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Entry version 222 (22 Apr 2020)
Sequence version 3 (23 Jan 2007)
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Protein

Aquaporin-1

Gene

AQP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.1 Publication

Miscellaneous

Pharmacologically inhibited by submillimolar concentrations of mercury.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei56Substrate discrimination1
Sitei180Substrate discrimination1
Sitei189Hg(2+)-sensitive residue1
Sitei195Substrate discrimination1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionBlood group antigen
Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-432047 Passive transport by Aquaporins

SIGNOR Signaling Network Open Resource

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SIGNORi
P29972

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.8.8.1 the major intrinsic protein (mip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aquaporin-1
Short name:
AQP-1
Alternative name(s):
Aquaporin-CHIP
Urine water channel
Water channel protein for red blood cells and kidney proximal tubule
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AQP1
Synonyms:CHIP28
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:633 AQP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
107776 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29972

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 7Cytoplasmic1 Publication6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 36Helical; Name=Helix 1Add BLAST29
Topological domaini37 – 48Extracellular1 PublicationAdd BLAST12
Transmembranei49 – 66Helical; Name=Helix 2Add BLAST18
Topological domaini67 – 70Cytoplasmic1 Publication4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei71 – 766
Intramembranei77 – 84Helical; Name=Helix B8
Topological domaini85 – 94Cytoplasmic1 Publication10
Transmembranei95 – 115Helical; Name=Helix 3Add BLAST21
Topological domaini116 – 136Extracellular1 PublicationAdd BLAST21
Transmembranei137 – 155Helical; Name=Helix 4Add BLAST19
Topological domaini156 – 166Cytoplasmic1 PublicationAdd BLAST11
Transmembranei167 – 183Helical; Name=Helix 5Add BLAST17
Topological domaini184 – 186Extracellular1 Publication3
Intramembranei187 – 1926
Intramembranei193 – 200Helical; Name=Helix E8
Topological domaini201 – 207Extracellular1 Publication7
Transmembranei208 – 228Helical; Name=Helix 6Add BLAST21
Topological domaini229 – 269Cytoplasmic1 PublicationAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
358

MalaCards human disease database

More...
MalaCardsi
AQP1
MIMi110450 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000240583

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24918

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P29972 Tbio

Chemistry databases

Drug and drug target database

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DrugBanki
DB00819 Acetazolamide
DB02451 B-nonylglucoside
DB09338 Mersalyl

DrugCentral

More...
DrugCentrali
P29972

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AQP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
267412

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000639202 – 269Aquaporin-1Add BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi42N-linked (GlcNAc...) asparagine1
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei247PhosphoserineBy similarity1
Modified residuei253PhosphotyrosineBy similarity1
Modified residuei262PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P29972

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P29972

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P29972

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P29972

PeptideAtlas

More...
PeptideAtlasi
P29972

PRoteomics IDEntifications database

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PRIDEi
P29972

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
16873
19345
24598
54613 [P29972-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29972

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P29972

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000240583 Expressed in right lung and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P29972 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P29972 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000240583 Tissue enhanced (kidney)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

Interacts with EPHB2; involved in endolymph production in the inner ear (By similarity).

