Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P29992 (GNA11_HUMAN)

Entry version 200 (02 Jun 2021)
Sequence version 2 (15 Jul 1998)
Previous versions | rss
Add a publicationFeedback
Protein

Guanine nucleotide-binding protein subunit alpha-11

Gene

GNA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs).

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi53MagnesiumBy similarity1
Metal bindingi186MagnesiumBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei331GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi46 – 53GTPBy similarity8
Nucleotide bindingi180 – 186GTPBy similarity7
Nucleotide bindingi205 – 209GTPBy similarity5
Nucleotide bindingi274 – 277GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P29992

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-399997, Acetylcholine regulates insulin secretion
R-HSA-416476, G alpha (q) signalling events
R-HSA-418592, ADP signalling through P2Y purinoceptor 1
R-HSA-428930, Thromboxane signalling through TP receptor
R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs)

SIGNOR Signaling Network Open Resource

More...SIGNORi		P29992

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.92.1.5, the g-protein AlphaBetaGama complex (gpc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit alpha-11
Short name:
G alpha-11
Short name:
G-protein subunit alpha-11
Alternative name(s):
Guanine nucleotide-binding protein G(y) subunit alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GNA11
Synonyms:GA11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4379, GNA11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		139313, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P29992

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000088256.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypocalciuric hypercalcemia, familial 2 (HHC2)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of hypocalciuric hypercalcemia, a disorder of mineral homeostasis that is transmitted as an autosomal dominant trait with a high degree of penetrance. It is characterized biochemically by lifelong elevation of serum calcium concentrations and is associated with inappropriately low urinary calcium excretion and a normal or mildly elevated circulating parathyroid hormone level. Hypermagnesemia is typically present. Affected individuals are usually asymptomatic and the disorder is considered benign. However, chondrocalcinosis and pancreatitis occur in some adults.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070166135L → Q in HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations. 1 PublicationCorresponds to variant dbSNP:rs587777019EnsemblClinVar.1
Natural variantiVAR_070168200Missing in HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations. 1 PublicationCorresponds to variant dbSNP:rs672601249Ensembl.1
Hypocalcemia, autosomal dominant 2 (HYPOC2)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of hypocalcemia, a disorder of mineral homeostasis characterized by blood calcium levels below normal, and low or normal serum parathyroid hormone concentrations. Disease manifestations include hypocalcemia, paresthesias, carpopedal spasm, seizures, hypercalciuria with nephrocalcinosis or kidney stones, and ectopic and basal ganglia calcifications.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07016560R → C in HYPOC2. 1 PublicationCorresponds to variant dbSNP:rs587777021EnsemblClinVar.1
Natural variantiVAR_070167181R → Q in HYPOC2; induces an increase in sensitivity to changes in extracellular calcium concentrations. 1 PublicationCorresponds to variant dbSNP:rs587777020EnsemblClinVar.1
Natural variantiVAR_070169211S → W in HYPOC2. 1 PublicationCorresponds to variant dbSNP:rs587777022EnsemblClinVar.1
Natural variantiVAR_070170341F → L in HYPOC2; induces an increase in sensitivity to changes in extracellular calcium concentrations. 1 PublicationCorresponds to variant dbSNP:rs140749796EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		2767

MalaCards human disease database

More...MalaCardsi		GNA11
MIMi145981, phenotype
615361, phenotype

Open Targets

More...OpenTargetsi		ENSG00000088256

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		428, Autosomal dominant hypocalcemia
101049, Familial hypocalciuric hypercalcemia type 2
79483, Phakomatosis cesioflammea
79484, Phakomatosis cesiomarmorata
39044, Uveal melanoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28764

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P29992, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295740

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GNA11

Domain mapping of disease mutations (DMDM)

More...DMDMi		3041682

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002037461 – 359Guanine nucleotide-binding protein subunit alpha-11Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi9S-palmitoyl cysteine1 Publication1
Lipidationi10S-palmitoyl cysteine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei183ADP-ribosylarginine; by cholera toxinBy similarity1
Modified residuei209Deamidated glutamine; by Photorhabdus PAU_022301 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

(Microbial infection) Deamidated at Gln-209 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.1 Publication

Keywords - PTMi

ADP-ribosylation, Lipoprotein, Palmitate

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P29992

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P29992

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P29992

MaxQB - The MaxQuant DataBase

More...MaxQBi		P29992

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P29992

PeptideAtlas

More...PeptideAtlasi		P29992

PRoteomics IDEntifications database

More...PRIDEi		P29992

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54615

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P29992

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P29992

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P29992

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000088256, Expressed in colonic mucosa and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P29992, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P29992, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000088256, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Interacts with RGS22.

