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Entry version 178 (22 Apr 2020)
Sequence version 4 (23 Jan 2007)
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Protein

Myristoylated alanine-rich C-kinase substrate

Gene

MARCKS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-399997 Acetylcholine regulates insulin secretion

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P29966

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myristoylated alanine-rich C-kinase substrate
Short name:
MARCKS
Alternative name(s):
Protein kinase C substrate, 80 kDa protein, light chain
Short name:
80K-L protein
Short name:
PKCSL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MARCKS
Synonyms:MACS, PRKCSL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6759 MARCKS

Online Mendelian Inheritance in Man (OMIM)

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MIMi
177061 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29966

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4082

Open Targets

More...
OpenTargetsi
ENSG00000277443

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30637

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P29966 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MARCKS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
76803798

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001571482 – 332Myristoylated alanine-rich C-kinase substrateAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26PhosphoserineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei29PhosphoserineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei128PhosphoserineBy similarity1
Modified residuei135PhosphoserineCombined sources1
Modified residuei143PhosphothreonineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei150PhosphothreonineCombined sources1
Modified residuei159Phosphoserine; by PKC1 Publication1
Modified residuei163Phosphoserine; by PKCCombined sources1 Publication1
Modified residuei167Phosphoserine; by PKCCombined sources1
Modified residuei170Phosphoserine; by PKCCombined sources1 Publication1
Modified residuei262PhosphoserineBy similarity1
Modified residuei314PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-976

Encyclopedia of Proteome Dynamics

More...
EPDi
P29966

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P29966

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P29966

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P29966

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29966

PeptideAtlas

More...
PeptideAtlasi
P29966

PRoteomics IDEntifications database

More...
PRIDEi
P29966

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54612

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P29966

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29966

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P29966

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P29966

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000277443 Expressed in forebrain and 239 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P29966 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000277443 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110257, 45 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P29966

Protein interaction database and analysis system

More...
IntActi
P29966, 20 interactors

Molecular INTeraction database

More...
MINTi
P29966

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000478061

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P29966 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P29966

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni152 – 176Calmodulin-binding (PSD)Add BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MARCKS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J04K Eukaryota
ENOG4111SZ0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111419

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_073091_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P29966

KEGG Orthology (KO)

More...
KOi
K12561

Identification of Orthologs from Complete Genome Data

More...
OMAi
VRRDAQN

Database of Orthologous Groups

More...
OrthoDBi
1636177at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332815

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002101 MARCKS

The PANTHER Classification System

More...
PANTHERi
PTHR14353 PTHR14353, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02063 MARCKS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00963 MARCKS

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00826 MARCKS_1, 1 hit
PS00827 MARCKS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P29966-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAQFSKTAA KGEAAAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA
60 70 80 90 100
ESGAKEELQA NGSAPAADKE EPAAAGSGAA SPSAAEKGEP AAAAAPEAGA
110 120 130 140 150
SPVEKEAPAE GEAAEPGSPT AAEGEAASAA SSTSSPKAED GATPSPSNET
160 170 180 190 200
PKKKKKRFSF KKSFKLSGFS FKKNKKEAGE GGEAEAPAAE GGKDEAAGGA
210 220 230 240 250
AAAAAEAGAA SGEQAAAPGE EAAAGEEGAA GGDPQEAKPQ EAAVAPEKPP
260 270 280 290 300
ASDETKAAEE PSKVEEKKAE EAGASAAACE APSAAGPGAP PEQEAAPAEE
310 320 330
PAAAAASSAC AAPSQEAQPE CSPEAPPAEA AE
Length:332
Mass (Da):31,555
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0AB247801EF8FCBF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84A → S in BAA01392 (PubMed:1427823).Curated1
Sequence conflicti119P → A in BAA01392 (PubMed:1427823).Curated1
Sequence conflicti225G → R (PubMed:1396720).Curated1
Sequence conflicti234P → S in AAA59555 (PubMed:1860846).Curated1
Sequence conflicti235Q → E (PubMed:1396720).Curated1
Sequence conflicti287 – 308PGAPP…AAASS → LVCPRRGGSPRGGARGRRSL NQ in AAA59555 (PubMed:1860846).CuratedAdd BLAST22

