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Protein

CD40 ligand

Gene

CD40LG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity).By similarity3 Publications
Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • CD40 receptor binding Source: UniProtKB
  • cytokine activity Source: UniProtKB-KW
  • tumor necrosis factor receptor binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P29965

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD40 ligand
Short name:
CD40-L
Alternative name(s):
T-cell antigen Gp39
TNF-related activation protein
Short name:
TRAP
Tumor necrosis factor ligand superfamily member 5
CD_antigen: CD154
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD40LG
Synonyms:CD40L, TNFSF5, TRAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000102245.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11935 CD40LG

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300386 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29965

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei23 – 46Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST24
Topological domaini47 – 261ExtracellularSequence analysisAdd BLAST215

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency with hyper-IgM, type 1 (HIGM1)11 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionImmunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
See also OMIM:308230
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00751336M → R in HIGM1. 2 PublicationsCorresponds to variant dbSNP:rs104894774EnsemblClinVar.1
Natural variantiVAR_01792538G → R in HIGM1. 1 Publication1
Natural variantiVAR_017929116G → R in HIGM1. 1
Natural variantiVAR_017930116G → S in HIGM1. 2 Publications1
Natural variantiVAR_007514123A → E in HIGM1. 1 PublicationCorresponds to variant dbSNP:rs104894778EnsemblClinVar.1
Natural variantiVAR_017926125H → R in HIGM1. 1 Publication1
Natural variantiVAR_007515126V → A in HIGM1. 1 Publication1
Natural variantiVAR_017931126V → D in HIGM1. 1
Natural variantiVAR_007516128 – 129SE → RG in HIGM1. 2
Natural variantiVAR_007517140W → C in HIGM1. 1 Publication1
Natural variantiVAR_007518140W → G in HIGM1. 1 PublicationCorresponds to variant dbSNP:rs104894777EnsemblClinVar.1
Natural variantiVAR_007519140W → R in HIGM1. 1 Publication1
Natural variantiVAR_017932143K → T in HIGM1. 1
Natural variantiVAR_007520144G → E in HIGM1. 1 PublicationCorresponds to variant dbSNP:rs886039326EnsemblClinVar.1
Natural variantiVAR_017922147T → N in HIGM1. 1 PublicationCorresponds to variant dbSNP:rs1057521127Ensembl.1
Natural variantiVAR_007521155L → P in HIGM1. 2 PublicationsCorresponds to variant dbSNP:rs104894769EnsemblClinVar.1
Natural variantiVAR_017923170Y → C in HIGM1. 1 PublicationCorresponds to variant dbSNP:rs756468554Ensembl.1
Natural variantiVAR_017933173A → D in HIGM1. 1
Natural variantiVAR_017927174Q → R in HIGM1. 1 Publication1
Natural variantiVAR_017934176T → I in HIGM1. 1
Natural variantiVAR_017935195L → P in HIGM1. 1
Natural variantiVAR_017936208A → D in HIGM1. 1
Natural variantiVAR_007522211T → N in HIGM1. 1 Publication1
Natural variantiVAR_017937224H → Y in HIGM1. 1
Natural variantiVAR_017938226G → A in HIGM1. 1
Natural variantiVAR_007524227G → V in HIGM1. 3 PublicationsCorresponds to variant dbSNP:rs104894768EnsemblClinVar.1
Natural variantiVAR_007525227Missing in HIGM1. 1 Publication1
Natural variantiVAR_007526231L → S in HIGM1. 2 Publications1
Natural variantiVAR_007527235A → P in HIGM1. 2 PublicationsCorresponds to variant dbSNP:rs104894771EnsemblClinVar.1
Natural variantiVAR_017939237V → E in HIGM1. 1 Publication1
Natural variantiVAR_007528254T → M in HIGM1. 2 PublicationsCorresponds to variant dbSNP:rs193922136EnsemblClinVar.1
Natural variantiVAR_017940257G → D in HIGM1. 1
Natural variantiVAR_017928257G → S in HIGM1. 1 Publication1
Natural variantiVAR_017924258L → S in HIGM1. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
959

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
CD40LG

MalaCards human disease database

More...
MalaCardsi
CD40LG
MIMi308230 phenotype

Open Targets

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OpenTargetsi
ENSG00000102245

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
101088 X-linked hyper-IgM syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36626

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3580491

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD40LG

Domain mapping of disease mutations (DMDM)

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DMDMi
231718

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000344841 – 261CD40 ligand, membrane formAdd BLAST261
ChainiPRO_0000034485113 – 261CD40 ligand, soluble form1 PublicationAdd BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi178 ↔ 218Sequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi240N-linked (GlcNAc...) (complex) asparagine; alternate1 Publication1
Glycosylationi240N-linked (GlcNAc...) (high mannose) asparagine; alternate1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.1 Publication
N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.1 Publication
Not O-glycosylated.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei112 – 113Cleavage2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P29965

