The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P29836 (ICP0_BHV1K)
Protein
E3 ubiquitin-protein ligase ICP0
Gene
BICP0
Organism
Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Status
Functioni
Evades nuclear antiviral defenses triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100.
By similarityCatalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 13 – 52 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- transferase activity Source: UniProtKB-KW
GO - Biological processi
- disruption by symbiont of host cell PML body Source: UniProtKB
- modulation by virus of host protein ubiquitination Source: UniProtKB-KW
- suppression by virus of host exit from mitosis Source: UniProtKB-KW
- suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase ICP0 (EC:2.3.2.27)Alternative name(s): IER 2.9/ER2.6 P135 protein RING-type E3 ubiquitin transferase ICP0Curated |
Gene namesi | Name:BICP0 |
Organismi | Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus) |
Taxonomic identifieri | 31519 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › |
Virus hosti | Bos taurus (Bovine) [TaxID: 9913] |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056357 | 1 – 676 | E3 ubiquitin-protein ligase ICP0Add BLAST | 676 |
Post-translational modificationi
Auto-ubiquitinated.By similarity
The strongly acidic region might serve as a transcriptional activation domain, possibly regulated through phosphorylation by casein kinase II.
Keywords - PTMi
Phosphoprotein, Ubl conjugationFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 101 – 135 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 266 – 486 | DisorderedSequence analysisAdd BLAST | 221 | |
Regioni | 555 – 676 | DisorderedSequence analysisAdd BLAST | 122 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 302 – 316 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 440 – 471 | Basic and acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 616 – 631 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 13 – 52 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
Keywords - Domaini
Zinc-fingerFamily and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P29836-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPPAAAPEL GSCCICLDAI TGAARALPCL HAFCLACIRR WLEGRPTCPL
60 70 80 90 100
CKAPVQSLIH SVASDECFEE IPVGGGPGAD GALEPDAAVI WGEDYDAGPI
110 120 130 140 150
DLTAADGEAP GAGGEAGAAG GSEAGGGAGG AEAAGEARGA GAGRAAGAAG
160 170 180 190 200
GRAGRGADAA QEFIDRVARG PRLPLLPNTP GHGPGAPYLR RVVEWVEGAL
210 220 230 240 250
VGTFAVTARE LAAMTDYVMA MLAECGFDDD GLADAMEPLI GEDDAPAFVR
260 270 280 290 300
SLLFVAARCV TVGPSHLIPQ QSAPPGGRGV VFLDTSDSDS EGSEDDSWSE
310 320 330 340 350
SEESSSGLST SDLTAIDDTE TEPETDAEVE SRRTRGASGA ARARRPAERQ
360 370 380 390 400
YVSTRGRQTP AVQPAPRSLA RRPCGRAAAV SAPPSSRSRG GRRDPRLPAA
410 420 430 440 450
PRAAPAAQAR ACSPEPREEG RGAGLGVAAG ETAGWGVGSE EGRGERRAKL
460 470 480 490 500
LGEAGPPRVQ ARRRRRTELD RAPTPAPAPA PAPAPISTMI DLTANAPARP
510 520 530 540 550
ADPAPAAALG PALAGAQIGT PAAAAAVTAA AAAPSVARGS APSPAVTAAA
560 570 580 590 600
TGTAAAISTR APTPSPAGRA PAADPRRAGA PALAGAARAE AGRNGNPGRE
610 620 630 640 650
RRPASAMARG DLDPGPESSA QKRRRTEMEV AAWVRESLLG TPRRSSAALA
660 670
PQPGGRQGPS LAGLLGRCSG GSAWRQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84464 Genomic DNA Translation: AAA46061.1 |
PIRi | A38209, EDBE22 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84464 Genomic DNA Translation: AAA46061.1 |
PIRi | A38209, EDBE22 |
3D structure databases
SMRi | P29836 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ICP0_BHV1K | |
Accessioni | P29836Primary (citable) accession number: P29836 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |