GNA11

Functionⁱ

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	53	MagnesiumBy similarity	1
Metal bindingⁱ	186	MagnesiumBy similarity	1
Binding siteⁱ	331	GTP; via amide nitrogenBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	46 – 53	GTPBy similarity	8
Nucleotide bindingⁱ	180 – 186	GTPBy similarity	7
Nucleotide bindingⁱ	205 – 209	GTPBy similarity	5
Nucleotide bindingⁱ	274 – 277	GTPBy similarity	4

GO - Molecular functionⁱ

G-protein beta/gamma-subunit complex binding Source: GO_Central
GTPase activity Source: GO_Central
GTP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
type 2A serotonin receptor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

action potential Source: GO_Central
adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: GO_Central
cellular response to pH Source: Ensembl
developmental pigmentation Source: Ensembl
entrainment of circadian clock Source: AgBase
G-protein coupled acetylcholine receptor signaling pathway Source: AgBase
G-protein coupled receptor signaling pathway Source: Reactome
heart development Source: Ensembl
phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
phototransduction, visible light Source: AgBase
platelet activation Source: Reactome
regulation of melanocyte differentiation Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 8530500
skeletal system development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transducer
Ligand	GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-399997 Acetylcholine regulates insulin secretion R-HSA-416476 G alpha (q) signalling events R-HSA-418592 ADP signalling through P2Y purinoceptor 1 R-HSA-428930 Thromboxane signalling through TP receptor R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
SIGNORⁱ	P29992

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Guanine nucleotide-binding protein subunit alpha-11 Short name: G alpha-11 Short name: G-protein subunit alpha-11 Alternative name(s): Guanine nucleotide-binding protein G(y) subunit alpha
Gene namesⁱ	Name:GNA11 Synonyms:GA11
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000088256.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4379 GNA11
MIMⁱ	139313 gene
neXtProtⁱ	NX_P29992

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hypocalciuric hypercalcemia, familial 2 (HHC2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of hypocalciuric hypercalcemia, a disorder of mineral homeostasis that is transmitted as an autosomal dominant trait with a high degree of penetrance. It is characterized biochemically by lifelong elevation of serum calcium concentrations and is associated with inappropriately low urinary calcium excretion and a normal or mildly elevated circulating parathyroid hormone level. Hypermagnesemia is typically present. Affected individuals are usually asymptomatic and the disorder is considered benign. However, chondrocalcinosis and pancreatitis occur in some adults.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_070166	135	L → Q in HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations. 1 PublicationCorresponds to variant dbSNP:rs587777019EnsemblClinVar.		1
Natural variantⁱVAR_070168	200	Missing in HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations. 1 Publication		1

Hypocalcemia, autosomal dominant 2 (HYPOC2)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of hypocalcemia, a disorder of mineral homeostasis characterized by blood calcium levels below normal, and low or normal serum parathyroid hormone concentrations. Disease manifestations include hypocalcemia, paresthesias, carpopedal spasm, seizures, hypercalciuria with nephrocalcinosis or kidney stones, and ectopic and basal ganglia calcifications.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2767
MalaCards human disease database More...MalaCardsⁱ	GNA11
MIMⁱ	145981 phenotype 615361 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000088256
Orphanetⁱ	428 Autosomal dominant hypocalcemia 101049 Familial hypocalciuric hypercalcemia type 2
PharmGKBⁱ	PA28764

Polymorphism and mutation databases

DMDMⁱ	3041682

DMDMⁱ

3041682

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000203746	1 – 359	Guanine nucleotide-binding protein subunit alpha-11Add BLAST		359

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	9	S-palmitoyl cysteine1 Publication	1
Lipidationⁱ	10	S-palmitoyl cysteine1 Publication	1
Modified residueⁱ	183	ADP-ribosylarginine; by cholera toxinBy similarity	1
Modified residueⁱ	209	Deamidated glutamine; by Photorhabdus PAU_022301 Publication	1