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P29965

PeptideAtlas

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PeptideAtlasi
P29965

PRoteomics IDEntifications database

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PRIDEi
P29965

ProteomicsDB human proteome resource

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ProteomicsDBi
54611

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
610

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P29965

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P29965

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P29965

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P29965

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed on activated CD4+ T-lymphocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102245 Expressed in 63 organ(s), highest expression level in leukocyte

CleanEx database of gene expression profiles

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CleanExi
HS_CD40LG

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P29965 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P29965 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045827

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (PubMed:8589998, PubMed:8626375, PubMed:11676606). Interacts with isoform 3 of CD28 (PubMed:15067037).4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107397, 9 interactors

Database of interacting proteins

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DIPi
DIP-3013N

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359663

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P29965

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29965

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P29965

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IVYF Eukaryota
ENOG4111TET LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153350

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000111291

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG079629

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P29965

KEGG Orthology (KO)

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KOi
K03161

Identification of Orthologs from Complete Genome Data

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OMAi
NCEEIRS

Database of Orthologous Groups

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OrthoDBi
EOG091G0I9G

Database for complete collections of gene phylogenies

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PhylomeDBi
P29965

TreeFam database of animal gene trees

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TreeFami
TF332169

Family and domain databases

Conserved Domains Database

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CDDi
cd00184 TNF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.40, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003263 CD40L
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom

The PANTHER Classification System

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PANTHERi
PTHR11471:SF5 PTHR11471:SF5, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00229 TNF, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF016527 TNF_5, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01702 CD40LIGAND

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00207 TNF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49842 SSF49842, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P29965-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIETYNQTSP RSAATGLPIS MKIFMYLLTV FLITQMIGSA LFAVYLHRRL
60 70 80 90 100
DKIEDERNLH EDFVFMKTIQ RCNTGERSLS LLNCEEIKSQ FEGFVKDIML
110 120 130 140 150
NKEETKKENS FEMQKGDQNP QIAAHVISEA SSKTTSVLQW AEKGYYTMSN
160 170 180 190 200
NLVTLENGKQ LTVKRQGLYY IYAQVTFCSN REASSQAPFI ASLCLKSPGR
210 220 230 240 250
FERILLRAAN THSSAKPCGQ QSIHLGGVFE LQPGASVFVN VTDPSQVSHG
260
TGFTSFGLLK L
Length:261
Mass (Da):29,274
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16F5CEB093BCC2BB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3L8U2Q3L8U2_HUMAN
CD40 ligand
CD40LG TNFSF5
240Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00751336M → R in HIGM1. 2 PublicationsCorresponds to variant dbSNP:rs104894774EnsemblClinVar.1
Natural variantiVAR_01792538G → R in HIGM1. 1 Publication1
Natural variantiVAR_017929116G → R in HIGM1. 1
Natural variantiVAR_017930116G → S in HIGM1. 2 Publications1
Natural variantiVAR_007514123A → E in HIGM1. 1 PublicationCorresponds to variant dbSNP:rs104894778EnsemblClinVar.1
Natural variantiVAR_017926125H → R in HIGM1. 1 Publication1
Natural variantiVAR_007515126V → A in HIGM1. 1 Publication1
Natural variantiVAR_017931126V → D in HIGM1. 1
Natural variantiVAR_007516128 – 129SE → RG in HIGM1. 2
Natural variantiVAR_007517140W → C in HIGM1. 1 Publication1
Natural variantiVAR_007518140W → G in HIGM1. 1 PublicationCorresponds to variant dbSNP:rs104894777EnsemblClinVar.1
Natural variantiVAR_007519140W → R in HIGM1. 1 Publication1
Natural variantiVAR_017932143K → T in HIGM1. 1
Natural variantiVAR_007520144G → E in HIGM1. 1 PublicationCorresponds to variant dbSNP:rs886039326EnsemblClinVar.1
Natural variantiVAR_017922147T → N in HIGM1. 1 PublicationCorresponds to variant dbSNP:rs1057521127Ensembl.1
Natural variantiVAR_007521155L → P in HIGM1. 2 PublicationsCorresponds to variant dbSNP:rs104894769EnsemblClinVar.1
Natural variantiVAR_017923170Y → C in HIGM1. 1 PublicationCorresponds to variant dbSNP:rs756468554Ensembl.1
Natural variantiVAR_017933173A → D in HIGM1. 1
Natural variantiVAR_017927174Q → R in HIGM1. 1 Publication1
Natural variantiVAR_017934176T → I in HIGM1. 1
Natural variantiVAR_017935195L → P in HIGM1. 1
Natural variantiVAR_017936208A → D in HIGM1. 1
Natural variantiVAR_007522211T → N in HIGM1. 1 Publication1
Natural variantiVAR_007523219G → R1 PublicationCorresponds to variant dbSNP:rs148594123EnsemblClinVar.1
Natural variantiVAR_017937224H → Y in HIGM1. 1
Natural variantiVAR_017938226G → A in HIGM1. 1
Natural variantiVAR_007524227G → V in HIGM1. 3 PublicationsCorresponds to variant dbSNP:rs104894768EnsemblClinVar.1
Natural variantiVAR_007525227Missing in HIGM1. 1 Publication1
Natural variantiVAR_007526231L → S in HIGM1. 2 Publications1
Natural variantiVAR_007527235A → P in HIGM1. 2 PublicationsCorresponds to variant dbSNP:rs104894771EnsemblClinVar.1
Natural variantiVAR_017939237V → E in HIGM1. 1 Publication1
Natural variantiVAR_007528254T → M in HIGM1. 2 PublicationsCorresponds to variant dbSNP:rs193922136EnsemblClinVar.1
Natural variantiVAR_017940257G → D in HIGM1. 1
Natural variantiVAR_017928257G → S in HIGM1. 1 Publication1
Natural variantiVAR_017924258L → S in HIGM1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X68550 mRNA Translation: CAA48554.1
Z15017 mRNA Translation: CAA78737.1
X67878 mRNA Translation: CAA48077.1
L07414 mRNA Translation: AAA35662.1
D31797 Genomic DNA Translation: BAA06599.1
BC071754 mRNA Translation: AAH71754.1
BC074950 mRNA Translation: AAH74950.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14659.1