Identified in a complex with STOM.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P29972
With#Exp.IntAct
itself3EBI-745213,EBI-745213
AMOT [A2BDD9]3EBI-745213,EBI-17286414
AQP6 [Q13520]3EBI-745213,EBI-13059134
BCL2L13 [Q9BXK5]3EBI-745213,EBI-747430
BEGAIN [Q9BUH8]3EBI-745213,EBI-742722
BHLHB9 [Q6PI77]3EBI-745213,EBI-11519926
BLZF1 [Q9H2G9]3EBI-745213,EBI-2548012
BMF [Q96LC9]3EBI-745213,EBI-3919268
CCDC136 - isoform 2 [Q96JN2-2]3EBI-745213,EBI-10171416
CCDC36 [Q8IYA8]3EBI-745213,EBI-8638439
CCDC57 [Q2TAC2]3EBI-745213,EBI-2808286
CCNDBP1 [O95273]3EBI-745213,EBI-748961
CD79A [P11912]3EBI-745213,EBI-7797864
CDR2 [Q01850]3EBI-745213,EBI-1181367
CEP44 [Q9C0F1]3EBI-745213,EBI-744115
CLDN5 [O00501]3EBI-745213,EBI-18400628
COMP [P49747]3EBI-745213,EBI-2531022
CPLX4 [Q7Z7G2]3EBI-745213,EBI-18013275
CREB3 - isoform 1 [O43889-2]3EBI-745213,EBI-625022
CRTAC1 [Q9NQ79]3EBI-745213,EBI-10205543
CSRNP1 [Q96S65]3EBI-745213,EBI-4311573
CYSRT1 [A8MQ03]3EBI-745213,EBI-3867333
ESM1 [Q9NQ30]3EBI-745213,EBI-12260294
EVI2B - isoform 2 [P34910-2]3EBI-745213,EBI-17640610
FAM161A [Q3B820]3EBI-745213,EBI-719941
FAM209A [Q5JX71]3EBI-745213,EBI-18304435
FNDC9 [Q8TBE3]3EBI-745213,EBI-12142257
FOS [Q6FG41]3EBI-745213,EBI-10198738
FSD2 [A1L4K1]3EBI-745213,EBI-5661036
GJB5 [O95377]3EBI-745213,EBI-3909454
GLI1 [P08151]3EBI-745213,EBI-308084
GOLGA2 [Q08379]3EBI-745213,EBI-618309
GPR37L1 [O60883]3EBI-745213,EBI-2927498
GPX8 [Q8TED1]3EBI-745213,EBI-11721746
IFT20 - isoform 3 [Q8IY31-3]3EBI-745213,EBI-9091197
IGFBP6 [P24592]3EBI-745213,EBI-947015
IKZF2 [Q9UKS7]3EBI-745213,EBI-3893057
IKZF3 [Q9UKT9]6EBI-745213,EBI-747204
IL21R [Q9HBE5]3EBI-745213,EBI-12558959
KCNK5 [O95279]3EBI-745213,EBI-3934936
KCTD9 [Q7L273]3EBI-745213,EBI-4397613
KHDRBS3 [O75525]3EBI-745213,EBI-722504
KIAA1958 [Q8N8K9]3EBI-745213,EBI-10181113
KLHL26 [Q53HC5]3EBI-745213,EBI-724915
KRT31 [Q15323]3EBI-745213,EBI-948001
KRT33B [Q14525]3EBI-745213,EBI-1049638
KRT37 [O76014]3EBI-745213,EBI-1045716
KRT40 [Q6A162]3EBI-745213,EBI-10171697
KRTAP1-1 [Q07627]3EBI-745213,EBI-11959885
KRTAP1-5 [Q9BYS1]3EBI-745213,EBI-11741292
KRTAP10-7 [P60409]3EBI-745213,EBI-10172290
KRTAP10-8 [P60410]3EBI-745213,EBI-10171774
KRTAP12-4 [P60329]3EBI-745213,EBI-10176396
KRTAP3-2 [Q9BYR7]3EBI-745213,EBI-751260
KRTAP4-2 [Q9BYR5]6EBI-745213,EBI-10172511
KRTAP4-4 [Q9BYR3]3EBI-745213,EBI-11958132
KRTAP6-2 [Q3LI66]3EBI-745213,EBI-11962084
KRTAP9-2 [Q9BYQ4]3EBI-745213,EBI-1044640
KRTAP9-8 [Q9BYQ0]3EBI-745213,EBI-11958364
LCE1A [Q5T7P2]3EBI-745213,EBI-11962058
LDLRAD1 [Q5T700]3EBI-745213,EBI-10173166
LDOC1 [O95751]3EBI-745213,EBI-740738