Interacts with NTSR1.

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109029, 55 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P29992

Protein interaction database and analysis system

More...IntActi		P29992, 13 interactors

Molecular INTeraction database

More...MINTi		P29992

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000078429

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P29992

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P29992, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P29992

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 359G-alphaPROSITE-ProRule annotationAdd BLAST322

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 54G1 motifPROSITE-ProRule annotationAdd BLAST14
Regioni178 – 186G2 motifPROSITE-ProRule annotation9
Regioni201 – 210G3 motifPROSITE-ProRule annotation10
Regioni270 – 277G4 motifPROSITE-ProRule annotation8
Regioni329 – 334G5 motifPROSITE-ProRule annotation6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-alpha family. G(q) subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0085, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161033

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014184_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P29992

Identification of Orthologs from Complete Genome Data

More...OMAi		QMRYIHT

Database of Orthologous Groups

More...OrthoDBi		754573at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P29992

TreeFam database of animal gene trees

More...TreeFami		TF300673

Family and domain databases

Conserved Domains Database

More...CDDi		cd00066, G-alpha, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.400.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000654, Gprotein_alpha_Q
IPR001019, Gprotein_alpha_su
IPR011025, GproteinA_insert
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR10218, PTHR10218, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00503, G-alpha, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00318, GPROTEINA
PR00442, GPROTEINAQ

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00275, G_alpha, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47895, SSF47895, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51882, G_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P29992-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES 
        60         70         80         90        100
GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM IRAMETLKIL 
       110        120        130        140        150
YKYEQNKANA LLIREVDVEK VTTFEHQYVS AIKTLWEDPG IQECYDRRRE 
       160        170        180        190        200
YQLSDSAKYY LTDVDRIATL GYLPTQQDVL RVRVPTTGII EYPFDLENII 
       210        220        230        240        250
FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE 
       260        270        280        290        300
SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILYSHLVD YFPEFDGPQR 
       310        320        330        340        350
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ 

LNLKEYNLV
Length:359
Mass (Da):42,123
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD37176589E66046
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EL62K7EL62_HUMAN
Guanine nucleotide-binding protein ...
GNA11
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVZ3A0A087WVZ3_HUMAN
Guanine nucleotide-binding protein ...
GNA11
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6M → I in AAB64303 (Ref. 2) Curated1
Sequence conflicti266N → H in AAA99949 (PubMed:7492305).Curated1
Sequence conflicti285Y → H in AAA99949 (PubMed:7492305).Curated1
Sequence conflicti301 – 302DA → EP in AAA58624 (PubMed:1902575).Curated2
Sequence conflicti310L → P in AAB64303 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07016560R → C in HYPOC2. 1 PublicationCorresponds to variant dbSNP:rs587777021EnsemblClinVar.1
Natural variantiVAR_070166135L → Q in HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations. 1 PublicationCorresponds to variant dbSNP:rs587777019EnsemblClinVar.1
Natural variantiVAR_070167181R → Q in HYPOC2; induces an increase in sensitivity to changes in extracellular calcium concentrations. 1 PublicationCorresponds to variant dbSNP:rs587777020EnsemblClinVar.1
Natural variantiVAR_070168200Missing in HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations. 1 PublicationCorresponds to variant dbSNP:rs672601249Ensembl.1
Natural variantiVAR_070169211S → W in HYPOC2. 1 PublicationCorresponds to variant dbSNP:rs587777022EnsemblClinVar.1
Natural variantiVAR_070170341F → L in HYPOC2; induces an increase in sensitivity to changes in extracellular calcium concentrations. 1 PublicationCorresponds to variant dbSNP:rs140749796EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M69013 mRNA Translation: AAA58624.1
AF011497 mRNA Translation: AAB64303.1
AF493900 mRNA Translation: AAM12614.1
CR457004 mRNA Translation: CAG33285.1
AC005262 Genomic DNA Translation: AAC25615.1
BC089041 mRNA Translation: AAH89041.1
BC096225 mRNA Translation: AAH96225.1
BC096226 mRNA Translation: AAH96226.1
BC096227 mRNA Translation: AAH96227.1
L40630 mRNA Translation: AAA99949.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12103.1