Protein sequence database of the Protein Information Resource

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PIRi
S28017 I53476

NCBI Reference Sequences

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RefSeqi
NP_000065.1, NM_000074.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.592244

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000370629; ENSP00000359663; ENSG00000102245

Database of genes from NCBI RefSeq genomes

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GeneIDi
959

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:959

UCSC genome browser

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UCSCi
uc004faa.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

CD40Lbase

CD40L defect database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68550 mRNA Translation: CAA48554.1
Z15017 mRNA Translation: CAA78737.1
X67878 mRNA Translation: CAA48077.1
L07414 mRNA Translation: AAA35662.1
D31797 Genomic DNA Translation: BAA06599.1
BC071754 mRNA Translation: AAH71754.1
BC074950 mRNA Translation: AAH74950.1
CCDSiCCDS14659.1
PIRiS28017 I53476
RefSeqiNP_000065.1, NM_000074.2
UniGeneiHs.592244

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ALYX-ray2.00A116-261[»]
1I9RX-ray3.10A/B/C116-261[»]
3LKJX-ray2.50A/B/C121-261[»]
3QD6X-ray3.50A/B/C/D/E/F116-261[»]
ProteinModelPortaliP29965
SMRiP29965
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107397, 9 interactors
DIPiDIP-3013N
STRINGi9606.ENSP00000359663

Chemistry databases

ChEMBLiCHEMBL3580491

PTM databases

GlyConnecti610
iPTMnetiP29965
PhosphoSitePlusiP29965
UniCarbKBiP29965

Polymorphism and mutation databases

BioMutaiCD40LG
DMDMi231718

Proteomic databases

MaxQBiP29965
PaxDbiP29965
PeptideAtlasiP29965
PRIDEiP29965
ProteomicsDBi54611

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
959
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370629; ENSP00000359663; ENSG00000102245
GeneIDi959
KEGGihsa:959
UCSCiuc004faa.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
959
DisGeNETi959
EuPathDBiHostDB:ENSG00000102245.7

GeneCards: human genes, protein and diseases

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GeneCardsi
CD40LG
GeneReviewsiCD40LG
HGNCiHGNC:11935 CD40LG
HPAiHPA045827
MalaCardsiCD40LG
MIMi300386 gene
308230 phenotype
neXtProtiNX_P29965
OpenTargetsiENSG00000102245
Orphaneti101088 X-linked hyper-IgM syndrome
PharmGKBiPA36626

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVYF Eukaryota
ENOG4111TET LUCA
GeneTreeiENSGT00940000153350
HOGENOMiHOG000111291
HOVERGENiHBG079629
InParanoidiP29965
KOiK03161
OMAiNCEEIRS
OrthoDBiEOG091G0I9G
PhylomeDBiP29965
TreeFamiTF332169

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
SIGNORiP29965

Miscellaneous databases

EvolutionaryTraceiP29965

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD154

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
959
PMAP-CutDBiP29965

Protein Ontology

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PROi
PR:P29965

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102245 Expressed in 63 organ(s), highest expression level in leukocyte
CleanExiHS_CD40LG
ExpressionAtlasiP29965 baseline and differential
GenevisibleiP29965 HS

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR003263 CD40L
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR11471:SF5 PTHR11471:SF5, 1 hit
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PIRSFiPIRSF016527 TNF_5, 1 hit
PRINTSiPR01702 CD40LIGAND
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD40L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29965
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: December 5, 2018
This is version 204 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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