LIME1 [Q9H400]3EBI-745213,EBI-2830566
LPXN [O60711]3EBI-745213,EBI-744222
LRRC59 [Q96AG4]3EBI-745213,EBI-358888
MDFI [Q99750]7EBI-745213,EBI-724076
MGST3 [O14880]3EBI-745213,EBI-724754
MID2 - isoform 2 [Q9UJV3-2]3EBI-745213,EBI-10172526
MIF4GD - isoform 2 [A9UHW6-2]3EBI-745213,EBI-9118295
MKRN3 [Q13064]3EBI-745213,EBI-2340269
MRM1 [Q6IN84]3EBI-745213,EBI-5454865
MTUS2 [Q5JR59]3EBI-745213,EBI-742948
MTUS2 - isoform 2 [Q5JR59-3]3EBI-745213,EBI-11522433
MUC1 - isoform Y-LSP [P15941-11]3EBI-745213,EBI-17263240
MYF5 [P13349]3EBI-745213,EBI-17491620
NOTCH2NLA [Q7Z3S9]3EBI-745213,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-745213,EBI-22310682
PGPEP1 - isoform 2 [Q9NXJ5-2]3EBI-745213,EBI-12813581
PLA2G10 [O15496]3EBI-745213,EBI-726466
PLSCR2 [Q9NRY7]3EBI-745213,EBI-3937430
PRDM14 [Q9GZV8]3EBI-745213,EBI-3957793
PRDM6 [Q9NQX0]3EBI-745213,EBI-11320284
RBAK [Q9NYW8]3EBI-745213,EBI-1210429
REL - isoform 2 [Q04864-2]3EBI-745213,EBI-10829018
RGS17 [Q9UGC6]6EBI-745213,EBI-3918154
RGS20 [O76081]3EBI-745213,EBI-1052678
RGS20 - isoform 5 [O76081-6]3EBI-745213,EBI-10178530
RIMBP3 [Q9UFD9]3EBI-745213,EBI-10182375
RNF122 [Q9H9V4]3EBI-745213,EBI-2129998
SAR1A [Q9NR31]3EBI-745213,EBI-3920694
SIAH1 [Q8IUQ4]3EBI-745213,EBI-747107
SIVA1 - isoform 2 [O15304-2]3EBI-745213,EBI-12372219
SLC15A2 [Q16348]3EBI-745213,EBI-12806032
SLC39A2 [Q9NP94]3EBI-745213,EBI-12898013
SPDYA [Q5MJ70]3EBI-745213,EBI-7125479
SPRED1 [Q7Z699]3EBI-745213,EBI-5235340
SPRED2 [Q7Z698]3EBI-745213,EBI-7082156
SPRY2 [O43597]3EBI-745213,EBI-742487
SPRY3 [O43610]3EBI-745213,EBI-12290641
SPRYD7 - isoform 2 [Q5W111-2]3EBI-745213,EBI-12408727
SSMEM1 [Q8WWF3]3EBI-745213,EBI-17280858
TCF4 [P15884]3EBI-745213,EBI-533224
TMEM237 - isoform 2 [Q96Q45-2]3EBI-745213,EBI-10982110
TMEM38B [Q9NVV0]3EBI-745213,EBI-1055114
TMEM45B [Q96B21]3EBI-745213,EBI-3923061
TMEM80 [Q96HE8]3EBI-745213,EBI-11742770
TMPRSS2 - isoform 2 [O15393-2]3EBI-745213,EBI-12345267
TNK2 [Q07912]3EBI-745213,EBI-603457
TNS2 [Q63HR2]3EBI-745213,EBI-949753
TRAF1 [Q13077]3EBI-745213,EBI-359224
TRAF2 [Q12933]3EBI-745213,EBI-355744
TRIM23 [P36406]6EBI-745213,EBI-740098
TRIM37 [O94972]3EBI-745213,EBI-741602
TRIM41 [Q8WV44]3EBI-745213,EBI-725997
TRIM42 [Q8IWZ5]3EBI-745213,EBI-5235829
TRIM7 [Q9C029]3EBI-745213,EBI-2813981
TRIP6 [Q15654]7EBI-745213,EBI-742327
TSC1 [Q86WV8]3EBI-745213,EBI-12806590
WRB [O00258]3EBI-745213,EBI-18908258
ZBTB39 [O15060]3EBI-745213,EBI-9995672
ZIM2 [Q9NZV7]3EBI-745213,EBI-11962760
ZNF16 [P17020]3EBI-745213,EBI-3921553
ZNF398 [Q8TD17]3EBI-745213,EBI-8643207
ZNF792 [Q3KQV3]3EBI-745213,EBI-10240849