Protein sequence database of the Protein Information Resource

More...PIRi		A39394, RGHUGY

NCBI Reference Sequences

More...RefSeqi		NP_002058.2, NM_002067.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000078429; ENSP00000078429; ENSG00000088256

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2767

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2767

UCSC genome browser

More...UCSCi		uc010xhe.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69013 mRNA Translation: AAA58624.1
AF011497 mRNA Translation: AAB64303.1
AF493900 mRNA Translation: AAM12614.1
CR457004 mRNA Translation: CAG33285.1
AC005262 Genomic DNA Translation: AAC25615.1
BC089041 mRNA Translation: AAH89041.1
BC096225 mRNA Translation: AAH96225.1
BC096226 mRNA Translation: AAH96226.1
BC096227 mRNA Translation: AAH96227.1
L40630 mRNA Translation: AAA99949.1
CCDSiCCDS12103.1
PIRiA39394, RGHUGY
RefSeqiNP_002058.2, NM_002067.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6OIJelectron microscopy3.30A36-359[»]
SMRiP29992
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109029, 55 interactors
CORUMiP29992
IntActiP29992, 13 interactors
MINTiP29992
STRINGi9606.ENSP00000078429

Chemistry databases

BindingDBiP29992
ChEMBLiCHEMBL4295740

Protein family/group databases

TCDBi8.A.92.1.5, the g-protein AlphaBetaGama complex (gpc) family

PTM databases

iPTMnetiP29992
PhosphoSitePlusiP29992
SwissPalmiP29992

Genetic variation databases

BioMutaiGNA11
DMDMi3041682

Proteomic databases

EPDiP29992
jPOSTiP29992
MassIVEiP29992
MaxQBiP29992
PaxDbiP29992
PeptideAtlasiP29992
PRIDEiP29992
ProteomicsDBi54615

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		53288, 259 antibodies

The DNASU plasmid repository

More...DNASUi		2767

Genome annotation databases

EnsembliENST00000078429; ENSP00000078429; ENSG00000088256
GeneIDi2767
KEGGihsa:2767
UCSCiuc010xhe.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2767
DisGeNETi2767

GeneCards: human genes, protein and diseases

More...GeneCardsi		GNA11
HGNCiHGNC:4379, GNA11
HPAiENSG00000088256, Tissue enhanced (intestine)
MalaCardsiGNA11
MIMi139313, gene
145981, phenotype
615361, phenotype
neXtProtiNX_P29992
OpenTargetsiENSG00000088256
Orphaneti428, Autosomal dominant hypocalcemia
101049, Familial hypocalciuric hypercalcemia type 2
79483, Phakomatosis cesioflammea
79484, Phakomatosis cesiomarmorata
39044, Uveal melanoma
PharmGKBiPA28764
VEuPathDBiHostDB:ENSG00000088256.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0085, Eukaryota
GeneTreeiENSGT00940000161033
HOGENOMiCLU_014184_6_0_1
InParanoidiP29992
OMAiQMRYIHT
OrthoDBi754573at2759
PhylomeDBiP29992
TreeFamiTF300673

Enzyme and pathway databases

PathwayCommonsiP29992
ReactomeiR-HSA-399997, Acetylcholine regulates insulin secretion
R-HSA-416476, G alpha (q) signalling events
R-HSA-418592, ADP signalling through P2Y purinoceptor 1
R-HSA-428930, Thromboxane signalling through TP receptor
R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs)
SIGNORiP29992

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2767, 23 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GNA11, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GNA11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2767
PharosiP29992, Tbio

Protein Ontology

More...PROi		PR:P29992
RNActiP29992, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000088256, Expressed in colonic mucosa and 251 other tissues
ExpressionAtlasiP29992, baseline and differential
GenevisibleiP29992, HS

Family and domain databases

CDDicd00066, G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000654, Gprotein_alpha_Q
IPR001019, Gprotein_alpha_su
IPR011025, GproteinA_insert
IPR027417, P-loop_NTPase
PANTHERiPTHR10218, PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503, G-alpha, 1 hit
PRINTSiPR00318, GPROTEINA
PR00442, GPROTEINAQ
SMARTiView protein in SMART
SM00275, G_alpha, 1 hit
SUPFAMiSSF47895, SSF47895, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51882, G_ALPHA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGNA11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29992
Secondary accession number(s): O15109, Q14350, Q6IB00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 15, 1998
Last modified: June 2, 2021
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again