Post-translational modificationⁱ

(Microbial infection) Deamidated at Gln-209 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.1 Publication

Keywords - PTMⁱ

ADP-ribosylation, Lipoprotein, Palmitate

Proteomic databases

EPDⁱ	P29992
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P29992
PaxDbⁱ	P29992
PeptideAtlas More...PeptideAtlasⁱ	P29992
PRIDEⁱ	P29992
ProteomicsDBⁱ	54615

PTM databases

iPTMnetⁱ	P29992
PhosphoSitePlusⁱ	P29992
SwissPalmⁱ	P29992

Expressionⁱ

Tissue specificityⁱ

Expressed in testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000088256 Expressed in 238 organ(s), highest expression level in colonic mucosa
CleanExⁱ	HS_GNA11
ExpressionAtlasⁱ	P29992 baseline and differential
Genevisibleⁱ	P29992 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048886

HPAⁱ

HPA048886

Interactionⁱ

Subunit structureⁱ

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22. Interacts with NTSR1.2 Publications

GO - Molecular functionⁱ

type 2A serotonin receptor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109029, 39 interactors
CORUMⁱ	P29992
IntActⁱ	P29992, 8 interactors
STRINGⁱ	9606.ENSP00000078429

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P29992
SMRⁱ	P29992
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-alpha family. G(q) subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0085 Eukaryota ENOG410XNVQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118851
HOGENOMⁱ	HOG000038729
HOVERGENⁱ	HBG063184
InParanoidⁱ	P29992
KEGG Orthology (KO) More...KOⁱ	K04635
OMAⁱ	FEHQYVN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0VUT
PhylomeDBⁱ	P29992
TreeFamⁱ	TF300673

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00066 G-alpha, 1 hit
Gene3Dⁱ	1.10.400.10, 1 hit
InterProⁱ	View protein in InterPro IPR000654 Gprotein_alpha_Q IPR001019 Gprotein_alpha_su IPR011025 GproteinA_insert IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR10218 PTHR10218, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00503 G-alpha, 1 hit
PRINTSⁱ	PR00318 GPROTEINA PR00442 GPROTEINAQ
SMARTⁱ	View protein in SMART SM00275 G_alpha, 1 hit
SUPFAMⁱ	SSF47895 SSF47895, 1 hit SSF52540 SSF52540, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P29992-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES 
        60         70         80         90        100
GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM IRAMETLKIL 
       110        120        130        140        150
YKYEQNKANA LLIREVDVEK VTTFEHQYVS AIKTLWEDPG IQECYDRRRE 
       160        170        180        190        200
YQLSDSAKYY LTDVDRIATL GYLPTQQDVL RVRVPTTGII EYPFDLENII 
       210        220        230        240        250
FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE 
       260        270        280        290        300
SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILYSHLVD YFPEFDGPQR 
       310        320        330        340        350
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ 