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106854, 46 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P29972

Database of interacting proteins

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DIPi
DIP-29607N

Protein interaction database and analysis system

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IntActi
P29972, 144 interactors

Molecular INTeraction database

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MINTi
P29972

STRING: functional protein association networks

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STRINGi
9606.ENSP00000311165

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P29972

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P29972 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1269
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29972

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P29972

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi76 – 78NPA 13
Motifi192 – 194NPA 23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi159 – 162Poly-Arg4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0223 Eukaryota
COG0580 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157015

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020019_3_3_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P29972

KEGG Orthology (KO)

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KOi
K09864

Identification of Orthologs from Complete Genome Data

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OMAi
ELFGTFW

Database of Orthologous Groups

More...
OrthoDBi
1152704at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P29972

TreeFam database of animal gene trees

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TreeFami
TF312940

Family and domain databases

Conserved Domains Database

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CDDi
cd00333 MIP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1080.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023271 Aquaporin-like
IPR023274 Aquaporin_1
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS

The PANTHER Classification System

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PANTHERi
PTHR19139 PTHR19139, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00230 MIP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02013 AQUAPORIN1
PR00783 MINTRINSICP

Superfamily database of structural and functional annotation

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SUPFAMi
SSF81338 SSF81338, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00861 MIP, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00221 MIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P29972-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASEFKKKLF WRAVVAEFLA TTLFVFISIG SALGFKYPVG NNQTAVQDNV
60 70 80 90 100
KVSLAFGLSI ATLAQSVGHI SGAHLNPAVT LGLLLSCQIS IFRALMYIIA
110 120 130 140 150
QCVGAIVATA ILSGITSSLT GNSLGRNDLA DGVNSGQGLG IEIIGTLQLV
160 170 180 190 200
LCVLATTDRR RRDLGGSAPL AIGLSVALGH LLAIDYTGCG INPARSFGSA
210 220 230 240 250
VITHNFSNHW IFWVGPFIGG ALAVLIYDFI LAPRSSDLTD RVKVWTSGQV
260
EEYDLDADDI NSRVEMKPK
Length:269
Mass (Da):28,526
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA204D82FB26352E
GO
Isoform 2 (identifier: P29972-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MASEFKKKLF...KYPVGNNQTA → MPGARPLPLV...LGRVGPGSRQ
     46-128: Missing.

Show »
Length:186
Mass (Da):19,956
Checksum:i5C132B4A21FCC8BC
GO
Isoform 3 (identifier: P29972-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: MASEFKKKLF...LTGNSLGRND → MFWTFGYEAV...LGRVGPGSRQ

Show »
Length:218
Mass (Da):23,425
Checksum:i409D14C5A0F352CE
GO
Isoform 4 (identifier: P29972-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MASEFKKKLFWRA → MQSGMGWNVLDFW
     14-128: Missing.

Show »
Length:154
Mass (Da):16,677
Checksum:i764FA0B49CB3B1FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494C1U4A0A494C1U4_HUMAN
Aquaporin-1
AQP1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C115A0A494C115_HUMAN
Aquaporin-1
AQP1
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45A → T in AAH22486 (PubMed:15489334).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

AQP1 is responsible for the Colton blood group system [MIMi:110450]. Approximately 92% of Caucasians are Co(A+B-) (Ala-45), approximately 8% are Co(A+B+), and only 0.2% are Co(A-B+) (Val-45). Co(A-B-) which is very rare, is due to a complete absence of AQP1.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01327938P → L in Co(A-B-) antigen; non functional AQP1; red cells show low osmotic water permeability. 1 PublicationCorresponds to variant dbSNP:rs104894004EnsemblClinVar.1
Natural variantiVAR_00440045A → V in Co(A-B+) antigen. 2 PublicationsCorresponds to variant dbSNP:rs28362692EnsemblClinVar.1
Natural variantiVAR_022318165G → D1 PublicationCorresponds to variant dbSNP:rs28362731Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0466791 – 128MASEF…LGRND → MFWTFGYEAVSPAGPSHLFA SLLLGVLLTITFMPGARPLP LVLVPQNTLAWMQLDAKAPA HPRPLQLLGRVGPGSRQ in isoform 3. CuratedAdd BLAST128
Alternative sequenceiVSP_0461091 – 45MASEF…NNQTA → MPGARPLPLVLVPQNTLAWM QLDAKAPAHPRPLQLLGRVG PGSRQ in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_0466801 – 13MASEF…LFWRA → MQSGMGWNVLDFW in isoform 4. CuratedAdd BLAST13
Alternative sequenceiVSP_04668114 – 128Missing in isoform 4. CuratedAdd BLAST115
Alternative sequenceiVSP_04611046 – 128Missing in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M77829 mRNA Translation: AAA58425.1
U41517 mRNA Translation: AAC50648.1
U41518 mRNA Translation: AAC50649.1
S73482 mRNA Translation: AAB31193.1
AK309608 mRNA No translation available.
AY953319 Genomic DNA Translation: AAX24129.1
AC004691 Genomic DNA Translation: AAC16481.1
AC005155 Genomic DNA Translation: AAC23788.1
AB451275 mRNA Translation: BAG70089.1
AB451402 mRNA Translation: BAG70216.1
CH471073 Genomic DNA Translation: EAW93971.1
BC022486 mRNA Translation: AAH22486.1
AF480415 Genomic DNA Translation: AAL87136.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5431.1 [P29972-1]