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025825250P → L1 PublicationCorresponds to variant dbSNP:rs45593337Ensembl.1
Natural variantiVAR_025826274A → V1 PublicationCorresponds to variant dbSNP:rs3734458Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M68956 mRNA Translation: AAA59555.1
M68955 Genomic DNA Translation: AAA59554.1
D10522 mRNA Translation: BAA01392.1
DQ341274 Genomic DNA Translation: ABC67467.1
AL132660 Genomic DNA Translation: CAI19942.1
CH471051 Genomic DNA Translation: EAW48258.1
CH471051 Genomic DNA Translation: EAW48259.1
BC089040 mRNA Translation: AAH89040.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5101.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A38873

NCBI Reference Sequences

More...
RefSeqi
NP_002347.5, NM_002356.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000612661; ENSP00000478061; ENSG00000277443

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4082

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4082

UCSC genome browser

More...
UCSCi
uc032xir.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68956 mRNA Translation: AAA59555.1
M68955 Genomic DNA Translation: AAA59554.1
D10522 mRNA Translation: BAA01392.1
DQ341274 Genomic DNA Translation: ABC67467.1
AL132660 Genomic DNA Translation: CAI19942.1
CH471051 Genomic DNA Translation: EAW48258.1
CH471051 Genomic DNA Translation: EAW48259.1
BC089040 mRNA Translation: AAH89040.1
CCDSiCCDS5101.1
PIRiA38873
RefSeqiNP_002347.5, NM_002356.6

3D structure databases

SMRiP29966
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110257, 45 interactors
ELMiP29966
IntActiP29966, 20 interactors
MINTiP29966
STRINGi9606.ENSP00000478061

PTM databases

iPTMnetiP29966
PhosphoSitePlusiP29966
SwissPalmiP29966

Polymorphism and mutation databases

BioMutaiMARCKS
DMDMi76803798

Proteomic databases

CPTACiCPTAC-976
EPDiP29966
jPOSTiP29966
MassIVEiP29966
MaxQBiP29966
PaxDbiP29966
PeptideAtlasiP29966
PRIDEiP29966
ProteomicsDBi54612
TopDownProteomicsiP29966

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
72851 858 antibodies

The DNASU plasmid repository

More...
DNASUi
4082

Genome annotation databases

EnsembliENST00000612661; ENSP00000478061; ENSG00000277443
GeneIDi4082
KEGGihsa:4082
UCSCiuc032xir.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4082
DisGeNETi4082

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MARCKS
HGNCiHGNC:6759 MARCKS
HPAiENSG00000277443 Low tissue specificity
MIMi177061 gene
neXtProtiNX_P29966
OpenTargetsiENSG00000277443
PharmGKBiPA30637

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J04K Eukaryota
ENOG4111SZ0 LUCA
GeneTreeiENSGT00730000111419
HOGENOMiCLU_073091_0_0_1
InParanoidiP29966
KOiK12561
OMAiVRRDAQN
OrthoDBi1636177at2759
TreeFamiTF332815

Enzyme and pathway databases

ReactomeiR-HSA-399997 Acetylcholine regulates insulin secretion
SIGNORiP29966

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MARCKS human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MARCKS

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4082
PharosiP29966 Tbio

Protein Ontology

More...
PROi
PR:P29966
RNActiP29966 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000277443 Expressed in forebrain and 239 other tissues
GenevisibleiP29966 HS

Family and domain databases

InterProiView protein in InterPro
IPR002101 MARCKS
PANTHERiPTHR14353 PTHR14353, 1 hit
PfamiView protein in Pfam
PF02063 MARCKS, 1 hit
PRINTSiPR00963 MARCKS
PROSITEiView protein in PROSITE
PS00826 MARCKS_1, 1 hit
PS00827 MARCKS_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMARCS_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29966
Secondary accession number(s): E1P560, Q2LA83, Q5TDB7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: April 22, 2020
This is version 178 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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