LNLKEYNLV

Length:359

Mass (Da):42,123

Last modified:July 15, 1998 - v2

Checksum:ⁱDD37176589E66046

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EL62	K7EL62_HUMAN	Guanine nucleotide-binding protein ... Guanine nucleotide-binding protein subunit alpha-11	GNA11	236	Annotation score:
A0A087WVZ3	A0A087WVZ3_HUMAN	Guanine nucleotide-binding protein ... Guanine nucleotide-binding protein subunit alpha-11	GNA11	72	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	6	M → I in AAB64303 (Ref. 2) Curated	1
Sequence conflictⁱ	266	N → H in AAA99949 (PubMed:7492305).Curated	1
Sequence conflictⁱ	285	Y → H in AAA99949 (PubMed:7492305).Curated	1
Sequence conflictⁱ	301 – 302	DA → EP in AAA58624 (PubMed:1902575).Curated	2
Sequence conflictⁱ	310	L → P in AAB64303 (Ref. 2) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_070165	60	R → C in HYPOC2. 1 PublicationCorresponds to variant dbSNP:rs587777021EnsemblClinVar.	1
Natural variantⁱVAR_070166	135	L → Q in HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations. 1 PublicationCorresponds to variant dbSNP:rs587777019EnsemblClinVar.	1
Natural variantⁱVAR_070167	181	R → Q in HYPOC2; induces an increase in sensitivity to changes in extracellular calcium concentrations. 1 PublicationCorresponds to variant dbSNP:rs587777020EnsemblClinVar.	1
Natural variantⁱVAR_070168	200	Missing in HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations. 1 Publication	1
Natural variantⁱVAR_070169	211	S → W in HYPOC2. 1 PublicationCorresponds to variant dbSNP:rs587777022EnsemblClinVar.	1
Natural variantⁱVAR_070170	341	F → L in HYPOC2; induces an increase in sensitivity to changes in extracellular calcium concentrations. 1 PublicationCorresponds to variant dbSNP:rs140749796EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M69013 mRNA Translation: AAA58624.1 AF011497 mRNA Translation: AAB64303.1 AF493900 mRNA Translation: AAM12614.1 CR457004 mRNA Translation: CAG33285.1 AC005262 Genomic DNA Translation: AAC25615.1 BC089041 mRNA Translation: AAH89041.1 BC096225 mRNA Translation: AAH96225.1 BC096226 mRNA Translation: AAH96226.1 BC096227 mRNA Translation: AAH96227.1 L40630 mRNA Translation: AAA99949.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12103.1
PIRⁱ	A39394 RGHUGY
NCBI Reference Sequences More...RefSeqⁱ	NP_002058.2, NM_002067.4
UniGeneⁱ	Hs.650575 Hs.654784

Genome annotation databases

Ensemblⁱ	ENST00000078429; ENSP00000078429; ENSG00000088256
GeneIDⁱ	2767
KEGGⁱ	hsa:2767
UCSC genome browser More...UCSCⁱ	uc010xhe.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P29992	G protein subunit alpha 11		PANTR		359	UniRef100_P29992
Guanine nucleotide-binding protein G, alpha subunit variant (Fragment)		HUMAN		357
Uncharacterized protein		PANPA		319
G protein subunit alpha 11		GORGO		313
UPI0004F051FF		GORGO		301

Protein	Similar proteins		Species	Score	Length	Source
P29992	Guanine nucleotide-binding protein subunit alpha-11		XENLA		359	UniRef90_P29992
Guanine nucleotide-binding protein subunit alpha-11		RAT		359
Guanine nucleotide-binding protein subunit alpha-11		PIG		359
Guanine nucleotide-binding protein subunit alpha-11		MOUSE		359
Guanine nucleotide-binding protein subunit alpha-11		MELGA		359
+181

Protein	Similar proteins		Species	Score	Length	Source
P29992	Isoform A of G protein alpha q subunit		DROME		353	UniRef50_P23625-2
Guanine nucleotide-binding protein subunit alpha-11		MELGA		359
Guanine nucleotide-binding protein G(q) subunit alpha		XENLA		359
Guanine nucleotide-binding protein subunit alpha-11		RAT		359
Guanine nucleotide-binding protein subunit alpha-11		PIG		359
+420

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M69013 mRNA Translation: AAA58624.1 AF011497 mRNA Translation: AAB64303.1 AF493900 mRNA Translation: AAM12614.1 CR457004 mRNA Translation: CAG33285.1 AC005262 Genomic DNA Translation: AAC25615.1 BC089041 mRNA Translation: AAH89041.1 BC096225 mRNA Translation: AAH96225.1 BC096226 mRNA Translation: AAH96226.1 BC096227 mRNA Translation: AAH96227.1 L40630 mRNA Translation: AAA99949.1
CCDSⁱ	CCDS12103.1
PIRⁱ	A39394 RGHUGY
RefSeqⁱ	NP_002058.2, NM_002067.4
UniGeneⁱ	Hs.650575 Hs.654784