Protein sequence database of the Protein Information Resource

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PIRi
A41616
I52366

NCBI Reference Sequences

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RefSeqi
NP_932766.1, NM_198098.3 [P29972-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311813; ENSP00000311165; ENSG00000240583 [P29972-1]
ENST00000409611; ENSP00000387178; ENSG00000240583 [P29972-3]
ENST00000409899; ENSP00000386712; ENSG00000240583 [P29972-4]
ENST00000441328; ENSP00000405698; ENSG00000240583 [P29972-2]
ENST00000652696; ENSP00000498672; ENSG00000240583 [P29972-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
358

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:358

UCSC genome browser

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UCSCi
uc003tbv.3 human [P29972-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs
Protein Spotlight

Liquid states - Issue 36 of July 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77829 mRNA Translation: AAA58425.1
U41517 mRNA Translation: AAC50648.1
U41518 mRNA Translation: AAC50649.1
S73482 mRNA Translation: AAB31193.1
AK309608 mRNA No translation available.
AY953319 Genomic DNA Translation: AAX24129.1
AC004691 Genomic DNA Translation: AAC16481.1
AC005155 Genomic DNA Translation: AAC23788.1
AB451275 mRNA Translation: BAG70089.1
AB451402 mRNA Translation: BAG70216.1
CH471073 Genomic DNA Translation: EAW93971.1
BC022486 mRNA Translation: AAH22486.1
AF480415 Genomic DNA Translation: AAL87136.1
CCDSiCCDS5431.1 [P29972-1]
PIRiA41616
I52366
RefSeqiNP_932766.1, NM_198098.3 [P29972-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FQYX-ray3.80A1-269[»]
1H6IX-ray3.54A1-269[»]
1IH5X-ray3.70A1-269[»]
4CSKX-ray3.28A1-269[»]
6POJNMR-A1-269[»]
SMRiP29972
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi106854, 46 interactors
CORUMiP29972
DIPiDIP-29607N
IntActiP29972, 144 interactors
MINTiP29972
STRINGi9606.ENSP00000311165

Chemistry databases

BindingDBiP29972
DrugBankiDB00819 Acetazolamide
DB02451 B-nonylglucoside
DB09338 Mersalyl
DrugCentraliP29972

Protein family/group databases

TCDBi1.A.8.8.1 the major intrinsic protein (mip) family

PTM databases

iPTMnetiP29972
PhosphoSitePlusiP29972

Polymorphism and mutation databases

BioMutaiAQP1
DMDMi267412

Proteomic databases

EPDiP29972
jPOSTiP29972
MassIVEiP29972
PaxDbiP29972
PeptideAtlasiP29972
PRIDEiP29972
ProteomicsDBi16873
19345
24598
54613 [P29972-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
35017 533 antibodies

The DNASU plasmid repository

More...
DNASUi
358

Genome annotation databases

EnsembliENST00000311813; ENSP00000311165; ENSG00000240583 [P29972-1]
ENST00000409611; ENSP00000387178; ENSG00000240583 [P29972-3]
ENST00000409899; ENSP00000386712; ENSG00000240583 [P29972-4]
ENST00000441328; ENSP00000405698; ENSG00000240583 [P29972-2]
ENST00000652696; ENSP00000498672; ENSG00000240583 [P29972-1]
GeneIDi358
KEGGihsa:358
UCSCiuc003tbv.3 human [P29972-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
358
DisGeNETi358

GeneCards: human genes, protein and diseases

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GeneCardsi
AQP1
HGNCiHGNC:633 AQP1
HPAiENSG00000240583 Tissue enhanced (kidney)
MalaCardsiAQP1
MIMi107776 gene
110450 phenotype
neXtProtiNX_P29972
OpenTargetsiENSG00000240583
PharmGKBiPA24918

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00940000157015
HOGENOMiCLU_020019_3_3_1
InParanoidiP29972
KOiK09864
OMAiELFGTFW
OrthoDBi1152704at2759
PhylomeDBiP29972
TreeFamiTF312940

Enzyme and pathway databases

ReactomeiR-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-432047 Passive transport by Aquaporins
SIGNORiP29972

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AQP1 human
EvolutionaryTraceiP29972

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Aquaporin_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
358
PharosiP29972 Tbio

Protein Ontology

More...
PROi
PR:P29972
RNActiP29972 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000240583 Expressed in right lung and 221 other tissues
ExpressionAtlasiP29972 baseline and differential
GenevisibleiP29972 HS

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023274 Aquaporin_1
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02013 AQUAPORIN1
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAQP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29972
Secondary accession number(s): B5BU39
, E7EM69, E9PC21, F5GY19, Q8TBI5, Q8TDC1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: April 22, 2020
This is version 222 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  8. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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