Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 72 (10 Apr 2019)
Sequence version 1 (01 Apr 1993)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Aerobic cobaltochelatase subunit CobN

Gene

cobN

Organism
Sinorhizobium sp.
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes cobalt insertion in the corrin ring.

Caution

Was originally thought to originate from Pseudomonas denitrificans, but similarity searches show that the sequence is much closer to Sinorhizobium. The entry's taxonomy has been changed.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 10 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route).
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. Precorrin-2 C(20)-methyltransferase (cobI)
  2. Precorrin-3B synthase (cobG)
  3. Precorrin-3B C(17)-methyltransferase (cobJ)
  4. Precorrin-4 C(11)-methyltransferase (cobM)
  5. Precorrin-6A synthase [deacetylating] (cobF)
  6. Precorrin-6A reductase (cobK)
  7. Precorrin-6Y C(5,15)-methyltransferase [decarboxylating] (cobL)
  8. Precorrin-8X methylmutase (cobH)
  9. Hydrogenobyrinate a,c-diamide synthase (cobB)
  10. Aerobic cobaltochelatase subunit CobT (cobT), Aerobic cobaltochelatase subunit CobS (cobS), Aerobic cobaltochelatase subunit CobN (cobN)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processCobalamin biosynthesis, Porphyrin biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-121

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00148;UER00221

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aerobic cobaltochelatase subunit CobN (EC:6.6.1.2)
Alternative name(s):
Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cobN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSinorhizobium sp.
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri42445 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000899911 – 1275Aerobic cobaltochelatase subunit CobNAdd BLAST1275

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P29929

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer of CobN, CobS and CobT.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P29929

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CobN family.Curated

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K02230

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011953 Cobalto_CobN
IPR003672 CobN/Mg_chltase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02514 CobN-Mg_chel, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02257 cobalto_cobN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P29929-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLLLAQKGT IADGNEAIDL GQTPADILFL SAADTELSSI AAAHGRRDGG
60 70 80 90 100
LSLRIASLMS LMHPMSVDTY VERTARHAKL IVVRPLGGAS YFRYLLEALH
110 120 130 140 150
AAAVTHRFEI AVLPGDDKPD PGLEPFSTVA ADDRQRLWAY FTEGGSDNAG
160 170 180 190 200
LFLDYAAALV TGAEKPQPAK PLLKAGIWWP GAGVIGVSEW QSLVQGRMVA
210 220 230 240 250
REGFEPPTVG ICFYRALVQS GETRPVEALI DALEAEGVRA LPVFVSSLKD
260 270 280 290 300
AVSVGTLQAI FSEAAPDVVM NATGFAVSSP GADRQPTVLE STGAPVLQVI
310 320 330 340 350
FSGSSRAQWE TSPQGLMARD LAMNVALPEV DGRILARAVS FKAASIYDAK
360 370 380 390 400
VEANIVGHEP LEGRVRFAAD LAVNWANVRR AEPAERRIAI VMANYPNRDG
410 420 430 440 450
RLGNGVGLDT PAGTVEVLSA MAREGYAVGE VPADGDALIR FLMAGPTNAA
460 470 480 490 500
SHDREIRERI SLNDYKTFFD SLPKQIKDEV AGRWGVPEAD PFFLDGAFAL
510 520 530 540 550
PLARFGEVIV GIQPARGYNI DPKESYHSPD LVPPHGYLAF YAFLRQQFGA
560 570 580 590 600
QAIVHMGKHG NLEWLPGKAL ALSETCYPEA IFGPLPHIYP FIVNDPGEGT
610 620 630 640 650
QAKRRTSAVI IDHLTPPLTR AESYGPLKDL EALVDEYYDA AGGDPRRLRL
660 670 680 690 700
LSRQILDLVR DIGLDSDAGI DRGDSDDKAL EKLDAYLCDL KEMQIRDGLH
710 720 730 740 750
IFGVAPEGRL LTDLTVALAR VPRGLGEGGD QSLQRAIAAD AGLRGFAIPT
760 770 780 790 800
SAGGNPARDA QPFDPLDCVM SDTWTGPKPS ILADLSDAPW RTAGDTVERI
810 820 830 840 850
ELLAANLVSG ELACPDHWAN TRAVLGEIET RLKPSISNSG AAEMTGFLTG
860 870 880 890 900
LSGRFVAPGP SGAPTRGRPD VLPTGRNFYS VDSRAVPTPA AYELGKKSAE
910 920 930 940 950
LLIRRYLQDH GEWPSSFGLT AWGTANMRTG GDDIAQALAL IGAKPTWDMV
960 970 980 990 1000
SRRVMGYEIV PLAVLGRPRV DVTLRISGFF RDAFPDQIAL FDKAIRAVAL
1010 1020 1030 1040 1050
EEDDADNMIA ARMRAESRRL EAEGVEAAEA ARRASYRVFG AKPGAYGAAL
1060 1070 1080 1090 1100
QALIDEKGWE TKADLAEAYL TWGAYAYGAG EEGKAERDLF EERLRTIEAV
1110 1120 1130 1140 1150
VQNQDNREHD LLDSDDYYQF EGGMSAAAEQ LGGHRPAIYH NDHSRPEKPV
1160 1170 1180 1190 1200
IRSLEEEIGR VVRARVVNPK WIDGVMRHGY KGAFEIAATV DYMFAFAATT
1210 1220 1230 1240 1250
GAVRDHHFEA AYQAFIVDER VADFMRDKNP AAFAELAERL LEAIDRNLWT
1260 1270
PRSNSARFEL AGIGTAATRL RAGNE
Length:1,275
Mass (Da):138,056
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3FDF2858434E4C78
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M62866 Genomic DNA Translation: AAA25780.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ag:AAA25780

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62866 Genomic DNA Translation: AAA25780.1

3D structure databases

SMRiP29929
ModBaseiSearch...

Proteomic databases

PRIDEiP29929

Genome annotation databases

KEGGiag:AAA25780

Phylogenomic databases

KOiK02230

Enzyme and pathway databases

UniPathwayiUPA00148;UER00221
BioCyciMetaCyc:MONOMER-121

Family and domain databases

InterProiView protein in InterPro
IPR011953 Cobalto_CobN
IPR003672 CobN/Mg_chltase
PfamiView protein in Pfam
PF02514 CobN-Mg_chel, 1 hit
TIGRFAMsiTIGR02257 cobalto_cobN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOBN_SINSX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29929
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 10, 2019
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again