3D structure databases

ProteinModelPortalⁱ	P29992
SMRⁱ	P29992
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109029, 39 interactors
CORUMⁱ	P29992
IntActⁱ	P29992, 8 interactors
STRINGⁱ	9606.ENSP00000078429

PTM databases

iPTMnetⁱ	P29992
PhosphoSitePlusⁱ	P29992
SwissPalmⁱ	P29992

Polymorphism and mutation databases

DMDMⁱ	3041682

DMDMⁱ

3041682

Proteomic databases

EPDⁱ	P29992
MaxQBⁱ	P29992
PaxDbⁱ	P29992
PeptideAtlasⁱ	P29992
PRIDEⁱ	P29992
ProteomicsDBⁱ	54615

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000078429; ENSP00000078429; ENSG00000088256
GeneIDⁱ	2767
KEGGⁱ	hsa:2767
UCSCⁱ	uc010xhe.5 human

Organism-specific databases

CTDⁱ	2767
DisGeNETⁱ	2767
EuPathDBⁱ	HostDB:ENSG00000088256.8
GeneCardsⁱ	GNA11
HGNCⁱ	HGNC:4379 GNA11
HPAⁱ	HPA048886
MalaCardsⁱ	GNA11
MIMⁱ	139313 gene 145981 phenotype 615361 phenotype
neXtProtⁱ	NX_P29992
OpenTargetsⁱ	ENSG00000088256
Orphanetⁱ	428 Autosomal dominant hypocalcemia 101049 Familial hypocalciuric hypercalcemia type 2
PharmGKBⁱ	PA28764
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0085 Eukaryota ENOG410XNVQ LUCA
GeneTreeⁱ	ENSGT00760000118851
HOGENOMⁱ	HOG000038729
HOVERGENⁱ	HBG063184
InParanoidⁱ	P29992
KOⁱ	K04635
OMAⁱ	FEHQYVN
OrthoDBⁱ	EOG091G0VUT
PhylomeDBⁱ	P29992
TreeFamⁱ	TF300673

Enzyme and pathway databases

Reactomeⁱ	R-HSA-399997 Acetylcholine regulates insulin secretion R-HSA-416476 G alpha (q) signalling events R-HSA-418592 ADP signalling through P2Y purinoceptor 1 R-HSA-428930 Thromboxane signalling through TP receptor R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
SIGNORⁱ	P29992

Miscellaneous databases

ChiTaRSⁱ	GNA11 human
GeneWikiⁱ	GNA11
GenomeRNAiⁱ	2767
Protein Ontology More...PROⁱ	PR:P29992
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000088256 Expressed in 238 organ(s), highest expression level in colonic mucosa
CleanExⁱ	HS_GNA11
ExpressionAtlasⁱ	P29992 baseline and differential
Genevisibleⁱ	P29992 HS

Family and domain databases

CDDⁱ	cd00066 G-alpha, 1 hit
Gene3Dⁱ	1.10.400.10, 1 hit
InterProⁱ	View protein in InterPro IPR000654 Gprotein_alpha_Q IPR001019 Gprotein_alpha_su IPR011025 GproteinA_insert IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR10218 PTHR10218, 1 hit
Pfamⁱ	View protein in Pfam PF00503 G-alpha, 1 hit
PRINTSⁱ	PR00318 GPROTEINA PR00442 GPROTEINAQ
SMARTⁱ	View protein in SMART SM00275 G_alpha, 1 hit
SUPFAMⁱ	SSF47895 SSF47895, 1 hit SSF52540 SSF52540, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GNA11_HUMAN
Accessionⁱ	P29992Primary (citable) accession number: P29992 Secondary accession number(s): O15109, Q14350, Q6IB00
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	July 15, 1998
	Last modified:	September 12, 2018
	This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P29992 (GNA11_HUMAN)

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Guanine nucleotide-binding protein subunit alpha-11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Extracellular region or secreted

Lysosome

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