 interactors
STRINGi10116.ENSRNOP00000047905

Protein family/group databases

TCDBi1.A.3.2.1 the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

PTM databases

iPTMnetiP29995
PhosphoSitePlusiP29995

Proteomic databases

jPOSTiP29995
PaxDbiP29995
PRIDEiP29995

Genome annotation databases

GeneIDi81678
KEGGirno:81678
UCSCiRGD:69649 rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3709
RGDi69649 Itpr2

Phylogenomic databases

eggNOGiKOG3533 Eukaryota
ENOG410XR97 LUCA
InParanoidiP29995
KOiK04959
OrthoDBi94996at2759
PhylomeDBiP29995

Enzyme and pathway databases

ReactomeiR-RNO-114508 Effects of PIP2 hydrolysis
R-RNO-139853 Elevation of cytosolic Ca2+ levels
R-RNO-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-RNO-5578775 Ion homeostasis
R-RNO-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

Protein Ontology

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PROi
PR:P29995

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR035910 RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits
PRINTSiPR00779 INSP3RECEPTR
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF48371 SSF48371, 1 hit
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITPR2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29995
Secondary accession number(s): Q99P56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 22, 2020
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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